Click here to switch to the map view.

The map label for this gene is ilvA [H]

Identifier: 77461602

GI number: 77461602

Start: 6043453

End: 6044967

Strand: Reverse

Name: ilvA [H]

Synonym: Pfl01_5381

Alternate gene names: 77461602

Gene position: 6044967-6043453 (Counterclockwise)

Preceding gene: 77461604

Following gene: 77461601

Centisome position: 93.89

GC content: 63.63

Gene sequence:

>1515_bases
ATGCTCGAACAGTACGTCAAGAAGATCCTCACCTCGCGCGTTTATGACGTTGCCGTAGAAACCCCGCTGCAGAACGCCCG
CCAGCTCTCCGAGCGGCTGGGCAACGACATCTGGCTCAAGCGCGAAGACTTGCAGCCGGTGTTCTCGTTCAAGATTCGCG
GTGCCTACAACAAGCTGACCCAGTTGAGCGACGAAGAGCGCGCTCGCGGCGTGGTCACCGCGTCGGCGGGCAACCATGCA
CAGGGCCTGGCCCTGGCGGCGAAAGTGTTGGGCGTGAAAGCGACCATCGTGATGCCCAAGACCACCCCGGAGATCAAGGT
CGAAGGCGTGCGCTCGCGCGGTGGCAAAGTGGTGCTGCACGGCGATTCCTTCCCGGAAGCGCTGGCCTACTCGCTGAAGC
TGGTCGACGAAAAAGGCTACGTCTACATCCACCCGTACGACGATCCGCACACCATTGCCGGGCAGGGCACCGTGGCGATG
GAAATTCTGCGCCAGCACCCGCAGCCGCTGGATGCGATTTTCGTTCCGGTGGGCGGCGGCGGTCTGATCGCCGGCATCGC
GGCCTACGTGAAATACCTGCGTCCGGACATCAAGGTCATCGGCGTCGAGCCCGACGACTCCAACTGCCTGCAAGCGGCGA
TGGCGGCAGGCGAACGCGTGGTGCTGCCGACTGTAGGCATCTTCGCCGACGGCGTGGCGGTGGCGCAGATCGGCCAGCAC
ACCTTCGATATCTGCAAGGATTACGTCGACGAGGTGATCACCGTCAGCACCGACGAGATTTGCGCGGCGATCAAGGACAT
CTACGACGACACCCGTTCGATCACCGAACCGGCCGGCGCCCTGGGCGTGGCCGGGATCAAGAAGTATGTCGAGCAGCGCG
GCGTCAGCGGCCAGACCTTCGTCGCCATCGACTCCGGGGCCAACGTCAACTTCGACCGCTTGCGCCACGTCGCCGAGCGC
GCCGAACTGGGTGAAGGCCGCGAAGCGATCATCGCCGTGACCATCCCGGAGAAGGCCGGCAGCTTCAAGGCCTTCTGCGA
GGCCATCGGCAAGCGCCAGATCACCGAATTCAACTACCGCTATAACAATGGCAGCGAAGCGCACATCTTCGTCGGCGTGC
AGACCCACCCGGACAACGACCCGCGCAGTGCTTTGCTGGCGAGCCTGACCGAACAGGGTTTCCCGGTGCTCGACCTGACC
GACAACGAACTGGCCAAACTGCACATCCGCCACATGGTCGGCGGTCGCGCCGCGCACGTGGTCGATGAAGTGGTGCTGCG
CTTCGAGTTCCCGGAGCGTCCGGGCGCGCTGTTCAACTTCCTCAACAAGCTCGGCGGGCGCTGGAACATCTCGATGTTCC
ACTACCGCAACCACGGTGCAGCGGACGGTCGTGTGGTGGCGGGTCTGCAAGTGCCCCACGACGAGCGTCATCTGGTGCCC
GCAGCCCTTGAGGAAATCGGCTACCCATACTGGGACGAAAGCGACAACCCGGCCTATCAGCTGTTTCTTGGCTGA

Upstream 100 bases:

>100_bases
TAGCCTCAAGCCGGGCTAAAACCTCTGGATTCGTGTGGTCGTCCGGCCGAAACCCGGGTTAGACTCGCTGGTCCCGCCCA
ACCGCCAGTGATGCTTTCCG

Downstream 100 bases:

>100_bases
ACGGCTACGCTGATGGGTATGGCCCAAGGAAAGAGAAATTCATGGAAACCCTGACCACCCTGAAAGTCCTTCACGTCGCG
GCGACCGTGGTGATACTGGC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MLEQYVKKILTSRVYDVAVETPLQNARQLSERLGNDIWLKREDLQPVFSFKIRGAYNKLTQLSDEERARGVVTASAGNHA
QGLALAAKVLGVKATIVMPKTTPEIKVEGVRSRGGKVVLHGDSFPEALAYSLKLVDEKGYVYIHPYDDPHTIAGQGTVAM
EILRQHPQPLDAIFVPVGGGGLIAGIAAYVKYLRPDIKVIGVEPDDSNCLQAAMAAGERVVLPTVGIFADGVAVAQIGQH
TFDICKDYVDEVITVSTDEICAAIKDIYDDTRSITEPAGALGVAGIKKYVEQRGVSGQTFVAIDSGANVNFDRLRHVAER
AELGEGREAIIAVTIPEKAGSFKAFCEAIGKRQITEFNYRYNNGSEAHIFVGVQTHPDNDPRSALLASLTEQGFPVLDLT
DNELAKLHIRHMVGGRAAHVVDEVVLRFEFPERPGALFNFLNKLGGRWNISMFHYRNHGAADGRVVAGLQVPHDERHLVP
AALEEIGYPYWDESDNPAYQLFLG

Sequences:

>Translated_504_residues
MLEQYVKKILTSRVYDVAVETPLQNARQLSERLGNDIWLKREDLQPVFSFKIRGAYNKLTQLSDEERARGVVTASAGNHA
QGLALAAKVLGVKATIVMPKTTPEIKVEGVRSRGGKVVLHGDSFPEALAYSLKLVDEKGYVYIHPYDDPHTIAGQGTVAM
EILRQHPQPLDAIFVPVGGGGLIAGIAAYVKYLRPDIKVIGVEPDDSNCLQAAMAAGERVVLPTVGIFADGVAVAQIGQH
TFDICKDYVDEVITVSTDEICAAIKDIYDDTRSITEPAGALGVAGIKKYVEQRGVSGQTFVAIDSGANVNFDRLRHVAER
AELGEGREAIIAVTIPEKAGSFKAFCEAIGKRQITEFNYRYNNGSEAHIFVGVQTHPDNDPRSALLASLTEQGFPVLDLT
DNELAKLHIRHMVGGRAAHVVDEVVLRFEFPERPGALFNFLNKLGGRWNISMFHYRNHGAADGRVVAGLQVPHDERHLVP
AALEEIGYPYWDESDNPAYQLFLG
>Mature_504_residues
MLEQYVKKILTSRVYDVAVETPLQNARQLSERLGNDIWLKREDLQPVFSFKIRGAYNKLTQLSDEERARGVVTASAGNHA
QGLALAAKVLGVKATIVMPKTTPEIKVEGVRSRGGKVVLHGDSFPEALAYSLKLVDEKGYVYIHPYDDPHTIAGQGTVAM
EILRQHPQPLDAIFVPVGGGGLIAGIAAYVKYLRPDIKVIGVEPDDSNCLQAAMAAGERVVLPTVGIFADGVAVAQIGQH
TFDICKDYVDEVITVSTDEICAAIKDIYDDTRSITEPAGALGVAGIKKYVEQRGVSGQTFVAIDSGANVNFDRLRHVAER
AELGEGREAIIAVTIPEKAGSFKAFCEAIGKRQITEFNYRYNNGSEAHIFVGVQTHPDNDPRSALLASLTEQGFPVLDLT
DNELAKLHIRHMVGGRAAHVVDEVVLRFEFPERPGALFNFLNKLGGRWNISMFHYRNHGAADGRVVAGLQVPHDERHLVP
AALEEIGYPYWDESDNPAYQLFLG

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=307, Percent_Identity=34.8534201954397, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI33469958, Length=312, Percent_Identity=30.7692307692308, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI19923959, Length=321, Percent_Identity=28.0373831775701, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI295821202, Length=204, Percent_Identity=29.9019607843137, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI295821200, Length=204, Percent_Identity=29.9019607843137, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI4557415, Length=204, Percent_Identity=29.9019607843137, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1790207, Length=500, Percent_Identity=52.6, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI1789505, Length=312, Percent_Identity=39.4230769230769, Blast_Score=198, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI71991565, Length=332, Percent_Identity=35.8433734939759, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17508781, Length=270, Percent_Identity=35.9259259259259, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17537387, Length=343, Percent_Identity=34.6938775510204, Blast_Score=154, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6320930, Length=513, Percent_Identity=51.4619883040936, Blast_Score=483, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6322631, Length=303, Percent_Identity=38.6138613861386, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319788, Length=260, Percent_Identity=26.1538461538462, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355833, Length=318, Percent_Identity=34.2767295597484, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24645328, Length=250, Percent_Identity=32.4, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24643623, Length=212, Percent_Identity=28.3018867924528, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI20129101, Length=212, Percent_Identity=28.3018867924528, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 55132; Mature: 55132

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQYVKKILTSRVYDVAVETPLQNARQLSERLGNDIWLKREDLQPVFSFKIRGAYNKLT
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEHHCCCCEEEEEECCHHHHHH
QLSDEERARGVVTASAGNHAQGLALAAKVLGVKATIVMPKTTPEIKVEGVRSRGGKVVLH
HCCCHHHHCEEEEECCCCCCHHHHHHHHHHCEEEEEEECCCCCCEEEEEEECCCCEEEEE
GDSFPEALAYSLKLVDEKGYVYIHPYDDPHTIAGQGTVAMEILRQHPQPLDAIFVPVGGG
CCCCHHHHHHHHEEEECCCEEEEECCCCCCEECCCCHHHHHHHHHCCCCCCEEEEEECCC
GLIAGIAAYVKYLRPDIKVIGVEPDDSNCLQAAMAAGERVVLPTVGIFADGVAVAQIGQH
HHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCEEEEECCCHHHCCHHHHHHHHH
TFDICKDYVDEVITVSTDEICAAIKDIYDDTRSITEPAGALGVAGIKKYVEQRGVSGQTF
HHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEE
VAIDSGANVNFDRLRHVAERAELGEGREAIIAVTIPEKAGSFKAFCEAIGKRQITEFNYR
EEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEE
YNNGSEAHIFVGVQTHPDNDPRSALLASLTEQGFPVLDLTDNELAKLHIRHMVGGRAAHV
ECCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCHHHHH
VDEVVLRFEFPERPGALFNFLNKLGGRWNISMFHYRNHGAADGRVVAGLQVPHDERHLVP
HHHHHHEEECCCCCCHHHHHHHHHCCEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCCH
AALEEIGYPYWDESDNPAYQLFLG
HHHHHCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MLEQYVKKILTSRVYDVAVETPLQNARQLSERLGNDIWLKREDLQPVFSFKIRGAYNKLT
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEHHCCCCEEEEEECCHHHHHH
QLSDEERARGVVTASAGNHAQGLALAAKVLGVKATIVMPKTTPEIKVEGVRSRGGKVVLH
HCCCHHHHCEEEEECCCCCCHHHHHHHHHHCEEEEEEECCCCCCEEEEEEECCCCEEEEE
GDSFPEALAYSLKLVDEKGYVYIHPYDDPHTIAGQGTVAMEILRQHPQPLDAIFVPVGGG
CCCCHHHHHHHHEEEECCCEEEEECCCCCCEECCCCHHHHHHHHHCCCCCCEEEEEECCC
GLIAGIAAYVKYLRPDIKVIGVEPDDSNCLQAAMAAGERVVLPTVGIFADGVAVAQIGQH
HHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCEEEEECCCHHHCCHHHHHHHHH
TFDICKDYVDEVITVSTDEICAAIKDIYDDTRSITEPAGALGVAGIKKYVEQRGVSGQTF
HHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEE
VAIDSGANVNFDRLRHVAERAELGEGREAIIAVTIPEKAGSFKAFCEAIGKRQITEFNYR
EEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEE
YNNGSEAHIFVGVQTHPDNDPRSALLASLTEQGFPVLDLTDNELAKLHIRHMVGGRAAHV
ECCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCHHHHH
VDEVVLRFEFPERPGALFNFLNKLGGRWNISMFHYRNHGAADGRVVAGLQVPHDERHLVP
HHHHHHEEECCCCCCHHHHHHHHHCCEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCCH
AALEEIGYPYWDESDNPAYQLFLG
HHHHHCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA