Click here to switch to the map view.

The map label for this gene is tktA [H]

Identifier: 77461488

GI number: 77461488

Start: 5926451

End: 5928496

Strand: Reverse

Name: tktA [H]

Synonym: Pfl01_5267

Alternate gene names: 77461488

Gene position: 5928496-5926451 (Counterclockwise)

Preceding gene: 77461493

Following gene: 77461487

Centisome position: 92.08

GC content: 61.88

Gene sequence:

>2046_bases
ATGCCCTCCTTTTTCCGTTTCAATCTATTCACACCCAGGAGATCAGCGATGCCTAGCCGTCGTGAGCGTGCCAACGCCAT
TCGTGCCCTCAGCATGGATGCCGTGCAAAAAGCCAACAGCGGCCATCCCGGTGCCCCTATGGGTATGGCAGATATCGCCG
AAGTGCTTTGGCGCGACTACCTCAAGCACAACCCGAGCAATCCATTGTTCGCCGACCGTGACCGCTTTGTGCTGTCCAAC
GGCCACGGCTCGATGTTGATCTACTCGCTGCTGCACCTGACCGGTTACGACCTGTCGATCGACGATCTGAAGCAATTCCG
TCAACTGCACAGCCGTACCCCGGGTCACCCGGAATTCGGTTACACCCCGGGCGTTGAAACCACCACCGGCCCGCTGGGTC
AGGGTCTGGCCAACGCCGTGGGCTTCGCCTTGGCAGAAAAAGTCCTGGGCGCGCAGTTCAACCGTCCTGGCCACAACATC
GTCGACCACCACACCTACGTGTTCCTGGGTGATGGCTGCATGATGGAAGGCATTTCCCACGAAGTCGCTTCCCTGGCCGG
TACCCTGGGCCTGGGCAAGCTGATTGCCTTCTACGATGACAACGGCATCTCCATCGACGGCGAAGTCGAAGGCTGGTTCA
CCGACGACACGCCGAAGCGTTTCGAATCGTACAACTGGCAAGTGATCCGCAACGTCGACGGTCACGACCCGGAAGAGATC
AAGACCGCCATCGAGACCGCTCGCAAGAGCCCGCTGCCGACCCTGATCTGCTGCAAGACCACCATCGGTTTCGGTTCGCC
GAACAAGCAAGGCAAGGAAGATTGCCACGGCGCCCCGCTGGGTGACGCGGAAATCGCCCTGACCCGTCAGGCGCTGAACT
GGAACCACGGCCCGTTCGAAATCCCGGCCGACATCTATGCCGAGTGGGATGCCAAGGAAAAAGGCCGCGCCGCCGAAGCC
GAGTGGGATCAGCGTTTCGCTGCCTACTCCGCCGCGTTCCCGACCGAAGCCAACGAACTGATCCGTCGCCTGAGCGGCGA
GCTGCCGGCCGACTTCTCCGAGAAGGCCGATGCCTACATCGCTGAAGTCGCGGCCAAAGGCGAAACCATCGCCAGCCGTA
AAGCCAGCCAGAACGCCCTGAACGCGTTCGGCCCGCTGCTGCCGGAAGTGCTGGGCGGTTCGGCTGACCTGGCCGGTTCC
AACCTGACCCTGTGGAAAGGCTGCAAAGGCGTCAGCGCCGAAGACGCCAGCGGCAACTACATGTACTACGGCGTGCGCGA
ATTCGGCATGACCGCGATCATGAACGGCGTTGCCCTGCACGGCGGTCTGGTGCCTTACGGCGCGACCTTCCTGATGTTCA
TGGAATACGCCCGCAACGCCGTGCGCATGTCCGCTCTGATGAAGCAGCGTGTGATCCACGTCTACACCCACGACTCCATC
GGTCTGGGCGAAGACGGCCCGACGCACCAGCCGATCGAGCAACTGACCAGCCTGCGCAGCACGCCGAACCTCGACACCTG
GCGTCCAGCCGATGCCGTTGAATCGGCCGTGGCCTGGAAAAACGCTCTGGAGCGCAAGGACGGCCCGTCGGCGCTGATCT
TCTCGCGTCAGAACCTGCAGCACCAAACCCGTGATGCCGGCCAGATCGCCGACATCCGTCGTGGTGGTTATGTGCTGAAG
GACTGCGCAGGCGAGCCTGAGCTGATTCTGATCGCCACCGGTTCGGAAGTTGGTCTGGCCGTTCAGGCCTACGACAAACT
CACCGAGCAGGGCCGCAAGGTGCGCGTGGTTTCCATGCCATGCACCAGCGCGTTCGACGCTCAGGACGCCAGCTACAAGC
AATCGGTCCTGCCGTTGCAGGTTGGCGCGCGTATCGCGATCGAAGCGGCTCACGCCGACTTCTGGTTCAAGTACGTGGGT
CTGGAAGGTCGCGTGATCGGCATGACCACCTACGGCGAATCGGCTCCGGCTTCGGCACTGTTCGAAGAGTTCGGCTTCAC
CCTGGAAAACATCCTGGGTCAGGCTGAAGAGCTGCTGGAAGACTGA

Upstream 100 bases:

>100_bases
ACAGCGGAAAGGTTTCACCAACCGAAACCGATGTTATCCATGGGAAAAACGCCTCCGGATGACTATCTGTCATTGCCCCG
AGGCGCTCGGGTGAGGGAAA

Downstream 100 bases:

>100_bases
TCCAGAAAAGGTGTCGCCTGAACTGACGCCTTCGCGAGCAAGCTCGCTCCCACAGGGTTATGTATGACTCATGTGGGAGC
GAGCTTGCTCGCGATAGCGA

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 681; Mature: 680

Protein sequence:

>681_residues
MPSFFRFNLFTPRRSAMPSRRERANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDYLKHNPSNPLFADRDRFVLSN
GHGSMLIYSLLHLTGYDLSIDDLKQFRQLHSRTPGHPEFGYTPGVETTTGPLGQGLANAVGFALAEKVLGAQFNRPGHNI
VDHHTYVFLGDGCMMEGISHEVASLAGTLGLGKLIAFYDDNGISIDGEVEGWFTDDTPKRFESYNWQVIRNVDGHDPEEI
KTAIETARKSPLPTLICCKTTIGFGSPNKQGKEDCHGAPLGDAEIALTRQALNWNHGPFEIPADIYAEWDAKEKGRAAEA
EWDQRFAAYSAAFPTEANELIRRLSGELPADFSEKADAYIAEVAAKGETIASRKASQNALNAFGPLLPEVLGGSADLAGS
NLTLWKGCKGVSAEDASGNYMYYGVREFGMTAIMNGVALHGGLVPYGATFLMFMEYARNAVRMSALMKQRVIHVYTHDSI
GLGEDGPTHQPIEQLTSLRSTPNLDTWRPADAVESAVAWKNALERKDGPSALIFSRQNLQHQTRDAGQIADIRRGGYVLK
DCAGEPELILIATGSEVGLAVQAYDKLTEQGRKVRVVSMPCTSAFDAQDASYKQSVLPLQVGARIAIEAAHADFWFKYVG
LEGRVIGMTTYGESAPASALFEEFGFTLENILGQAEELLED

Sequences:

>Translated_681_residues
MPSFFRFNLFTPRRSAMPSRRERANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDYLKHNPSNPLFADRDRFVLSN
GHGSMLIYSLLHLTGYDLSIDDLKQFRQLHSRTPGHPEFGYTPGVETTTGPLGQGLANAVGFALAEKVLGAQFNRPGHNI
VDHHTYVFLGDGCMMEGISHEVASLAGTLGLGKLIAFYDDNGISIDGEVEGWFTDDTPKRFESYNWQVIRNVDGHDPEEI
KTAIETARKSPLPTLICCKTTIGFGSPNKQGKEDCHGAPLGDAEIALTRQALNWNHGPFEIPADIYAEWDAKEKGRAAEA
EWDQRFAAYSAAFPTEANELIRRLSGELPADFSEKADAYIAEVAAKGETIASRKASQNALNAFGPLLPEVLGGSADLAGS
NLTLWKGCKGVSAEDASGNYMYYGVREFGMTAIMNGVALHGGLVPYGATFLMFMEYARNAVRMSALMKQRVIHVYTHDSI
GLGEDGPTHQPIEQLTSLRSTPNLDTWRPADAVESAVAWKNALERKDGPSALIFSRQNLQHQTRDAGQIADIRRGGYVLK
DCAGEPELILIATGSEVGLAVQAYDKLTEQGRKVRVVSMPCTSAFDAQDASYKQSVLPLQVGARIAIEAAHADFWFKYVG
LEGRVIGMTTYGESAPASALFEEFGFTLENILGQAEELLED
>Mature_680_residues
PSFFRFNLFTPRRSAMPSRRERANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDYLKHNPSNPLFADRDRFVLSNG
HGSMLIYSLLHLTGYDLSIDDLKQFRQLHSRTPGHPEFGYTPGVETTTGPLGQGLANAVGFALAEKVLGAQFNRPGHNIV
DHHTYVFLGDGCMMEGISHEVASLAGTLGLGKLIAFYDDNGISIDGEVEGWFTDDTPKRFESYNWQVIRNVDGHDPEEIK
TAIETARKSPLPTLICCKTTIGFGSPNKQGKEDCHGAPLGDAEIALTRQALNWNHGPFEIPADIYAEWDAKEKGRAAEAE
WDQRFAAYSAAFPTEANELIRRLSGELPADFSEKADAYIAEVAAKGETIASRKASQNALNAFGPLLPEVLGGSADLAGSN
LTLWKGCKGVSAEDASGNYMYYGVREFGMTAIMNGVALHGGLVPYGATFLMFMEYARNAVRMSALMKQRVIHVYTHDSIG
LGEDGPTHQPIEQLTSLRSTPNLDTWRPADAVESAVAWKNALERKDGPSALIFSRQNLQHQTRDAGQIADIRRGGYVLKD
CAGEPELILIATGSEVGLAVQAYDKLTEQGRKVRVVSMPCTSAFDAQDASYKQSVLPLQVGARIAIEAAHADFWFKYVGL
EGRVIGMTTYGESAPASALFEEFGFTLENILGQAEELLED

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=590, Percent_Identity=26.271186440678, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI4507521, Length=590, Percent_Identity=26.271186440678, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI133778974, Length=591, Percent_Identity=25.7191201353638, Blast_Score=139, Evalue=1e-32,
Organism=Escherichia coli, GI48994911, Length=664, Percent_Identity=72.8915662650602, Blast_Score=1033, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=662, Percent_Identity=68.1268882175227, Blast_Score=957, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=686, Percent_Identity=23.7609329446064, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6325331, Length=666, Percent_Identity=48.3483483483483, Blast_Score=575, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319593, Length=670, Percent_Identity=44.0298507462687, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45551847, Length=691, Percent_Identity=25.7597684515195, Blast_Score=162, Evalue=8e-40,
Organism=Drosophila melanogaster, GI45550715, Length=691, Percent_Identity=25.7597684515195, Blast_Score=162, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24645119, Length=648, Percent_Identity=25.6172839506173, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24666278, Length=677, Percent_Identity=23.9290989660266, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 74317; Mature: 74186

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSFFRFNLFTPRRSAMPSRRERANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDY
CCCEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
LKHNPSNPLFADRDRFVLSNGHGSMLIYSLLHLTGYDLSIDDLKQFRQLHSRTPGHPEFG
HHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCC
YTPGVETTTGPLGQGLANAVGFALAEKVLGAQFNRPGHNIVDHHTYVFLGDGCMMEGISH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHH
EVASLAGTLGLGKLIAFYDDNGISIDGEVEGWFTDDTPKRFESYNWQVIRNVDGHDPEEI
HHHHHHHHHCCCCEEEEECCCCEEECCCCCCEECCCCHHHHHCCCCEEEECCCCCCHHHH
KTAIETARKSPLPTLICCKTTIGFGSPNKQGKEDCHGAPLGDAEIALTRQALNWNHGPFE
HHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHCCCCCCCCCHHEEEHHHHCCCCCCEE
IPADIYAEWDAKEKGRAAEAEWDQRFAAYSAAFPTEANELIRRLSGELPADFSEKADAYI
CCHHHHCCCCCHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHH
AEVAAKGETIASRKASQNALNAFGPLLPEVLGGSADLAGSNLTLWKGCKGVSAEDASGNY
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCE
MYYGVREFGMTAIMNGVALHGGLVPYGATFLMFMEYARNAVRMSALMKQRVIHVYTHDSI
EEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCC
GLGEDGPTHQPIEQLTSLRSTPNLDTWRPADAVESAVAWKNALERKDGPSALIFSRQNLQ
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHH
HQTRDAGQIADIRRGGYVLKDCAGEPELILIATGSEVGLAVQAYDKLTEQGRKVRVVSMP
HHHCCCHHHHHHHCCCEEEECCCCCCCEEEEECCCCCCEEHHHHHHHHHCCCEEEEEECC
CTSAFDAQDASYKQSVLPLQVGARIAIEAAHADFWFKYVGLEGRVIGMTTYGESAPASAL
CCCCCCCCCCHHHHCCCEEECCCEEEEEECCCCEEEEEECCCCEEEEEEECCCCCCHHHH
FEEFGFTLENILGQAEELLED
HHHHCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PSFFRFNLFTPRRSAMPSRRERANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWRDY
CCEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
LKHNPSNPLFADRDRFVLSNGHGSMLIYSLLHLTGYDLSIDDLKQFRQLHSRTPGHPEFG
HHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCC
YTPGVETTTGPLGQGLANAVGFALAEKVLGAQFNRPGHNIVDHHTYVFLGDGCMMEGISH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHH
EVASLAGTLGLGKLIAFYDDNGISIDGEVEGWFTDDTPKRFESYNWQVIRNVDGHDPEEI
HHHHHHHHHCCCCEEEEECCCCEEECCCCCCEECCCCHHHHHCCCCEEEECCCCCCHHHH
KTAIETARKSPLPTLICCKTTIGFGSPNKQGKEDCHGAPLGDAEIALTRQALNWNHGPFE
HHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHCCCCCCCCCHHEEEHHHHCCCCCCEE
IPADIYAEWDAKEKGRAAEAEWDQRFAAYSAAFPTEANELIRRLSGELPADFSEKADAYI
CCHHHHCCCCCHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHH
AEVAAKGETIASRKASQNALNAFGPLLPEVLGGSADLAGSNLTLWKGCKGVSAEDASGNY
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCE
MYYGVREFGMTAIMNGVALHGGLVPYGATFLMFMEYARNAVRMSALMKQRVIHVYTHDSI
EEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCC
GLGEDGPTHQPIEQLTSLRSTPNLDTWRPADAVESAVAWKNALERKDGPSALIFSRQNLQ
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHH
HQTRDAGQIADIRRGGYVLKDCAGEPELILIATGSEVGLAVQAYDKLTEQGRKVRVVSMP
HHHCCCHHHHHHHCCCEEEECCCCCCCEEEEECCCCCCEEHHHHHHHHHCCCEEEEEECC
CTSAFDAQDASYKQSVLPLQVGARIAIEAAHADFWFKYVGLEGRVIGMTTYGESAPASAL
CCCCCCCCCCHHHHCCCEEECCCEEEEEECCCCEEEEEECCCCEEEEEEECCCCCCHHHH
FEEFGFTLENILGQAEELLED
HHHHCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]