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The map label for this gene is hemH

Identifier: 77460951

GI number: 77460951

Start: 5335928

End: 5336953

Strand: Reverse

Name: hemH

Synonym: Pfl01_4730

Alternate gene names: 77460951

Gene position: 5336953-5335928 (Counterclockwise)

Preceding gene: 77460952

Following gene: 77460948

Centisome position: 82.89

GC content: 61.11

Gene sequence:

>1026_bases
ATGACCGATCACGCCTTGCTTCTGGTCAACCTGGGTTCGCCGGCCTCCACTTCGGTGGCCGACGTGCGCCGCTATCTCAA
TCAATTCCTGATGGATCCTTACGTGATCGACCTGCCGTGGCCGGTGCGGCGTCTGCTGGTGTCGCTGATCCTGATCAAGC
GCCCCGAGCAGTCGGCCCACGCCTACGCCTCGATCTGGTGGGATGAAGGCTCGCCGCTGGTGGTCCTCAGTCGTCGCCTG
CAGCAGCAGATGAAGGCGCAATGGACCCACGGCCCGGTTGAGCTGGCCATGCGTTACGGCGAGCCGTCCATCGAGACAAA
TCTGCTGAAACTGGTCGCGGCGGGACACAAACGCATCACCCTCGCGCCGCTTTATCCACAGTTTGCCGACAGCACCACGA
CCACCGTGATCGAAGAAGCCAAGCGTGTGGTGCGCGAGAAAAAACTCGATGTGCAGCTGTCGGTGTTGCAGCCGTTCTAC
GATCAGCCGGAATACCTCGACGCGCTGGTGGCGAGCGCCAGACCGCACTTGCAGCAGGATTACGATCACCTGTTGCTGAG
CTTCCATGGTTTGCCGGAGCGGCACCTGACCAAGCTTGACCCGACCGGTAACCATTGCTTCAAGAATGAAGATTGCTGCA
AGAATGCTTCGGCTGCTGTATTGGCCACCTGTTATCGCGCCCAGTGCCTGCGCACAGCGGCGCTGTTCGCAGAACGCATG
GGCCTGCCGGACGGCAAATGGTCGGTGTCGTTTCAGTCGCGGCTGGGCCGGGCGAAATGGATCGAACCCTACACCGAAGC
GCGGCTGGATGAGCTGGCCAAAAGTGGCGTGAAGAAGATTCTGGTGATGTGCCCGGCGTTTGTCGCCGATTGCATCGAGA
CCCTGGAAGAGATCGGCGATCGCGGCAAGGAGCAGTTCCGCGAGGCGGGGGGAGAAGAGTTGGTGCTGGTGCCGTGTCTG
AATGACGACCCGCAATGGGCGAAGGCGTTGGCAACGTTGTGTGAACGGGCGCCATTGGCCCTCTAA

Upstream 100 bases:

>100_bases
ATGCCCAAGCGCTTGCTGGAAGCGGGATTCACTTTCCGGTTCACGGATTTACGCGCGGCCCTGGACGATCTTTCCAGCCG
CCTCTGAAATAGGACGTTGC

Downstream 100 bases:

>100_bases
AAGCATCGCCAGCAGGCTTGCTCCCACAGGAAAGCGCATTTCAATGTGGGAGCCAGCCTGCTGGCGATAGCGGTCTTTCA
GGCGATGAAGCTAAGGGCTT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTDHALLLVNLGSPASTSVADVRRYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPEQSAHAYASIWWDEGSPLVVLSRRL
QQQMKAQWTHGPVELAMRYGEPSIETNLLKLVAAGHKRITLAPLYPQFADSTTTTVIEEAKRVVREKKLDVQLSVLQPFY
DQPEYLDALVASARPHLQQDYDHLLLSFHGLPERHLTKLDPTGNHCFKNEDCCKNASAAVLATCYRAQCLRTAALFAERM
GLPDGKWSVSFQSRLGRAKWIEPYTEARLDELAKSGVKKILVMCPAFVADCIETLEEIGDRGKEQFREAGGEELVLVPCL
NDDPQWAKALATLCERAPLAL

Sequences:

>Translated_341_residues
MTDHALLLVNLGSPASTSVADVRRYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPEQSAHAYASIWWDEGSPLVVLSRRL
QQQMKAQWTHGPVELAMRYGEPSIETNLLKLVAAGHKRITLAPLYPQFADSTTTTVIEEAKRVVREKKLDVQLSVLQPFY
DQPEYLDALVASARPHLQQDYDHLLLSFHGLPERHLTKLDPTGNHCFKNEDCCKNASAAVLATCYRAQCLRTAALFAERM
GLPDGKWSVSFQSRLGRAKWIEPYTEARLDELAKSGVKKILVMCPAFVADCIETLEEIGDRGKEQFREAGGEELVLVPCL
NDDPQWAKALATLCERAPLAL
>Mature_340_residues
TDHALLLVNLGSPASTSVADVRRYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPEQSAHAYASIWWDEGSPLVVLSRRLQ
QQMKAQWTHGPVELAMRYGEPSIETNLLKLVAAGHKRITLAPLYPQFADSTTTTVIEEAKRVVREKKLDVQLSVLQPFYD
QPEYLDALVASARPHLQQDYDHLLLSFHGLPERHLTKLDPTGNHCFKNEDCCKNASAAVLATCYRAQCLRTAALFAERMG
LPDGKWSVSFQSRLGRAKWIEPYTEARLDELAKSGVKKILVMCPAFVADCIETLEEIGDRGKEQFREAGGEELVLVPCLN
DDPQWAKALATLCERAPLAL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Escherichia coli, GI1786681, Length=339, Percent_Identity=37.1681415929204, Blast_Score=201, Evalue=4e-53,
Organism=Drosophila melanogaster, GI17864156, Length=345, Percent_Identity=23.1884057971014, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_PSEPF (Q3K6Y7)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_350458.1
- ProteinModelPortal:   Q3K6Y7
- SMR:   Q3K6Y7
- STRING:   Q3K6Y7
- GeneID:   3715151
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_4730
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   GLPERHL
- ProtClustDB:   PRK00035
- BioCyc:   PFLU205922:PFL_4730-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 38373; Mature: 38241

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDHALLLVNLGSPASTSVADVRRYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPEQSAH
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCHHHC
AYASIWWDEGSPLVVLSRRLQQQMKAQWTHGPVELAMRYGEPSIETNLLKLVAAGHKRIT
EEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCEEE
LAPLYPQFADSTTTTVIEEAKRVVREKKLDVQLSVLQPFYDQPEYLDALVASARPHLQQD
EEECCCHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHCCCHHHHH
YDHLLLSFHGLPERHLTKLDPTGNHCFKNEDCCKNASAAVLATCYRAQCLRTAALFAERM
HHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLPDGKWSVSFQSRLGRAKWIEPYTEARLDELAKSGVKKILVMCPAFVADCIETLEEIGD
CCCCCCEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGKEQFREAGGEELVLVPCLNDDPQWAKALATLCERAPLAL
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TDHALLLVNLGSPASTSVADVRRYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPEQSAH
CCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCHHHC
AYASIWWDEGSPLVVLSRRLQQQMKAQWTHGPVELAMRYGEPSIETNLLKLVAAGHKRIT
EEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCEEE
LAPLYPQFADSTTTTVIEEAKRVVREKKLDVQLSVLQPFYDQPEYLDALVASARPHLQQD
EEECCCHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHCCCHHHHH
YDHLLLSFHGLPERHLTKLDPTGNHCFKNEDCCKNASAAVLATCYRAQCLRTAALFAERM
HHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLPDGKWSVSFQSRLGRAKWIEPYTEARLDELAKSGVKKILVMCPAFVADCIETLEEIGD
CCCCCCEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGKEQFREAGGEELVLVPCLNDDPQWAKALATLCERAPLAL
HHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA