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The map label for this gene is serA [H]

Identifier: 77461608

GI number: 77461608

Start: 6050359

End: 6051588

Strand: Direct

Name: serA [H]

Synonym: Pfl01_5387

Alternate gene names: 77461608

Gene position: 6050359-6051588 (Clockwise)

Preceding gene: 77461603

Following gene: 77461610

Centisome position: 93.97

GC content: 60.81

Gene sequence:

>1230_bases
ATGAGCAAGACTTCTCTCGATAAGAGCAAGATCAAGTTCCTTCTTCTCGAAGGCGTCCACCAATCGGCTGTCGACGTCCT
CAAGGCGGCGGGCTACACCAGCATCGAATACCTGACAGGCTCCCTGCCGGAAGCCCAGCTCAAGGAAAAGATCGCTGACG
CTCACTTCATCGGCATTCGCTCACGCACCCAGCTGACCGAAGAGATCTTCGATCACGCGAAGAAGCTGGTCGCTGTCGGC
TGTTTCTGCATCGGCACCAACCAGGTCGACCTGGAAGCGGCCCGCGAGCGCGGCATCGCCGTGTTCAACGCACCGTACTC
CAACACCCGCTCCGTGGCCGAGCTGGTGCTGGCCGAAGCGATCCTGCTGCTGCGCGGCATCCCTGAGAAAAACGCTTCCT
GCCACCGTGGCGGCTGGATCAAGTCCGCAGCCAACTCCTTCGAGATCCGTGGCAAGAAACTGGGCATCGTCGGCTACGGC
TCGATCGGTACTCAGCTGTCGGTCCTGGCGGAAGGTCTGGGCATGCAGGTGTTCTTCTACGACACCGTGACCAAGCTGCC
ACTGGGCAACGCGACCCAGGTCGGCAACCTGCACGAGCTGCTGGGCATGTCCGACATCGTCACCCTGCACGTTCCGGAAA
CCGCTGCGACCCAGTGGATGATCGGCGAGAAGGAAATCCGCGCCATCAAGAAGGGCGGCATCCTGATCAACGCTGCACGC
GGCACCGTGGTCGAACTGGATCACCTGGCCGCTGCGATCAAGGACAAGCACCTGATCGGCGCCGCCATCGACGTGTTCCC
GGTCGAGCCGCGCTCCAACGACGAAGAGTTCGAAAGCCCGCTGCGTGGCCTGGATAACGTGATCCTGACCCCGCACATCG
GCGGCTCCACCGCTGAAGCGCAGGCCAACATCGGTCTGGAAGTGGCAGAAAAACTGGTCAAGTACAGCGACAACGGTACT
TCGGTATCGTCGGTGAACTTCCCGGAAGTGGCCCTGCCGGCGCACCCTGGCAAGCACCGCCTGCTGCACATCCACGAGAA
CATCCCGGGTGTGATGAGCGAGATCAACAAGGTCTTCGCCGAAAACGGCATCAACATCTCCGGTCAGTTCCTGCAGACCA
ACGAAAAGGTCGGCTACGTCGTGATCGACGTCGACGCCGAGTACTCGGAACTGGCGCAAGAGAAGCTGCAACACGTCAAC
GGCACCATCCGAAGCCGTGTGTTGTTCTGA

Upstream 100 bases:

>100_bases
GTGCCCAAGGCCGGTTCTGCGGTGACGGCTTTCTTGTCGTCCAGGTCAATGTCTGTTGACCATTTCCTGCCATTTTTCTC
CGGGATACAGGTTTACGCAG

Downstream 100 bases:

>100_bases
TCCGTCGCTGAGCGACAAAAAAAGGGAGCCTTCGGGCTCCCTTTTTAATGCACGCGAAAACGTCATTCGACGTTGACGGT
GATCTTCTTCGACACGATCG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MSKTSLDKSKIKFLLLEGVHQSAVDVLKAAGYTSIEYLTGSLPEAQLKEKIADAHFIGIRSRTQLTEEIFDHAKKLVAVG
CFCIGTNQVDLEAARERGIAVFNAPYSNTRSVAELVLAEAILLLRGIPEKNASCHRGGWIKSAANSFEIRGKKLGIVGYG
SIGTQLSVLAEGLGMQVFFYDTVTKLPLGNATQVGNLHELLGMSDIVTLHVPETAATQWMIGEKEIRAIKKGGILINAAR
GTVVELDHLAAAIKDKHLIGAAIDVFPVEPRSNDEEFESPLRGLDNVILTPHIGGSTAEAQANIGLEVAEKLVKYSDNGT
SVSSVNFPEVALPAHPGKHRLLHIHENIPGVMSEINKVFAENGINISGQFLQTNEKVGYVVIDVDAEYSELAQEKLQHVN
GTIRSRVLF

Sequences:

>Translated_409_residues
MSKTSLDKSKIKFLLLEGVHQSAVDVLKAAGYTSIEYLTGSLPEAQLKEKIADAHFIGIRSRTQLTEEIFDHAKKLVAVG
CFCIGTNQVDLEAARERGIAVFNAPYSNTRSVAELVLAEAILLLRGIPEKNASCHRGGWIKSAANSFEIRGKKLGIVGYG
SIGTQLSVLAEGLGMQVFFYDTVTKLPLGNATQVGNLHELLGMSDIVTLHVPETAATQWMIGEKEIRAIKKGGILINAAR
GTVVELDHLAAAIKDKHLIGAAIDVFPVEPRSNDEEFESPLRGLDNVILTPHIGGSTAEAQANIGLEVAEKLVKYSDNGT
SVSSVNFPEVALPAHPGKHRLLHIHENIPGVMSEINKVFAENGINISGQFLQTNEKVGYVVIDVDAEYSELAQEKLQHVN
GTIRSRVLF
>Mature_408_residues
SKTSLDKSKIKFLLLEGVHQSAVDVLKAAGYTSIEYLTGSLPEAQLKEKIADAHFIGIRSRTQLTEEIFDHAKKLVAVGC
FCIGTNQVDLEAARERGIAVFNAPYSNTRSVAELVLAEAILLLRGIPEKNASCHRGGWIKSAANSFEIRGKKLGIVGYGS
IGTQLSVLAEGLGMQVFFYDTVTKLPLGNATQVGNLHELLGMSDIVTLHVPETAATQWMIGEKEIRAIKKGGILINAARG
TVVELDHLAAAIKDKHLIGAAIDVFPVEPRSNDEEFESPLRGLDNVILTPHIGGSTAEAQANIGLEVAEKLVKYSDNGTS
VSSVNFPEVALPAHPGKHRLLHIHENIPGVMSEINKVFAENGINISGQFLQTNEKVGYVVIDVDAEYSELAQEKLQHVNG
TIRSRVLF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=31.2302839116719, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI4557497, Length=260, Percent_Identity=29.6153846153846, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI61743967, Length=260, Percent_Identity=29.6153846153846, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI145580578, Length=246, Percent_Identity=31.3008130081301, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4557499, Length=246, Percent_Identity=31.3008130081301, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI145580575, Length=246, Percent_Identity=31.3008130081301, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI6912396, Length=279, Percent_Identity=25.8064516129032, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI1789279, Length=411, Percent_Identity=64.2335766423358, Blast_Score=542, Evalue=1e-155,
Organism=Escherichia coli, GI87082289, Length=287, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787645, Length=270, Percent_Identity=26.6666666666667, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788660, Length=365, Percent_Identity=27.6712328767123, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=32.2981366459627, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI25147481, Length=281, Percent_Identity=28.1138790035587, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=49.0338164251208, Blast_Score=391, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=48.3091787439614, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6324964, Length=257, Percent_Identity=29.9610894941634, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=236, Percent_Identity=26.6949152542373, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6324980, Length=200, Percent_Identity=27.5, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921140, Length=319, Percent_Identity=28.5266457680251, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI62472511, Length=250, Percent_Identity=32, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646446, Length=250, Percent_Identity=32, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646448, Length=250, Percent_Identity=32, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646452, Length=250, Percent_Identity=32, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646450, Length=250, Percent_Identity=32, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28571528, Length=303, Percent_Identity=29.042904290429, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28574286, Length=268, Percent_Identity=29.8507462686567, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24585514, Length=305, Percent_Identity=26.2295081967213, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574282, Length=305, Percent_Identity=26.2295081967213, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574284, Length=305, Percent_Identity=26.2295081967213, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45552429, Length=305, Percent_Identity=26.2295081967213, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45551003, Length=305, Percent_Identity=26.2295081967213, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585516, Length=303, Percent_Identity=23.7623762376238, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44242; Mature: 44111

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTSLDKSKIKFLLLEGVHQSAVDVLKAAGYTSIEYLTGSLPEAQLKEKIADAHFIGIR
CCCCCCCHHHHHHHEECCCHHHHHHHHHHCCCCEEHHHCCCCCHHHHHHHHCCHHEEECC
SRTQLTEEIFDHAKKLVAVGCFCIGTNQVDLEAARERGIAVFNAPYSNTRSVAELVLAEA
HHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHCCCEEEECCCCCHHHHHHHHHHHH
ILLLRGIPEKNASCHRGGWIKSAANSFEIRGKKLGIVGYGSIGTQLSVLAEGLGMQVFFY
HHHHHCCCCCCCCCCCCCCHHHCCCCEEECCEEEEEEECCCCHHHHHHHHHCCCCEEEEE
DTVTKLPLGNATQVGNLHELLGMSDIVTLHVPETAATQWMIGEKEIRAIKKGGILINAAR
ECHHHCCCCCCCCCCCHHHHHCCCCEEEEECCCHHHHHEECCHHHHHHHHHCCEEEEECC
GTVVELDHLAAAIKDKHLIGAAIDVFPVEPRSNDEEFESPLRGLDNVILTPHIGGSTAEA
CCEEEHHHHHHHHHCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCH
QANIGLEVAEKLVKYSDNGTSVSSVNFPEVALPAHPGKHRLLHIHENIPGVMSEINKVFA
HCCCCHHHHHHHHHCCCCCCEEEECCCCCEECCCCCCCCCEEEEECCCCHHHHHHHHHHH
ENGINISGQFLQTNEKVGYVVIDVDAEYSELAQEKLQHVNGTIRSRVLF
HCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure 
SKTSLDKSKIKFLLLEGVHQSAVDVLKAAGYTSIEYLTGSLPEAQLKEKIADAHFIGIR
CCCCCCHHHHHHHEECCCHHHHHHHHHHCCCCEEHHHCCCCCHHHHHHHHCCHHEEECC
SRTQLTEEIFDHAKKLVAVGCFCIGTNQVDLEAARERGIAVFNAPYSNTRSVAELVLAEA
HHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHCCCEEEECCCCCHHHHHHHHHHHH
ILLLRGIPEKNASCHRGGWIKSAANSFEIRGKKLGIVGYGSIGTQLSVLAEGLGMQVFFY
HHHHHCCCCCCCCCCCCCCHHHCCCCEEECCEEEEEEECCCCHHHHHHHHHCCCCEEEEE
DTVTKLPLGNATQVGNLHELLGMSDIVTLHVPETAATQWMIGEKEIRAIKKGGILINAAR
ECHHHCCCCCCCCCCCHHHHHCCCCEEEEECCCHHHHHEECCHHHHHHHHHCCEEEEECC
GTVVELDHLAAAIKDKHLIGAAIDVFPVEPRSNDEEFESPLRGLDNVILTPHIGGSTAEA
CCEEEHHHHHHHHHCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCH
QANIGLEVAEKLVKYSDNGTSVSSVNFPEVALPAHPGKHRLLHIHENIPGVMSEINKVFA
HCCCCHHHHHHHHHCCCCCCEEEECCCCCEECCCCCCCCCEEEEECCCCHHHHHHHHHHH
ENGINISGQFLQTNEKVGYVVIDVDAEYSELAQEKLQHVNGTIRSRVLF
HCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]