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The map label for this gene is envZ [H]

Identifier: 77460593

GI number: 77460593

Start: 4926009

End: 4927436

Strand: Reverse

Name: envZ [H]

Synonym: Pfl01_4372

Alternate gene names: 77460593

Gene position: 4927436-4926009 (Counterclockwise)

Preceding gene: 77460594

Following gene: 77460592

Centisome position: 76.53

GC content: 62.82

Gene sequence:

>1428_bases
ATGCCGCGTTCGCTGCTCGGGCGGATGCTGCTGCTGACGTTGCTCGCGGTGTTGTTCGCCCAGACGCTGTCCAGCGTGAT
CTGGGTGTCCCAATTGCGCGCGACCCAGCTCGAAGGCCTGGTCACCAGCGCCCGCAGCCTCGCCCATTCGATGACCGCCA
GCGTCAGTTATTTCCGCTCGTTGCCGGTGGCTTATCGGCCGCTGGTGCTCGACCAATTGCGCAGCATGGGCGGCACGCGT
TTTGTGGTGACACTGAATGACAAACCGCTGGGCATGGAGGTGTTGCCGGTGACGCCGCGCAAGGCCGCGGTGCTGAAAGC
GGTGGATGAAGTGCTGCGCCAGTCGCTGGGCCAGGACACCGACATTCTGGTGACCTTCGTCAGCCCCGATGACTTACGGA
TCTTCAACGCCGGGTTGAAACTTGATGAGTTGCCGCGTTCGTGGGCGCATTACGCGTTGACCCTGGAACCGGTGAATCCA
CCGGTGCTGGTGACCCAGATTCAATTGGCGCCGGGTGAATGGCTGTACATCGCCTCGCTGCTGCCCGAACCCTACACCAG
TCTTGAAGAACAGGGTCTGCCGACCCAGCAAGTGTGGTTCATCGTCTTCACCAGTGGTTTTCTGTTGTTGTTCATCGGTC
TGCTGGTGCACTGGCAGAGCCGGCCGCTAAAGCGTCTGGCGCGAGCCGCGCGGGATTTGTCGCTGGGCGCCGACGTCGAG
CCGGTGGCCGAGGGCGGCGGCAGTGAAGTGGTCGAAGTGGGCCGCGCCTTCAACACCATGCGCGAGCGGATCAGCCGTTA
CCTGACCGAGCGCAGCCAGCTGTTCAGCGCGATTTCCCATGACCTGCGCACGCCGATCACTCGCTTGCGACTGCGGGTTG
AACTGCTGGAAGACGAAACGCTGCAGACCAAGTTCGGCCGCGATCTGGATGAACTGGAGCTGCTGGTCAAAGGCGCGCTG
CAATGCGTGAAGGACACCGACATCCACGAAAACATCGAGCCGGTGGATCTGAACCATGTGCTCGACTGCCTGGTGGAACC
CTATCTGGCGCCGGCCGGCAATGGTCGCGTGACGCAGCAGGGGCGGGCGCTGGCGGCGTATCCGGGCAAGCCATTGGCGC
TCAAGCGCTGCATCGGCAACCTGATCGACAACGCGTTGAAGTACGGCCAGAACGCGCACCTGCACATCGATGACGACGAA
AGCGCATTCGTGCTGCATGTCGACGATGAAGGGCCGGGCGTGCCGGAGCAGCGGCTGGAGCAGGTGTTCGAGCCGCACTT
CCGCTTGGCGGGACAGCAGCAGGGTTACGGTCTCGGTTTGGGGATCGCCCGCAACATTGCCCATAGCCATGGGGGGGAGG
TGACGTTGCAGAATCTGCGTGAGGGTGGATTACGCGTGACCCTGCAATTGCCGCGTTCGGCGGATTGA

Upstream 100 bases:

>100_bases
CTGATCCGCACCGTGCGTGGCAGCGGCTACCAACTGGCAGCCAATGTGGTTGCCGGCAATGGTCACTGAGTTCCTGCGCA
CCACCGCGCGCAAAGTGCCG

Downstream 100 bases:

>100_bases
TCTGATTGTCACCGCTCGGTGACAAAACCCGCCCCCTTCGTTACAAGACCCTCCCGGCCCGTTGTTTAGACTGCCCGCAG
TCATAACAACAAAAAAGGCC

Product: periplasmic sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MPRSLLGRMLLLTLLAVLFAQTLSSVIWVSQLRATQLEGLVTSARSLAHSMTASVSYFRSLPVAYRPLVLDQLRSMGGTR
FVVTLNDKPLGMEVLPVTPRKAAVLKAVDEVLRQSLGQDTDILVTFVSPDDLRIFNAGLKLDELPRSWAHYALTLEPVNP
PVLVTQIQLAPGEWLYIASLLPEPYTSLEEQGLPTQQVWFIVFTSGFLLLFIGLLVHWQSRPLKRLARAARDLSLGADVE
PVAEGGGSEVVEVGRAFNTMRERISRYLTERSQLFSAISHDLRTPITRLRLRVELLEDETLQTKFGRDLDELELLVKGAL
QCVKDTDIHENIEPVDLNHVLDCLVEPYLAPAGNGRVTQQGRALAAYPGKPLALKRCIGNLIDNALKYGQNAHLHIDDDE
SAFVLHVDDEGPGVPEQRLEQVFEPHFRLAGQQQGYGLGLGIARNIAHSHGGEVTLQNLREGGLRVTLQLPRSAD

Sequences:

>Translated_475_residues
MPRSLLGRMLLLTLLAVLFAQTLSSVIWVSQLRATQLEGLVTSARSLAHSMTASVSYFRSLPVAYRPLVLDQLRSMGGTR
FVVTLNDKPLGMEVLPVTPRKAAVLKAVDEVLRQSLGQDTDILVTFVSPDDLRIFNAGLKLDELPRSWAHYALTLEPVNP
PVLVTQIQLAPGEWLYIASLLPEPYTSLEEQGLPTQQVWFIVFTSGFLLLFIGLLVHWQSRPLKRLARAARDLSLGADVE
PVAEGGGSEVVEVGRAFNTMRERISRYLTERSQLFSAISHDLRTPITRLRLRVELLEDETLQTKFGRDLDELELLVKGAL
QCVKDTDIHENIEPVDLNHVLDCLVEPYLAPAGNGRVTQQGRALAAYPGKPLALKRCIGNLIDNALKYGQNAHLHIDDDE
SAFVLHVDDEGPGVPEQRLEQVFEPHFRLAGQQQGYGLGLGIARNIAHSHGGEVTLQNLREGGLRVTLQLPRSAD
>Mature_474_residues
PRSLLGRMLLLTLLAVLFAQTLSSVIWVSQLRATQLEGLVTSARSLAHSMTASVSYFRSLPVAYRPLVLDQLRSMGGTRF
VVTLNDKPLGMEVLPVTPRKAAVLKAVDEVLRQSLGQDTDILVTFVSPDDLRIFNAGLKLDELPRSWAHYALTLEPVNPP
VLVTQIQLAPGEWLYIASLLPEPYTSLEEQGLPTQQVWFIVFTSGFLLLFIGLLVHWQSRPLKRLARAARDLSLGADVEP
VAEGGGSEVVEVGRAFNTMRERISRYLTERSQLFSAISHDLRTPITRLRLRVELLEDETLQTKFGRDLDELELLVKGALQ
CVKDTDIHENIEPVDLNHVLDCLVEPYLAPAGNGRVTQQGRALAAYPGKPLALKRCIGNLIDNALKYGQNAHLHIDDDES
AFVLHVDDEGPGVPEQRLEQVFEPHFRLAGQQQGYGLGLGIARNIAHSHGGEVTLQNLREGGLRVTLQLPRSAD

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=327, Percent_Identity=31.4984709480122, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1787894, Length=312, Percent_Identity=28.8461538461538, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1790346, Length=279, Percent_Identity=32.258064516129, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1790861, Length=292, Percent_Identity=27.0547945205479, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788393, Length=287, Percent_Identity=27.5261324041812, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790551, Length=300, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=289, Percent_Identity=25.9515570934256, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081816, Length=218, Percent_Identity=27.0642201834862, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1787374, Length=293, Percent_Identity=24.9146757679181, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI48994928, Length=255, Percent_Identity=24.7058823529412, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI145693157, Length=257, Percent_Identity=24.124513618677, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790436, Length=214, Percent_Identity=25.7009345794392, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789403, Length=282, Percent_Identity=26.5957446808511, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52616; Mature: 52485

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRSLLGRMLLLTLLAVLFAQTLSSVIWVSQLRATQLEGLVTSARSLAHSMTASVSYFRS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPVAYRPLVLDQLRSMGGTRFVVTLNDKPLGMEVLPVTPRKAAVLKAVDEVLRQSLGQDT
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCC
DILVTFVSPDDLRIFNAGLKLDELPRSWAHYALTLEPVNPPVLVTQIQLAPGEWLYIASL
EEEEEEECCCCEEEEECCCCHHHCCCCHHCEEEEEECCCCCEEEEEEEECCCCEEEEEHH
LPEPYTSLEEQGLPTQQVWFIVFTSGFLLLFIGLLVHWQSRPLKRLARAARDLSLGADVE
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC
PVAEGGGSEVVEVGRAFNTMRERISRYLTERSQLFSAISHDLRTPITRLRLRVELLEDET
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCH
LQTKFGRDLDELELLVKGALQCVKDTDIHENIEPVDLNHVLDCLVEPYLAPAGNGRVTQQ
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEECC
GRALAAYPGKPLALKRCIGNLIDNALKYGQNAHLHIDDDESAFVLHVDDEGPGVPEQRLE
CCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHH
QVFEPHFRLAGQQQGYGLGLGIARNIAHSHGGEVTLQNLREGGLRVTLQLPRSAD
HHHCHHHHCCCCCCCCEECHHHHHHHHHCCCCCEEHHHHHCCCEEEEEECCCCCC
>Mature Secondary Structure 
PRSLLGRMLLLTLLAVLFAQTLSSVIWVSQLRATQLEGLVTSARSLAHSMTASVSYFRS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPVAYRPLVLDQLRSMGGTRFVVTLNDKPLGMEVLPVTPRKAAVLKAVDEVLRQSLGQDT
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCC
DILVTFVSPDDLRIFNAGLKLDELPRSWAHYALTLEPVNPPVLVTQIQLAPGEWLYIASL
EEEEEEECCCCEEEEECCCCHHHCCCCHHCEEEEEECCCCCEEEEEEEECCCCEEEEEHH
LPEPYTSLEEQGLPTQQVWFIVFTSGFLLLFIGLLVHWQSRPLKRLARAARDLSLGADVE
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC
PVAEGGGSEVVEVGRAFNTMRERISRYLTERSQLFSAISHDLRTPITRLRLRVELLEDET
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCH
LQTKFGRDLDELELLVKGALQCVKDTDIHENIEPVDLNHVLDCLVEPYLAPAGNGRVTQQ
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEECC
GRALAAYPGKPLALKRCIGNLIDNALKYGQNAHLHIDDDESAFVLHVDDEGPGVPEQRLE
CCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHH
QVFEPHFRLAGQQQGYGLGLGIARNIAHSHGGEVTLQNLREGGLRVTLQLPRSAD
HHHCHHHHCCCCCCCCEECHHHHHHHHHCCCCCEEHHHHHCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]