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The map label for this gene is ybhO [H]

Identifier: 77461258

GI number: 77461258

Start: 5673957

End: 5675243

Strand: Direct

Name: ybhO [H]

Synonym: Pfl01_5037

Alternate gene names: 77461258

Gene position: 5673957-5675243 (Clockwise)

Preceding gene: 77461257

Following gene: 77461259

Centisome position: 88.13

GC content: 62.47

Gene sequence:

>1287_bases
ATGAGCAGTGCACCGTTGGAGAAATCCGCCGTGGAGCCCGTCAGCATCACCCCGCCCGTGCGCGAGCCCGGCACCGTCGA
TGTCGAGTATCGCTGGCAGGGCAACAACCGGATCGAGCTGCTGGAAAACGGCGAGGAATATTTTCCCCGGGTGTTCGAAG
CGATGCGCGCGGCGAAAAGCGAAATCCTGCTGGAGACCTTCATCGTCTTCGAAGACAAGGTCGGCAAGGAATTGCAGGAG
ATTCTGATCGATGCTGCTCGGCGTGGCGTGCGCACCACCGTCAGCCTCGACGGCTTCGGTTGCGGCGAACTGAGCACCGG
CTATCTCGCCGCGCTGAGTGAAGCCGGCGTGCATCTGCAAATCTTCGATCCGGCCCCCAAACGCCTGGGCATTCGCACCA
ACTGGTTCCGTCGTTTGCATCGCAAGATCGTGGTGGTCGACGGGTTGATCGCGTTCATCGGCGGGATCAATTTCTCCGGC
GATCACCTGGCCGATTTCGGCCCCGAAGCGAAGCAGGATTACTCGGTGGAGATTCAGGGCCCGGCGGTGACCGACATCCA
TCATTTCGCTTTGCTGCAAAGCGGCCGACCGGGACGGGCGAGATTCTGGTGGCAGCGTCGCCGGCAACGGCGTGCCGAGA
TGGCGTTCGACGATCACGACGGTCAGGTGCGCCTGGTGTTCCGCGACAACGACCGGCACCACACCGATATCGAAGACGTT
TATTTGCAGGTACTGCGCCGCGCCCAACGGCGGGTGGTGATCGCCAACGCCTACTTCTTTCCCGGCTATCGCCTGCTGCG
CGAGATTCGCAACGCCGCCCGACGCGGGGTCGAGGTGCGGCTGATTCTGCAGGGGCAGCCGGACATGCTGGTGGCCAAAC
TCGCCGCGCGCATGACCTACGACTACCTGCTCAAGGCCGGGGTGCAGATTCACGAATATTGCGAGCGGCCGCTGCACGGC
AAGGTGGCGCTGGTGGACGAGGAATGGAGCACCGTCGGCTCGAGCAATCTCGATCCGCTGAGCCTGTCGCTGAACCTGGA
AGCCAACGTGTTGATTCGCGACCGCGCCTTCAATCGCCACCTGTTCGAACGTCTCGAAGACCTCAGCCACAACCACTGCA
AAGCGATGGACGCCGCGAAGTCGCCACGCGGGCGAATCTGGCACATGACCGTGGGCTTTCTGGTGTTTCACTTCCTGCGG
CATTTTCCGGCCATGGCCGGCTGGCTGCCGGCGCACAAGCCACGACTCAAACCCTTTTCCCATGCCGCCGGGAGCGATCA
TTCATGA

Upstream 100 bases:

>100_bases
TCTACGTAAGCAACCTCAAGGCCAGTCAGCCAAAAGTACTGGCGAACCGTCCCTGGTCACACCTTTCCGACCACGCACCG
CTATCGGTGGAGATTGAACT

Downstream 100 bases:

>100_bases
GCCAATCCGAAGCCCACGCGGCGGTGCATCCGACACCGGCGGGCAAGTCCCGCTGGAGTCGCTGGAAACGTCCGCTGACC
TTGTTGTTCTTTCTGGCGCT

Product: cardiolipin synthase 2

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSSAPLEKSAVEPVSITPPVREPGTVDVEYRWQGNNRIELLENGEEYFPRVFEAMRAAKSEILLETFIVFEDKVGKELQE
ILIDAARRGVRTTVSLDGFGCGELSTGYLAALSEAGVHLQIFDPAPKRLGIRTNWFRRLHRKIVVVDGLIAFIGGINFSG
DHLADFGPEAKQDYSVEIQGPAVTDIHHFALLQSGRPGRARFWWQRRRQRRAEMAFDDHDGQVRLVFRDNDRHHTDIEDV
YLQVLRRAQRRVVIANAYFFPGYRLLREIRNAARRGVEVRLILQGQPDMLVAKLAARMTYDYLLKAGVQIHEYCERPLHG
KVALVDEEWSTVGSSNLDPLSLSLNLEANVLIRDRAFNRHLFERLEDLSHNHCKAMDAAKSPRGRIWHMTVGFLVFHFLR
HFPAMAGWLPAHKPRLKPFSHAAGSDHS

Sequences:

>Translated_428_residues
MSSAPLEKSAVEPVSITPPVREPGTVDVEYRWQGNNRIELLENGEEYFPRVFEAMRAAKSEILLETFIVFEDKVGKELQE
ILIDAARRGVRTTVSLDGFGCGELSTGYLAALSEAGVHLQIFDPAPKRLGIRTNWFRRLHRKIVVVDGLIAFIGGINFSG
DHLADFGPEAKQDYSVEIQGPAVTDIHHFALLQSGRPGRARFWWQRRRQRRAEMAFDDHDGQVRLVFRDNDRHHTDIEDV
YLQVLRRAQRRVVIANAYFFPGYRLLREIRNAARRGVEVRLILQGQPDMLVAKLAARMTYDYLLKAGVQIHEYCERPLHG
KVALVDEEWSTVGSSNLDPLSLSLNLEANVLIRDRAFNRHLFERLEDLSHNHCKAMDAAKSPRGRIWHMTVGFLVFHFLR
HFPAMAGWLPAHKPRLKPFSHAAGSDHS
>Mature_427_residues
SSAPLEKSAVEPVSITPPVREPGTVDVEYRWQGNNRIELLENGEEYFPRVFEAMRAAKSEILLETFIVFEDKVGKELQEI
LIDAARRGVRTTVSLDGFGCGELSTGYLAALSEAGVHLQIFDPAPKRLGIRTNWFRRLHRKIVVVDGLIAFIGGINFSGD
HLADFGPEAKQDYSVEIQGPAVTDIHHFALLQSGRPGRARFWWQRRRQRRAEMAFDDHDGQVRLVFRDNDRHHTDIEDVY
LQVLRRAQRRVVIANAYFFPGYRLLREIRNAARRGVEVRLILQGQPDMLVAKLAARMTYDYLLKAGVQIHEYCERPLHGK
VALVDEEWSTVGSSNLDPLSLSLNLEANVLIRDRAFNRHLFERLEDLSHNHCKAMDAAKSPRGRIWHMTVGFLVFHFLRH
FPAMAGWLPAHKPRLKPFSHAAGSDHS

Specific function: Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787007, Length=385, Percent_Identity=54.8051948051948, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1787502, Length=377, Percent_Identity=25.1989389920424, Blast_Score=99, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 48865; Mature: 48733

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAPLEKSAVEPVSITPPVREPGTVDVEYRWQGNNRIELLENGEEYFPRVFEAMRAAKS
CCCCCCCHHCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHH
EILLETFIVFEDKVGKELQEILIDAARRGVRTTVSLDGFGCGELSTGYLAALSEAGVHLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHCCCEEE
IFDPAPKRLGIRTNWFRRLHRKIVVVDGLIAFIGGINFSGDHLADFGPEAKQDYSVEIQG
EECCCCHHCCCCHHHHHHHHHHEEHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCEEEECC
PAVTDIHHFALLQSGRPGRARFWWQRRRQRRAEMAFDDHDGQVRLVFRDNDRHHTDIEDV
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHH
YLQVLRRAQRRVVIANAYFFPGYRLLREIRNAARRGVEVRLILQGQPDMLVAKLAARMTY
HHHHHHHHHCEEEEEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHH
DYLLKAGVQIHEYCERPLHGKVALVDEEWSTVGSSNLDPLSLSLNLEANVLIRDRAFNRH
HHHHHCCCHHHHHHCCCCCCEEEEEECCHHHCCCCCCCCEEEEEECEEEEEEECCHHHHH
LFERLEDLSHNHCKAMDAAKSPRGRIWHMTVGFLVFHFLRHFPAMAGWLPAHKPRLKPFS
HHHHHHHCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
HAAGSDHS
CCCCCCCC
>Mature Secondary Structure 
SSAPLEKSAVEPVSITPPVREPGTVDVEYRWQGNNRIELLENGEEYFPRVFEAMRAAKS
CCCCCCHHCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHH
EILLETFIVFEDKVGKELQEILIDAARRGVRTTVSLDGFGCGELSTGYLAALSEAGVHLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHCCCEEE
IFDPAPKRLGIRTNWFRRLHRKIVVVDGLIAFIGGINFSGDHLADFGPEAKQDYSVEIQG
EECCCCHHCCCCHHHHHHHHHHEEHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCEEEECC
PAVTDIHHFALLQSGRPGRARFWWQRRRQRRAEMAFDDHDGQVRLVFRDNDRHHTDIEDV
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHH
YLQVLRRAQRRVVIANAYFFPGYRLLREIRNAARRGVEVRLILQGQPDMLVAKLAARMTY
HHHHHHHHHCEEEEEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHH
DYLLKAGVQIHEYCERPLHGKVALVDEEWSTVGSSNLDPLSLSLNLEANVLIRDRAFNRH
HHHHHCCCHHHHHHCCCCCCEEEEEECCHHHCCCCCCCCEEEEEECEEEEEEECCHHHHH
LFERLEDLSHNHCKAMDAAKSPRGRIWHMTVGFLVFHFLRHFPAMAGWLPAHKPRLKPFS
HHHHHHHCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
HAAGSDHS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]