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The map label for this gene is pfeR [H]

Identifier: 77460442

GI number: 77460442

Start: 4764607

End: 4765329

Strand: Reverse

Name: pfeR [H]

Synonym: Pfl01_4221

Alternate gene names: 77460442

Gene position: 4765329-4764607 (Counterclockwise)

Preceding gene: 77460445

Following gene: 77460441

Centisome position: 74.01

GC content: 61.96

Gene sequence:

>723_bases
ATGACTCCTGTCTCCATTGGCCAACCCCGCATTCTTTCCATCGAAGACGACCCCGTCCTCGGTGCCTATGTCCATGAACA
TCTGGGCCGCAGCGGCTTTCAGGTCACCTGGTGCCAGAACGGCAGCGAAGGCCTGAGTATCGCCCGGCGCCAGCCGTTCG
ATGTGGTGTTGATGGACATTCTGTTGCCGGGGCTCGACGGATTGAATGTCCTGACCCAACTGCGTCAGAGCCATTCCACC
CCGGTGTTGCTGATGTCGGCCCTCGGTGCCGAGGCCGACCGTATCAGCGGGTTCCGCCTTGGCGCCGACGACTATTTGCC
CAAACCCTTCAGCATGGCTGAGCTGCATGTGCGCATTGAAGCGATCCTGCGCCGGGTCGCCCTCGATCGTCGCCCGACGG
CCGTCGCTGCGGTGGTGCCGGTCGGCGGGCTGCGTTTCGACGACGAGCAGTGCGAGGTGTTCTACCTCGACCAGCCCGCC
GGCCTGACCCGCAGCGAATACCGCCTGCTGGAAACCCTCAATCGCAACGACGAGGAAGTGCTGAGCAAGGCCTTCCTTTA
TCAGCACGTTCTTCAGCGCGGTTATGCGGCCCACGATCGCAGCCTTGATATGCACATCAGCCAGATTCGCCGCAAACTCA
AGTCGGTCGGCTACACCGAGCGCGAAGTGCGCACGGTGTGGGGCAAGGGTTACGTTCTGAGTGCCGTCGATGAAAGTGTC
TGA

Upstream 100 bases:

>100_bases
CGCTTGGGGAGCGGTCATCTGTCCGACAGGTCAAGCTTGGGTTGCCGGGCGCGGGGCAATCTTGAATAATCGCCCAACTG
AGAATTATTTGCAGATAGTC

Downstream 100 bases:

>100_bases
CCTGCCGGGCCGGCACTCGCTGTTCTGGAAGCTCGCCTGTCTGCTGGTGGCGTTCTGTCTGCTGATGATCTGGCTGAGCT
GGTCCTGGGGCTGGTACATG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MTPVSIGQPRILSIEDDPVLGAYVHEHLGRSGFQVTWCQNGSEGLSIARRQPFDVVLMDILLPGLDGLNVLTQLRQSHST
PVLLMSALGAEADRISGFRLGADDYLPKPFSMAELHVRIEAILRRVALDRRPTAVAAVVPVGGLRFDDEQCEVFYLDQPA
GLTRSEYRLLETLNRNDEEVLSKAFLYQHVLQRGYAAHDRSLDMHISQIRRKLKSVGYTEREVRTVWGKGYVLSAVDESV

Sequences:

>Translated_240_residues
MTPVSIGQPRILSIEDDPVLGAYVHEHLGRSGFQVTWCQNGSEGLSIARRQPFDVVLMDILLPGLDGLNVLTQLRQSHST
PVLLMSALGAEADRISGFRLGADDYLPKPFSMAELHVRIEAILRRVALDRRPTAVAAVVPVGGLRFDDEQCEVFYLDQPA
GLTRSEYRLLETLNRNDEEVLSKAFLYQHVLQRGYAAHDRSLDMHISQIRRKLKSVGYTEREVRTVWGKGYVLSAVDESV
>Mature_239_residues
TPVSIGQPRILSIEDDPVLGAYVHEHLGRSGFQVTWCQNGSEGLSIARRQPFDVVLMDILLPGLDGLNVLTQLRQSHSTP
VLLMSALGAEADRISGFRLGADDYLPKPFSMAELHVRIEAILRRVALDRRPTAVAAVVPVGGLRFDDEQCEVFYLDQPAG
LTRSEYRLLETLNRNDEEVLSKAFLYQHVLQRGYAAHDRSLDMHISQIRRKLKSVGYTEREVRTVWGKGYVLSAVDESV

Specific function: Member of the two-component regulatory system pfeR/pfeS. Activates expression of the ferric enterobactin receptor [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=38.3259911894273, Blast_Score=153, Evalue=9e-39,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=33.9055793991416, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=34.5132743362832, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=33.6244541484716, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=35.2422907488987, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=32.579185520362, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=31.4410480349345, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=30.1310043668122, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=30.2631578947368, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=29.7872340425532, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=27.1111111111111, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=31.7180616740088, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1790552, Length=234, Percent_Identity=31.6239316239316, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=26.4069264069264, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790299, Length=124, Percent_Identity=34.6774193548387, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=32.7586206896552, Blast_Score=67, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6322000, Length=123, Percent_Identity=32.520325203252, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26883; Mature: 26752

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPVSIGQPRILSIEDDPVLGAYVHEHLGRSGFQVTWCQNGSEGLSIARRQPFDVVLMDI
CCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHCCCHHHHHHHH
LLPGLDGLNVLTQLRQSHSTPVLLMSALGAEADRISGFRLGADDYLPKPFSMAELHVRIE
HHCCCCHHHHHHHHHHHCCCCEEHHHHHCCCHHHCCCEEECCCCCCCCCCCHHHHHHHHH
AILRRVALDRRPTAVAAVVPVGGLRFDDEQCEVFYLDQPAGLTRSEYRLLETLNRNDEEV
HHHHHHHHCCCCCEEEEEECCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHH
LSKAFLYQHVLQRGYAAHDRSLDMHISQIRRKLKSVGYTEREVRTVWGKGYVLSAVDESV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEECCCCCC
>Mature Secondary Structure 
TPVSIGQPRILSIEDDPVLGAYVHEHLGRSGFQVTWCQNGSEGLSIARRQPFDVVLMDI
CCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHCCCHHHHHHHH
LLPGLDGLNVLTQLRQSHSTPVLLMSALGAEADRISGFRLGADDYLPKPFSMAELHVRIE
HHCCCCHHHHHHHHHHHCCCCEEHHHHHCCCHHHCCCEEECCCCCCCCCCCHHHHHHHHH
AILRRVALDRRPTAVAAVVPVGGLRFDDEQCEVFYLDQPAGLTRSEYRLLETLNRNDEEV
HHHHHHHHCCCCCEEEEEECCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHH
LSKAFLYQHVLQRGYAAHDRSLDMHISQIRRKLKSVGYTEREVRTVWGKGYVLSAVDESV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8361354; 10984043 [H]