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The map label for this gene is gpsA

Identifier: 77460429

GI number: 77460429

Start: 4748262

End: 4749326

Strand: Reverse

Name: gpsA

Synonym: Pfl01_4208

Alternate gene names: 77460429

Gene position: 4749326-4748262 (Counterclockwise)

Preceding gene: 77460436

Following gene: 77460428

Centisome position: 73.77

GC content: 62.16

Gene sequence:

>1065_bases
ATGCCGGCATCGCCACTGGTATGGATTAACGGATTACATATGACTGAACAGCGCCCGATTGCGGTCCTGGGAGGCGGAAG
TTTCGGTACCGCCGTGGCCAATCTGTTGGCCGAGAACGGCCATCAAGTCCGGCAGTGGATGCGTGACCCGGAACAGGCCG
AGGCTATCCGGGTCAATCGCGAGAACCCGCGTTACCTCAAAGGCATCAAGATTCTGCCCGGCGTGACCGCGGTCACCGAC
CTGCAGGAAACCCTCGACGCCTGCGAGTTGTGTTTCGTCGCGTTGCCGTCCAGCGCACTGCGCACAGTGCTGGCGGCGCA
TGCCGAACGCCTGAGCGGCAAGATGCTGGTCAGCCTGACCAAAGGCATCGAAGCGCAGACCTTCAAACTGATGAGCCAGA
TTCTCGAAGAAATCGCCCCGCAGGCACGCATCGGCGTGCTGTCCGGGCCGAACCTCGCGCGGGAAATCGCCGAGCACGCG
CTGACCGCCACCGTGGTCGCCAGCGAAGACGAAGAACTCTGCAAAGCCGTGCAGGCTGCATTGCATGGCCGCACTTTCCG
CGTCTACGCCAGCGCCGACCGTTTCGGCGTGGAGCTGGGCGGCGCACTGAAAAACGTCTACGCGATCATCGCCGGCATGG
CGGTGGCGCTGGAAATGGGCGAGAACACCAAGAGCATGCTGATCACCCGCGCCCTGGCCGAAATGACCCGGTTTGCGGTG
AATCAGGGCGCCAACCCGATGACCTTCCTCGGTCTGGCCGGTGTCGGCGATCTGATCGTTACCTGCTCGTCGCCGAAAAG
CCGCAACTACCAGGTCGGTTTCGCCCTCGGTCAGGGCTTGAGCCTCGACGAAGCGGTGTCGCGCCTGGGTGAAGTGGCCG
AAGGCGTCAACACCCTGAAAGTGCTCAAGGCCAAGGCCCAGGAGGTCGGCGTGTACATGCCGCTGGTCGCCGGACTGCAT
GCAATCCTGTTCGAAGGGCGCACGCTTGAGCAGGTGATCGGTCTGCTGATGCGTGCCGAACCGAAAACCGATGTCGACTT
TATTTCCACCAGTGGTTTCAACTGA

Upstream 100 bases:

>100_bases
CCAGTCACGTTGCAGGCATTTTCCTCGGTTTTATTGGTCTTCTTCCTACAAGTGCGGGTAATTGACGCCGGGGCTGTCCG
AGAAGGGGACGCTCCGTATA

Downstream 100 bases:

>100_bases
TTCAGCAGGGAGCAGGCCATGAACGATCCGAAAACCGAAGCCAAATATGAATCCATCCTCCTGCGGGTGTTGTGGATGAT
TGTTTACATCCTGGTCTGGC

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MPASPLVWINGLHMTEQRPIAVLGGGSFGTAVANLLAENGHQVRQWMRDPEQAEAIRVNRENPRYLKGIKILPGVTAVTD
LQETLDACELCFVALPSSALRTVLAAHAERLSGKMLVSLTKGIEAQTFKLMSQILEEIAPQARIGVLSGPNLAREIAEHA
LTATVVASEDEELCKAVQAALHGRTFRVYASADRFGVELGGALKNVYAIIAGMAVALEMGENTKSMLITRALAEMTRFAV
NQGANPMTFLGLAGVGDLIVTCSSPKSRNYQVGFALGQGLSLDEAVSRLGEVAEGVNTLKVLKAKAQEVGVYMPLVAGLH
AILFEGRTLEQVIGLLMRAEPKTDVDFISTSGFN

Sequences:

>Translated_354_residues
MPASPLVWINGLHMTEQRPIAVLGGGSFGTAVANLLAENGHQVRQWMRDPEQAEAIRVNRENPRYLKGIKILPGVTAVTD
LQETLDACELCFVALPSSALRTVLAAHAERLSGKMLVSLTKGIEAQTFKLMSQILEEIAPQARIGVLSGPNLAREIAEHA
LTATVVASEDEELCKAVQAALHGRTFRVYASADRFGVELGGALKNVYAIIAGMAVALEMGENTKSMLITRALAEMTRFAV
NQGANPMTFLGLAGVGDLIVTCSSPKSRNYQVGFALGQGLSLDEAVSRLGEVAEGVNTLKVLKAKAQEVGVYMPLVAGLH
AILFEGRTLEQVIGLLMRAEPKTDVDFISTSGFN
>Mature_353_residues
PASPLVWINGLHMTEQRPIAVLGGGSFGTAVANLLAENGHQVRQWMRDPEQAEAIRVNRENPRYLKGIKILPGVTAVTDL
QETLDACELCFVALPSSALRTVLAAHAERLSGKMLVSLTKGIEAQTFKLMSQILEEIAPQARIGVLSGPNLAREIAEHAL
TATVVASEDEELCKAVQAALHGRTFRVYASADRFGVELGGALKNVYAIIAGMAVALEMGENTKSMLITRALAEMTRFAVN
QGANPMTFLGLAGVGDLIVTCSSPKSRNYQVGFALGQGLSLDEAVSRLGEVAEGVNTLKVLKAKAQEVGVYMPLVAGLHA
ILFEGRTLEQVIGLLMRAEPKTDVDFISTSGFN

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=351, Percent_Identity=27.9202279202279, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI24307999, Length=341, Percent_Identity=28.7390029325513, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1790037, Length=324, Percent_Identity=38.8888888888889, Blast_Score=216, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI32564399, Length=334, Percent_Identity=30.5389221556886, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI193210136, Length=343, Percent_Identity=30.0291545189504, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI32564403, Length=343, Percent_Identity=30.0291545189504, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17507425, Length=356, Percent_Identity=27.8089887640449, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193210134, Length=325, Percent_Identity=27.3846153846154, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324513, Length=354, Percent_Identity=25.9887005649718, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320181, Length=361, Percent_Identity=26.8698060941828, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17136204, Length=335, Percent_Identity=28.0597014925373, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17136202, Length=335, Percent_Identity=28.0597014925373, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17136200, Length=335, Percent_Identity=28.0597014925373, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI22026922, Length=351, Percent_Identity=26.7806267806268, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI281362270, Length=243, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45551945, Length=243, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648969, Length=237, Percent_Identity=27.0042194092827, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_PSEPF (Q3K8F9)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_349936.1
- ProteinModelPortal:   Q3K8F9
- SMR:   Q3K8F9
- STRING:   Q3K8F9
- GeneID:   3717628
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_4208
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- ProtClustDB:   PRK00094
- BioCyc:   PFLU205922:PFL_4208-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 37807; Mature: 37676

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 204-204 BINDING 121-121 BINDING 121-121 BINDING 153-153 BINDING 268-268 BINDING 294-294

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASPLVWINGLHMTEQRPIAVLGGGSFGTAVANLLAENGHQVRQWMRDPEQAEAIRVNR
CCCCCEEEEECEEECCCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHCCCCHHHHEEECC
ENPRYLKGIKILPGVTAVTDLQETLDACELCFVALPSSALRTVLAAHAERLSGKMLVSLT
CCCHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHEEHHH
KGIEAQTFKLMSQILEEIAPQARIGVLSGPNLAREIAEHALTATVVASEDEELCKAVQAA
CCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHEEEECCHHHHHHHHHHH
LHGRTFRVYASADRFGVELGGALKNVYAIIAGMAVALEMGENTKSMLITRALAEMTRFAV
HCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NQGANPMTFLGLAGVGDLIVTCSSPKSRNYQVGFALGQGLSLDEAVSRLGEVAEGVNTLK
HCCCCCEEEEECCCCCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
VLKAKAQEVGVYMPLVAGLHAILFEGRTLEQVIGLLMRAEPKTDVDFISTSGFN
HHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEECCCCCC
>Mature Secondary Structure 
PASPLVWINGLHMTEQRPIAVLGGGSFGTAVANLLAENGHQVRQWMRDPEQAEAIRVNR
CCCCEEEEECEEECCCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHCCCCHHHHEEECC
ENPRYLKGIKILPGVTAVTDLQETLDACELCFVALPSSALRTVLAAHAERLSGKMLVSLT
CCCHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHEEHHH
KGIEAQTFKLMSQILEEIAPQARIGVLSGPNLAREIAEHALTATVVASEDEELCKAVQAA
CCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHEEEECCHHHHHHHHHHH
LHGRTFRVYASADRFGVELGGALKNVYAIIAGMAVALEMGENTKSMLITRALAEMTRFAV
HCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NQGANPMTFLGLAGVGDLIVTCSSPKSRNYQVGFALGQGLSLDEAVSRLGEVAEGVNTLK
HCCCCCEEEEECCCCCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
VLKAKAQEVGVYMPLVAGLHAILFEGRTLEQVIGLLMRAEPKTDVDFISTSGFN
HHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA