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The map label for this gene is irlR [H]

Identifier: 77460719

GI number: 77460719

Start: 5073156

End: 5073839

Strand: Reverse

Name: irlR [H]

Synonym: Pfl01_4498

Alternate gene names: 77460719

Gene position: 5073839-5073156 (Counterclockwise)

Preceding gene: 77460722

Following gene: 77460718

Centisome position: 78.81

GC content: 63.01

Gene sequence:

>684_bases
ATGCGAATTCTATTGGTCGAAGACAACCGCGATATCCTGGCCAATCTGGCCGATTACCTGGGGCTCAAAGGCTACACCGT
CGATTGCGCCCAGGACGGTCTGTCGGGCCTGCATCTGGCCGCCACCGAGCATTACGACCTGATCGTGCTCGACATCATGC
TGCCGGGCATCGACGGCTACACCCTGTGCAAGCGCTTGCGCGAAGACGCCCGTCGCGATACGCCGGTGATCATGCTCACC
GCCCGCGATCAGCTCGACGATCGCCTGCAGGGCTTCAAGTCCGGGGCCGACGATTATCTGGTCAAGCCGTTCGCGCTGTC
GGAACTGGCGGCGCGGGTCGAAGCGGTGATGCGTCGCACCCAGGGCGGCGGTCGCCGGGCCCTGCAGGTCGGCGATCTGA
GCTACGACCTCGATACCCTAGAAGTGACCCGCGAAGGCAAATTGCTCAAGCTCAACCCGGTCGGCCTCAAGCTGCTGGCA
GTGCTGATGCAAAAGAGCCCGCATGTCCTGCGTCGGGAAATTCTCGAAGAAGCGCTGTGGGGCGATGACTGCCCGGACAG
CGACAGCCTGCGCAGCCATGTCCACCAGTTGCGCCAGGTGATCGACAAACCGTTCGCCAAGCCATTGCTGCACACCGTGC
ACGGCGTGGGATACCGCTTGGCCGAGGGCCGCGATGGAGTTTAA

Upstream 100 bases:

>100_bases
AAGACTCGATTTGTGGGGCTTGCCGCCCTAGCCCTGAGCCGGCGATGGTCGTAAGCTGCGCGGGCCAAGACGGCCGCTAC
CGTGTACGGAGGAGGTGCCC

Downstream 100 bases:

>100_bases
GCAAAGCCTTGCCCAGCGGATCATCATCGCCTTTGCGTTGATGAGTGCGCTGGTGGCCGGGGCGTTTGCCATGGGCATCG
TCGCGACCGTGCATCTGGTC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MRILLVEDNRDILANLADYLGLKGYTVDCAQDGLSGLHLAATEHYDLIVLDIMLPGIDGYTLCKRLREDARRDTPVIMLT
ARDQLDDRLQGFKSGADDYLVKPFALSELAARVEAVMRRTQGGGRRALQVGDLSYDLDTLEVTREGKLLKLNPVGLKLLA
VLMQKSPHVLRREILEEALWGDDCPDSDSLRSHVHQLRQVIDKPFAKPLLHTVHGVGYRLAEGRDGV

Sequences:

>Translated_227_residues
MRILLVEDNRDILANLADYLGLKGYTVDCAQDGLSGLHLAATEHYDLIVLDIMLPGIDGYTLCKRLREDARRDTPVIMLT
ARDQLDDRLQGFKSGADDYLVKPFALSELAARVEAVMRRTQGGGRRALQVGDLSYDLDTLEVTREGKLLKLNPVGLKLLA
VLMQKSPHVLRREILEEALWGDDCPDSDSLRSHVHQLRQVIDKPFAKPLLHTVHGVGYRLAEGRDGV
>Mature_227_residues
MRILLVEDNRDILANLADYLGLKGYTVDCAQDGLSGLHLAATEHYDLIVLDIMLPGIDGYTLCKRLREDARRDTPVIMLT
ARDQLDDRLQGFKSGADDYLVKPFALSELAARVEAVMRRTQGGGRRALQVGDLSYDLDTLEVTREGKLLKLNPVGLKLLA
VLMQKSPHVLRREILEEALWGDDCPDSDSLRSHVHQLRQVIDKPFAKPLLHTVHGVGYRLAEGRDGV

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=38.4615384615385, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=41.2556053811659, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=39.7321428571429, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=37.4449339207048, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=36.322869955157, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=36.6071428571429, Blast_Score=117, Evalue=4e-28,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=34.6846846846847, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=32.3008849557522, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=29.1479820627803, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=35.2422907488987, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=30.9417040358744, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=31.7391304347826, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=37.962962962963, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=27.3504273504274, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788713, Length=86, Percent_Identity=39.5348837209302, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=27.8969957081545, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=35.8490566037736, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790299, Length=119, Percent_Identity=32.7731092436975, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25349; Mature: 25349

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLVEDNRDILANLADYLGLKGYTVDCAQDGLSGLHLAATEHYDLIVLDIMLPGIDGY
CEEEEEECCHHHHHHHHHHHCCCCCEEHHHHCCCCCEEEEECCCCCEEEEEEECCCCCHH
TLCKRLREDARRDTPVIMLTARDQLDDRLQGFKSGADDYLVKPFALSELAARVEAVMRRT
HHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHC
QGGGRRALQVGDLSYDLDTLEVTREGKLLKLNPVGLKLLAVLMQKSPHVLRREILEEALW
CCCCCEEEEECCCCCCCHHHEEECCCCEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHC
GDDCPDSDSLRSHVHQLRQVIDKPFAKPLLHTVHGVGYRLAEGRDGV
CCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEECCCCCCC
>Mature Secondary Structure
MRILLVEDNRDILANLADYLGLKGYTVDCAQDGLSGLHLAATEHYDLIVLDIMLPGIDGY
CEEEEEECCHHHHHHHHHHHCCCCCEEHHHHCCCCCEEEEECCCCCEEEEEEECCCCCHH
TLCKRLREDARRDTPVIMLTARDQLDDRLQGFKSGADDYLVKPFALSELAARVEAVMRRT
HHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHC
QGGGRRALQVGDLSYDLDTLEVTREGKLLKLNPVGLKLLAVLMQKSPHVLRREILEEALW
CCCCCEEEEECCCCCCCHHHEEECCCCEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHC
GDDCPDSDSLRSHVHQLRQVIDKPFAKPLLHTVHGVGYRLAEGRDGV
CCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]