Click here to switch to the map view.

The map label for this gene is tlpA [H]

Identifier: 77460413

GI number: 77460413

Start: 4731305

End: 4733269

Strand: Reverse

Name: tlpA [H]

Synonym: Pfl01_4192

Alternate gene names: 77460413

Gene position: 4733269-4731305 (Counterclockwise)

Preceding gene: 77460414

Following gene: 77460407

Centisome position: 73.52

GC content: 60.97

Gene sequence:

>1965_bases
ATGATTTCGGCCGTGCAAGGACGTTTTGCCAACCTCGGTATGGCAAAAAAACTGGGTATCGGGTTTGTGTTGGTGTTGTT
GCTGACTGCACTGGTGGCGGCGATTGGCGTCTGGTCCCTGCAAACCATCAGTCAGCGCTTCGACGGCCTCAAGCAGATGT
CATCGCTCAACAGTGGCTTGCTCAAGGTGCGGCTGCTGGAGCAGGACTACGCCTTGCACGGCAACCCGAAAACCGTCGAT
GCCTTGCACGAAGGTGTGGACGGTCTGATTGCCATGGCCAATGGGCTCAAGGCGCAATCCTCGGCGAATGTGCCGGTGAT
GAGCGACGTAGAACAGTCGCTGGTTGCCTATCGCAAGGCGTTTGATGAATTCGTCTCGTTGTCCCAGGCCAAGGACCTGG
CGCTGGAAATGGCCAGTTGGTCGGTGTCCAGCGTCGCCAACAATCTCGATGTGCTGCAGGCCGGTCTTGCCGATGACGGC
GCGTACACCCTGAAAGACAGCGAAGGCAAGGACGGGGCGCAATTCATCGAGCAGGCTGGCCAGGTCAGCCAAGTCTCACG
CTTGATGTTGCAGGCAATGAACGAAGCACGGGTACGTCTGGATCAAAGCCGCAAGGGTGATGACAGTGCAGGTCAGGGCA
ATATCGAGCAGGCTGCCCAAGCTCAGGCCCAGGCCGAGCAGCTCAAATCCACGGTCAAGGACGAGGGTTACCTGACGGTG
CTCAATGAAGTGTCCGGGCACATTGCCGGTTTCAGCGACAAGCTTGCCGAGTACACCGGGTTGCTGGCTCAGGAAAAGAC
TGTCTATCAACAGTTGCACCAGCGGGCCGATGAAGTCGTGGCGCGGGTCGATCAGGCCTATGTCGCGCAAGACGGCGCGA
TGCAGGGCGAACTGAAAAAGAATTCGGTGCTGATCATTGGCTCGTCGGCGCTGGCGTTGCTGGTCGGGCTGATCGCGGCG
TGGGTGATCACCCGACTGATTGTGGCGCCGTTGCGCAGCGTGATTCATGTGGCGCAACAGATTGCGGCCGGTGATCTGAG
TGCAACGATCGAGGTCACCCGGCGGGACGAAATCGGTCAGTTGATGCTGGCCATGCAGCAGATGGGCGCGGGTTTGAGCA
CGATTGTCAGCGGGTTGCAGGCGGGGATCGAACAGTTGGCGAGTTCGGCGCAATCGCTGTCGGCGGTGACCGAACAGACC
AACCTTGAGGTCAGCAGCCAGAAAGAGGAAACCGAACAGGTCGCCACGGCCATGAACCAGATGACCGCCACCGTTCACGA
TGTGGCGCGCAATGCCGAAGAGGCGGCGCTCGCGGCGCAGACTGCCGATGGCAAGGTTGAAAGCGGTCAGCAGGTGGTGC
GTCAGAGCATGGCGCGGATCGAGCAACTGGCGGATTCGGCGACGTCGGCCAGTTCGAGCATCGAAAGCCTCAGTGCGGAA
ATCCAGAACATCGGCACGGTGCTGGGTGTGATCAAGAGTGTCGCCGAGCAGACCAACCTGCTGGCGCTCAACGCGGCGAT
CGAAGCGGCGCGGGCGGGCGAGCAGGGCAGGGGCTTTGCGGTGGTCGCCGATGAAGTGCGGGCGCTGGCCCGGCGCACGC
AGCAGTCGACCGAGGAGATCGAGCGGCTGGTCAGCGCCTTGCGCTCGGCGGCGCATTCGTCGGTGCAGCAGATTCAGAGC
AGTGGCGAACTGGTGAAGCTGGCGGTAAGTGATGCGTTGCAGACCGAGAGTGCGTTGGGGAGTATTGCGGCGGCGGTTTC
GTTGATTCAGCAGATGAACCAGCAGATTGCGGCGGCGGCCGAGGAGCAGAGTTCGGTGGCCGAGGAGATCAATCGCAGTG
TGACGAGTATTCGGGCGAGTGCGGATCAGTCTTCGATTGCCATGCGGGGGAATGCGGCTTCGAGTGTTGAGCTGGCGCAG
TTGGGGAGTGAGTTGCGGGGGATGGTGGGGCACTTTCGGCTTTGA

Upstream 100 bases:

>100_bases
CGTGCGTAGCTTTTTGCCATTATTCCGACGCCAGAGACTTGTGCTGGTTCAAGGCCGTTGCGAATCTTCGGCAACAGACT
ATGGCAGGGGGCTACGCGCA

Downstream 100 bases:

>100_bases
CCTTGGCGGCCTTTGGGCCGACCAGGTTGTTGGTTGTTTGGGGTGAATATCCGTTGCTTCGGGTGCTGCCGCTGGCGGTT
TCGCCCTTACGGCGAGTCCC

Product: chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 654; Mature: 654

Protein sequence:

>654_residues
MISAVQGRFANLGMAKKLGIGFVLVLLLTALVAAIGVWSLQTISQRFDGLKQMSSLNSGLLKVRLLEQDYALHGNPKTVD
ALHEGVDGLIAMANGLKAQSSANVPVMSDVEQSLVAYRKAFDEFVSLSQAKDLALEMASWSVSSVANNLDVLQAGLADDG
AYTLKDSEGKDGAQFIEQAGQVSQVSRLMLQAMNEARVRLDQSRKGDDSAGQGNIEQAAQAQAQAEQLKSTVKDEGYLTV
LNEVSGHIAGFSDKLAEYTGLLAQEKTVYQQLHQRADEVVARVDQAYVAQDGAMQGELKKNSVLIIGSSALALLVGLIAA
WVITRLIVAPLRSVIHVAQQIAAGDLSATIEVTRRDEIGQLMLAMQQMGAGLSTIVSGLQAGIEQLASSAQSLSAVTEQT
NLEVSSQKEETEQVATAMNQMTATVHDVARNAEEAALAAQTADGKVESGQQVVRQSMARIEQLADSATSASSSIESLSAE
IQNIGTVLGVIKSVAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALARRTQQSTEEIERLVSALRSAAHSSVQQIQS
SGELVKLAVSDALQTESALGSIAAAVSLIQQMNQQIAAAAEEQSSVAEEINRSVTSIRASADQSSIAMRGNAASSVELAQ
LGSELRGMVGHFRL

Sequences:

>Translated_654_residues
MISAVQGRFANLGMAKKLGIGFVLVLLLTALVAAIGVWSLQTISQRFDGLKQMSSLNSGLLKVRLLEQDYALHGNPKTVD
ALHEGVDGLIAMANGLKAQSSANVPVMSDVEQSLVAYRKAFDEFVSLSQAKDLALEMASWSVSSVANNLDVLQAGLADDG
AYTLKDSEGKDGAQFIEQAGQVSQVSRLMLQAMNEARVRLDQSRKGDDSAGQGNIEQAAQAQAQAEQLKSTVKDEGYLTV
LNEVSGHIAGFSDKLAEYTGLLAQEKTVYQQLHQRADEVVARVDQAYVAQDGAMQGELKKNSVLIIGSSALALLVGLIAA
WVITRLIVAPLRSVIHVAQQIAAGDLSATIEVTRRDEIGQLMLAMQQMGAGLSTIVSGLQAGIEQLASSAQSLSAVTEQT
NLEVSSQKEETEQVATAMNQMTATVHDVARNAEEAALAAQTADGKVESGQQVVRQSMARIEQLADSATSASSSIESLSAE
IQNIGTVLGVIKSVAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALARRTQQSTEEIERLVSALRSAAHSSVQQIQS
SGELVKLAVSDALQTESALGSIAAAVSLIQQMNQQIAAAAEEQSSVAEEINRSVTSIRASADQSSIAMRGNAASSVELAQ
LGSELRGMVGHFRL
>Mature_654_residues
MISAVQGRFANLGMAKKLGIGFVLVLLLTALVAAIGVWSLQTISQRFDGLKQMSSLNSGLLKVRLLEQDYALHGNPKTVD
ALHEGVDGLIAMANGLKAQSSANVPVMSDVEQSLVAYRKAFDEFVSLSQAKDLALEMASWSVSSVANNLDVLQAGLADDG
AYTLKDSEGKDGAQFIEQAGQVSQVSRLMLQAMNEARVRLDQSRKGDDSAGQGNIEQAAQAQAQAEQLKSTVKDEGYLTV
LNEVSGHIAGFSDKLAEYTGLLAQEKTVYQQLHQRADEVVARVDQAYVAQDGAMQGELKKNSVLIIGSSALALLVGLIAA
WVITRLIVAPLRSVIHVAQQIAAGDLSATIEVTRRDEIGQLMLAMQQMGAGLSTIVSGLQAGIEQLASSAQSLSAVTEQT
NLEVSSQKEETEQVATAMNQMTATVHDVARNAEEAALAAQTADGKVESGQQVVRQSMARIEQLADSATSASSSIESLSAE
IQNIGTVLGVIKSVAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALARRTQQSTEEIERLVSALRSAAHSSVQQIQS
SGELVKLAVSDALQTESALGSIAAAVSLIQQMNQQIAAAAEEQSSVAEEINRSVTSIRASADQSSIAMRGNAASSVELAQ
LGSELRGMVGHFRL

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=356, Percent_Identity=34.2696629213483, Blast_Score=161, Evalue=2e-40,
Organism=Escherichia coli, GI1788195, Length=292, Percent_Identity=34.2465753424658, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI2367378, Length=313, Percent_Identity=34.8242811501597, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788194, Length=343, Percent_Identity=32.3615160349854, Blast_Score=126, Evalue=5e-30,
Organism=Escherichia coli, GI1789453, Length=341, Percent_Identity=29.0322580645161, Blast_Score=125, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 68947; Mature: 68947

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISAVQGRFANLGMAKKLGIGFVLVLLLTALVAAIGVWSLQTISQRFDGLKQMSSLNSGL
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LKVRLLEQDYALHGNPKTVDALHEGVDGLIAMANGLKAQSSANVPVMSDVEQSLVAYRKA
EEEEEEHHCCCCCCCCCHHHHHHHCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
FDEFVSLSQAKDLALEMASWSVSSVANNLDVLQAGLADDGAYTLKDSEGKDGAQFIEQAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHCC
QVSQVSRLMLQAMNEARVRLDQSRKGDDSAGQGNIEQAAQAQAQAEQLKSTVKDEGYLTV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEH
LNEVSGHIAGFSDKLAEYTGLLAQEKTVYQQLHQRADEVVARVDQAYVAQDGAMQGELKK
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NSVLIIGSSALALLVGLIAAWVITRLIVAPLRSVIHVAQQIAAGDLSATIEVTRRDEIGQ
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEHHHHHHHH
LMLAMQQMGAGLSTIVSGLQAGIEQLASSAQSLSAVTEQTNLEVSSQKEETEQVATAMNQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MTATVHDVARNAEEAALAAQTADGKVESGQQVVRQSMARIEQLADSATSASSSIESLSAE
HHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQNIGTVLGVIKSVAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALARRTQQSTEEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
ERLVSALRSAAHSSVQQIQSSGELVKLAVSDALQTESALGSIAAAVSLIQQMNQQIAAAA
HHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEQSSVAEEINRSVTSIRASADQSSIAMRGNAASSVELAQLGSELRGMVGHFRL
HHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MISAVQGRFANLGMAKKLGIGFVLVLLLTALVAAIGVWSLQTISQRFDGLKQMSSLNSGL
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LKVRLLEQDYALHGNPKTVDALHEGVDGLIAMANGLKAQSSANVPVMSDVEQSLVAYRKA
EEEEEEHHCCCCCCCCCHHHHHHHCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
FDEFVSLSQAKDLALEMASWSVSSVANNLDVLQAGLADDGAYTLKDSEGKDGAQFIEQAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHCC
QVSQVSRLMLQAMNEARVRLDQSRKGDDSAGQGNIEQAAQAQAQAEQLKSTVKDEGYLTV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEH
LNEVSGHIAGFSDKLAEYTGLLAQEKTVYQQLHQRADEVVARVDQAYVAQDGAMQGELKK
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NSVLIIGSSALALLVGLIAAWVITRLIVAPLRSVIHVAQQIAAGDLSATIEVTRRDEIGQ
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEHHHHHHHH
LMLAMQQMGAGLSTIVSGLQAGIEQLASSAQSLSAVTEQTNLEVSSQKEETEQVATAMNQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
MTATVHDVARNAEEAALAAQTADGKVESGQQVVRQSMARIEQLADSATSASSSIESLSAE
HHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQNIGTVLGVIKSVAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALARRTQQSTEEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
ERLVSALRSAAHSSVQQIQSSGELVKLAVSDALQTESALGSIAAAVSLIQQMNQQIAAAA
HHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEQSSVAEEINRSVTSIRASADQSSIAMRGNAASSVELAQLGSELRGMVGHFRL
HHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]