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The map label for this gene is envZ [H]

Identifier: 77460419

GI number: 77460419

Start: 4738763

End: 4739812

Strand: Direct

Name: envZ [H]

Synonym: Pfl01_4198

Alternate gene names: 77460419

Gene position: 4738763-4739812 (Clockwise)

Preceding gene: 77460418

Following gene: 77460420

Centisome position: 73.6

GC content: 66.86

Gene sequence:

>1050_bases
ATGCGAGCGCGCTTCGACACGCTGTTCGGCCGCCTGTTTGGCATGCTGTTGGTGGCGATCGTCCTGGCGCACTTGCTGGC
CTTCGCCTGGTTCCGCCTCTACGGCCCGCCCCCCCCGCCCCCCCCGCCGGAGTTCTCGCAAAACCTCGACGGTCAACAGC
CGGCTCAGGATCCACGCTACCCGCCCCGTCCACCGCGCCCCTGGTTCGGCGGGCCGATCGTGCCGCTGACCTTCCAGTTC
ATTTCGCTGATCATCGCCGCCTGGTACGGCGCCAAGCTGCTGACCCGGCCGATCCAGCGCCTGAGCGATGCCGCCGAGCG
CCTGAGCGAAGACCTCGACAGCCCGCCGCTGGACGAAACCGGCCCCCGGGAAGCCCGGCAGGCCGCACACACGTTCAACC
TGATGCAACACCGCATCCGCGAACAGGTGCAGCAACGGGCACGCATGCTCGGCGCCGTCTCCCACGACCTGCGCACCCCG
CTGTCGCGGCTGAAACTGCGCCTGGAAAACATCAACGACGACAAGCTGCAGGGCCAGATGCGCCAGGATCTGGACGACAT
GATCGGCATGCTCGACGCCACCCTCACCTACCTGCACGAACAACGCACCAGCGAAGCGTTGCAGTTGATGGACGTGCAGG
CGCTGGTCGAATCACTGTGCGAAAACGCCCAGGATCAAGGCGCCGACGTGCAGGTCAGCGGCCACTGCGCCCCGTTGCAG
GTACAGCCGATGGCCCTGCGCTCGTGCATCAACAACCTGATGGACAACGCCCTGCGCTACGCCGGCCAAGCGCACATCGA
ACTGCAAGACCAACGCGAACAACTGCTGATCCGCGTCATCGACCACGGCCCGGGCATCGCGGCGGACAAGCGTGAAGCCG
TGTTCGAACCGTTCTTCCGCCTCGAAGGCTCACGCAATCGCAACTCCGGCGGCGTCGGCCTGGGCATGACCATCGCCCGG
GAAGCCGCACAGCGCCAAAGTGGCCAACTGACCCTGGCAGAAACGCCCGGCGGCGGCCTGACCGCCGTGATCCAACTGCC
TCGCCGCTGA

Upstream 100 bases:

>100_bases
CGCGTCTGCGGCAAAAACTCGGCGACGACCCGAAAGCCCCGCAACTGATCAAGACCGTACGTGGTGAAGGCTACCTGTTC
GACGCCCGGGACATTGGCTG

Downstream 100 bases:

>100_bases
GCCCGACTGTGTACCGGCCGGTACAAACCTCACATACCCACGACACCTTGCACCTTGAGGCTGCATAAGCCGGTACACCC
ACCGGTTTTCCAGTCCAAGG

Product: periplasmic sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MRARFDTLFGRLFGMLLVAIVLAHLLAFAWFRLYGPPPPPPPPEFSQNLDGQQPAQDPRYPPRPPRPWFGGPIVPLTFQF
ISLIIAAWYGAKLLTRPIQRLSDAAERLSEDLDSPPLDETGPREARQAAHTFNLMQHRIREQVQQRARMLGAVSHDLRTP
LSRLKLRLENINDDKLQGQMRQDLDDMIGMLDATLTYLHEQRTSEALQLMDVQALVESLCENAQDQGADVQVSGHCAPLQ
VQPMALRSCINNLMDNALRYAGQAHIELQDQREQLLIRVIDHGPGIAADKREAVFEPFFRLEGSRNRNSGGVGLGMTIAR
EAAQRQSGQLTLAETPGGGLTAVIQLPRR

Sequences:

>Translated_349_residues
MRARFDTLFGRLFGMLLVAIVLAHLLAFAWFRLYGPPPPPPPPEFSQNLDGQQPAQDPRYPPRPPRPWFGGPIVPLTFQF
ISLIIAAWYGAKLLTRPIQRLSDAAERLSEDLDSPPLDETGPREARQAAHTFNLMQHRIREQVQQRARMLGAVSHDLRTP
LSRLKLRLENINDDKLQGQMRQDLDDMIGMLDATLTYLHEQRTSEALQLMDVQALVESLCENAQDQGADVQVSGHCAPLQ
VQPMALRSCINNLMDNALRYAGQAHIELQDQREQLLIRVIDHGPGIAADKREAVFEPFFRLEGSRNRNSGGVGLGMTIAR
EAAQRQSGQLTLAETPGGGLTAVIQLPRR
>Mature_349_residues
MRARFDTLFGRLFGMLLVAIVLAHLLAFAWFRLYGPPPPPPPPEFSQNLDGQQPAQDPRYPPRPPRPWFGGPIVPLTFQF
ISLIIAAWYGAKLLTRPIQRLSDAAERLSEDLDSPPLDETGPREARQAAHTFNLMQHRIREQVQQRARMLGAVSHDLRTP
LSRLKLRLENINDDKLQGQMRQDLDDMIGMLDATLTYLHEQRTSEALQLMDVQALVESLCENAQDQGADVQVSGHCAPLQ
VQPMALRSCINNLMDNALRYAGQAHIELQDQREQLLIRVIDHGPGIAADKREAVFEPFFRLEGSRNRNSGGVGLGMTIAR
EAAQRQSGQLTLAETPGGGLTAVIQLPRR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=287, Percent_Identity=28.5714285714286, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1790346, Length=273, Percent_Identity=31.1355311355311, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=28.9377289377289, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=31.5315315315315, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082128, Length=301, Percent_Identity=25.9136212624585, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87081816, Length=327, Percent_Identity=26.2996941896024, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=28.9473684210526, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786783, Length=271, Percent_Identity=27.3062730627306, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=288, Percent_Identity=24.6527777777778, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788713, Length=248, Percent_Identity=20.9677419354839, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787374, Length=284, Percent_Identity=25.7042253521127, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI145693157, Length=224, Percent_Identity=25.4464285714286, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=26.1061946902655, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=306, Percent_Identity=24.5098039215686, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789403, Length=269, Percent_Identity=26.0223048327138, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789149, Length=234, Percent_Identity=22.2222222222222, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=26.457399103139, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39048; Mature: 39048

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARFDTLFGRLFGMLLVAIVLAHLLAFAWFRLYGPPPPPPPPEFSQNLDGQQPAQDPRY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCC
PPRPPRPWFGGPIVPLTFQFISLIIAAWYGAKLLTRPIQRLSDAAERLSEDLDSPPLDET
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GPREARQAAHTFNLMQHRIREQVQQRARMLGAVSHDLRTPLSRLKLRLENINDDKLQGQM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RQDLDDMIGMLDATLTYLHEQRTSEALQLMDVQALVESLCENAQDQGADVQVSGHCAPLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCEEECCCCCCCE
VQPMALRSCINNLMDNALRYAGQAHIELQDQREQLLIRVIDHGPGIAADKREAVFEPFFR
ECHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LEGSRNRNSGGVGLGMTIAREAAQRQSGQLTLAETPGGGLTAVIQLPRR
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCC
>Mature Secondary Structure
MRARFDTLFGRLFGMLLVAIVLAHLLAFAWFRLYGPPPPPPPPEFSQNLDGQQPAQDPRY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCC
PPRPPRPWFGGPIVPLTFQFISLIIAAWYGAKLLTRPIQRLSDAAERLSEDLDSPPLDET
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GPREARQAAHTFNLMQHRIREQVQQRARMLGAVSHDLRTPLSRLKLRLENINDDKLQGQM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RQDLDDMIGMLDATLTYLHEQRTSEALQLMDVQALVESLCENAQDQGADVQVSGHCAPLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCEEECCCCCCCE
VQPMALRSCINNLMDNALRYAGQAHIELQDQREQLLIRVIDHGPGIAADKREAVFEPFFR
ECHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LEGSRNRNSGGVGLGMTIAREAAQRQSGQLTLAETPGGGLTAVIQLPRR
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]