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The map label for this gene is glyA1 [H]

Identifier: 77461429

GI number: 77461429

Start: 5856964

End: 5858217

Strand: Reverse

Name: glyA1 [H]

Synonym: Pfl01_5208

Alternate gene names: 77461429

Gene position: 5858217-5856964 (Counterclockwise)

Preceding gene: 77461430

Following gene: 77461428

Centisome position: 90.99

GC content: 63.48

Gene sequence:

>1254_bases
ATGTTCAGCAAGCAAGACCAGATCCAGGGTTACGACGATGCACTGCTGGCGGCGATGAATGCCGAGGAGCAACGTCAGGA
AGATCACATCGAGCTGATCGCGTCGGAGAACTACACCAGCAAACGCGTCATGCAAGCGCAAGGCAGCGGCCTGACCAACA
AATACGCCGAAGGCTATCCGGGCAAGCGCTACTACGGTGGCTGCGAGCACGTCGACAAGGTCGAAGCCCTGGCCATCGAA
CGCGCCAAGCAACTGTTCGGCGCCGATTACGCCAACGTCCAGCCGCACTCCGGTTCCTCGGCCAACAGCGCCGTGTACCT
GGCCCTGCTGCAAGCGGGCGACACCATTCTCGGCATGAGCCTGGCCCACGGCGGTCACCTGACCCACGGCGCCAAGGTCT
CGTCCTCGGGCAAGCTGTACAACGCCGTGCAGTACGGCATCGACACCAAAACCGGCCTGATCGATTACGACGAAGTCGAG
CGTCTGGCTGTCGAGTGCAAGCCGAAGATGATCGTCGCTGGTTTCTCGGCCTACTCGAAAACCCTCGACTTCCCGCGCTT
CCGTCAGATCGCCGACAAGGTTGGCGCGCTGCTGTTCGTCGATATGGCCCACGTCGCCGGTCTGGTGGCTGCCGGTCTGT
ACCCGAACCCGCTGCCGTACGCCGACGTGGTCACCACCACGACCCACAAGACCCTGCGCGGTCCACGTGGCGGCCTGATC
CTGGCCAAGGCCAACGAAGAAATCGAGAAGAAGCTCAACGCGGCGGTATTCCCCGGCGCCCAGGGCGGCCCGCTGATGCA
CGTTATCGCCGGCAAGGCCGTGTGCTTCAAGGAAGCGCTGGAGCCCGGCTTCAAGGCCTATCAGCAACAAGTGATCGACA
ACGCCCAGGCGATGGCGAGCGTCTTTATCAAACGTGGCTACGATGTAGTGTCCGGCGGCACCGACAACCACCTGTTCCTG
GTCAGCCTGATCCGTCAGGGCCTTACCGGTAAGGACGCCGACGCCGCCCTCGGTCGCGCGCACATCACCGTCAACAAGAA
CGCCGTACCGAACGACCCGCAGTCGCCGTTCGTCACCTCCGGCCTGCGCATCGGCACCCCGGCGGTGACCACCCGCGGCT
TCAAGGTGACCCAGTGCGTGACGCTGGCCGGCTGGATCTGCGACATCCTCGACAACCTCGGCGATGCCGATGTCGAGGCC
AACGTCGCCCAGCAGGTTTCGGCCCTGTGCGCTGACTTCCCGGTTTATCGCTGA

Upstream 100 bases:

>100_bases
GACCTCCCTGCGCCGGCCATACCATCGCATCAAAGGGCACTGGCTGAGCGCCGTGCCTTACCGAGACGAATGGCGCACAG
ATGCCGCTGGGAGAGACGCG

Downstream 100 bases:

>100_bases
GCGTTCTGGAGTACATGACTATGCAACGCTATTCGGGCTTCGGCCTCTTCAAACACTCCCTCAGCCACCACGAAAACTGG
CAGCGCATGTGGCGCACGCC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MFSKQDQIQGYDDALLAAMNAEEQRQEDHIELIASENYTSKRVMQAQGSGLTNKYAEGYPGKRYYGGCEHVDKVEALAIE
RAKQLFGADYANVQPHSGSSANSAVYLALLQAGDTILGMSLAHGGHLTHGAKVSSSGKLYNAVQYGIDTKTGLIDYDEVE
RLAVECKPKMIVAGFSAYSKTLDFPRFRQIADKVGALLFVDMAHVAGLVAAGLYPNPLPYADVVTTTTHKTLRGPRGGLI
LAKANEEIEKKLNAAVFPGAQGGPLMHVIAGKAVCFKEALEPGFKAYQQQVIDNAQAMASVFIKRGYDVVSGGTDNHLFL
VSLIRQGLTGKDADAALGRAHITVNKNAVPNDPQSPFVTSGLRIGTPAVTTRGFKVTQCVTLAGWICDILDNLGDADVEA
NVAQQVSALCADFPVYR

Sequences:

>Translated_417_residues
MFSKQDQIQGYDDALLAAMNAEEQRQEDHIELIASENYTSKRVMQAQGSGLTNKYAEGYPGKRYYGGCEHVDKVEALAIE
RAKQLFGADYANVQPHSGSSANSAVYLALLQAGDTILGMSLAHGGHLTHGAKVSSSGKLYNAVQYGIDTKTGLIDYDEVE
RLAVECKPKMIVAGFSAYSKTLDFPRFRQIADKVGALLFVDMAHVAGLVAAGLYPNPLPYADVVTTTTHKTLRGPRGGLI
LAKANEEIEKKLNAAVFPGAQGGPLMHVIAGKAVCFKEALEPGFKAYQQQVIDNAQAMASVFIKRGYDVVSGGTDNHLFL
VSLIRQGLTGKDADAALGRAHITVNKNAVPNDPQSPFVTSGLRIGTPAVTTRGFKVTQCVTLAGWICDILDNLGDADVEA
NVAQQVSALCADFPVYR
>Mature_417_residues
MFSKQDQIQGYDDALLAAMNAEEQRQEDHIELIASENYTSKRVMQAQGSGLTNKYAEGYPGKRYYGGCEHVDKVEALAIE
RAKQLFGADYANVQPHSGSSANSAVYLALLQAGDTILGMSLAHGGHLTHGAKVSSSGKLYNAVQYGIDTKTGLIDYDEVE
RLAVECKPKMIVAGFSAYSKTLDFPRFRQIADKVGALLFVDMAHVAGLVAAGLYPNPLPYADVVTTTTHKTLRGPRGGLI
LAKANEEIEKKLNAAVFPGAQGGPLMHVIAGKAVCFKEALEPGFKAYQQQVIDNAQAMASVFIKRGYDVVSGGTDNHLFL
VSLIRQGLTGKDADAALGRAHITVNKNAVPNDPQSPFVTSGLRIGTPAVTTRGFKVTQCVTLAGWICDILDNLGDADVEA
NVAQQVSALCADFPVYR

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=396, Percent_Identity=47.2222222222222, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI261862352, Length=396, Percent_Identity=47.2222222222222, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI261862350, Length=396, Percent_Identity=47.2222222222222, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI261862348, Length=396, Percent_Identity=47.2222222222222, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI261862346, Length=396, Percent_Identity=45.7070707070707, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI22547186, Length=378, Percent_Identity=47.3544973544974, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI22547189, Length=365, Percent_Identity=44.3835616438356, Blast_Score=282, Evalue=5e-76,
Organism=Escherichia coli, GI1788902, Length=417, Percent_Identity=70.5035971223022, Blast_Score=586, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI25144732, Length=391, Percent_Identity=49.1048593350384, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI25144729, Length=391, Percent_Identity=49.1048593350384, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319739, Length=397, Percent_Identity=46.8513853904282, Blast_Score=356, Evalue=4e-99,
Organism=Saccharomyces cerevisiae, GI6323087, Length=385, Percent_Identity=45.974025974026, Blast_Score=339, Evalue=4e-94,
Organism=Drosophila melanogaster, GI24640005, Length=384, Percent_Identity=49.7395833333333, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI221329721, Length=384, Percent_Identity=49.7395833333333, Blast_Score=372, Evalue=1e-103,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44656; Mature: 44656

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSKQDQIQGYDDALLAAMNAEEQRQEDHIELIASENYTSKRVMQAQGSGLTNKYAEGYP
CCCCCCCCCCCHHHHHHHHCCHHHHHHHHEEEEECCCCCHHHHHHHCCCCCCCHHHCCCC
GKRYYGGCEHVDKVEALAIERAKQLFGADYANVQPHSGSSANSAVYLALLQAGDTILGMS
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEE
LAHGGHLTHGAKVSSSGKLYNAVQYGIDTKTGLIDYDEVERLAVECKPKMIVAGFSAYSK
ECCCCCCCCCCEECCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHH
TLDFPRFRQIADKVGALLFVDMAHVAGLVAAGLYPNPLPYADVVTTTTHKTLRGPRGGLI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCHHHHCCCCCCEE
LAKANEEIEKKLNAAVFPGAQGGPLMHVIAGKAVCFKEALEPGFKAYQQQVIDNAQAMAS
EEECCHHHHHHHHHHCCCCCCCCCEEEEHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHH
VFIKRGYDVVSGGTDNHLFLVSLIRQGLTGKDADAALGRAHITVNKNAVPNDPQSPFVTS
HHHHCCCEEECCCCCCCHHHHHHHHCCCCCCCCHHHCCEEEEEECCCCCCCCCCCCCHHC
GLRIGTPAVTTRGFKVTQCVTLAGWICDILDNLGDADVEANVAQQVSALCADFPVYR
CEEECCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFSKQDQIQGYDDALLAAMNAEEQRQEDHIELIASENYTSKRVMQAQGSGLTNKYAEGYP
CCCCCCCCCCCHHHHHHHHCCHHHHHHHHEEEEECCCCCHHHHHHHCCCCCCCHHHCCCC
GKRYYGGCEHVDKVEALAIERAKQLFGADYANVQPHSGSSANSAVYLALLQAGDTILGMS
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEE
LAHGGHLTHGAKVSSSGKLYNAVQYGIDTKTGLIDYDEVERLAVECKPKMIVAGFSAYSK
ECCCCCCCCCCEECCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHH
TLDFPRFRQIADKVGALLFVDMAHVAGLVAAGLYPNPLPYADVVTTTTHKTLRGPRGGLI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCHHHHCCCCCCEE
LAKANEEIEKKLNAAVFPGAQGGPLMHVIAGKAVCFKEALEPGFKAYQQQVIDNAQAMAS
EEECCHHHHHHHHHHCCCCCCCCCEEEEHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHH
VFIKRGYDVVSGGTDNHLFLVSLIRQGLTGKDADAALGRAHITVNKNAVPNDPQSPFVTS
HHHHCCCEEECCCCCCCHHHHHHHHCCCCCCCCHHHCCEEEEEECCCCCCCCCCCCCHHC
GLRIGTPAVTTRGFKVTQCVTLAGWICDILDNLGDADVEANVAQQVSALCADFPVYR
CEEECCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]