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The map label for this gene is dxs [H]

Identifier: 77461228

GI number: 77461228

Start: 5642933

End: 5644831

Strand: Direct

Name: dxs [H]

Synonym: Pfl01_5007

Alternate gene names: 77461228

Gene position: 5642933-5644831 (Clockwise)

Preceding gene: 77461227

Following gene: 77461229

Centisome position: 87.64

GC content: 64.77

Gene sequence:

>1899_bases
ATGCCCACGACGTTTCATGAGATTCCCCGCAAGCGCCCGACCACGCCCCTGCTCGACCGCGCGAACACGCCGGACGGCCT
GCGCCGGTTAGGCGAAGCCGAGCTGGAAACCCTGGCTGATGAGTTGCGCCTGGAATTGCTCTACACGGTCGGCCAGACCG
GTGGGCACTTCGGTGCCGGCCTGGGCGTCATCGAGCTGACCATCGCGTTGCATTACGTCTTCGACACCCCGGACGACCGG
TTGGTGTGGGACGTCGGTCATCAGGCCTATCCGCACAAGATCCTCACCGGTCGTCGCGAGCGCATGGAAACCCTGCGCCA
GAAGGACGGCATCGCCGCCTTCCCGCGCCGTTCCGAGAGCGAGTACGACACCTTCGGCGTCGGCCACTCCAGCACCTCGA
TCAGTGCCGCGCTGGGCATGGCCATCGCCGCCCGCCTGCAGAACAGCGATCGCAAGGCGATTGCGGTGATCGGCGACGGC
GCCCTGACCGCCGGCATGGCCTTCGAGGCGCTGAACCACGCGCCGGAAGTCGACGCCAACATGCTGGTGATCCTCAACGA
CAACGACATGTCGATCTCGCGCAACGTCGGCGGTCTGTCGAACTATCTGGCGAAGATCCTTTCCAGCCGCACTTACGCGA
GCATGCGTGAGGGCAGCAAGAAAGTGCTGTCGCGCCTGCCCGGTGCCTGGGAAATCGCCCGTCGTACCGAAGAGTACGCA
AAAGGCATGCTGGTCCCCGGCACCCTGTTCGAAGAATTGGGCTGGAACTACATCGGCCCGATCGACGGCCACGACCTGCC
GACCCTGATCGCCACCCTGCGCAACATGCGCGATCTGAAAGGCCCGCAGTTCCTGCATATCGTCACCAAGAAGGGCAAAG
GCTTCGCACCGGCGGAAGTCGACCCGATCGGTTACCACGCCATCACCAAACTCGAACCGCTGGACGCCCCGGCCGCTGCG
CCGAAAAAGGCCGGCGGGCCGAAGTATTCCGGCGTGTTCGGTGAGTGGCTGTGCGACATGGCCGCTGCCGACCCGCGTCT
GGTGGGCATCACCCCCGCGATGAAGGAAGGCTCGGATCTGGTGGCGTTCAGCGAACGCTTCCCGCTGCGCTACTTCGACG
TGGCGATTGCCGAGCAACACGCCGTGACCCTCGCCGCCGGCATGGCCTGCGAAGGCGCAAAACCGGTGGTGGCGATCTAC
TCGACATTCCTGCAGCGCGGTTATGACCAGTTGGTGCATGACGTCGCGGTACAGAACCTCGACGTGCTGTTCGCCATCGA
CCGCGCCGGTCTGGTGGGCGAAGACGGCCCGACCCACGCCGGCAGTTTCGACCTGTCGTTCCTGCGCTGCATCCCGGGCA
TGGTCATCATGACCCCGAGCGATGAAAATGAACTCCGCAAGATGCTCACCACCGGCCACCTGTACAACGGCCCGGCGGCG
GTGCGTTACCCGCGCGGCACCGGCCCGAACGCGACCATCGAGAAAGACCTCGAACCGATCGAGATCGGTAAGGGCGTGGT
ACGTCGTCAGGGCAGCAAGGTCGCCCTGCTGGTGTTCGGCGTGCAAATGGCCGAAGCCCTGAAAGTCGCCGAGACGCTGG
ACGCGACCGTGGTCGACATGCGTTTCGTCAAACCGATGGACGAAGCGCTGGTACGCGAGATCGCCAACAGCCACGACCTG
CTGGTGACCATCGAAGAGAACGCGATCATGGGCGGCGCCGGTGGCGCGGTCAGCGAATTCCTCGCCCGCGAGAACATCCT
CAAGTCGGTGCTGCACCTGGGCTTGCCGGACGTTTACGTCGAGCACGCCAAGCCGGCGCAAATGCTGGCCGAGTGCGGAC
TGGATGAAGTGGGGATCGAAGCGGCGGTGCGGGAGCGCCTGGAGCTGCTTAACCGCTAA

Upstream 100 bases:

>100_bases
CGCAACTGAAGGCTTATCTGCCAAAAAAGACCAACGCGTGGGCAGGGGGCGATGCATCAGGTAAACTGCCGCATCTTTTA
TACCTATAACGATTCGCCTG

Downstream 100 bases:

>100_bases
CTCGCTGGATACACGTAAAACCCCATGTGGGAGCGGGCTTGCTCGCGAAAGCGTCGGATCAGTCGATGATGAGTTGACTG
ACACTCCGCTTTCGCGAGCA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MPTTFHEIPRKRPTTPLLDRANTPDGLRRLGEAELETLADELRLELLYTVGQTGGHFGAGLGVIELTIALHYVFDTPDDR
LVWDVGHQAYPHKILTGRRERMETLRQKDGIAAFPRRSESEYDTFGVGHSSTSISAALGMAIAARLQNSDRKAIAVIGDG
ALTAGMAFEALNHAPEVDANMLVILNDNDMSISRNVGGLSNYLAKILSSRTYASMREGSKKVLSRLPGAWEIARRTEEYA
KGMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLKGPQFLHIVTKKGKGFAPAEVDPIGYHAITKLEPLDAPAAA
PKKAGGPKYSGVFGEWLCDMAAADPRLVGITPAMKEGSDLVAFSERFPLRYFDVAIAEQHAVTLAAGMACEGAKPVVAIY
STFLQRGYDQLVHDVAVQNLDVLFAIDRAGLVGEDGPTHAGSFDLSFLRCIPGMVIMTPSDENELRKMLTTGHLYNGPAA
VRYPRGTGPNATIEKDLEPIEIGKGVVRRQGSKVALLVFGVQMAEALKVAETLDATVVDMRFVKPMDEALVREIANSHDL
LVTIEENAIMGGAGGAVSEFLARENILKSVLHLGLPDVYVEHAKPAQMLAECGLDEVGIEAAVRERLELLNR

Sequences:

>Translated_632_residues
MPTTFHEIPRKRPTTPLLDRANTPDGLRRLGEAELETLADELRLELLYTVGQTGGHFGAGLGVIELTIALHYVFDTPDDR
LVWDVGHQAYPHKILTGRRERMETLRQKDGIAAFPRRSESEYDTFGVGHSSTSISAALGMAIAARLQNSDRKAIAVIGDG
ALTAGMAFEALNHAPEVDANMLVILNDNDMSISRNVGGLSNYLAKILSSRTYASMREGSKKVLSRLPGAWEIARRTEEYA
KGMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLKGPQFLHIVTKKGKGFAPAEVDPIGYHAITKLEPLDAPAAA
PKKAGGPKYSGVFGEWLCDMAAADPRLVGITPAMKEGSDLVAFSERFPLRYFDVAIAEQHAVTLAAGMACEGAKPVVAIY
STFLQRGYDQLVHDVAVQNLDVLFAIDRAGLVGEDGPTHAGSFDLSFLRCIPGMVIMTPSDENELRKMLTTGHLYNGPAA
VRYPRGTGPNATIEKDLEPIEIGKGVVRRQGSKVALLVFGVQMAEALKVAETLDATVVDMRFVKPMDEALVREIANSHDL
LVTIEENAIMGGAGGAVSEFLARENILKSVLHLGLPDVYVEHAKPAQMLAECGLDEVGIEAAVRERLELLNR
>Mature_631_residues
PTTFHEIPRKRPTTPLLDRANTPDGLRRLGEAELETLADELRLELLYTVGQTGGHFGAGLGVIELTIALHYVFDTPDDRL
VWDVGHQAYPHKILTGRRERMETLRQKDGIAAFPRRSESEYDTFGVGHSSTSISAALGMAIAARLQNSDRKAIAVIGDGA
LTAGMAFEALNHAPEVDANMLVILNDNDMSISRNVGGLSNYLAKILSSRTYASMREGSKKVLSRLPGAWEIARRTEEYAK
GMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLKGPQFLHIVTKKGKGFAPAEVDPIGYHAITKLEPLDAPAAAP
KKAGGPKYSGVFGEWLCDMAAADPRLVGITPAMKEGSDLVAFSERFPLRYFDVAIAEQHAVTLAAGMACEGAKPVVAIYS
TFLQRGYDQLVHDVAVQNLDVLFAIDRAGLVGEDGPTHAGSFDLSFLRCIPGMVIMTPSDENELRKMLTTGHLYNGPAAV
RYPRGTGPNATIEKDLEPIEIGKGVVRRQGSKVALLVFGVQMAEALKVAETLDATVVDMRFVKPMDEALVREIANSHDLL
VTIEENAIMGGAGGAVSEFLARENILKSVLHLGLPDVYVEHAKPAQMLAECGLDEVGIEAAVRERLELLNR

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=302, Percent_Identity=27.8145695364238, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI4507521, Length=302, Percent_Identity=27.8145695364238, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI133778974, Length=423, Percent_Identity=25.7683215130024, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI225637459, Length=381, Percent_Identity=25.7217847769029, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI225637461, Length=381, Percent_Identity=25.7217847769029, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI225637463, Length=377, Percent_Identity=25.1989389920424, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI1786622, Length=619, Percent_Identity=61.389337641357, Blast_Score=774, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=405, Percent_Identity=28.8888888888889, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24666278, Length=592, Percent_Identity=26.1824324324324, Blast_Score=121, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45551847, Length=632, Percent_Identity=24.8417721518987, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI45550715, Length=632, Percent_Identity=24.8417721518987, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24645119, Length=525, Percent_Identity=25.7142857142857, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68588; Mature: 68456

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTTFHEIPRKRPTTPLLDRANTPDGLRRLGEAELETLADELRLELLYTVGQTGGHFGAG
CCCCHHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LGVIELTIALHYVFDTPDDRLVWDVGHQAYPHKILTGRRERMETLRQKDGIAAFPRRSES
HHHHHHEEEEEEEECCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCEECCCCCCC
EYDTFGVGHSSTSISAALGMAIAARLQNSDRKAIAVIGDGALTAGMAFEALNHAPEVDAN
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCC
MLVILNDNDMSISRNVGGLSNYLAKILSSRTYASMREGSKKVLSRLPGAWEIARRTEEYA
EEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KGMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLKGPQFLHIVTKKGKGFAPAEV
CCCCCCHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCC
DPIGYHAITKLEPLDAPAAAPKKAGGPKYSGVFGEWLCDMAAADPRLVGITPAMKEGSDL
CCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCE
VAFSERFPLRYFDVAIAEQHAVTLAAGMACEGAKPVVAIYSTFLQRGYDQLVHDVAVQNL
EEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
DVLFAIDRAGLVGEDGPTHAGSFDLSFLRCIPGMVIMTPSDENELRKMLTTGHLYNGPAA
EEEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHCCEECCCCE
VRYPRGTGPNATIEKDLEPIEIGKGVVRRQGSKVALLVFGVQMAEALKVAETLDATVVDM
EECCCCCCCCCCHHCCCCHHHHCCHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHH
RFVKPMDEALVREIANSHDLLVTIEENAIMGGAGGAVSEFLARENILKSVLHLGLPDVYV
HHHCCHHHHHHHHHCCCCCEEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
EHAKPAQMLAECGLDEVGIEAAVRERLELLNR
HCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PTTFHEIPRKRPTTPLLDRANTPDGLRRLGEAELETLADELRLELLYTVGQTGGHFGAG
CCCHHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LGVIELTIALHYVFDTPDDRLVWDVGHQAYPHKILTGRRERMETLRQKDGIAAFPRRSES
HHHHHHEEEEEEEECCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCEECCCCCCC
EYDTFGVGHSSTSISAALGMAIAARLQNSDRKAIAVIGDGALTAGMAFEALNHAPEVDAN
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCC
MLVILNDNDMSISRNVGGLSNYLAKILSSRTYASMREGSKKVLSRLPGAWEIARRTEEYA
EEEEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KGMLVPGTLFEELGWNYIGPIDGHDLPTLIATLRNMRDLKGPQFLHIVTKKGKGFAPAEV
CCCCCCHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCC
DPIGYHAITKLEPLDAPAAAPKKAGGPKYSGVFGEWLCDMAAADPRLVGITPAMKEGSDL
CCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCE
VAFSERFPLRYFDVAIAEQHAVTLAAGMACEGAKPVVAIYSTFLQRGYDQLVHDVAVQNL
EEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
DVLFAIDRAGLVGEDGPTHAGSFDLSFLRCIPGMVIMTPSDENELRKMLTTGHLYNGPAA
EEEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHCCEECCCCE
VRYPRGTGPNATIEKDLEPIEIGKGVVRRQGSKVALLVFGVQMAEALKVAETLDATVVDM
EECCCCCCCCCCHHCCCCHHHHCCHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHH
RFVKPMDEALVREIANSHDLLVTIEENAIMGGAGGAVSEFLARENILKSVLHLGLPDVYV
HHHCCHHHHHHHHHCCCCCEEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
EHAKPAQMLAECGLDEVGIEAAVRERLELLNR
HCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA