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The map label for this gene is exuT [H]

Identifier: 77461128

GI number: 77461128

Start: 5529716

End: 5531053

Strand: Direct

Name: exuT [H]

Synonym: Pfl01_4907

Alternate gene names: 77461128

Gene position: 5529716-5531053 (Clockwise)

Preceding gene: 77461124

Following gene: 77461132

Centisome position: 85.89

GC content: 62.03

Gene sequence:

>1338_bases
ATGATTCCTTCACAGACTTCCCGCATGGCTCCGGCCATGAGCACTGCCACGGGTGGCATCGGCGACAAGATCCGCGGCGC
CATGGCCGTCGGCAAGACCCGTTGGGGCATGCTGGCGCTGGTGTTTTTCGCCACCACCCTCAATTACATCGACCGCGCCG
CCCTCGGCGTCATGCAGCCGATCCTTGCCAAGGAAATGAGCTGGACGGCGATGGACTACGCCAACATCAACTTCTGGTTT
CAGGTCGGCTACGCGATCGGCTTCGTGCTGCAAGGACGACTGATCGACCGGGTCGGCGTCAAGCGCGTGTTCTTCTGCGC
GGTGCTGCTCTGGAGCCTGGCCACCGGTGCCCACGGTCTGGCGACCTCGGCGGTGGGCTTCATGGTCTGCCGGTTCATCC
TCGGCCTGACTGAAGCGGCGAACTACCCGGCCTGCGTAAAGACCACGCGCCTGTGGTTCCCGGCCGGCGAGCGCGCCGTG
GCCACCGGCATCTTCAACGCCGGCACCAACGTCGGTGCGATGTTCACTCCGATGCTGCTGCCACTGATCCTTCACGTGTG
GGGCTGGCAGGCCGCGTTCCTGTGCATGTCGGCGCTGGGCGGGATCTGGCTGCTGTTCTGGGGCCTGAAGTATTTCAACC
CTGAAGATCACCCGAGCGTGAAACAGTCGGAGCTGGAATACATCCAGAAAGAAGTCGAACCGGAACAGGCCCGCGTGCCG
TTCTCGAAAATCCTGCGCATGCGCGGCACCTGGGCCTTCGCCCTCGCCTACTCGCTGACCGCGCCGGTGTTCTGGTTCTA
CCTGTACTGGCTGCCGCCGTTTCTCAATCAGCAATACAACCTGGGCATCAACGTCACCCAGATGGGCATTCCGCTGATCA
TCATCTACGTCACCGCCGACTTCGGCAGCGTGGGCGGCGGGATTCTGTCTTCGTTCCTGATCGGTCGCGGCATGAACTCG
ATCAAGGCTCGACTGCTGTCGATGTTCCTGTTCGCCTGCTGCATCATTGGTGTGGTCATGGCCGCCGGCTCCGCCAACCT
GTGGATCGCGGTTGCCGCCATCTCCCTGGCCATCGGCGCGCATCAGGCCTGGACCGCCAACATCTGGAGCCTGGTGATGG
ACTACACGCCCAAGCACATGATGAGCACGGTGTTCGGTTTCGGCGGCATGTGCGCGGCGATCGGCGGGATGTTCATGACC
CAGATCGTCGGCCACATCCTGACCGTCACCAACAACAACTACACCGTGCTGTTCACTCTGATCCCGGCGATGTACTTCAT
TGCCCTGACCTGGATGTACTTCATGGCACCGCGCAAGATTCCTACCGTCACTGAGTAG

Upstream 100 bases:

>100_bases
GCCCAACATCCCTTTCACCTTGAGTCCGGAACTGAACCACCGGTCGCAGCGTGCACAAAAAAAGCACACCAAATAACAAA
TCCAAAAACGGGTGGAACAC

Downstream 100 bases:

>100_bases
CCTTCCAATACTGAATAACCTTCCTGCACCGACCGGCCTGATTTCAGGCCGGTTTTGCTTTTAGCGCCGGCTCTGCTGCC
ACGCTGCCGCCAGCCCGCTG

Product: major facilitator transporter

Products: galacturonate [Cytoplasm]; Proton [Cytoplasm]; glucuronate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MIPSQTSRMAPAMSTATGGIGDKIRGAMAVGKTRWGMLALVFFATTLNYIDRAALGVMQPILAKEMSWTAMDYANINFWF
QVGYAIGFVLQGRLIDRVGVKRVFFCAVLLWSLATGAHGLATSAVGFMVCRFILGLTEAANYPACVKTTRLWFPAGERAV
ATGIFNAGTNVGAMFTPMLLPLILHVWGWQAAFLCMSALGGIWLLFWGLKYFNPEDHPSVKQSELEYIQKEVEPEQARVP
FSKILRMRGTWAFALAYSLTAPVFWFYLYWLPPFLNQQYNLGINVTQMGIPLIIIYVTADFGSVGGGILSSFLIGRGMNS
IKARLLSMFLFACCIIGVVMAAGSANLWIAVAAISLAIGAHQAWTANIWSLVMDYTPKHMMSTVFGFGGMCAAIGGMFMT
QIVGHILTVTNNNYTVLFTLIPAMYFIALTWMYFMAPRKIPTVTE

Sequences:

>Translated_445_residues
MIPSQTSRMAPAMSTATGGIGDKIRGAMAVGKTRWGMLALVFFATTLNYIDRAALGVMQPILAKEMSWTAMDYANINFWF
QVGYAIGFVLQGRLIDRVGVKRVFFCAVLLWSLATGAHGLATSAVGFMVCRFILGLTEAANYPACVKTTRLWFPAGERAV
ATGIFNAGTNVGAMFTPMLLPLILHVWGWQAAFLCMSALGGIWLLFWGLKYFNPEDHPSVKQSELEYIQKEVEPEQARVP
FSKILRMRGTWAFALAYSLTAPVFWFYLYWLPPFLNQQYNLGINVTQMGIPLIIIYVTADFGSVGGGILSSFLIGRGMNS
IKARLLSMFLFACCIIGVVMAAGSANLWIAVAAISLAIGAHQAWTANIWSLVMDYTPKHMMSTVFGFGGMCAAIGGMFMT
QIVGHILTVTNNNYTVLFTLIPAMYFIALTWMYFMAPRKIPTVTE
>Mature_445_residues
MIPSQTSRMAPAMSTATGGIGDKIRGAMAVGKTRWGMLALVFFATTLNYIDRAALGVMQPILAKEMSWTAMDYANINFWF
QVGYAIGFVLQGRLIDRVGVKRVFFCAVLLWSLATGAHGLATSAVGFMVCRFILGLTEAANYPACVKTTRLWFPAGERAV
ATGIFNAGTNVGAMFTPMLLPLILHVWGWQAAFLCMSALGGIWLLFWGLKYFNPEDHPSVKQSELEYIQKEVEPEQARVP
FSKILRMRGTWAFALAYSLTAPVFWFYLYWLPPFLNQQYNLGINVTQMGIPLIIIYVTADFGSVGGGILSSFLIGRGMNS
IKARLLSMFLFACCIIGVVMAAGSANLWIAVAAISLAIGAHQAWTANIWSLVMDYTPKHMMSTVFGFGGMCAAIGGMFMT
QIVGHILTVTNNNYTVLFTLIPAMYFIALTWMYFMAPRKIPTVTE

Specific function: Aldohexuronate transport system [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI154350196, Length=437, Percent_Identity=23.7986270022883, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI9966811, Length=344, Percent_Identity=23.2558139534884, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI9945322, Length=357, Percent_Identity=23.5294117647059, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI2367193, Length=378, Percent_Identity=30.6878306878307, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1789515, Length=400, Percent_Identity=27.5, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789152, Length=411, Percent_Identity=27.7372262773723, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI2367379, Length=411, Percent_Identity=26.0340632603406, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI87082320, Length=391, Percent_Identity=26.0869565217391, Blast_Score=128, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17535049, Length=407, Percent_Identity=23.8329238329238, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI115533556, Length=458, Percent_Identity=25.5458515283843, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115533554, Length=398, Percent_Identity=26.3819095477387, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17552542, Length=283, Percent_Identity=26.1484098939929, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560030, Length=180, Percent_Identity=24.4444444444444, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19920686, Length=385, Percent_Identity=23.3766233766234, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24583789, Length=380, Percent_Identity=22.1052631578947, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129235, Length=366, Percent_Identity=27.3224043715847, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641682, Length=270, Percent_Identity=24.8148148148148, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI62484226, Length=322, Percent_Identity=25.776397515528, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24584153, Length=355, Percent_Identity=23.0985915492958, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24580790, Length=207, Percent_Identity=24.6376811594203, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48997; Mature: 48997

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPSQTSRMAPAMSTATGGIGDKIRGAMAVGKTRWGMLALVFFATTLNYIDRAALGVMQP
CCCCCCHHCCCCHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILAKEMSWTAMDYANINFWFQVGYAIGFVLQGRLIDRVGVKRVFFCAVLLWSLATGAHGL
HHHHHCCHHEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ATSAVGFMVCRFILGLTEAANYPACVKTTRLWFPAGERAVATGIFNAGTNVGAMFTPMLL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEECCCCCHHHHHHHHHCCCCCHHHHHHHHH
PLILHVWGWQAAFLCMSALGGIWLLFWGLKYFNPEDHPSVKQSELEYIQKEVEPEQARVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHCCC
FSKILRMRGTWAFALAYSLTAPVFWFYLYWLPPFLNQQYNLGINVTQMGIPLIIIYVTAD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCEEEEECCCCEEEEEEECC
FGSVGGGILSSFLIGRGMNSIKARLLSMFLFACCIIGVVMAAGSANLWIAVAAISLAIGA
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
HQAWTANIWSLVMDYTPKHMMSTVFGFGGMCAAIGGMFMTQIVGHILTVTNNNYTVLFTL
CCHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEECCCEEEHHHH
IPAMYFIALTWMYFMAPRKIPTVTE
HHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIPSQTSRMAPAMSTATGGIGDKIRGAMAVGKTRWGMLALVFFATTLNYIDRAALGVMQP
CCCCCCHHCCCCHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILAKEMSWTAMDYANINFWFQVGYAIGFVLQGRLIDRVGVKRVFFCAVLLWSLATGAHGL
HHHHHCCHHEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ATSAVGFMVCRFILGLTEAANYPACVKTTRLWFPAGERAVATGIFNAGTNVGAMFTPMLL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHEEECCCCCHHHHHHHHHCCCCCHHHHHHHHH
PLILHVWGWQAAFLCMSALGGIWLLFWGLKYFNPEDHPSVKQSELEYIQKEVEPEQARVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHCCC
FSKILRMRGTWAFALAYSLTAPVFWFYLYWLPPFLNQQYNLGINVTQMGIPLIIIYVTAD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCEEEEECCCCEEEEEEECC
FGSVGGGILSSFLIGRGMNSIKARLLSMFLFACCIIGVVMAAGSANLWIAVAAISLAIGA
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
HQAWTANIWSLVMDYTPKHMMSTVFGFGGMCAAIGGMFMTQIVGHILTVTNNNYTVLFTL
CCHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEECCCEEEHHHH
IPAMYFIALTWMYFMAPRKIPTVTE
HHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: galacturonate [Periplasm]; Proton [Periplasm]; glucuronate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + galacturonate [Periplasm] = galacturonate [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + glucuronate [Periplasm] = Proton [Cytoplasm] + glucuronate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]