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The map label for this gene is mtnA

Identifier: 77460300

GI number: 77460300

Start: 4610773

End: 4611849

Strand: Reverse

Name: mtnA

Synonym: Pfl01_4079

Alternate gene names: 77460300

Gene position: 4611849-4610773 (Counterclockwise)

Preceding gene: 77460306

Following gene: 77460299

Centisome position: 71.63

GC content: 63.23

Gene sequence:

>1077_bases
ATGCGCGATCGACTGTTGGCTGCGGAGAAAGTAAAGGCCATCGATTGGCGTGATGGCGCGCTCCACCTGCTGGATCAGCG
CGTTTTGCCGTTCGAGGAAAACTGGATCGCCTACACCAGCGCCGCCGGCGTGGCCGAAGCGATTCGTTCGATGGTGGTGC
GCGGTGCGCCGGCCATCGGCATCAGTGCCGCCTACGGCATCGTACTGGCGGCCCGTGCCCGGATTGCCGAGGGGGGCGAC
TGGTATGCGGCGCTGGAAGAGGATTTCATGCTGCTGGCCGATTCCCGGCCGACAGCGGTCAACCTGTTCTGGGCGTTGAA
TCGCATGCATGACCGGCTGGACCGCTTGAAGGAAAACGCCGATCCGCTGGCGGCGCTGGAAGCCGAAGCCATCGCTATCC
ATGAAAGCGATCGTGAAGCCAACCTGACCATGGCCCAGCTCGGCGTCGACCTGATCCGCAAGCATCAGGGCAATGCCCAG
GCGATTCTGACTCACTGCAACACCGGCGCCCTGGCCACTGGCGGTTTCGGCACGGCACTCGGGGTGATTCGCGCAGCGTT
CATCGAGGGCATGGTCGAGCGTGTCTACGCCGACGAAACCCGGCCGTGGCTGCAAGGCTCGCGGCTGACCGCGTGGGAGC
TGGCCAACGAAGGCATTCCGGTGACCCTGAACGCTGACTCCGCCGCTGCGCACATCATGAAAACCAAAGGGGTGACCTGG
GTGATCGTCGGCGCCGACCGGATTACCGCCAACGGTGACGTGGCGAACAAGATCGGCACCTATCAACTGGCGGTCAACGC
CATGCACCACGGCGTGCGTTTCATGGTGGTAGCACCGAGTTCGACCATCGACATGAATCTGGCCAGCGGTGATGACATCC
CGATCGAAGAGCGCGACGGCGCCGAGTTGCTGGAGGTTGGCGGCAAGCGTGTCGGGGCTGACGTTGAGGCGTTCAACCCG
GTGTTTGACGTGACCCCGGCGGATCTGATCGATGCGATCGTCACCGAAAAAGGCATCGTCGAGCGCCCGGACACCGCGAA
AATGGCGCAGTTGATGTGCCGCAAGCGCTTGCATTGA

Upstream 100 bases:

>100_bases
GGTTCCAGTGCTTTTGTGAAGGATGGCGAAGTATACCCGAGCGTCTTCGCGGGGGGATCGCTATAATCGGCGGCTTTTGT
TCATGAGTGCGGGGTGAGGG

Downstream 100 bases:

>100_bases
TTGGTTTGATGTCTACGTTGTCTTCTTCGCGAGCAGGCTCGCTCCCACAGGTTTTGTGATCGTTACAGAACCTTGTGAGA
GTAAGCCTGCTCGCGAAGAG

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MRDRLLAAEKVKAIDWRDGALHLLDQRVLPFEENWIAYTSAAGVAEAIRSMVVRGAPAIGISAAYGIVLAARARIAEGGD
WYAALEEDFMLLADSRPTAVNLFWALNRMHDRLDRLKENADPLAALEAEAIAIHESDREANLTMAQLGVDLIRKHQGNAQ
AILTHCNTGALATGGFGTALGVIRAAFIEGMVERVYADETRPWLQGSRLTAWELANEGIPVTLNADSAAAHIMKTKGVTW
VIVGADRITANGDVANKIGTYQLAVNAMHHGVRFMVVAPSSTIDMNLASGDDIPIEERDGAELLEVGGKRVGADVEAFNP
VFDVTPADLIDAIVTEKGIVERPDTAKMAQLMCRKRLH

Sequences:

>Translated_358_residues
MRDRLLAAEKVKAIDWRDGALHLLDQRVLPFEENWIAYTSAAGVAEAIRSMVVRGAPAIGISAAYGIVLAARARIAEGGD
WYAALEEDFMLLADSRPTAVNLFWALNRMHDRLDRLKENADPLAALEAEAIAIHESDREANLTMAQLGVDLIRKHQGNAQ
AILTHCNTGALATGGFGTALGVIRAAFIEGMVERVYADETRPWLQGSRLTAWELANEGIPVTLNADSAAAHIMKTKGVTW
VIVGADRITANGDVANKIGTYQLAVNAMHHGVRFMVVAPSSTIDMNLASGDDIPIEERDGAELLEVGGKRVGADVEAFNP
VFDVTPADLIDAIVTEKGIVERPDTAKMAQLMCRKRLH
>Mature_358_residues
MRDRLLAAEKVKAIDWRDGALHLLDQRVLPFEENWIAYTSAAGVAEAIRSMVVRGAPAIGISAAYGIVLAARARIAEGGD
WYAALEEDFMLLADSRPTAVNLFWALNRMHDRLDRLKENADPLAALEAEAIAIHESDREANLTMAQLGVDLIRKHQGNAQ
AILTHCNTGALATGGFGTALGVIRAAFIEGMVERVYADETRPWLQGSRLTAWELANEGIPVTLNADSAAAHIMKTKGVTW
VIVGADRITANGDVANKIGTYQLAVNAMHHGVRFMVVAPSSTIDMNLASGDDIPIEERDGAELLEVGGKRVGADVEAFNP
VFDVTPADLIDAIVTEKGIVERPDTAKMAQLMCRKRLH

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=341, Percent_Identity=43.9882697947214, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI23943880, Length=336, Percent_Identity=39.5833333333333, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI187607323, Length=166, Percent_Identity=30.7228915662651, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI78000158, Length=166, Percent_Identity=30.7228915662651, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI78000156, Length=166, Percent_Identity=30.7228915662651, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4503503, Length=192, Percent_Identity=31.25, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17557462, Length=336, Percent_Identity=37.797619047619, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6325375, Length=386, Percent_Identity=34.7150259067358, Blast_Score=193, Evalue=3e-50,
Organism=Drosophila melanogaster, GI21357667, Length=350, Percent_Identity=39.4285714285714, Blast_Score=224, Evalue=5e-59,
Organism=Drosophila melanogaster, GI24651647, Length=350, Percent_Identity=39.4285714285714, Blast_Score=224, Evalue=5e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_PSEPF (Q3K8T8)

Other databases:

- EMBL:   CP000094
- RefSeq:   YP_349807.1
- ProteinModelPortal:   Q3K8T8
- SMR:   Q3K8T8
- STRING:   Q3K8T8
- GeneID:   3712324
- GenomeReviews:   CP000094_GR
- KEGG:   pfo:Pfl01_4079
- eggNOG:   COG0182
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- ProtClustDB:   PRK05720
- BioCyc:   PFLU205922:PFL_4079-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 38721; Mature: 38721

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: ACT_SITE 246-246 BINDING 96-96 BINDING 205-205

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDRLLAAEKVKAIDWRDGALHLLDQRVLPFEENWIAYTSAAGVAEAIRSMVVRGAPAIG
CCCCHHHHHHHHEECCCCCHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCC
ISAAYGIVLAARARIAEGGDWYAALEEDFMLLADSRPTAVNLFWALNRMHDRLDRLKENA
HHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCC
DPLAALEAEAIAIHESDREANLTMAQLGVDLIRKHQGNAQAILTHCNTGALATGGFGTAL
CCHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEECCCHHHHH
GVIRAAFIEGMVERVYADETRPWLQGSRLTAWELANEGIPVTLNADSAAAHIMKTKGVTW
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEECCCHHHHHHHCCCCCEE
VIVGADRITANGDVANKIGTYQLAVNAMHHGVRFMVVAPSSTIDMNLASGDDIPIEERDG
EEEECCEEECCCCCHHHCCHHHEEHHHHHCCEEEEEECCCCCEEEEECCCCCCCCCCCCC
AELLEVGGKRVGADVEAFNPVFDVTPADLIDAIVTEKGIVERPDTAKMAQLMCRKRLH
HHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRDRLLAAEKVKAIDWRDGALHLLDQRVLPFEENWIAYTSAAGVAEAIRSMVVRGAPAIG
CCCCHHHHHHHHEECCCCCHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCC
ISAAYGIVLAARARIAEGGDWYAALEEDFMLLADSRPTAVNLFWALNRMHDRLDRLKENA
HHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHCCC
DPLAALEAEAIAIHESDREANLTMAQLGVDLIRKHQGNAQAILTHCNTGALATGGFGTAL
CCHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEECCCHHHHH
GVIRAAFIEGMVERVYADETRPWLQGSRLTAWELANEGIPVTLNADSAAAHIMKTKGVTW
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEECCCHHHHHHHCCCCCEE
VIVGADRITANGDVANKIGTYQLAVNAMHHGVRFMVVAPSSTIDMNLASGDDIPIEERDG
EEEECCEEECCCCCHHHCCHHHEEHHHHHCCEEEEEECCCCCEEEEECCCCCCCCCCCCC
AELLEVGGKRVGADVEAFNPVFDVTPADLIDAIVTEKGIVERPDTAKMAQLMCRKRLH
HHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA