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The map label for this gene is bvgA [H]

Identifier: 77460736

GI number: 77460736

Start: 5089748

End: 5090374

Strand: Reverse

Name: bvgA [H]

Synonym: Pfl01_4515

Alternate gene names: 77460736

Gene position: 5090374-5089748 (Counterclockwise)

Preceding gene: 77460738

Following gene: 77460727

Centisome position: 79.06

GC content: 54.39

Gene sequence:

>627_bases
ATGAATAAAGTGCTGATCGTGGATGATCACCCCGTCATTCGTCTTGCGGTACGTATGCTGATGGAACGTCATGGCTACGA
AGTCATTGCAGAAACGGATAACGGCGTGGATGCATTACAACTTGCTCGTGACCAGATGCCGGATATCGTCATTCTGGATA
TCGGCATACCGAAACTGGATGGTCTGGAAGTCATTGCGCGTCTTACGACCATTGCAATGCCATTGAAGGTGCTGGTGCTG
ACGTCCCAGTCACCGGGACATTTTTCCATGCGCTGCATGCAGTCGGGGGCGGCGGGCTATGTCTGCAAGCAACAGGATCT
GACGGAGTTGCTGAGTGCCATCAAGGCGGTACTGTCCGGATACAGCTATTTTCCGAATCAGGCGCTGCATACCGTGCGGA
CCAGCCTTGGAAACGCCAGCGAAGCGGACATGGTCGATCGCCTGTCCGGGAGGGAAATGATGGTGTTGCAGCAGTTGGCG
CGCGGCAAGACCAACAAGGAAATTGCCGACGGAATGTTCCTCAGCAACAAGACCGTGAGTACCTACAAAACCCGGTTACT
ATTGAAGCTCAACGCGCGCTCGCTGGTGGATCTGATCGAACTGGCGCAGCGAAACGGTCTGGTCTGA

Upstream 100 bases:

>100_bases
CTCTCGGTGCTGGTGTAGAGGAACTTATCCATGCCATGGAGGAAATGACTGAGTTATTGTGCCGGTTCTAAAAATTCGAA
CAGCGAAACTGGACTTGCCC

Downstream 100 bases:

>100_bases
GAGTTTCAGTGGCTGACGGATCATGGGCGGATCGGAATCAGCGTGTGACAGAAACAGAAAAGCCTCCGTTTCGGGAGGCT
TTCAAATGTCAGAGATCAAA

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MNKVLIVDDHPVIRLAVRMLMERHGYEVIAETDNGVDALQLARDQMPDIVILDIGIPKLDGLEVIARLTTIAMPLKVLVL
TSQSPGHFSMRCMQSGAAGYVCKQQDLTELLSAIKAVLSGYSYFPNQALHTVRTSLGNASEADMVDRLSGREMMVLQQLA
RGKTNKEIADGMFLSNKTVSTYKTRLLLKLNARSLVDLIELAQRNGLV

Sequences:

>Translated_208_residues
MNKVLIVDDHPVIRLAVRMLMERHGYEVIAETDNGVDALQLARDQMPDIVILDIGIPKLDGLEVIARLTTIAMPLKVLVL
TSQSPGHFSMRCMQSGAAGYVCKQQDLTELLSAIKAVLSGYSYFPNQALHTVRTSLGNASEADMVDRLSGREMMVLQQLA
RGKTNKEIADGMFLSNKTVSTYKTRLLLKLNARSLVDLIELAQRNGLV
>Mature_208_residues
MNKVLIVDDHPVIRLAVRMLMERHGYEVIAETDNGVDALQLARDQMPDIVILDIGIPKLDGLEVIARLTTIAMPLKVLVL
TSQSPGHFSMRCMQSGAAGYVCKQQDLTELLSAIKAVLSGYSYFPNQALHTVRTSLGNASEADMVDRLSGREMMVLQQLA
RGKTNKEIADGMFLSNKTVSTYKTRLLLKLNARSLVDLIELAQRNGLV

Specific function: Member of the two-component regulatory system BvgS/BvgA. Activates the transcription of virulence genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788712, Length=203, Percent_Identity=37.4384236453202, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1786747, Length=206, Percent_Identity=34.9514563106796, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1788222, Length=209, Percent_Identity=32.5358851674641, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1788521, Length=195, Percent_Identity=34.8717948717949, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1790102, Length=206, Percent_Identity=28.6407766990291, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787375, Length=176, Percent_Identity=25.5681818181818, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787473, Length=183, Percent_Identity=27.8688524590164, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1788550, Length=110, Percent_Identity=30.9090909090909, Blast_Score=61, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR011990
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 22952; Mature: 22952

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVLIVDDHPVIRLAVRMLMERHGYEVIAETDNGVDALQLARDQMPDIVILDIGIPKLD
CCCEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCC
GLEVIARLTTIAMPLKVLVLTSQSPGHFSMRCMQSGAAGYVCKQQDLTELLSAIKAVLSG
HHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHCC
YSYFPNQALHTVRTSLGNASEADMVDRLSGREMMVLQQLARGKTNKEIADGMFLSNKTVS
CCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCHHHCCEEECCCCHH
TYKTRLLLKLNARSLVDLIELAQRNGLV
HHHHEEEEEECHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKVLIVDDHPVIRLAVRMLMERHGYEVIAETDNGVDALQLARDQMPDIVILDIGIPKLD
CCCEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCC
GLEVIARLTTIAMPLKVLVLTSQSPGHFSMRCMQSGAAGYVCKQQDLTELLSAIKAVLSG
HHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHCC
YSYFPNQALHTVRTSLGNASEADMVDRLSGREMMVLQQLARGKTNKEIADGMFLSNKTVS
CCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCHHHCCEEECCCCHH
TYKTRLLLKLNARSLVDLIELAQRNGLV
HHHHEEEEEECHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1791760; 12910271 [H]