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The map label for this gene is degS [H]

Identifier: 77461348

GI number: 77461348

Start: 5759978

End: 5762377

Strand: Reverse

Name: degS [H]

Synonym: Pfl01_5127

Alternate gene names: 77461348

Gene position: 5762377-5759978 (Counterclockwise)

Preceding gene: 77461350

Following gene: 77461347

Centisome position: 89.5

GC content: 64.17

Gene sequence:

>2400_bases
ATGATGCGTTTTTGCTGCCTGTGGGTTATCGGCTGTCTGGCGTTTCCCTTGATGGGCTGGGCGGCGCCTGCGCCCCCGAG
TCACCTCGCACGGTTGTCGGCGAGCGAACAACAGTGGCTCGCACAGCACAATGAATTGCGCGTGGGCCTGGTGTTGCAGG
CGCCGTACGCGCAATACGACCGGCGCTTGCAGCGGCTGTCGGGGGCCAACGTCGAGGTGATGAAGGCATTGGCGAGGGCG
CTGAATGTCGAGCTGAGCTGGCGCAACTTTCAGGATCTGGCCCAACTCGAGGCCGCTGCCCGGGACGGCGAGATCGACAT
CGCTCCGGGCCTGACCCAGACCCCGGGCGGGCTGCGTCTGTGGCAGTTCTCCGACCCGTACATGCGCGTGCCGCAACTGG
TGGTCAGCGACCAGAAAAGCAGCGCGACCGTGGAGCTGGAAAAACTCGACAGCCAGACCCGCGTCGCCGTGCGCATGCCC
GGCGTCACCGCCGATTACCTGCGCGGCAACTATCCGCACCTGAATCTGCAAGGCGTACCGATGGAGCGTCAGGCGCTGCA
ACTGTTGCTGAGTCAGCAGGCGTCCTACGCGGTGGTCGATGAGGCGCAGCTCGGTCGACTGTCGGCGGAGCCGGAGTTTG
CCGGGCTGGTGGTGGTCGGTGATATCGGTCTGCCGCAACTGCTGCGCATCGGCACCCGCCGCGACTGGCCGGAACTGGCC
GGAATCGTTGAAAGCGCCCTGCGCGCAATCCCGGCCAAGGATCTGGAACGCCTGCATGCGCAATGGCTGCAACCCAAGTA
TCCACGGCTTTCCGAGTCGCCGGGCTTCTGGCAGAACCTGAGTCTGTTGTTCGCAGTGTTGCTGCTCAGCTGCGTGGCCA
TCGTGTTCTGGCAACGCCGCCAGCAACGCAGTCTTGAACAACGTTTGTTCGACGCGCGTGAAGACATCGCCCTGCGTGCC
GCCAGCGAAGAAGCCCTGCGCCTGACCCAGTTTTCCATCGATCAGAGCACCGTCGGCATTCTCTGGGTCAACTGGGACAG
CCATGTGCGCTACGCCAACCGTGCGGCAGAAAACATGCTCGGTTATCCGCAGGGCGCCATCATCGATCGACCGTTGATCG
ACTTCGAACCGGGCCTGCACATGGATCGCTGGCTCAACCTGTGGAAGCGCGCCCGGGCCAGCGAAGAAGGGCCGCTGAGT
TTTGAAACCAACTGCGTGCGGGCCGATGGCAGTGTGCTGCCGGCCGACGTGTCGCTGAGCTTCCTGCGATTTCGCGATGG
CGAGTACCTGGTGGTTTACCTCACCGATGTCACCGAGCGCCGTCGTGCCCTGGCGGCGTTGCAGGAAAGCGAGGCGCGGC
TGCAAGGCATCGCGGCCAATGTGCCGGGGCTGGTGTTCCGTCTCGAGCGCGCACCGGTCACCGGGCAGATCGACTTTGCC
TACATCAGCGAGGGCAGCGAAAGTCTGGTCGGCTACGCGCCGGCCGCCATCGCCCATCGCGACATGGGCTTGCGCAGTCT
GGTGCATCCGGATGACCGGGCCGCCTATCACCAGACCCAGGATCAGGCGCTGGACACCGACAGCGACTGGTCGTGGCAGG
GCCGAATTCTCACGCGTCAGGGCGAGCAGCGCTGGGCCGAAATCAAGGCCATCACCCGTCAGCTGGAAGGCGGGTCCTAT
GTCTGGGACGGCATCGTCTGGGACATCACCGAAAGCAAACGCATCGAACTGGAGCTGGCGGCCTCCCGTGAACAATTGCG
CGAATTGTCGGCGCATCTGGAAAGCGTGCGGGAAGAGGAAAAGGCGCGCATCGCCCGCGAGGTTCACGATGAGCTGGGGC
AGATGCTGACGGTGCTGAAACTGGAGACGTCGATGTGCGAACTGGCCTACGCGCAACTCGACCCAGGCCTGAACGAGCGG
CTGAACAGCATGAAGCGCCTGATCGCCCAGTTGTTCCAGTTGGTGCGCGATGTGGCGACGGCATTGCGCCCGCCGATCCT
CGATGCCGGGATCGCCTCGGCCATCGAGTGGCAGGCGCGGCGGTTCGAGGCGCGCACGCAGATTCCGTGTCTGGTGCAGG
TGCCGGACAACCTTGCACCGCTCAGCGACGCCAAGGCCATCGGCCTGTTCCGCATTCTTCAGGAGGCGTTGACCAACGTC
ATGCGCCATGCCCAGGCGCATACTGTAGAACTGACGCTGACGCAGGAAGGTGACGAATTGTGTCTGACGGTCAGCGATGA
TGGCGTAGGATTTGTCGCCGCTGCCGGCAGGCCGACATCCTTTGGGCTGGTGGGCATGCGCGAGCGGGTGTTGATCATGG
GCGGGCAGCTGTCACTCGACAGCGAACCGGGCGAGGGCACCACGCTGAGCGTGCGGGTGCCACTGGATGAGGAGAAGTAA

Upstream 100 bases:

>100_bases
CATTGCCAGGCGATAGACAGGGGGCATCGGTTATTCCAGGCCAGAAGTTATCCCGGCAGCCTAATGGGTTGGTCAGAATT
TGTCAGTGTATGAGACTTCA

Downstream 100 bases:

>100_bases
GTGATCCGTGTACTGGTAGCCGAAGACCACACCATCGTTCGCGAAGGCATCAAGCAATTGATCGGCCTGGCCAAGGATCT
GCAAGTGGTGGGGGAGGCGA

Product: PAS/PAC sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 799; Mature: 799

Protein sequence:

>799_residues
MMRFCCLWVIGCLAFPLMGWAAPAPPSHLARLSASEQQWLAQHNELRVGLVLQAPYAQYDRRLQRLSGANVEVMKALARA
LNVELSWRNFQDLAQLEAAARDGEIDIAPGLTQTPGGLRLWQFSDPYMRVPQLVVSDQKSSATVELEKLDSQTRVAVRMP
GVTADYLRGNYPHLNLQGVPMERQALQLLLSQQASYAVVDEAQLGRLSAEPEFAGLVVVGDIGLPQLLRIGTRRDWPELA
GIVESALRAIPAKDLERLHAQWLQPKYPRLSESPGFWQNLSLLFAVLLLSCVAIVFWQRRQQRSLEQRLFDAREDIALRA
ASEEALRLTQFSIDQSTVGILWVNWDSHVRYANRAAENMLGYPQGAIIDRPLIDFEPGLHMDRWLNLWKRARASEEGPLS
FETNCVRADGSVLPADVSLSFLRFRDGEYLVVYLTDVTERRRALAALQESEARLQGIAANVPGLVFRLERAPVTGQIDFA
YISEGSESLVGYAPAAIAHRDMGLRSLVHPDDRAAYHQTQDQALDTDSDWSWQGRILTRQGEQRWAEIKAITRQLEGGSY
VWDGIVWDITESKRIELELAASREQLRELSAHLESVREEEKARIAREVHDELGQMLTVLKLETSMCELAYAQLDPGLNER
LNSMKRLIAQLFQLVRDVATALRPPILDAGIASAIEWQARRFEARTQIPCLVQVPDNLAPLSDAKAIGLFRILQEALTNV
MRHAQAHTVELTLTQEGDELCLTVSDDGVGFVAAAGRPTSFGLVGMRERVLIMGGQLSLDSEPGEGTTLSVRVPLDEEK

Sequences:

>Translated_799_residues
MMRFCCLWVIGCLAFPLMGWAAPAPPSHLARLSASEQQWLAQHNELRVGLVLQAPYAQYDRRLQRLSGANVEVMKALARA
LNVELSWRNFQDLAQLEAAARDGEIDIAPGLTQTPGGLRLWQFSDPYMRVPQLVVSDQKSSATVELEKLDSQTRVAVRMP
GVTADYLRGNYPHLNLQGVPMERQALQLLLSQQASYAVVDEAQLGRLSAEPEFAGLVVVGDIGLPQLLRIGTRRDWPELA
GIVESALRAIPAKDLERLHAQWLQPKYPRLSESPGFWQNLSLLFAVLLLSCVAIVFWQRRQQRSLEQRLFDAREDIALRA
ASEEALRLTQFSIDQSTVGILWVNWDSHVRYANRAAENMLGYPQGAIIDRPLIDFEPGLHMDRWLNLWKRARASEEGPLS
FETNCVRADGSVLPADVSLSFLRFRDGEYLVVYLTDVTERRRALAALQESEARLQGIAANVPGLVFRLERAPVTGQIDFA
YISEGSESLVGYAPAAIAHRDMGLRSLVHPDDRAAYHQTQDQALDTDSDWSWQGRILTRQGEQRWAEIKAITRQLEGGSY
VWDGIVWDITESKRIELELAASREQLRELSAHLESVREEEKARIAREVHDELGQMLTVLKLETSMCELAYAQLDPGLNER
LNSMKRLIAQLFQLVRDVATALRPPILDAGIASAIEWQARRFEARTQIPCLVQVPDNLAPLSDAKAIGLFRILQEALTNV
MRHAQAHTVELTLTQEGDELCLTVSDDGVGFVAAAGRPTSFGLVGMRERVLIMGGQLSLDSEPGEGTTLSVRVPLDEEK
>Mature_799_residues
MMRFCCLWVIGCLAFPLMGWAAPAPPSHLARLSASEQQWLAQHNELRVGLVLQAPYAQYDRRLQRLSGANVEVMKALARA
LNVELSWRNFQDLAQLEAAARDGEIDIAPGLTQTPGGLRLWQFSDPYMRVPQLVVSDQKSSATVELEKLDSQTRVAVRMP
GVTADYLRGNYPHLNLQGVPMERQALQLLLSQQASYAVVDEAQLGRLSAEPEFAGLVVVGDIGLPQLLRIGTRRDWPELA
GIVESALRAIPAKDLERLHAQWLQPKYPRLSESPGFWQNLSLLFAVLLLSCVAIVFWQRRQQRSLEQRLFDAREDIALRA
ASEEALRLTQFSIDQSTVGILWVNWDSHVRYANRAAENMLGYPQGAIIDRPLIDFEPGLHMDRWLNLWKRARASEEGPLS
FETNCVRADGSVLPADVSLSFLRFRDGEYLVVYLTDVTERRRALAALQESEARLQGIAANVPGLVFRLERAPVTGQIDFA
YISEGSESLVGYAPAAIAHRDMGLRSLVHPDDRAAYHQTQDQALDTDSDWSWQGRILTRQGEQRWAEIKAITRQLEGGSY
VWDGIVWDITESKRIELELAASREQLRELSAHLESVREEEKARIAREVHDELGQMLTVLKLETSMCELAYAQLDPGLNER
LNSMKRLIAQLFQLVRDVATALRPPILDAGIASAIEWQARRFEARTQIPCLVQVPDNLAPLSDAKAIGLFRILQEALTNV
MRHAQAHTVELTLTQEGDELCLTVSDDGVGFVAAAGRPTSFGLVGMRERVLIMGGQLSLDSEPGEGTTLSVRVPLDEEK

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=195, Percent_Identity=29.7435897435897, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI87082311, Length=239, Percent_Identity=31.7991631799163, Blast_Score=83, Evalue=9e-17,
Organism=Escherichia coli, GI1788812, Length=194, Percent_Identity=24.2268041237113, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 89399; Mature: 89399

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRFCCLWVIGCLAFPLMGWAAPAPPSHLARLSASEQQWLAQHNELRVGLVLQAPYAQYD
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHCCCEEEEEEEECCHHHHH
RRLQRLSGANVEVMKALARALNVELSWRNFQDLAQLEAAARDGEIDIAPGLTQTPGGLRL
HHHHHHCCCCHHHHHHHHHHHCCEECCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCEEE
WQFSDPYMRVPQLVVSDQKSSATVELEKLDSQTRVAVRMPGVTADYLRGNYPHLNLQGVP
EECCCCHHHCCHHHHCCCCCCCEEEHHHCCCCCEEEEECCCCCHHHHCCCCCCCEEECCC
MERQALQLLLSQQASYAVVDEAQLGRLSAEPEFAGLVVVGDIGLPQLLRIGTRRDWPELA
CHHHHHHHHHHCCCCEEEECCHHHCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCHHHH
GIVESALRAIPAKDLERLHAQWLQPKYPRLSESPGFWQNLSLLFAVLLLSCVAIVFWQRR
HHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QQRSLEQRLFDAREDIALRAASEEALRLTQFSIDQSTVGILWVNWDSHVRYANRAAENML
HHHHHHHHHHHHHHHHHEECCCHHHHHHHHEECCCCCEEEEEEECCCHHHHHHHHHHHHC
GYPQGAIIDRPLIDFEPGLHMDRWLNLWKRARASEEGPLSFETNCVRADGSVLPADVSLS
CCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCEE
FLRFRDGEYLVVYLTDVTERRRALAALQESEARLQGIAANVPGLVFRLERAPVTGQIDFA
EEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEE
YISEGSESLVGYAPAAIAHRDMGLRSLVHPDDRAAYHQTQDQALDTDSDWSWQGRILTRQ
EECCCCCCHHCCCCHHHHHHCCCHHHHCCCCCCHHHHCCHHHCCCCCCCCCCCCEEEECC
GEQRWAEIKAITRQLEGGSYVWDGIVWDITESKRIELELAASREQLRELSAHLESVREEE
HHHHHHHHHHHHHHHCCCCEEECCEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
KARIAREVHDELGQMLTVLKLETSMCELAYAQLDPGLNERLNSMKRLIAQLFQLVRDVAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALRPPILDAGIASAIEWQARRFEARTQIPCLVQVPDNLAPLSDAKAIGLFRILQEALTNV
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
MRHAQAHTVELTLTQEGDELCLTVSDDGVGFVAAAGRPTSFGLVGMRERVLIMGGQLSLD
HHHCCCEEEEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCEEEEECCEEEEC
SEPGEGTTLSVRVPLDEEK
CCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MMRFCCLWVIGCLAFPLMGWAAPAPPSHLARLSASEQQWLAQHNELRVGLVLQAPYAQYD
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHCCCEEEEEEEECCHHHHH
RRLQRLSGANVEVMKALARALNVELSWRNFQDLAQLEAAARDGEIDIAPGLTQTPGGLRL
HHHHHHCCCCHHHHHHHHHHHCCEECCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCEEE
WQFSDPYMRVPQLVVSDQKSSATVELEKLDSQTRVAVRMPGVTADYLRGNYPHLNLQGVP
EECCCCHHHCCHHHHCCCCCCCEEEHHHCCCCCEEEEECCCCCHHHHCCCCCCCEEECCC
MERQALQLLLSQQASYAVVDEAQLGRLSAEPEFAGLVVVGDIGLPQLLRIGTRRDWPELA
CHHHHHHHHHHCCCCEEEECCHHHCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCHHHH
GIVESALRAIPAKDLERLHAQWLQPKYPRLSESPGFWQNLSLLFAVLLLSCVAIVFWQRR
HHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QQRSLEQRLFDAREDIALRAASEEALRLTQFSIDQSTVGILWVNWDSHVRYANRAAENML
HHHHHHHHHHHHHHHHHEECCCHHHHHHHHEECCCCCEEEEEEECCCHHHHHHHHHHHHC
GYPQGAIIDRPLIDFEPGLHMDRWLNLWKRARASEEGPLSFETNCVRADGSVLPADVSLS
CCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCEE
FLRFRDGEYLVVYLTDVTERRRALAALQESEARLQGIAANVPGLVFRLERAPVTGQIDFA
EEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEE
YISEGSESLVGYAPAAIAHRDMGLRSLVHPDDRAAYHQTQDQALDTDSDWSWQGRILTRQ
EECCCCCCHHCCCCHHHHHHCCCHHHHCCCCCCHHHHCCHHHCCCCCCCCCCCCEEEECC
GEQRWAEIKAITRQLEGGSYVWDGIVWDITESKRIELELAASREQLRELSAHLESVREEE
HHHHHHHHHHHHHHHCCCCEEECCEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
KARIAREVHDELGQMLTVLKLETSMCELAYAQLDPGLNERLNSMKRLIAQLFQLVRDVAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ALRPPILDAGIASAIEWQARRFEARTQIPCLVQVPDNLAPLSDAKAIGLFRILQEALTNV
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
MRHAQAHTVELTLTQEGDELCLTVSDDGVGFVAAAGRPTSFGLVGMRERVLIMGGQLSLD
HHHCCCEEEEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCEEEEECCEEEEC
SEPGEGTTLSVRVPLDEEK
CCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]