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The map label for this gene is pfeS [H]

Identifier: 77460441

GI number: 77460441

Start: 4763196

End: 4764614

Strand: Reverse

Name: pfeS [H]

Synonym: Pfl01_4220

Alternate gene names: 77460441

Gene position: 4764614-4763196 (Counterclockwise)

Preceding gene: 77460442

Following gene: 77460440

Centisome position: 74.0

GC content: 63.99

Gene sequence:

>1419_bases
GTGTCTGACCTGCCGGGCCGGCACTCGCTGTTCTGGAAGCTCGCCTGTCTGCTGGTGGCGTTCTGTCTGCTGATGATCTG
GCTGAGCTGGTCCTGGGGCTGGTACATGGAGCAGCGCAATCAGTTCCTCTCCGACGACGCCCGTCGCACCCTGAGCCGTT
ATGCCGCCGAGGCGGAGCGCGCCTGGCAGCAGGGCGAGCGCGATGGCATCGATAGCTGGTTGCAAAGCATGGAGCTGCGC
GAGGCCGGCTGGGTCGGCGTGATCGGCGGCAACCTGCAGTCGCTGGGCAGCCAACCGTTCAACGCTCAAGAGCTTCAGCA
CCTGACCTTCCTGCGAGGTCTGGACTGGCCGATTCATAAAAGGGGCCGACCGTGGCTGCGGGTTCCGTTCCCCACTGACC
CGACTGCCGGCAGTCTGGTCATCGAGTTGCCCGAGCGATTCCTGCCGGGGAAATACCGGGTGTTCTGGCGGGTCATCACC
AACGGTGTGATTCCCGGCCTGTTCACCCTGCTGCTGTGCGTCGGCCTGTATCGCCTGCTGGTGGTGCCGCTTAACAATCT
GCGCGAGCAGGCCAACGCCTGGCGCGCCGATGAACTGAATGTGCGGTTGTCGAGCGGCATCACCCAGCGCCCCGATGAAC
TCGGCGAACTGGCCCGCGCCTTCGATTCGATGTCCGAACGCCTGCAGTCCACCGTGGCCTTGCAACAGCAACTGCTGCGC
GACCTGTCCCACGAACTGCGCACGCCCCTGAGCCGGTTGCGGGTCGCCAGTGAAAGCGAGCAACAGCTGCAACCGTTGCG
CGAGCGCATCGGTCGCGAAGTCGACGTGATGCAGCGACTAGTGGAGGACACCCTGCAACTGGCCTGGCTCGACACCGAAC
GCGCACCGTTGCCGGACGAAGCGATCCAGATTCAGGCGCTGTGGGAAATGCTCACGGAAAACGCCTGCTACGAAAGCTGC
TGTCCGGTGGGGCAGTTGCAGTGCGGTGTTGAAGCTTCCTGCTGGGTACGCGGCAATCTCAACACCCTGGCCCAGGCTCT
GGAAAACATCCTGCGCAATGCGATTCGTCATTCGCCACCGGGCGGCATCGTGCGGCTCGACGGTCGACGAGAGGGCGATT
ACTGGCACCTGTGGCTGGAGGACGAGGGCGGTGGTGTGGCCGACGCGGATCTTGAGCGGATCTTTTCGCCCTTCATCCGC
CTCGACGGCTCGCGGCCGGGGGATGATGGATTCGGTCTGGGCCTGAGCATCGCGAGGAACGCGGTGCAACGCCAGGGCGG
TACTTTGTGGGCTGAGAATGGCCCGTCGGGATTGCGACTGAATCTGCGCTTGGTGGCGGAGGACAGTGCTGTCATTCCTG
AAGTCTTCGCTGGCAAGCCAGATCCCACAGTGGACATGGGCCGCCCGCAGATTGTGTGA

Upstream 100 bases:

>100_bases
ATCAGCCAGATTCGCCGCAAACTCAAGTCGGTCGGCTACACCGAGCGCGAAGTGCGCACGGTGTGGGGCAAGGGTTACGT
TCTGAGTGCCGTCGATGAAA

Downstream 100 bases:

>100_bases
GCGGCACAGGAAAGTGTCAGCACTGCCGACACTCTTTAAAAAGTCTCACCACTGGTGAGACTTTTACTGCTTATTCCAAG
AAACCATAAGCACCACACTT

Product: periplasmic sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSDLPGRHSLFWKLACLLVAFCLLMIWLSWSWGWYMEQRNQFLSDDARRTLSRYAAEAERAWQQGERDGIDSWLQSMELR
EAGWVGVIGGNLQSLGSQPFNAQELQHLTFLRGLDWPIHKRGRPWLRVPFPTDPTAGSLVIELPERFLPGKYRVFWRVIT
NGVIPGLFTLLLCVGLYRLLVVPLNNLREQANAWRADELNVRLSSGITQRPDELGELARAFDSMSERLQSTVALQQQLLR
DLSHELRTPLSRLRVASESEQQLQPLRERIGREVDVMQRLVEDTLQLAWLDTERAPLPDEAIQIQALWEMLTENACYESC
CPVGQLQCGVEASCWVRGNLNTLAQALENILRNAIRHSPPGGIVRLDGRREGDYWHLWLEDEGGGVADADLERIFSPFIR
LDGSRPGDDGFGLGLSIARNAVQRQGGTLWAENGPSGLRLNLRLVAEDSAVIPEVFAGKPDPTVDMGRPQIV

Sequences:

>Translated_472_residues
MSDLPGRHSLFWKLACLLVAFCLLMIWLSWSWGWYMEQRNQFLSDDARRTLSRYAAEAERAWQQGERDGIDSWLQSMELR
EAGWVGVIGGNLQSLGSQPFNAQELQHLTFLRGLDWPIHKRGRPWLRVPFPTDPTAGSLVIELPERFLPGKYRVFWRVIT
NGVIPGLFTLLLCVGLYRLLVVPLNNLREQANAWRADELNVRLSSGITQRPDELGELARAFDSMSERLQSTVALQQQLLR
DLSHELRTPLSRLRVASESEQQLQPLRERIGREVDVMQRLVEDTLQLAWLDTERAPLPDEAIQIQALWEMLTENACYESC
CPVGQLQCGVEASCWVRGNLNTLAQALENILRNAIRHSPPGGIVRLDGRREGDYWHLWLEDEGGGVADADLERIFSPFIR
LDGSRPGDDGFGLGLSIARNAVQRQGGTLWAENGPSGLRLNLRLVAEDSAVIPEVFAGKPDPTVDMGRPQIV
>Mature_471_residues
SDLPGRHSLFWKLACLLVAFCLLMIWLSWSWGWYMEQRNQFLSDDARRTLSRYAAEAERAWQQGERDGIDSWLQSMELRE
AGWVGVIGGNLQSLGSQPFNAQELQHLTFLRGLDWPIHKRGRPWLRVPFPTDPTAGSLVIELPERFLPGKYRVFWRVITN
GVIPGLFTLLLCVGLYRLLVVPLNNLREQANAWRADELNVRLSSGITQRPDELGELARAFDSMSERLQSTVALQQQLLRD
LSHELRTPLSRLRVASESEQQLQPLRERIGREVDVMQRLVEDTLQLAWLDTERAPLPDEAIQIQALWEMLTENACYESCC
PVGQLQCGVEASCWVRGNLNTLAQALENILRNAIRHSPPGGIVRLDGRREGDYWHLWLEDEGGGVADADLERIFSPFIRL
DGSRPGDDGFGLGLSIARNAVQRQGGTLWAENGPSGLRLNLRLVAEDSAVIPEVFAGKPDPTVDMGRPQIV

Specific function: Member of the two-component regulatory system pfeR/pfeS. May activate pfeR by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=259, Percent_Identity=34.3629343629344, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788393, Length=267, Percent_Identity=29.2134831460674, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1786783, Length=304, Percent_Identity=26.6447368421053, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1787894, Length=234, Percent_Identity=31.6239316239316, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790551, Length=291, Percent_Identity=28.8659793814433, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1789808, Length=220, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI87082128, Length=275, Percent_Identity=25.8181818181818, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790861, Length=233, Percent_Identity=29.1845493562232, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786600, Length=232, Percent_Identity=26.7241379310345, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=234, Percent_Identity=25.6410256410256, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87081816, Length=128, Percent_Identity=35.15625, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788279, Length=305, Percent_Identity=23.9344262295082, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53357; Mature: 53225

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLPGRHSLFWKLACLLVAFCLLMIWLSWSWGWYMEQRNQFLSDDARRTLSRYAAEAER
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWQQGERDGIDSWLQSMELREAGWVGVIGGNLQSLGSQPFNAQELQHLTFLRGLDWPIHK
HHHCCCCCCHHHHHHHHHHHHCCEEEEECCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCC
RGRPWLRVPFPTDPTAGSLVIELPERFLPGKYRVFWRVITNGVIPGLFTLLLCVGLYRLL
CCCCEEECCCCCCCCCCCEEEECCHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VVPLNNLREQANAWRADELNVRLSSGITQRPDELGELARAFDSMSERLQSTVALQQQLLR
HHHHHHHHHHHHCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLSHELRTPLSRLRVASESEQQLQPLRERIGREVDVMQRLVEDTLQLAWLDTERAPLPDE
HHHHHHHCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEECCCCCCCCHH
AIQIQALWEMLTENACYESCCPVGQLQCGVEASCWVRGNLNTLAQALENILRNAIRHSPP
HHHHHHHHHHHHHCCHHHHCCCCCHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCC
GGIVRLDGRREGDYWHLWLEDEGGGVADADLERIFSPFIRLDGSRPGDDGFGLGLSIARN
CCEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
AVQRQGGTLWAENGPSGLRLNLRLVAEDSAVIPEVFAGKPDPTVDMGRPQIV
HHHHCCCEEEECCCCCCEEEEEEEEECCCCCCHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDLPGRHSLFWKLACLLVAFCLLMIWLSWSWGWYMEQRNQFLSDDARRTLSRYAAEAER
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWQQGERDGIDSWLQSMELREAGWVGVIGGNLQSLGSQPFNAQELQHLTFLRGLDWPIHK
HHHCCCCCCHHHHHHHHHHHHCCEEEEECCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCC
RGRPWLRVPFPTDPTAGSLVIELPERFLPGKYRVFWRVITNGVIPGLFTLLLCVGLYRLL
CCCCEEECCCCCCCCCCCEEEECCHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VVPLNNLREQANAWRADELNVRLSSGITQRPDELGELARAFDSMSERLQSTVALQQQLLR
HHHHHHHHHHHHCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLSHELRTPLSRLRVASESEQQLQPLRERIGREVDVMQRLVEDTLQLAWLDTERAPLPDE
HHHHHHHCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEECCCCCCCCHH
AIQIQALWEMLTENACYESCCPVGQLQCGVEASCWVRGNLNTLAQALENILRNAIRHSPP
HHHHHHHHHHHHHCCHHHHCCCCCHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCC
GGIVRLDGRREGDYWHLWLEDEGGGVADADLERIFSPFIRLDGSRPGDDGFGLGLSIARN
CCEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
AVQRQGGTLWAENGPSGLRLNLRLVAEDSAVIPEVFAGKPDPTVDMGRPQIV
HHHHCCCEEEECCCCCCEEEEEEEEECCCCCCHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8361354; 10984043 [H]