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The map label for this gene is proC [H]

Identifier: 77461541

GI number: 77461541

Start: 5983969

End: 5984787

Strand: Direct

Name: proC [H]

Synonym: Pfl01_5320

Alternate gene names: 77461541

Gene position: 5983969-5984787 (Clockwise)

Preceding gene: 77461540

Following gene: 77461542

Centisome position: 92.94

GC content: 65.57

Gene sequence:

>819_bases
ATGAGCAACACACGTATTGCCTTTATCGGTGCCGGCAACATGGCCGCCAGCCTGATCGGCGGCCTGCGGGCCAAGGGTCT
GGAAGCTGCACACATCCGCGCCAGCGATCCGGGTGAAGAAACCCGCGCCAAAGTCAGCGCCGAACACGGCATCGAAACCT
TCGCCGACAACGCCCAGGCCATCGACGGCGCCGATGTAGTGGTACTGGCGGTCAAGCCACAAGCCATGAAGCTGGTGTGC
GAAGCGATTCGCCCGAGCCTGAAACCGAATCAACTGGTGGTGTCCATCGCCGCCGGCATCACCTGCGCCAGCATGACGGC
CTGGCTCGGCGAACAGCCGATCGTGCGCTGCATGCCGAACACCCCGGCGCTGCTGCGCCAGGGCGTGAGCGGCTTGTACG
CCACAGGCAAAGTGAGCGCCGAACAGCGTCAACAGGCTGAAGAACTGCTGTCCGCCGTGGGCATCGCCCTGTGGCTGAAC
GAAGAGCAGCAACTGGACGCGGTCACCGCTGTCTCCGGTTCCGGCCCGGCGTACTTCTTCCTGCTGATCGAAGCCATGAC
CGCCGCCGGCGTCAAACTCGGCCTGCCGAAGGAAACCGCCGAGCAGCTGACCTTGCAGACCGCGCTGGGCGCCGCGCAGA
TGGCGGTATCCAGCGACGTCGACGCGGCCGAACTGCGCCGCCGCGTGACCTCGCCGGCCGGCACCACGGAAGCTGCGATC
AAATCGTTCCAGGCCGGCGGCTTCGAAGCCCTGGTGGAAAAAGCACTCGGCGCCGCCGCGCACCGCTCGGCCGAAATGGC
CGAACAATTGGGCAAATAA

Upstream 100 bases:

>100_bases
CGGCCATTGCCCAGGGCGCGACCTGGGTCCGTATCGGTACGGCCCTGTTCGGCGCCCGTGACTATTCCCAATCTTGACCA
TTTCCAGATAAGGACCTGAC

Downstream 100 bases:

>100_bases
GGAGCCTTACATGATTGGATTGAACACCGCAGCGGTCTACGTGCTGCAAACCCTCGGCAGCCTGTACCTGCTGATCGTGC
TGCTGCGCTTCGTCCTGCAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSNTRIAFIGAGNMAASLIGGLRAKGLEAAHIRASDPGEETRAKVSAEHGIETFADNAQAIDGADVVVLAVKPQAMKLVC
EAIRPSLKPNQLVVSIAAGITCASMTAWLGEQPIVRCMPNTPALLRQGVSGLYATGKVSAEQRQQAEELLSAVGIALWLN
EEQQLDAVTAVSGSGPAYFFLLIEAMTAAGVKLGLPKETAEQLTLQTALGAAQMAVSSDVDAAELRRRVTSPAGTTEAAI
KSFQAGGFEALVEKALGAAAHRSAEMAEQLGK

Sequences:

>Translated_272_residues
MSNTRIAFIGAGNMAASLIGGLRAKGLEAAHIRASDPGEETRAKVSAEHGIETFADNAQAIDGADVVVLAVKPQAMKLVC
EAIRPSLKPNQLVVSIAAGITCASMTAWLGEQPIVRCMPNTPALLRQGVSGLYATGKVSAEQRQQAEELLSAVGIALWLN
EEQQLDAVTAVSGSGPAYFFLLIEAMTAAGVKLGLPKETAEQLTLQTALGAAQMAVSSDVDAAELRRRVTSPAGTTEAAI
KSFQAGGFEALVEKALGAAAHRSAEMAEQLGK
>Mature_271_residues
SNTRIAFIGAGNMAASLIGGLRAKGLEAAHIRASDPGEETRAKVSAEHGIETFADNAQAIDGADVVVLAVKPQAMKLVCE
AIRPSLKPNQLVVSIAAGITCASMTAWLGEQPIVRCMPNTPALLRQGVSGLYATGKVSAEQRQQAEELLSAVGIALWLNE
EQQLDAVTAVSGSGPAYFFLLIEAMTAAGVKLGLPKETAEQLTLQTALGAAQMAVSSDVDAAELRRRVTSPAGTTEAAIK
SFQAGGFEALVEKALGAAAHRSAEMAEQLGK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=275, Percent_Identity=38.9090909090909, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI24797095, Length=275, Percent_Identity=38.9090909090909, Blast_Score=165, Evalue=3e-41,
Organism=Homo sapiens, GI21361454, Length=275, Percent_Identity=38.9090909090909, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI198041662, Length=270, Percent_Identity=30.3703703703704, Blast_Score=121, Evalue=6e-28,
Organism=Escherichia coli, GI1786585, Length=267, Percent_Identity=34.8314606741573, Blast_Score=137, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=39.9239543726236, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17540664, Length=285, Percent_Identity=29.8245614035088, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320861, Length=220, Percent_Identity=30.9090909090909, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21358587, Length=266, Percent_Identity=36.8421052631579, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24648116, Length=278, Percent_Identity=31.294964028777, Blast_Score=130, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=38.2352941176471, Blast_Score=111, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28151; Mature: 28019

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTRIAFIGAGNMAASLIGGLRAKGLEAAHIRASDPGEETRAKVSAEHGIETFADNAQA
CCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCHHHHHCCCCC
IDGADVVVLAVKPQAMKLVCEAIRPSLKPNQLVVSIAAGITCASMTAWLGEQPIVRCMPN
CCCCCEEEEEECCHHHHHHHHHHCCCCCCCCEEEEHHHCHHHHHHHHHHCCCCCEEECCC
TPALLRQGVSGLYATGKVSAEQRQQAEELLSAVGIALWLNEEQQLDAVTAVSGSGPAYFF
CHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEECCHHHHHHHHEECCCCCHHHH
LLIEAMTAAGVKLGLPKETAEQLTLQTALGAAQMAVSSDVDAAELRRRVTSPAGTTEAAI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHH
KSFQAGGFEALVEKALGAAAHRSAEMAEQLGK
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNTRIAFIGAGNMAASLIGGLRAKGLEAAHIRASDPGEETRAKVSAEHGIETFADNAQA
CCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCHHHHHCCCCC
IDGADVVVLAVKPQAMKLVCEAIRPSLKPNQLVVSIAAGITCASMTAWLGEQPIVRCMPN
CCCCCEEEEEECCHHHHHHHHHHCCCCCCCCEEEEHHHCHHHHHHHHHHCCCCCEEECCC
TPALLRQGVSGLYATGKVSAEQRQQAEELLSAVGIALWLNEEQQLDAVTAVSGSGPAYFF
CHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEECCHHHHHHHHEECCCCCHHHH
LLIEAMTAAGVKLGLPKETAEQLTLQTALGAAQMAVSSDVDAAELRRRVTSPAGTTEAAI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHH
KSFQAGGFEALVEKALGAAAHRSAEMAEQLGK
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]