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The map label for this gene is prs [H]

Identifier: 77460974

GI number: 77460974

Start: 5357049

End: 5357981

Strand: Direct

Name: prs [H]

Synonym: Pfl01_4753

Alternate gene names: 77460974

Gene position: 5357049-5357981 (Clockwise)

Preceding gene: 77460973

Following gene: 77460975

Centisome position: 83.2

GC content: 54.98

Gene sequence:

>933_bases
ATGATGGTCTTTACGGGGAACGCTAACCCCGATCTGGCTCGGCGTGTCGTACGTCAGCTGCATATCCCTCTCGGTGACAT
CTCTGTCGGTAAATTTTCCGACGGCGAAATTACAGCCGAGATCAATGAAAACGTTCGTGGTAAAGACGTCTTCATTATTC
AGCCGACTTGCGCTCCGACCAACGATAACCTGATGGAACTGGTAGTGATGGCTGATGCCTTCCGCCGCTCCTCGGCTACT
CGTATCACTGCTGTTATTCCTTATTTTGGTTATGCCCGTCAGGATCGCCGTCCGCGTTCCGCACGTGTGGCTATCAGCGC
GAAAGTCGTTGCTGACATGCTCACCGTAGTCGGCATCGACCGTGTTCTCACGGTGGATCTGCATGCTGACCAGATTCAGG
GTTTCTTCGATATTCCGGTAGATAACATCTACGGCTCCCCGGTTCTGGTGGATGACATTGAAGATCAGCGCTTCGAGAAC
CTGATGATCGTGTCCCCGGACATTGGTGGCGTCGTGCGTGCACGTGCCGTTGCCAAATCCCTGGGTGTGGATCTCGGGAT
CATCGACAAACGCCGTGAGAAAGCCAATCACTCTGAAGTGATGCATATCATCGGCGATGTCGAAGGGCGTACCTGCATTC
TGGTCGATGACATGGTCGATACCGCCGGCACTCTGTGCCACGCGGCCAAGGCCCTGAAAGAGCATGGCGCAGCCAAGGTC
TTTGCCTACTGCACACACCCTGTGCTGTCGGGTCGGGCCATCGAGAATATCGAAAATTCCGTGCTGGACGAGCTGGTGGT
CACTAACACCATCCCGCTGTCCGCTGCAGCACAAGCCTGTGCACGTATCCGTCAACTGGATATCGCACCGGTTGTTGCCG
AAGCGGTTCGCCGCATCAGCAATGAAGAATCGATCAGCGCGATGTTCCGTTAA

Upstream 100 bases:

>100_bases
TTTGATCCTGCCATGCGTTGGTTCGAATCCAGCCGCCCCTGCCATTTTCCTATACTCATCCAGGTATACCCTCAGCCTTC
AGGTACTGCGCGTGTCCAAG

Downstream 100 bases:

>100_bases
GGGCCCTGCCCTTCTCGAAATGTCTCGTTGACGAAAAGCGCCCCGCCCCGGCATTCCTGCCGGGGCGGGGCTTTTTTGCC
CATACCGTGTTCGGCGCTGG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MMVFTGNANPDLARRVVRQLHIPLGDISVGKFSDGEITAEINENVRGKDVFIIQPTCAPTNDNLMELVVMADAFRRSSAT
RITAVIPYFGYARQDRRPRSARVAISAKVVADMLTVVGIDRVLTVDLHADQIQGFFDIPVDNIYGSPVLVDDIEDQRFEN
LMIVSPDIGGVVRARAVAKSLGVDLGIIDKRREKANHSEVMHIIGDVEGRTCILVDDMVDTAGTLCHAAKALKEHGAAKV
FAYCTHPVLSGRAIENIENSVLDELVVTNTIPLSAAAQACARIRQLDIAPVVAEAVRRISNEESISAMFR

Sequences:

>Translated_310_residues
MMVFTGNANPDLARRVVRQLHIPLGDISVGKFSDGEITAEINENVRGKDVFIIQPTCAPTNDNLMELVVMADAFRRSSAT
RITAVIPYFGYARQDRRPRSARVAISAKVVADMLTVVGIDRVLTVDLHADQIQGFFDIPVDNIYGSPVLVDDIEDQRFEN
LMIVSPDIGGVVRARAVAKSLGVDLGIIDKRREKANHSEVMHIIGDVEGRTCILVDDMVDTAGTLCHAAKALKEHGAAKV
FAYCTHPVLSGRAIENIENSVLDELVVTNTIPLSAAAQACARIRQLDIAPVVAEAVRRISNEESISAMFR
>Mature_310_residues
MMVFTGNANPDLARRVVRQLHIPLGDISVGKFSDGEITAEINENVRGKDVFIIQPTCAPTNDNLMELVVMADAFRRSSAT
RITAVIPYFGYARQDRRPRSARVAISAKVVADMLTVVGIDRVLTVDLHADQIQGFFDIPVDNIYGSPVLVDDIEDQRFEN
LMIVSPDIGGVVRARAVAKSLGVDLGIIDKRREKANHSEVMHIIGDVEGRTCILVDDMVDTAGTLCHAAKALKEHGAAKV
FAYCTHPVLSGRAIENIENSVLDELVVTNTIPLSAAAQACARIRQLDIAPVVAEAVRRISNEESISAMFR

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=311, Percent_Identity=48.8745980707396, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI84875539, Length=313, Percent_Identity=48.2428115015974, Blast_Score=308, Evalue=5e-84,
Organism=Homo sapiens, GI4506127, Length=309, Percent_Identity=48.5436893203884, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI28557709, Length=309, Percent_Identity=46.9255663430421, Blast_Score=296, Evalue=1e-80,
Organism=Homo sapiens, GI4506133, Length=346, Percent_Identity=35.5491329479769, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=36.1516034985423, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI310128524, Length=149, Percent_Identity=32.8859060402685, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI310115209, Length=149, Percent_Identity=32.8859060402685, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI310118259, Length=149, Percent_Identity=32.8859060402685, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI310119946, Length=149, Percent_Identity=32.8859060402685, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1787458, Length=310, Percent_Identity=67.4193548387097, Blast_Score=436, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=47.5728155339806, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI25149168, Length=309, Percent_Identity=47.5728155339806, Blast_Score=302, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17554702, Length=309, Percent_Identity=47.5728155339806, Blast_Score=301, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI71989924, Length=309, Percent_Identity=47.5728155339806, Blast_Score=300, Evalue=6e-82,
Organism=Caenorhabditis elegans, GI17570245, Length=339, Percent_Identity=33.6283185840708, Blast_Score=200, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6319403, Length=311, Percent_Identity=45.016077170418, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6321776, Length=301, Percent_Identity=47.5083056478405, Blast_Score=269, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6320946, Length=310, Percent_Identity=44.1935483870968, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6322667, Length=201, Percent_Identity=40.2985074626866, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6324511, Length=114, Percent_Identity=42.9824561403509, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21355239, Length=309, Percent_Identity=49.8381877022654, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI45551540, Length=331, Percent_Identity=46.5256797583082, Blast_Score=293, Evalue=7e-80,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=35.7746478873239, Blast_Score=220, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=35.7746478873239, Blast_Score=220, Evalue=7e-58,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=35.7746478873239, Blast_Score=220, Evalue=9e-58,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=35.7746478873239, Blast_Score=220, Evalue=9e-58,
Organism=Drosophila melanogaster, GI24651462, Length=202, Percent_Identity=38.1188118811881, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24651464, Length=202, Percent_Identity=38.1188118811881, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI45552010, Length=202, Percent_Identity=38.1188118811881, Blast_Score=141, Evalue=5e-34,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33798; Mature: 33798

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVFTGNANPDLARRVVRQLHIPLGDISVGKFSDGEITAEINENVRGKDVFIIQPTCAPT
CEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCCCC
NDNLMELVVMADAFRRSSATRITAVIPYFGYARQDRRPRSARVAISAKVVADMLTVVGID
CCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHCCCCCCHHEEEEHHHHHHHHHHHHCCC
RVLTVDLHADQIQGFFDIPVDNIYGSPVLVDDIEDQRFENLMIVSPDIGGVVRARAVAKS
EEEEEEEEHHHCCCEEECCHHHCCCCCEEEECCCCHHHCCEEEECCCCCHHHHHHHHHHH
LGVDLGIIDKRREKANHSEVMHIIGDVEGRTCILVDDMVDTAGTLCHAAKALKEHGAAKV
HCCCEEECCHHHHHCCHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCEE
FAYCTHPVLSGRAIENIENSVLDELVVTNTIPLSAAAQACARIRQLDIAPVVAEAVRRIS
EEEECCCHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHC
NEESISAMFR
CHHHHHHHCC
>Mature Secondary Structure
MMVFTGNANPDLARRVVRQLHIPLGDISVGKFSDGEITAEINENVRGKDVFIIQPTCAPT
CEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCCCC
NDNLMELVVMADAFRRSSATRITAVIPYFGYARQDRRPRSARVAISAKVVADMLTVVGID
CCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHCCCCCCHHEEEEHHHHHHHHHHHHCCC
RVLTVDLHADQIQGFFDIPVDNIYGSPVLVDDIEDQRFENLMIVSPDIGGVVRARAVAKS
EEEEEEEEHHHCCCEEECCHHHCCCCCEEEECCCCHHHCCEEEECCCCCHHHHHHHHHHH
LGVDLGIIDKRREKANHSEVMHIIGDVEGRTCILVDDMVDTAGTLCHAAKALKEHGAAKV
HCCCEEECCHHHHHCCHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCEE
FAYCTHPVLSGRAIENIENSVLDELVVTNTIPLSAAAQACARIRQLDIAPVVAEAVRRIS
EEEECCCHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHC
NEESISAMFR
CHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]