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The map label for this gene is trpS [H]

Identifier: 77460920

GI number: 77460920

Start: 5301329

End: 5302684

Strand: Reverse

Name: trpS [H]

Synonym: Pfl01_4699

Alternate gene names: 77460920

Gene position: 5302684-5301329 (Counterclockwise)

Preceding gene: 77460921

Following gene: 77460919

Centisome position: 82.36

GC content: 62.39

Gene sequence:

>1356_bases
ATGACGAACCGTACCCGCATCCTCACCGGCATCACCACCACCGGCACCCCGCACCTGGGCAACTACGCCGGTGCCATTCG
CCCGGCGATTCTCGCCAGCCGCGACAGCAATGCCGACTCGTTCTACTTCCTGGCCGACTATCACGCCCTGATCAAGTGCG
ATGACCCGCTGCGCATCCAGCGCTCGCGTCTGGAAATCGCCGCGACCTGGCTGGCCGGTGGCCTGGATGTGGATCGCGTG
ACCTTCTACCGTCAGTCCGACATTCCGGAAATCCCCGAGCTGACCTGGCTGCTGACCTGCGTTGCCGCCAAAGGCCTGCT
CAACCGCGCCCATGCTTACAAGGCTTCGGTGGACAAGAATGTCGAGACCGGCGAAGACCCGGATGCCGGCATCACGATGG
GTTTGTACAGCTATCCGGTACTGATGGCGGCGGACATTCTGATGTTCAACGCGCACAAGGTGCCGGTCGGTCGCGATCAG
ATCCAGCACGTGGAAATGGCCCGTGATATCGGCCAGCGCTTCAACCACCTGTTCGGCCAGGGCAAGGAGTTCTTCACCAT
GCCCGAAGCGCTGATCGAGGAAAGCGTGGCCACGTTGCCGGGCCTGGACGGTCGCAAGATGTCCAAGAGCTACGACAACA
CCATCCCGCTGTTCACCAGCGCCAAGGACATGAAGGACGCGATTTCACGGATCGTTACCGACTCCCGTGCGCCAGGCGAA
GCGAAAGATCCGGACAACTCGCACCTGTTCACCCTGTTCCAGGCGTTCGCCACACCGGCGCAGGCTGATGAGTTCCGCAG
CGAGCTGCTGGGCGGTCTGGGTTGGGGCGAGGCGAAGAACCGTCTGTTCCAGTTGCTCGACAACGAGCTGGGCGAATCCC
GCGAGCGTTATCACCAGTTGATCGAGCGTCCGGCAGATCTGGAAGACATCCTGCAACACGGCGCCAAGAAGGCTCGTGCG
GTGGCGACGCCGTTCCTCAACGAGTTGCGCGAAGCGGTCGGCCTGCGCTCCTTCGTCAGTCAGGTTCAGGTGGCTGCGAC
CACCAAGAAGAAAGCTGCGAAAGCCGCACGTTTCGTCAGCTTCCGTGAAGACGACGGCAGCTTCCGTTTCCGTCTGCTGG
CGGCTGACGGCGAGCAACTGCTGCTGTCGCGCAACTTTGCCGACGGTAAAACCGCCGGTCAGGTGACCAAACAACTGCAA
TCGGGTCAGGCGCTGGATGTACGCAGCGAAGACCTGAGCTTCAGCGTCTGGCTGGAAGGCGAGTGCGTCGGCGACAGCCC
GGCGTTCGTCGACGTGGCTGCGCGGGATGCGGCTGTCGAGGCCTTGCGGATCGCTCTGACACCGGTTCAGGAATAA

Upstream 100 bases:

>100_bases
GGCAGAATGCGGACACTTTTTTCATGGCAAGCTGACCGATCTCAAGGATCTGATCCTGCCGCGTCTCTCGAATTGATTGC
AGTCTGACAAGCGATTACCC

Downstream 100 bases:

>100_bases
TCAACGGCTCGGCCCGACCAAGGGCCGATTGCCATTCCCACGGGCCATCGCTACAGTGACGGCCCGTTTTTGTTGCCTTG
CTAACGAATTATGACGCCCC

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTNRTRILTGITTTGTPHLGNYAGAIRPAILASRDSNADSFYFLADYHALIKCDDPLRIQRSRLEIAATWLAGGLDVDRV
TFYRQSDIPEIPELTWLLTCVAAKGLLNRAHAYKASVDKNVETGEDPDAGITMGLYSYPVLMAADILMFNAHKVPVGRDQ
IQHVEMARDIGQRFNHLFGQGKEFFTMPEALIEESVATLPGLDGRKMSKSYDNTIPLFTSAKDMKDAISRIVTDSRAPGE
AKDPDNSHLFTLFQAFATPAQADEFRSELLGGLGWGEAKNRLFQLLDNELGESRERYHQLIERPADLEDILQHGAKKARA
VATPFLNELREAVGLRSFVSQVQVAATTKKKAAKAARFVSFREDDGSFRFRLLAADGEQLLLSRNFADGKTAGQVTKQLQ
SGQALDVRSEDLSFSVWLEGECVGDSPAFVDVAARDAAVEALRIALTPVQE

Sequences:

>Translated_451_residues
MTNRTRILTGITTTGTPHLGNYAGAIRPAILASRDSNADSFYFLADYHALIKCDDPLRIQRSRLEIAATWLAGGLDVDRV
TFYRQSDIPEIPELTWLLTCVAAKGLLNRAHAYKASVDKNVETGEDPDAGITMGLYSYPVLMAADILMFNAHKVPVGRDQ
IQHVEMARDIGQRFNHLFGQGKEFFTMPEALIEESVATLPGLDGRKMSKSYDNTIPLFTSAKDMKDAISRIVTDSRAPGE
AKDPDNSHLFTLFQAFATPAQADEFRSELLGGLGWGEAKNRLFQLLDNELGESRERYHQLIERPADLEDILQHGAKKARA
VATPFLNELREAVGLRSFVSQVQVAATTKKKAAKAARFVSFREDDGSFRFRLLAADGEQLLLSRNFADGKTAGQVTKQLQ
SGQALDVRSEDLSFSVWLEGECVGDSPAFVDVAARDAAVEALRIALTPVQE
>Mature_450_residues
TNRTRILTGITTTGTPHLGNYAGAIRPAILASRDSNADSFYFLADYHALIKCDDPLRIQRSRLEIAATWLAGGLDVDRVT
FYRQSDIPEIPELTWLLTCVAAKGLLNRAHAYKASVDKNVETGEDPDAGITMGLYSYPVLMAADILMFNAHKVPVGRDQI
QHVEMARDIGQRFNHLFGQGKEFFTMPEALIEESVATLPGLDGRKMSKSYDNTIPLFTSAKDMKDAISRIVTDSRAPGEA
KDPDNSHLFTLFQAFATPAQADEFRSELLGGLGWGEAKNRLFQLLDNELGESRERYHQLIERPADLEDILQHGAKKARAV
ATPFLNELREAVGLRSFVSQVQVAATTKKKAAKAARFVSFREDDGSFRFRLLAADGEQLLLSRNFADGKTAGQVTKQLQS
GQALDVRSEDLSFSVWLEGECVGDSPAFVDVAARDAAVEALRIALTPVQE

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=342, Percent_Identity=29.2397660818713, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI41352700, Length=194, Percent_Identity=36.0824742268041, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI1789786, Length=339, Percent_Identity=35.3982300884956, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71982800, Length=346, Percent_Identity=30.0578034682081, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI71982793, Length=349, Percent_Identity=30.0859598853868, Blast_Score=131, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6320474, Length=346, Percent_Identity=30.0578034682081, Blast_Score=143, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24666151, Length=343, Percent_Identity=30.0291545189504, Blast_Score=128, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 49710; Mature: 49579

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRTRILTGITTTGTPHLGNYAGAIRPAILASRDSNADSFYFLADYHALIKCDDPLRIQ
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHEECCCCCCCEEEEEEECEEEEECCCCHHHH
RSRLEIAATWLAGGLDVDRVTFYRQSDIPEIPELTWLLTCVAAKGLLNRAHAYKASVDKN
HHHHHHHHHHHHCCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VETGEDPDAGITMGLYSYPVLMAADILMFNAHKVPVGRDQIQHVEMARDIGQRFNHLFGQ
CCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
GKEFFTMPEALIEESVATLPGLDGRKMSKSYDNTIPLFTSAKDMKDAISRIVTDSRAPGE
CCHHEECHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCEECHHHHHHHHHHHHHCCCCCCC
AKDPDNSHLFTLFQAFATPAQADEFRSELLGGLGWGEAKNRLFQLLDNELGESRERYHQL
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHH
IERPADLEDILQHGAKKARAVATPFLNELREAVGLRSFVSQVQVAATTKKKAAKAARFVS
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
FREDDGSFRFRLLAADGEQLLLSRNFADGKTAGQVTKQLQSGQALDVRSEDLSFSVWLEG
EECCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEEEC
ECVGDSPAFVDVAARDAAVEALRIALTPVQE
EECCCCCCEEEHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TNRTRILTGITTTGTPHLGNYAGAIRPAILASRDSNADSFYFLADYHALIKCDDPLRIQ
CCCEEEEEEEECCCCCCCCCHHHHHHHHHEECCCCCCCEEEEEEECEEEEECCCCHHHH
RSRLEIAATWLAGGLDVDRVTFYRQSDIPEIPELTWLLTCVAAKGLLNRAHAYKASVDKN
HHHHHHHHHHHHCCCCHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VETGEDPDAGITMGLYSYPVLMAADILMFNAHKVPVGRDQIQHVEMARDIGQRFNHLFGQ
CCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
GKEFFTMPEALIEESVATLPGLDGRKMSKSYDNTIPLFTSAKDMKDAISRIVTDSRAPGE
CCHHEECHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCEECHHHHHHHHHHHHHCCCCCCC
AKDPDNSHLFTLFQAFATPAQADEFRSELLGGLGWGEAKNRLFQLLDNELGESRERYHQL
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHH
IERPADLEDILQHGAKKARAVATPFLNELREAVGLRSFVSQVQVAATTKKKAAKAARFVS
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
FREDDGSFRFRLLAADGEQLLLSRNFADGKTAGQVTKQLQSGQALDVRSEDLSFSVWLEG
EECCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEEEC
ECVGDSPAFVDVAARDAAVEALRIALTPVQE
EECCCCCCEEEHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]