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The map label for this gene is ltaE [H]

Identifier: 77460497

GI number: 77460497

Start: 4825654

End: 4826658

Strand: Reverse

Name: ltaE [H]

Synonym: Pfl01_4276

Alternate gene names: 77460497

Gene position: 4826658-4825654 (Counterclockwise)

Preceding gene: 77460498

Following gene: 77460496

Centisome position: 74.97

GC content: 63.48

Gene sequence:

>1005_bases
ATGAGCGTTATCGATCTTCGCAGCGACACCGTCACTCAACCGACTCCCGCCATGCTCGACGCGATGACCCGCGCCGACAC
CGGTGACGACGTGTATGGCGAAGATCCGACGGTCAATCGTCTGGAAGCCGAACTGGCAAAACGGCTCGGTTTTGCTGCCG
CGCTGTTCGTCCCGACCGGCACCATGAGCAACCTGCTGGGCTTGATGGCGCACTGCGAGCGCGGTGACGAGTACATCGTC
GGTCAACAGGCACACACCTATAAATACGAAGGCGGCGGCGCAGCGGTGCTCGGCTCGATTCAGCCACAGCCGCTGGAAGT
GCAGGCCGACGGCTCGCTGGACCTGGATCAGGTGGCCGCGGCGATCAAGCCCGACGATTTCCACTTCGCCCGCACCCGCC
TGCTGGCGCTGGAAAACACCATGCAGGGCAAAGTGTTGCCGCTGGACTATCTGGCCCGGGCCCGCCAGTTCACTCGGGAC
AACGGCCTGCAACTGCATCTGGACGGCGCGCGGCTGTACAACGCGGCGGTCAAGCTGGGGGTCGATGCCCGGGAAATCAC
CCAATATTTCGATTCGGTCTCGGTGTGCCTGTCCAAAGGCCTCGGCGCGCCGGTCGGTTCGGTGCTGTGCGGTTCGTCGG
CGTTGATTGCAAAGGCCCGGCGCCTGCGCAAAATGGTCGGTGGCGGCATGCGTCAGGCCGGACTGCTGGCGGCGGCGGGG
CTGTATGCGCTGGATCACAACGTGGAGCGTCTTGCCGATGACCATGCCAACGCACAGTTGCTGGCCGAAGGCTTGCGCGA
GGCCGGTTTCAGTGTCGAGCCGGTGCAGACCAACATGGTTTACGTGCAGATGGGCGACCGTGCCGAGGCGATCAAGGCAT
TTGCCGCCGAACGCGGGATCAAGTTGAGCGCTGCCGCCCGTCTGCGGATGGTCACGCACATGGACGTCAATCGCTCGCAA
ATCGAGCAAGTGATCGCGACATTCGTCGAGTTTTCGCGCAAGTGA

Upstream 100 bases:

>100_bases
AAAACGACTTTTCCTTGCGCAAGGGTTGATTAATCCGCGCCATGCCCGCAGTAATTCCTCTTCGAAAAGGGATTTCCCCT
GCTGACTTGAGGCCAGGTTC

Downstream 100 bases:

>100_bases
CAGCGTTAGCGGCCCAATTGACCGTTTCTATCGTATAAACACGCTGTACCCCGCGCGCAGGGCCGATATAATGCGGCCCT
TTGCCGTCGTTTCGTCTGTT

Product: L-threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MSVIDLRSDTVTQPTPAMLDAMTRADTGDDVYGEDPTVNRLEAELAKRLGFAAALFVPTGTMSNLLGLMAHCERGDEYIV
GQQAHTYKYEGGGAAVLGSIQPQPLEVQADGSLDLDQVAAAIKPDDFHFARTRLLALENTMQGKVLPLDYLARARQFTRD
NGLQLHLDGARLYNAAVKLGVDAREITQYFDSVSVCLSKGLGAPVGSVLCGSSALIAKARRLRKMVGGGMRQAGLLAAAG
LYALDHNVERLADDHANAQLLAEGLREAGFSVEPVQTNMVYVQMGDRAEAIKAFAAERGIKLSAAARLRMVTHMDVNRSQ
IEQVIATFVEFSRK

Sequences:

>Translated_334_residues
MSVIDLRSDTVTQPTPAMLDAMTRADTGDDVYGEDPTVNRLEAELAKRLGFAAALFVPTGTMSNLLGLMAHCERGDEYIV
GQQAHTYKYEGGGAAVLGSIQPQPLEVQADGSLDLDQVAAAIKPDDFHFARTRLLALENTMQGKVLPLDYLARARQFTRD
NGLQLHLDGARLYNAAVKLGVDAREITQYFDSVSVCLSKGLGAPVGSVLCGSSALIAKARRLRKMVGGGMRQAGLLAAAG
LYALDHNVERLADDHANAQLLAEGLREAGFSVEPVQTNMVYVQMGDRAEAIKAFAAERGIKLSAAARLRMVTHMDVNRSQ
IEQVIATFVEFSRK
>Mature_333_residues
SVIDLRSDTVTQPTPAMLDAMTRADTGDDVYGEDPTVNRLEAELAKRLGFAAALFVPTGTMSNLLGLMAHCERGDEYIVG
QQAHTYKYEGGGAAVLGSIQPQPLEVQADGSLDLDQVAAAIKPDDFHFARTRLLALENTMQGKVLPLDYLARARQFTRDN
GLQLHLDGARLYNAAVKLGVDAREITQYFDSVSVCLSKGLGAPVGSVLCGSSALIAKARRLRKMVGGGMRQAGLLAAAGL
YALDHNVERLADDHANAQLLAEGLREAGFSVEPVQTNMVYVQMGDRAEAIKAFAAERGIKLSAAARLRMVTHMDVNRSQI
EQVIATFVEFSRK

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=330, Percent_Identity=57.8787878787879, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI193206522, Length=346, Percent_Identity=41.907514450867, Blast_Score=248, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI193206524, Length=346, Percent_Identity=41.907514450867, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI193206520, Length=346, Percent_Identity=41.907514450867, Blast_Score=248, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6320789, Length=328, Percent_Identity=38.109756097561, Blast_Score=210, Evalue=2e-55,
Organism=Drosophila melanogaster, GI21355439, Length=362, Percent_Identity=43.646408839779, Blast_Score=257, Evalue=7e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 36021; Mature: 35889

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIDLRSDTVTQPTPAMLDAMTRADTGDDVYGEDPTVNRLEAELAKRLGFAAALFVPTG
CCEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCC
TMSNLLGLMAHCERGDEYIVGQQAHTYKYEGGGAAVLGSIQPQPLEVQADGSLDLDQVAA
HHHHHHHHHHHHCCCCCEEECCCCEEEEECCCCEEEEECCCCCCEEEECCCCCCHHHHHH
AIKPDDFHFARTRLLALENTMQGKVLPLDYLARARQFTRDNGLQLHLDGARLYNAAVKLG
HCCCCCHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCC
VDAREITQYFDSVSVCLSKGLGAPVGSVLCGSSALIAKARRLRKMVGGGMRQAGLLAAAG
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LYALDHNVERLADDHANAQLLAEGLREAGFSVEPVQTNMVYVQMGDRAEAIKAFAAERGI
HHHHHCCHHHHHCCCCCHHHHHHHHHHCCCCCCEEECCEEEEEECCHHHHHHHHHHHCCC
KLSAAARLRMVTHMDVNRSQIEQVIATFVEFSRK
EEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVIDLRSDTVTQPTPAMLDAMTRADTGDDVYGEDPTVNRLEAELAKRLGFAAALFVPTG
CEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCC
TMSNLLGLMAHCERGDEYIVGQQAHTYKYEGGGAAVLGSIQPQPLEVQADGSLDLDQVAA
HHHHHHHHHHHHCCCCCEEECCCCEEEEECCCCEEEEECCCCCCEEEECCCCCCHHHHHH
AIKPDDFHFARTRLLALENTMQGKVLPLDYLARARQFTRDNGLQLHLDGARLYNAAVKLG
HCCCCCHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCC
VDAREITQYFDSVSVCLSKGLGAPVGSVLCGSSALIAKARRLRKMVGGGMRQAGLLAAAG
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LYALDHNVERLADDHANAQLLAEGLREAGFSVEPVQTNMVYVQMGDRAEAIKAFAAERGI
HHHHHCCHHHHHCCCCCHHHHHHHHHHCCCCCCEEECCEEEEEECCHHHHHHHHHHHCCC
KLSAAARLRMVTHMDVNRSQIEQVIATFVEFSRK
EEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]