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The map label for this gene is dppA [H]

Identifier: 77461759

GI number: 77461759

Start: 6206756

End: 6208342

Strand: Direct

Name: dppA [H]

Synonym: Pfl01_5538

Alternate gene names: 77461759

Gene position: 6206756-6208342 (Clockwise)

Preceding gene: 77461756

Following gene: 77461761

Centisome position: 96.4

GC content: 61.94

Gene sequence:

>1587_bases
ATGCGCCTCGCTGCCCTCCCCCTGCTCTTCGCCCCGCTGTTACTGAGTCCACTGGCCCAGGCCGCCGCCCTGAGCGTCTG
CACCGAGGCCAGTCCCGAAGGCTTCGACGTGGTGCAGTACAACTCGTTGACCACCACCAACGCCTCGGCGGACGTGCTGA
TGAACCGTCTGGTGGATTTCGACACCGCCAGCGGCAAGGTCGTCCCGAGCCTGGCCGACAGCTGGGAAGTCAGCACCGAT
GGCCTGAGCTATGTGTTCAAACTGCACCCGCAGGTGAAGTTTCACACCACCGACTACTTCAAGCCGACCCGTGAACTGAC
CGCCGAAGACGTCAAATTCAGTTTCGACCGCATGCTCGACCCGGCCAACCCGTGGCACAAGGTCGCCCAGAGCGGCTTCC
CCCACGCCCAGTCGATGCAGTTGCCGAGCCTGATCAAGAAGATCGACGCGCTGGACCCGCTGACCGTGCGCTTCACCCTC
GACCACCCGGACTCGACATTCCTCGCGACCCTGAGCATGGGATTCGCCTCCATTTATTCTGCTGAATACGCCGACAAGCT
GCTGAAGGCTGGCGCGACCGATAAGCTCAACAGCCAACCGGTCGGCACTGGCCCGTTCGTGTTCACCCGCTTCCAGAAAG
ACGCCTCGATCCGCTACAAGGCCAACCCGGACTACGTCCGTGGCAAGCCTGCGGTGGACCCGCTGATTTTCGCCATCACT
CCGGACGCCAACGTGCGCCTGCAAAAGCTGCGGCGCAACGAGTGCCAGATTGCCTTGTCGCCAAAACCGCTGGACGTACA
GGCCGCGAAGCAGGAGCCGACGCTGAAAGTCGAAAAGACTGACGCGTTCATGACCGCCTTCGTCGGCATCAACAGCCAGC
ATCCGCCGCTGGACAAACCGGAAGTGCGCCAGGCGATCAACCTCGCCTTCGACAAGGCCAACTACCTCAAGGCTGTATTC
GAAGACACCGCCGAAGCCGCCAACGGTCCGTATCCGCCGAATACCTGGAGCTACGCGAAAAACCTGCCGGGTTACGCCCA
CGACGTGGACAAGGCCAAGGCACTGCTCGCCAAGGCTGGATTGAAGGACGGTTTCCAGACCACCATCTGGACGCGCCCGT
CAGGCAGCCTGCTCAATCCGAATCCGAGCCTCGGCGCACAACTGCTGCAATCGGATCTGGCAGAAATCGGCATTCAGGCG
GAAATCCGCGTGATCGAATGGGGCGAACTGATCCGTCGCGCCAAGGCTGGCGAACATGACCTGCTGTTCATGGGCTGGGC
CGGCGACAACGGCGACCCGGACAACTTCCTCACCCCGCAGTTTTCCTGCGCGGCGGTCAAATCCGGCACCAACTTCGCCC
GCTATTGCAATGCCGACCTGGACAAGCTGATCAGCGCCGGCAAGACCACCAGCGAACAAGGTGTGCGCACCAAACTCTAC
GAACAGGCACAGGCGCAGATTCAGCAACAGGCACTGTGGCTGCCGCTGGCGCATCCGACTGCGTATGCGCTGACGCGTAA
AGACGTGCAGGGTTACTCGGTGAGCCCGTTCGGGCGGCAGGACTACTCCAAGGTCACCCTCAAGTAA

Upstream 100 bases:

>100_bases
ATGCAAAAAGGGGATAGTCATTTGCAATCGCGACCACTAGGGTAGGCTTTTTCCAGACTGCACTTGCAGATGGGCCTTCG
ATCTGTAAAGGAAGCCGACC

Downstream 100 bases:

>100_bases
TCCGCCCCGGCTTGCAGCGACTACAGTCGCTGCAAGCTACATCCAGCCACACTCCGCCATCGATAACGGTTCCCCATCGC
CAACGATGAAGTGGTCGAGC

Product: extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MRLAALPLLFAPLLLSPLAQAAALSVCTEASPEGFDVVQYNSLTTTNASADVLMNRLVDFDTASGKVVPSLADSWEVSTD
GLSYVFKLHPQVKFHTTDYFKPTRELTAEDVKFSFDRMLDPANPWHKVAQSGFPHAQSMQLPSLIKKIDALDPLTVRFTL
DHPDSTFLATLSMGFASIYSAEYADKLLKAGATDKLNSQPVGTGPFVFTRFQKDASIRYKANPDYVRGKPAVDPLIFAIT
PDANVRLQKLRRNECQIALSPKPLDVQAAKQEPTLKVEKTDAFMTAFVGINSQHPPLDKPEVRQAINLAFDKANYLKAVF
EDTAEAANGPYPPNTWSYAKNLPGYAHDVDKAKALLAKAGLKDGFQTTIWTRPSGSLLNPNPSLGAQLLQSDLAEIGIQA
EIRVIEWGELIRRAKAGEHDLLFMGWAGDNGDPDNFLTPQFSCAAVKSGTNFARYCNADLDKLISAGKTTSEQGVRTKLY
EQAQAQIQQQALWLPLAHPTAYALTRKDVQGYSVSPFGRQDYSKVTLK

Sequences:

>Translated_528_residues
MRLAALPLLFAPLLLSPLAQAAALSVCTEASPEGFDVVQYNSLTTTNASADVLMNRLVDFDTASGKVVPSLADSWEVSTD
GLSYVFKLHPQVKFHTTDYFKPTRELTAEDVKFSFDRMLDPANPWHKVAQSGFPHAQSMQLPSLIKKIDALDPLTVRFTL
DHPDSTFLATLSMGFASIYSAEYADKLLKAGATDKLNSQPVGTGPFVFTRFQKDASIRYKANPDYVRGKPAVDPLIFAIT
PDANVRLQKLRRNECQIALSPKPLDVQAAKQEPTLKVEKTDAFMTAFVGINSQHPPLDKPEVRQAINLAFDKANYLKAVF
EDTAEAANGPYPPNTWSYAKNLPGYAHDVDKAKALLAKAGLKDGFQTTIWTRPSGSLLNPNPSLGAQLLQSDLAEIGIQA
EIRVIEWGELIRRAKAGEHDLLFMGWAGDNGDPDNFLTPQFSCAAVKSGTNFARYCNADLDKLISAGKTTSEQGVRTKLY
EQAQAQIQQQALWLPLAHPTAYALTRKDVQGYSVSPFGRQDYSKVTLK
>Mature_528_residues
MRLAALPLLFAPLLLSPLAQAAALSVCTEASPEGFDVVQYNSLTTTNASADVLMNRLVDFDTASGKVVPSLADSWEVSTD
GLSYVFKLHPQVKFHTTDYFKPTRELTAEDVKFSFDRMLDPANPWHKVAQSGFPHAQSMQLPSLIKKIDALDPLTVRFTL
DHPDSTFLATLSMGFASIYSAEYADKLLKAGATDKLNSQPVGTGPFVFTRFQKDASIRYKANPDYVRGKPAVDPLIFAIT
PDANVRLQKLRRNECQIALSPKPLDVQAAKQEPTLKVEKTDAFMTAFVGINSQHPPLDKPEVRQAINLAFDKANYLKAVF
EDTAEAANGPYPPNTWSYAKNLPGYAHDVDKAKALLAKAGLKDGFQTTIWTRPSGSLLNPNPSLGAQLLQSDLAEIGIQA
EIRVIEWGELIRRAKAGEHDLLFMGWAGDNGDPDNFLTPQFSCAAVKSGTNFARYCNADLDKLISAGKTTSEQGVRTKLY
EQAQAQIQQQALWLPLAHPTAYALTRKDVQGYSVSPFGRQDYSKVTLK

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=526, Percent_Identity=42.9657794676806, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1787551, Length=499, Percent_Identity=32.8657314629259, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI1787052, Length=456, Percent_Identity=28.9473684210526, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1787762, Length=538, Percent_Identity=28.2527881040892, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1789887, Length=486, Percent_Identity=24.8971193415638, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1787495, Length=513, Percent_Identity=23.0019493177388, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789397, Length=522, Percent_Identity=22.6053639846743, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI87081878, Length=472, Percent_Identity=22.6694915254237, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 57986; Mature: 57986

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLAALPLLFAPLLLSPLAQAAALSVCTEASPEGFDVVQYNSLTTTNASADVLMNRLVDF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEECCCCHHHHHHHHHHCC
DTASGKVVPSLADSWEVSTDGLSYVFKLHPQVKFHTTDYFKPTRELTAEDVKFSFDRMLD
CCCCCEECCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC
PANPWHKVAQSGFPHAQSMQLPSLIKKIDALDPLTVRFTLDHPDSTFLATLSMGFASIYS
CCCHHHHHHHCCCCCHHCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
AEYADKLLKAGATDKLNSQPVGTGPFVFTRFQKDASIRYKANPDYVRGKPAVDPLIFAIT
HHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEEEC
PDANVRLQKLRRNECQIALSPKPLDVQAAKQEPTLKVEKTDAFMTAFVGINSQHPPLDKP
CCCCHHHHHHCCCCCEEEECCCCCCCEECCCCCCEEEECCHHEEEHEECCCCCCCCCCCH
EVRQAINLAFDKANYLKAVFEDTAEAANGPYPPNTWSYAKNLPGYAHDVDKAKALLAKAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHC
LKDGFQTTIWTRPSGSLLNPNPSLGAQLLQSDLAEIGIQAEIRVIEWGELIRRAKAGEHD
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCCCCC
LLFMGWAGDNGDPDNFLTPQFSCAAVKSGTNFARYCNADLDKLISAGKTTSEQGVRTKLY
EEEEEECCCCCCCCCCCCCCCCCEEECCCCCHHHHHCCCHHHHHHCCCCCCHHHHHHHHH
EQAQAQIQQQALWLPLAHPTAYALTRKDVQGYSVSPFGRQDYSKVTLK
HHHHHHHHHHHHEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCEECCC
>Mature Secondary Structure
MRLAALPLLFAPLLLSPLAQAAALSVCTEASPEGFDVVQYNSLTTTNASADVLMNRLVDF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEECCCCHHHHHHHHHHCC
DTASGKVVPSLADSWEVSTDGLSYVFKLHPQVKFHTTDYFKPTRELTAEDVKFSFDRMLD
CCCCCEECCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHCCC
PANPWHKVAQSGFPHAQSMQLPSLIKKIDALDPLTVRFTLDHPDSTFLATLSMGFASIYS
CCCHHHHHHHCCCCCHHCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
AEYADKLLKAGATDKLNSQPVGTGPFVFTRFQKDASIRYKANPDYVRGKPAVDPLIFAIT
HHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEEEC
PDANVRLQKLRRNECQIALSPKPLDVQAAKQEPTLKVEKTDAFMTAFVGINSQHPPLDKP
CCCCHHHHHHCCCCCEEEECCCCCCCEECCCCCCEEEECCHHEEEHEECCCCCCCCCCCH
EVRQAINLAFDKANYLKAVFEDTAEAANGPYPPNTWSYAKNLPGYAHDVDKAKALLAKAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHC
LKDGFQTTIWTRPSGSLLNPNPSLGAQLLQSDLAEIGIQAEIRVIEWGELIRRAKAGEHD
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCCCCCC
LLFMGWAGDNGDPDNFLTPQFSCAAVKSGTNFARYCNADLDKLISAGKTTSEQGVRTKLY
EEEEEECCCCCCCCCCCCCCCCCEEECCCCCHHHHHCCCHHHHHHCCCCCCHHHHHHHHH
EQAQAQIQQQALWLPLAHPTAYALTRKDVQGYSVSPFGRQDYSKVTLK
HHHHHHHHHHHHEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]