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The map label for this gene is folK [H]

Identifier: 77461031

GI number: 77461031

Start: 5427168

End: 5427653

Strand: Direct

Name: folK [H]

Synonym: Pfl01_4810

Alternate gene names: 77461031

Gene position: 5427168-5427653 (Clockwise)

Preceding gene: 77461030

Following gene: 77461032

Centisome position: 84.29

GC content: 63.58

Gene sequence:

>486_bases
ATGGAACGCATCTACATTGGCATGGGCAGCAACCTGGCTGACCCGGCCGAACAATTGCGCAGCGCGGTCGACGCACTGAA
GCAATTGCCCGACACCGAACTGGTCGGTGTATCTGCCTTCTACCAAAGCGACTCGCTGCTGCCGGGCCAACCGCGTTACA
CCAACGCGGTTGCCGCGCTCGACAGCGCGCTCGCCCCGCTGGATCTGCTCGATGCCTTGCAGGCGATCGAAAACGATCAG
GGCCGCGAACGCCTGGAGCGCTGGGGCCCGCGCACGCTGGATCTGGACATTCTGCTGTTCGGTGATCGCCTGATCGACGA
GCCGCGCCTCAAAGTCCCGCATTACCACATGCAGGAACGCGCGTTCGTTCTCTATCCCCTGGCCGAACTGGCTCCCGATG
ATCTGCGTCTGGCCGATGGCCGCACCCTTGCCGATCTTCTCGCAGCCTGCCCGTTCGTCGACCTCGAACGCCTCTCTCAC
GCCTGA

Upstream 100 bases:

>100_bases
CAAGGGTGATGACGCCAGTGGCGCACCGCGCAAACGTCGCCGCAGCAGCGGTTCCAAGCGCAAACGTGCCGGCGCACCGA
GCGCCACGGGCGAATAAGGC

Downstream 100 bases:

>100_bases
CAAAAACCGCTGATGCGGGAGCTCATCGGCTCCCGCATTTTGCGCTCTTGTAGGACAAAAACCCCGCAGATCAGGCCCGC
CGGCCCGCTGAATCGCATCA

Product: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MERIYIGMGSNLADPAEQLRSAVDALKQLPDTELVGVSAFYQSDSLLPGQPRYTNAVAALDSALAPLDLLDALQAIENDQ
GRERLERWGPRTLDLDILLFGDRLIDEPRLKVPHYHMQERAFVLYPLAELAPDDLRLADGRTLADLLAACPFVDLERLSH
A

Sequences:

>Translated_161_residues
MERIYIGMGSNLADPAEQLRSAVDALKQLPDTELVGVSAFYQSDSLLPGQPRYTNAVAALDSALAPLDLLDALQAIENDQ
GRERLERWGPRTLDLDILLFGDRLIDEPRLKVPHYHMQERAFVLYPLAELAPDDLRLADGRTLADLLAACPFVDLERLSH
A
>Mature_161_residues
MERIYIGMGSNLADPAEQLRSAVDALKQLPDTELVGVSAFYQSDSLLPGQPRYTNAVAALDSALAPLDLLDALQAIENDQ
GRERLERWGPRTLDLDILLFGDRLIDEPRLKVPHYHMQERAFVLYPLAELAPDDLRLADGRTLADLLAACPFVDLERLSH
A

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=159, Percent_Identity=49.0566037735849, Blast_Score=144, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324073, Length=137, Percent_Identity=32.1167883211679, Blast_Score=78, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17906; Mature: 17906

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERIYIGMGSNLADPAEQLRSAVDALKQLPDTELVGVSAFYQSDSLLPGQPRYTNAVAAL
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHH
DSALAPLDLLDALQAIENDQGRERLERWGPRTLDLDILLFGDRLIDEPRLKVPHYHMQER
HHHCCHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEEEECCHHCCCCCCCCCCCCCCCC
AFVLYPLAELAPDDLRLADGRTLADLLAACPFVDLERLSHA
EEEEEEHHHHCCCCEEECCCCCHHHHHHHCCCCCHHHHCCC
>Mature Secondary Structure
MERIYIGMGSNLADPAEQLRSAVDALKQLPDTELVGVSAFYQSDSLLPGQPRYTNAVAAL
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHH
DSALAPLDLLDALQAIENDQGRERLERWGPRTLDLDILLFGDRLIDEPRLKVPHYHMQER
HHHCCHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEEEECCHHCCCCCCCCCCCCCCCC
AFVLYPLAELAPDDLRLADGRTLADLLAACPFVDLERLSHA
EEEEEEHHHHCCCCEEECCCCCHHHHHHHCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]