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The map label for this gene is zraS [C]

Identifier: 77460776

GI number: 77460776

Start: 5138047

End: 5139450

Strand: Direct

Name: zraS [C]

Synonym: Pfl01_4555

Alternate gene names: 77460776

Gene position: 5138047-5139450 (Clockwise)

Preceding gene: 77460775

Following gene: 77460779

Centisome position: 79.8

GC content: 61.18

Gene sequence:

>1404_bases
ATGAGCGAGCTGTCTAACCGCCGCATCCTGCTGATCGATGACATGCCGTCGATTCACGAGGACTTTCGCAAGATCCTCGC
CCCGGCGCCGGCGCACTCGGCAAAACTGGACGAGATGGAAGCCGCCCTGTTCGGCGTGCCCGCCAAACCCCGGCAAGCAC
CTTTCGAGCTGGATTCGGCCTACGGTGGAGAGGAAGGCCTGGCCAAACTCAACCTGGCCCTGCAGGAGCAATGCCCGTAT
GCCCTGGCCTTCGTCGACATGCGCATGCCGGACGGTTGGGACGGAGCGCGCACCATCGAAGAACTCTGGAAGCAGGATCC
GCAGTTGCAGGTGGTGGTCTGCACCGCCTATTCCGATTACTCCTGGGACGAACTGCTGGATCGTCTGCACGCCCATGACC
GACTGCTGATCCTGAAAAAACCCTTCGACAACATCGAAGTCCAGCAGATGGCCAACACCCTGCTGACCAAATGGCAGATG
ACCGAACGCGCGTCCCTGCAGATGCATCACCTGGAACATCTGGTGGATCAGCGCACCGCCCAGTTCCGGCAGGCCAGTGA
AGCCTTGCAGCGGGAAATCGATGAGCGCAAACAGCTGGAAGGCCAACTGGTGCAATCGGAAAAACTCGCCTCGCTGGGTC
AACTGGCCGCCGGGGTCGCCCATGAAATCAACAACCCGATCGGCTTCATCTCCTCCAACCTCGGTACGCTCGACGGCTAC
TTCCAGCAACTGCTGGCCATGCTCGGCGCCTATCACACCGCCGGGCAGAACTTGCCCGCCGAAGCCGCCGCGCAGTTGCA
GCAATTGCGCGAGCGTCTTGAACTGGACTATCTGCTGGAAGACATCCCGACGCTGATTCGCGAATCCAAGGAGGGCATTG
GTCGGGTCGGACAGATCGTCCGGGATCTCAAGGATTTCTCCCGAGTCGACAGCCATCAGGAATGGCAGTGGGCCAATCTG
CAACAAGGCATCGAATCGACCCTGAACATCGTCGCCGGCGAACTCAAGTACAAGGCCGATGTGGTCAAGGAATATCAGGA
TCTGCCGGACATCGAATGCCTGCCCTCGCAAATCAATCAGGTCATCATGAACCTGGTGGTCAACGCGGCGCAGGCCATGG
GCCCGGAGCGCGGCACCATCACCCTGCGCACCGGCGTGCAGGGCGAAACGGCAATCATCGAAGTGGCCGACACCGGTTCT
GGCATCGCCCCCGAGACCTTGCAGAAAATCTTCGACCCGTTCTTCACCACCAAACCGGTGGGCCAGGGGACAGGCCTGGG
CCTGTCCCTGTCGTATGGCATCGTGAAGAAACACGGCGGCGATATTTCCGTGCGCAGCACGTTGGGCGCCGGCACGACGT
TCCGCGTGCAGTTGCCGTTACGCCAGACCCGCCCGGCGGCCTGA

Upstream 100 bases:

>100_bases
CCATCGAGATGAACGGCCACCTCACCGCCCACAGCGACGGACCGGGGCTGGGCGCCTTGTTCACCCTGCAGATTCCGCTG
ATCACCGTTACGGAGAACGC

Downstream 100 bases:

>100_bases
TGCCGGGTCAGGCGGCTTCCTGGAAATCCATCTCCGGCGGCTGCCGGCGGAAGCCACCCGTAAGCACCGCCAGGTACACC
ACGCCAATCGCCAGCCAGCT

Product: response regulator receiver Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSELSNRRILLIDDMPSIHEDFRKILAPAPAHSAKLDEMEAALFGVPAKPRQAPFELDSAYGGEEGLAKLNLALQEQCPY
ALAFVDMRMPDGWDGARTIEELWKQDPQLQVVVCTAYSDYSWDELLDRLHAHDRLLILKKPFDNIEVQQMANTLLTKWQM
TERASLQMHHLEHLVDQRTAQFRQASEALQREIDERKQLEGQLVQSEKLASLGQLAAGVAHEINNPIGFISSNLGTLDGY
FQQLLAMLGAYHTAGQNLPAEAAAQLQQLRERLELDYLLEDIPTLIRESKEGIGRVGQIVRDLKDFSRVDSHQEWQWANL
QQGIESTLNIVAGELKYKADVVKEYQDLPDIECLPSQINQVIMNLVVNAAQAMGPERGTITLRTGVQGETAIIEVADTGS
GIAPETLQKIFDPFFTTKPVGQGTGLGLSLSYGIVKKHGGDISVRSTLGAGTTFRVQLPLRQTRPAA

Sequences:

>Translated_467_residues
MSELSNRRILLIDDMPSIHEDFRKILAPAPAHSAKLDEMEAALFGVPAKPRQAPFELDSAYGGEEGLAKLNLALQEQCPY
ALAFVDMRMPDGWDGARTIEELWKQDPQLQVVVCTAYSDYSWDELLDRLHAHDRLLILKKPFDNIEVQQMANTLLTKWQM
TERASLQMHHLEHLVDQRTAQFRQASEALQREIDERKQLEGQLVQSEKLASLGQLAAGVAHEINNPIGFISSNLGTLDGY
FQQLLAMLGAYHTAGQNLPAEAAAQLQQLRERLELDYLLEDIPTLIRESKEGIGRVGQIVRDLKDFSRVDSHQEWQWANL
QQGIESTLNIVAGELKYKADVVKEYQDLPDIECLPSQINQVIMNLVVNAAQAMGPERGTITLRTGVQGETAIIEVADTGS
GIAPETLQKIFDPFFTTKPVGQGTGLGLSLSYGIVKKHGGDISVRSTLGAGTTFRVQLPLRQTRPAA
>Mature_466_residues
SELSNRRILLIDDMPSIHEDFRKILAPAPAHSAKLDEMEAALFGVPAKPRQAPFELDSAYGGEEGLAKLNLALQEQCPYA
LAFVDMRMPDGWDGARTIEELWKQDPQLQVVVCTAYSDYSWDELLDRLHAHDRLLILKKPFDNIEVQQMANTLLTKWQMT
ERASLQMHHLEHLVDQRTAQFRQASEALQREIDERKQLEGQLVQSEKLASLGQLAAGVAHEINNPIGFISSNLGTLDGYF
QQLLAMLGAYHTAGQNLPAEAAAQLQQLRERLELDYLLEDIPTLIRESKEGIGRVGQIVRDLKDFSRVDSHQEWQWANLQ
QGIESTLNIVAGELKYKADVVKEYQDLPDIECLPSQINQVIMNLVVNAAQAMGPERGTITLRTGVQGETAIIEVADTGSG
IAPETLQKIFDPFFTTKPVGQGTGLGLSLSYGIVKKHGGDISVRSTLGAGTTFRVQLPLRQTRPAA

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=282, Percent_Identity=32.6241134751773, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788549, Length=272, Percent_Identity=33.4558823529412, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1790300, Length=281, Percent_Identity=28.1138790035587, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI87081816, Length=146, Percent_Identity=36.986301369863, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693157, Length=179, Percent_Identity=32.9608938547486, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87082128, Length=170, Percent_Identity=30.5882352941176, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789808, Length=198, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786912, Length=187, Percent_Identity=28.8770053475936, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786783, Length=261, Percent_Identity=24.904214559387, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI48994928, Length=109, Percent_Identity=33.9449541284404, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788713, Length=284, Percent_Identity=24.6478873239437, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51922; Mature: 51791

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELSNRRILLIDDMPSIHEDFRKILAPAPAHSAKLDEMEAALFGVPAKPRQAPFELDSA
CCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHC
YGGEEGLAKLNLALQEQCPYALAFVDMRMPDGWDGARTIEELWKQDPQLQVVVCTAYSDY
CCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCC
SWDELLDRLHAHDRLLILKKPFDNIEVQQMANTLLTKWQMTERASLQMHHLEHLVDQRTA
CHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFRQASEALQREIDERKQLEGQLVQSEKLASLGQLAAGVAHEINNPIGFISSNLGTLDGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHH
FQQLLAMLGAYHTAGQNLPAEAAAQLQQLRERLELDYLLEDIPTLIRESKEGIGRVGQIV
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDLKDFSRVDSHQEWQWANLQQGIESTLNIVAGELKYKADVVKEYQDLPDIECLPSQINQ
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VIMNLVVNAAQAMGPERGTITLRTGVQGETAIIEVADTGSGIAPETLQKIFDPFFTTKPV
HHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCC
GQGTGLGLSLSYGIVKKHGGDISVRSTLGAGTTFRVQLPLRQTRPAA
CCCCCCCEEEECCHHHHCCCCEEEEEECCCCCEEEEEECHHHCCCCC
>Mature Secondary Structure 
SELSNRRILLIDDMPSIHEDFRKILAPAPAHSAKLDEMEAALFGVPAKPRQAPFELDSA
CCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHC
YGGEEGLAKLNLALQEQCPYALAFVDMRMPDGWDGARTIEELWKQDPQLQVVVCTAYSDY
CCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCC
SWDELLDRLHAHDRLLILKKPFDNIEVQQMANTLLTKWQMTERASLQMHHLEHLVDQRTA
CHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFRQASEALQREIDERKQLEGQLVQSEKLASLGQLAAGVAHEINNPIGFISSNLGTLDGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHH
FQQLLAMLGAYHTAGQNLPAEAAAQLQQLRERLELDYLLEDIPTLIRESKEGIGRVGQIV
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDLKDFSRVDSHQEWQWANLQQGIESTLNIVAGELKYKADVVKEYQDLPDIECLPSQINQ
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VIMNLVVNAAQAMGPERGTITLRTGVQGETAIIEVADTGSGIAPETLQKIFDPFFTTKPV
HHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCC
GQGTGLGLSLSYGIVKKHGGDISVRSTLGAGTTFRVQLPLRQTRPAA
CCCCCCCEEEECCHHHHCCCCEEEEEECCCCCEEEEEECHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1333793 [H]