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The map label for this gene is hpt [H]

Identifier: 77460948

GI number: 77460948

Start: 5333191

End: 5333748

Strand: Reverse

Name: hpt [H]

Synonym: Pfl01_4727

Alternate gene names: 77460948

Gene position: 5333748-5333191 (Counterclockwise)

Preceding gene: 77460951

Following gene: 77460947

Centisome position: 82.84

GC content: 58.42

Gene sequence:

>558_bases
ATGTCCGCTGATCTCGAGCATATCCGTCAAATCATGCGAGAGGCTGACTGCCTGTACACCGAAGCTGAAGTCGAGGCTGC
CATTGCCCGCGTCGGTGCACAAATCAACGAACAACTGGCCGACAGCAACCCGGTGGTGTTCTGCGTGATGAACGGCGGCC
TGATCTTCTCCGGCAAACTGCTGACGCATCTGCAGTTCCCGCTGGAAGCGTCCTACCTGCACGCCACCCGTTACCGCAAC
GAAACCAGCGGCGGCGACCTGTTCTGGAAAGCCAAGCCGGAAGTCTCGTTCATCGACCGTGACGTGCTGATCATCGACGA
CATCCTCGACGAAGGTCACACCCTGGGCGCGATCATCGACTTTTGCCGTCACGCCGGTGCACGTAAAGTGCACACCGCCG
TGCTGATCGACAAGGATCACGATCGCAAGGCCCGTCCTGACCTGAAAGCCGATTTCGTCGGTCTGCCGTGCATCGACCGT
TACATCTTCGGTTACGGCATGGACTACAAAGGCTACTGGCGCAACGCCAACGGGATCTTCGCCGTCAAAGGCATGTAA

Upstream 100 bases:

>100_bases
ATAGGACATACAGTACGTTAGTCCACAAATGCTTGATTCGGCCGTGCGGGATGCGTACCTTTGCCCGCTTTTCCGAAACA
GACCCCCCTTGGAGAGCGCC

Downstream 100 bases:

>100_bases
GAACCCCTGAAAGATCGCAGCCCCGGGCTGCGATCTTTTGCTTTAAAGGCTGCTAAAGTGCTCGGCCCCGCCCCCGGAGC
CTGTCATGAGCCTCTTGATC

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MSADLEHIRQIMREADCLYTEAEVEAAIARVGAQINEQLADSNPVVFCVMNGGLIFSGKLLTHLQFPLEASYLHATRYRN
ETSGGDLFWKAKPEVSFIDRDVLIIDDILDEGHTLGAIIDFCRHAGARKVHTAVLIDKDHDRKARPDLKADFVGLPCIDR
YIFGYGMDYKGYWRNANGIFAVKGM

Sequences:

>Translated_185_residues
MSADLEHIRQIMREADCLYTEAEVEAAIARVGAQINEQLADSNPVVFCVMNGGLIFSGKLLTHLQFPLEASYLHATRYRN
ETSGGDLFWKAKPEVSFIDRDVLIIDDILDEGHTLGAIIDFCRHAGARKVHTAVLIDKDHDRKARPDLKADFVGLPCIDR
YIFGYGMDYKGYWRNANGIFAVKGM
>Mature_184_residues
SADLEHIRQIMREADCLYTEAEVEAAIARVGAQINEQLADSNPVVFCVMNGGLIFSGKLLTHLQFPLEASYLHATRYRNE
TSGGDLFWKAKPEVSFIDRDVLIIDDILDEGHTLGAIIDFCRHAGARKVHTAVLIDKDHDRKARPDLKADFVGLPCIDRY
IFGYGMDYKGYWRNANGIFAVKGM

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=163, Percent_Identity=26.3803680981595, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI9910262, Length=166, Percent_Identity=25.3012048192771, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI87081689, Length=164, Percent_Identity=27.4390243902439, Blast_Score=74, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17510817, Length=167, Percent_Identity=25.748502994012, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20778; Mature: 20647

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADLEHIRQIMREADCLYTEAEVEAAIARVGAQINEQLADSNPVVFCVMNGGLIFSGKL
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCE
LTHLQFPLEASYLHATRYRNETSGGDLFWKAKPEVSFIDRDVLIIDDILDEGHTLGAIID
EEEEECCCCHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCEEEEEHHHCCCCHHHHHHH
FCRHAGARKVHTAVLIDKDHDRKARPDLKADFVGLPCIDRYIFGYGMDYKGYWRNANGIF
HHHCCCCCEEEEEEEEECCCCCCCCCCCCCCEECCCHHHHHHHHCCCCCCCEEECCCCEE
AVKGM
EEECC
>Mature Secondary Structure 
SADLEHIRQIMREADCLYTEAEVEAAIARVGAQINEQLADSNPVVFCVMNGGLIFSGKL
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCE
LTHLQFPLEASYLHATRYRNETSGGDLFWKAKPEVSFIDRDVLIIDDILDEGHTLGAIID
EEEEECCCCHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCEEEEEHHHCCCCHHHHHHH
FCRHAGARKVHTAVLIDKDHDRKARPDLKADFVGLPCIDRYIFGYGMDYKGYWRNANGIF
HHHCCCCCEEEEEEEEECCCCCCCCCCCCCCEECCCHHHHHHHHCCCCCCCEEECCCCEE
AVKGM
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]