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The map label for this gene is pfpI [H]

Identifier: 77461574

GI number: 77461574

Start: 6011786

End: 6012325

Strand: Direct

Name: pfpI [H]

Synonym: Pfl01_5353

Alternate gene names: 77461574

Gene position: 6011786-6012325 (Clockwise)

Preceding gene: 77461570

Following gene: 77461575

Centisome position: 93.37

GC content: 58.7

Gene sequence:

>540_bases
ATGGCGACTTCTCTCAGCGGCAAGCGCGTCGCTTTTTTGGTAACCGATGGTTTCGAGCAGGTTGAACTGACTGGCCCCAA
ACAGGCATTGGAGCAGGCCGGAGCGCAGGTTGACATCCTCTCTGCCGAAGCCGGCAGCGTCAAAGGCTGGAATCACGATA
AACCGGCGGACGACTTCAAGGTCGACCAGACCTTCCAAGGCGCAAGCATCGATCAATACGATGCCGTGGTGCTCCCGGGC
GGTGTGCAGAACTCTGACACCATCCGCATCGACCAGGACGCCCAGCATCTGGTCAAGACCGGTACCTCCGCCGGCAAACC
GATCGCAGTGATCTGCCATGGCAGCTGGCTGCTGATTTCGGCAGGGCTGGTCAATGGCAAGACCATGACCAGCTACAAGA
CCGTCAAGGACGATCTGGTCAACGCGGGGGCGAACTGGGTTGATCAGGAAGTCGTAAAAGACGGACACCTGATCAGCAGC
CGCCAACCAGACGATATTCCGGCGTTCAGCAATGCGCTGATCGACGCGTTGTCGGCATAG

Upstream 100 bases:

>100_bases
CAGGAACTTTCACTTTCCCCCAGCCTTCGGAATCTGTAGTGCCCGGAACAGATCTGCATCGGTCTCGGGCAGTAATTCCA
ACAGACTCAGGAGCTTAACG

Downstream 100 bases:

>100_bases
GGCATAAACGCGTGGAGACGGGGCGGGCCCGCTCGTGATGAGGTCAGCCGCGTTTCATCGCACGCCAAACCCGGCATAGG
GCGCAACACGGTATACTCCC

Product: peptidase C56, PfpI

Products: NA

Alternate protein names: Intracellular protease I [H]

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MATSLSGKRVAFLVTDGFEQVELTGPKQALEQAGAQVDILSAEAGSVKGWNHDKPADDFKVDQTFQGASIDQYDAVVLPG
GVQNSDTIRIDQDAQHLVKTGTSAGKPIAVICHGSWLLISAGLVNGKTMTSYKTVKDDLVNAGANWVDQEVVKDGHLISS
RQPDDIPAFSNALIDALSA

Sequences:

>Translated_179_residues
MATSLSGKRVAFLVTDGFEQVELTGPKQALEQAGAQVDILSAEAGSVKGWNHDKPADDFKVDQTFQGASIDQYDAVVLPG
GVQNSDTIRIDQDAQHLVKTGTSAGKPIAVICHGSWLLISAGLVNGKTMTSYKTVKDDLVNAGANWVDQEVVKDGHLISS
RQPDDIPAFSNALIDALSA
>Mature_178_residues
ATSLSGKRVAFLVTDGFEQVELTGPKQALEQAGAQVDILSAEAGSVKGWNHDKPADDFKVDQTFQGASIDQYDAVVLPGG
VQNSDTIRIDQDAQHLVKTGTSAGKPIAVICHGSWLLISAGLVNGKTMTSYKTVKDDLVNAGANWVDQEVVKDGHLISSR
QPDDIPAFSNALIDALSA

Specific function: Highly stable protease. Although the physiological function is unclear it is the dominant protease in P.furiosus [H]

COG id: COG0693

COG function: function code R; Putative intracellular protease/amidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PfpI endopeptidase domain [H]

Homologues:

Organism=Escherichia coli, GI87082219, Length=174, Percent_Identity=37.3563218390805, Blast_Score=116, Evalue=7e-28,
Organism=Drosophila melanogaster, GI28571932, Length=173, Percent_Identity=30.0578034682081, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006286
- InterPro:   IPR002818 [H]

Pfam domain/function: PF01965 DJ-1_PfpI [H]

EC number: NA

Molecular weight: Translated: 18919; Mature: 18788

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATSLSGKRVAFLVTDGFEQVELTGPKQALEQAGAQVDILSAEAGSVKGWNHDKPADDFK
CCCCCCCCEEEEEEECCCCEEEECCHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCC
VDQTFQGASIDQYDAVVLPGGVQNSDTIRIDQDAQHLVKTGTSAGKPIAVICHGSWLLIS
CCCCCCCCCCCCCCEEEECCCCCCCCEEEECCHHHHHHHCCCCCCCCEEEEEECCEEEEE
AGLVNGKTMTSYKTVKDDLVNAGANWVDQEVVKDGHLISSRQPDDIPAFSNALIDALSA
ECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ATSLSGKRVAFLVTDGFEQVELTGPKQALEQAGAQVDILSAEAGSVKGWNHDKPADDFK
CCCCCCCEEEEEEECCCCEEEECCHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCC
VDQTFQGASIDQYDAVVLPGGVQNSDTIRIDQDAQHLVKTGTSAGKPIAVICHGSWLLIS
CCCCCCCCCCCCCCEEEECCCCCCCCEEEECCHHHHHHHCCCCCCCCEEEEEECCEEEEE
AGLVNGKTMTSYKTVKDDLVNAGANWVDQEVVKDGHLISSRQPDDIPAFSNALIDALSA
ECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626329 [H]