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The map label for this gene is aroE [H]

Identifier: 77461124

GI number: 77461124

Start: 5525873

End: 5526727

Strand: Direct

Name: aroE [H]

Synonym: Pfl01_4903

Alternate gene names: 77461124

Gene position: 5525873-5526727 (Clockwise)

Preceding gene: 77461123

Following gene: 77461128

Centisome position: 85.83

GC content: 61.75

Gene sequence:

>855_bases
ATGAATCGCAACAACGTGATACTCGCCGGGCTGATCGGTGCCGGCATCCAGGCCTCCCGCACCCCGGCCCTGCACGAACA
CGAAGGTGACGAACAGGGCCTGCGTTACCTGTACCGGCTGATCGATCTCGATCAACTGCAACTGGACAGCAACGCCCTGC
CCGACCTGCTGCTGGCCGCCGAACGGATGAACTACACCGGGCTGAACATCACCTTCCCGTGCAAGCAGGCAATCATCCCG
CTGCTCGATGAATTGTCCCCGGAAGCCCGAGGCATCGGCGCCGTGAACACAGTGGTGCTGAAGGACGGCAAACGCGTCGG
CCACAACACCGATTGCCTGGGTTTTGCCGAAGGTTTTCGTCGCGGACTGCCAGACGTCGCCCGCGAACGTGTGGTCCAGA
TGGGCGCCGGTGGCGCAGGCGCGGCAGTCGCCCACGCCTTGTTGAGCGAAGGCGTACAGCAACTGAGCATTTTTGATGTG
GACGTGGAGCGCGCCGAAAGCCTGGCCAACAACCTCAACCAGCATTTCGGCGCTGGCCGGGCGGTTGCCGGGCATGATCT
GGCGAGCACACTGAGTCAGGCGAATGGCCTGGTAAACACCACGCCGATGGGCATGGCCAAATTGCCAGGCATGCCCGTGC
CGACGGAATTGCTGCGACCCGAGTTGTGGGTAGCGGAGATCGTGTATTTCCCGCTGGAAACCGAACTACTGCGCAACGCC
CGCGCCCTGGGTTGCCGAACCCTGGACGGCGGCAACATGGCGGTATTTCAGGCGGTGAAAGCGTTTGAACTGTTCAGCGG
CAGAGTGCCGGATGCGCAGCGAATGCTCGCGCATTTTCAAAGCATGAATGGATAA

Upstream 100 bases:

>100_bases
TCGTCTCCGCCATCGCCACCGCCGTGATGTGCGGCTTCGGCAGCCACGGCTATCGCCTGGCCCTGGAACATTTCAGCCAG
CGGCTGAAGGGGTGATCCGC

Downstream 100 bases:

>100_bases
AACCGTGAGGGGGCGACGCCCCCTCGACTTCAGTCACGCTTGCAGGTAGCGCAGCACCGACTCGCAAATCATCTCGCGAT
GACGCTGCTTGATGCTTTCG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNRNNVILAGLIGAGIQASRTPALHEHEGDEQGLRYLYRLIDLDQLQLDSNALPDLLLAAERMNYTGLNITFPCKQAIIP
LLDELSPEARGIGAVNTVVLKDGKRVGHNTDCLGFAEGFRRGLPDVARERVVQMGAGGAGAAVAHALLSEGVQQLSIFDV
DVERAESLANNLNQHFGAGRAVAGHDLASTLSQANGLVNTTPMGMAKLPGMPVPTELLRPELWVAEIVYFPLETELLRNA
RALGCRTLDGGNMAVFQAVKAFELFSGRVPDAQRMLAHFQSMNG

Sequences:

>Translated_284_residues
MNRNNVILAGLIGAGIQASRTPALHEHEGDEQGLRYLYRLIDLDQLQLDSNALPDLLLAAERMNYTGLNITFPCKQAIIP
LLDELSPEARGIGAVNTVVLKDGKRVGHNTDCLGFAEGFRRGLPDVARERVVQMGAGGAGAAVAHALLSEGVQQLSIFDV
DVERAESLANNLNQHFGAGRAVAGHDLASTLSQANGLVNTTPMGMAKLPGMPVPTELLRPELWVAEIVYFPLETELLRNA
RALGCRTLDGGNMAVFQAVKAFELFSGRVPDAQRMLAHFQSMNG
>Mature_284_residues
MNRNNVILAGLIGAGIQASRTPALHEHEGDEQGLRYLYRLIDLDQLQLDSNALPDLLLAAERMNYTGLNITFPCKQAIIP
LLDELSPEARGIGAVNTVVLKDGKRVGHNTDCLGFAEGFRRGLPDVARERVVQMGAGGAGAAVAHALLSEGVQQLSIFDV
DVERAESLANNLNQHFGAGRAVAGHDLASTLSQANGLVNTTPMGMAKLPGMPVPTELLRPELWVAEIVYFPLETELLRNA
RALGCRTLDGGNMAVFQAVKAFELFSGRVPDAQRMLAHFQSMNG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=270, Percent_Identity=29.6296296296296, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789675, Length=273, Percent_Identity=29.3040293040293, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320332, Length=169, Percent_Identity=31.9526627218935, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR013708
- InterPro:   IPR022893 [H]

Pfam domain/function: PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 30529; Mature: 30529

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRNNVILAGLIGAGIQASRTPALHEHEGDEQGLRYLYRLIDLDQLQLDSNALPDLLLAA
CCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ERMNYTGLNITFPCKQAIIPLLDELSPEARGIGAVNTVVLKDGKRVGHNTDCLGFAEGFR
HHCCCCCCEEECCHHHHHHHHHHHCCCHHCCCCHHEEEEEECCCCCCCCCCHHHHHHHHH
RGLPDVARERVVQMGAGGAGAAVAHALLSEGVQQLSIFDVDVERAESLANNLNQHFGAGR
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AVAGHDLASTLSQANGLVNTTPMGMAKLPGMPVPTELLRPELWVAEIVYFPLETELLRNA
CCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHH
RALGCRTLDGGNMAVFQAVKAFELFSGRVPDAQRMLAHFQSMNG
HHHCCEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNRNNVILAGLIGAGIQASRTPALHEHEGDEQGLRYLYRLIDLDQLQLDSNALPDLLLAA
CCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
ERMNYTGLNITFPCKQAIIPLLDELSPEARGIGAVNTVVLKDGKRVGHNTDCLGFAEGFR
HHCCCCCCEEECCHHHHHHHHHHHCCCHHCCCCHHEEEEEECCCCCCCCCCHHHHHHHHH
RGLPDVARERVVQMGAGGAGAAVAHALLSEGVQQLSIFDVDVERAESLANNLNQHFGAGR
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AVAGHDLASTLSQANGLVNTTPMGMAKLPGMPVPTELLRPELWVAEIVYFPLETELLRNA
CCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHH
RALGCRTLDGGNMAVFQAVKAFELFSGRVPDAQRMLAHFQSMNG
HHHCCEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12692562; 11572948 [H]