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The map label for this gene is mrdA [H]

Identifier: 77461191

GI number: 77461191

Start: 5598093

End: 5599988

Strand: Reverse

Name: mrdA [H]

Synonym: Pfl01_4970

Alternate gene names: 77461191

Gene position: 5599988-5598093 (Counterclockwise)

Preceding gene: 77461192

Following gene: 77461190

Centisome position: 86.98

GC content: 63.66

Gene sequence:

>1896_bases
ATGTCTCAGCCGATCCGCATCAAGGACCACGAAAAAGACGCCCGTCTGGTGCGTGGTCGCGTCGTGTTCGGCGCAATTGC
GGTGGTGGCACTGATCTGCGTGCTGATTGCGCGGCTGTATTACCTGCAGGTGATTCAGTACGAATATCACTCGACTCTGT
CGGAAAACAATCGGGTGCATGTCCAGCCGATCCCGCCGACCCGTGGCCTGATTTTCGATCGCAACGGCGTGGTGGTGGCG
GACAACCGTCCGAGCTTCAGCCTGAGCATGACCCGCGAGCGCTCCGGCGACTGGCAGCAGGTGCTCGACGTGATCGTCGA
GGTGCTGGAGCTGACGCCGGAAGACCGGGTGATCTTCGAGAAACGCATGCGCCAGGGCCGCCGGCCGTTCGAGCCGGTGC
CGATCCTGTTCGAGCTGACCGAAGAGCAGATCGCCCGGATCGCGGTGAACCAGTTCCGTCTGCCGGGCGTCGAGGTGGTC
GCGCAACTGGTGCGTCATTACCCGCAGGGCGCGCATTTCGCGCACTCGGTGGGTTACATGGGGCGGATCAACGAGAAAGA
GCTGAAGACCCTCGATCCGGTCAATTACAGCGGTACCCACCACATCGGCAAGACCGGCATCGAGCGCTTCTATGAAGCCG
AGCTGCACGGTCAGGTGGGTTACGAAGAGGTCGAGACCAACGCCCGTGGCCGCGTCCTGCGCGTGCTCAAGCGTACCGAT
CCGGTGCCAGGCAAGGACATTGTCCTGAGCCTCGACATCAAGTTGCAGGAAGCTGCCGAGGCTGCGCTGGGCGGTCGGCG
TGGCGCGGTGGTGGCGCTCGATCCGAAAACCGGCGAAGTGCTGGCGATGGTCAGCCAGCCGAGCTTCGACCCGAACCTGT
TCGTCACCGGCATCAGCTTCAAGGCCTACGCCGAGCTGCGCGATTCGATCGACCGGCCGCTGTTCAACCGCGTGCTGCGC
GGTCTGTACCCGCCGGGTTCGACGATCAAGCCGGCGGTGGCGATTGCCGGTCTCGATGCGGGCGTGGTGACGGCGTCGAG
CCGGGTGTTCGACCCCGGTTACTACATGCTGCCCAACTACGATCACAAGTACCGCAACTGGAACCGCACCGGGGACGGCT
TCGTCGACCTCGACACGGCGATCATGCGGTCCAACGACACCTACTTCTATGACCTGGCACACAAGCTGGGCATCGACCGG
TTGTCGGCCTACATGAACAAGTTCGGCATCGGCCAGAAGGTCTCGCTGGACATGTTCGAAGAATCCCCCGGCCTGATGCC
GTCCCGCGAGTGGAAACGCGCGACCCGGCGTCAGGCGTGGTTCCCCGGCGAAACCCTGATTCTCGGGATCGGCCAGGGCT
ACATGCAATCGACCCCGCTGCAACTGGCCCAGGCCACGGCGCTGGTGGCCAACAAGGGCGTGTGGAACCGCCCGCACCTG
GCCAAGACCATCGAAGGCGAGAAACCGAAGGATGAAAACCCGATGCCGGACATCATCCTGCGCGACCCGTCCGACTGGAA
CAAGGTCAACCACGGCATGCAGCAGGTGATGCACGGTGCCCGCGGCACCGCGCGCAAGGCCTCGATCGGCGCGCAATACC
GGATCGCCGGCAAGTCAGGTACGGCGCAGGTTGTGGCGATCAAACAGGGCGAGAAGTACGATCGTTCCAAGGTTCAGGAG
CGCCACCGCGACCACGCCCTGTTTGTCGGTTTCGCGCCGGCGGATGACCCGAAAATCGTGGTGTCGGTGATGGTCGAGAA
CGGTGAGTCCGGTTCCGGCGTCGCGGCACCGGTGGTGCGGCAGGTCATGGATGCCTGGCTGCTGGATCAGGACGGACGGT
TGAAGGCCGAATACGCCAGCCCTATCAGTGCGGAGGCTACGGCCCGTGATGAATAA

Upstream 100 bases:

>100_bases
GACGCTGCCGCACCCGCTGGTGCGCATCCTCATCGGCGAGCAGTTGTATCGTGCCTGGACCGTGCTGTCCGGCCACCCTT
ACCACAAGTAACCCGCCCTC

Downstream 100 bases:

>100_bases
TTTCGATCGCATGCTCTCCAGCGAGGATGTGATGCGTCGCCGGGCGACGCTGTTGCAACGTCTGCATATCGACGGCCCGT
TGCTGGTGCTGTTGTTGATT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 631; Mature: 630

Protein sequence:

>631_residues
MSQPIRIKDHEKDARLVRGRVVFGAIAVVALICVLIARLYYLQVIQYEYHSTLSENNRVHVQPIPPTRGLIFDRNGVVVA
DNRPSFSLSMTRERSGDWQQVLDVIVEVLELTPEDRVIFEKRMRQGRRPFEPVPILFELTEEQIARIAVNQFRLPGVEVV
AQLVRHYPQGAHFAHSVGYMGRINEKELKTLDPVNYSGTHHIGKTGIERFYEAELHGQVGYEEVETNARGRVLRVLKRTD
PVPGKDIVLSLDIKLQEAAEAALGGRRGAVVALDPKTGEVLAMVSQPSFDPNLFVTGISFKAYAELRDSIDRPLFNRVLR
GLYPPGSTIKPAVAIAGLDAGVVTASSRVFDPGYYMLPNYDHKYRNWNRTGDGFVDLDTAIMRSNDTYFYDLAHKLGIDR
LSAYMNKFGIGQKVSLDMFEESPGLMPSREWKRATRRQAWFPGETLILGIGQGYMQSTPLQLAQATALVANKGVWNRPHL
AKTIEGEKPKDENPMPDIILRDPSDWNKVNHGMQQVMHGARGTARKASIGAQYRIAGKSGTAQVVAIKQGEKYDRSKVQE
RHRDHALFVGFAPADDPKIVVSVMVENGESGSGVAAPVVRQVMDAWLLDQDGRLKAEYASPISAEATARDE

Sequences:

>Translated_631_residues
MSQPIRIKDHEKDARLVRGRVVFGAIAVVALICVLIARLYYLQVIQYEYHSTLSENNRVHVQPIPPTRGLIFDRNGVVVA
DNRPSFSLSMTRERSGDWQQVLDVIVEVLELTPEDRVIFEKRMRQGRRPFEPVPILFELTEEQIARIAVNQFRLPGVEVV
AQLVRHYPQGAHFAHSVGYMGRINEKELKTLDPVNYSGTHHIGKTGIERFYEAELHGQVGYEEVETNARGRVLRVLKRTD
PVPGKDIVLSLDIKLQEAAEAALGGRRGAVVALDPKTGEVLAMVSQPSFDPNLFVTGISFKAYAELRDSIDRPLFNRVLR
GLYPPGSTIKPAVAIAGLDAGVVTASSRVFDPGYYMLPNYDHKYRNWNRTGDGFVDLDTAIMRSNDTYFYDLAHKLGIDR
LSAYMNKFGIGQKVSLDMFEESPGLMPSREWKRATRRQAWFPGETLILGIGQGYMQSTPLQLAQATALVANKGVWNRPHL
AKTIEGEKPKDENPMPDIILRDPSDWNKVNHGMQQVMHGARGTARKASIGAQYRIAGKSGTAQVVAIKQGEKYDRSKVQE
RHRDHALFVGFAPADDPKIVVSVMVENGESGSGVAAPVVRQVMDAWLLDQDGRLKAEYASPISAEATARDE
>Mature_630_residues
SQPIRIKDHEKDARLVRGRVVFGAIAVVALICVLIARLYYLQVIQYEYHSTLSENNRVHVQPIPPTRGLIFDRNGVVVAD
NRPSFSLSMTRERSGDWQQVLDVIVEVLELTPEDRVIFEKRMRQGRRPFEPVPILFELTEEQIARIAVNQFRLPGVEVVA
QLVRHYPQGAHFAHSVGYMGRINEKELKTLDPVNYSGTHHIGKTGIERFYEAELHGQVGYEEVETNARGRVLRVLKRTDP
VPGKDIVLSLDIKLQEAAEAALGGRRGAVVALDPKTGEVLAMVSQPSFDPNLFVTGISFKAYAELRDSIDRPLFNRVLRG
LYPPGSTIKPAVAIAGLDAGVVTASSRVFDPGYYMLPNYDHKYRNWNRTGDGFVDLDTAIMRSNDTYFYDLAHKLGIDRL
SAYMNKFGIGQKVSLDMFEESPGLMPSREWKRATRRQAWFPGETLILGIGQGYMQSTPLQLAQATALVANKGVWNRPHLA
KTIEGEKPKDENPMPDIILRDPSDWNKVNHGMQQVMHGARGTARKASIGAQYRIAGKSGTAQVVAIKQGEKYDRSKVQER
HRDHALFVGFAPADDPKIVVSVMVENGESGSGVAAPVVRQVMDAWLLDQDGRLKAEYASPISAEATARDE

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=631, Percent_Identity=43.1061806656101, Blast_Score=527, Evalue=1e-151,
Organism=Escherichia coli, GI1786272, Length=627, Percent_Identity=24.8803827751196, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 70456; Mature: 70325

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPIRIKDHEKDARLVRGRVVFGAIAVVALICVLIARLYYLQVIQYEYHSTLSENNRVH
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VQPIPPTRGLIFDRNGVVVADNRPSFSLSMTRERSGDWQQVLDVIVEVLELTPEDRVIFE
EEECCCCCCEEEECCCEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
KRMRQGRRPFEPVPILFELTEEQIARIAVNQFRLPGVEVVAQLVRHYPQGAHFAHSVGYM
HHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHCCCC
GRINEKELKTLDPVNYSGTHHIGKTGIERFYEAELHGQVGYEEVETNARGRVLRVLKRTD
CCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHCC
PVPGKDIVLSLDIKLQEAAEAALGGRRGAVVALDPKTGEVLAMVSQPSFDPNLFVTGISF
CCCCCCEEEEEECCHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCCCCEEEEECCH
KAYAELRDSIDRPLFNRVLRGLYPPGSTIKPAVAIAGLDAGVVTASSRVFDPGYYMLPNY
HHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEECCCEEECCCEEECCCC
DHKYRNWNRTGDGFVDLDTAIMRSNDTYFYDLAHKLGIDRLSAYMNKFGIGQKVSLDMFE
CCHHCCCCCCCCCEEEECHHHHCCCCCEEEEHHHHHCHHHHHHHHHHHCCCCEEEEEHHH
ESPGLMPSREWKRATRRQAWFPGETLILGIGQGYMQSTPLQLAQATALVANKGVWNRPHL
CCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHCCCHHHHHHHHHHHCCCCCCCCCH
AKTIEGEKPKDENPMPDIILRDPSDWNKVNHGMQQVMHGARGTARKASIGAQYRIAGKSG
HHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCC
TAQVVAIKQGEKYDRSKVQERHRDHALFVGFAPADDPKIVVSVMVENGESGSGVAAPVVR
CEEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCHHHHHHH
QVMDAWLLDQDGRLKAEYASPISAEATARDE
HHHHHHHCCCCCCEEEHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SQPIRIKDHEKDARLVRGRVVFGAIAVVALICVLIARLYYLQVIQYEYHSTLSENNRVH
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VQPIPPTRGLIFDRNGVVVADNRPSFSLSMTRERSGDWQQVLDVIVEVLELTPEDRVIFE
EEECCCCCCEEEECCCEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
KRMRQGRRPFEPVPILFELTEEQIARIAVNQFRLPGVEVVAQLVRHYPQGAHFAHSVGYM
HHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHCCCC
GRINEKELKTLDPVNYSGTHHIGKTGIERFYEAELHGQVGYEEVETNARGRVLRVLKRTD
CCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHCC
PVPGKDIVLSLDIKLQEAAEAALGGRRGAVVALDPKTGEVLAMVSQPSFDPNLFVTGISF
CCCCCCEEEEEECCHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCCCCEEEEECCH
KAYAELRDSIDRPLFNRVLRGLYPPGSTIKPAVAIAGLDAGVVTASSRVFDPGYYMLPNY
HHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEECCCEEECCCEEECCCC
DHKYRNWNRTGDGFVDLDTAIMRSNDTYFYDLAHKLGIDRLSAYMNKFGIGQKVSLDMFE
CCHHCCCCCCCCCEEEECHHHHCCCCCEEEEHHHHHCHHHHHHHHHHHCCCCEEEEEHHH
ESPGLMPSREWKRATRRQAWFPGETLILGIGQGYMQSTPLQLAQATALVANKGVWNRPHL
CCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHCCCHHHHHHHHHHHCCCCCCCCCH
AKTIEGEKPKDENPMPDIILRDPSDWNKVNHGMQQVMHGARGTARKASIGAQYRIAGKSG
HHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCHHHCCCCEEEEECCCC
TAQVVAIKQGEKYDRSKVQERHRDHALFVGFAPADDPKIVVSVMVENGESGSGVAAPVVR
CEEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCHHHHHHH
QVMDAWLLDQDGRLKAEYASPISAEATARDE
HHHHHHHCCCCCCEEEHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]