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The map label for this gene is rmlA [H]

Identifier: 77460277

GI number: 77460277

Start: 4581369

End: 4582259

Strand: Reverse

Name: rmlA [H]

Synonym: Pfl01_4056

Alternate gene names: 77460277

Gene position: 4582259-4581369 (Counterclockwise)

Preceding gene: 77460278

Following gene: 77460276

Centisome position: 71.17

GC content: 55.33

Gene sequence:

>891_bases
ATGACCACGACAAATCGTAAAGGCATCATCCTCGCTGGCGGCTCGGGCACTCGTCTGCATCCGTTGACCCTTGGTGTTTC
CAAGCAGATGTTGCCGATTTACGACAAGCCGATGATCTTCTATCCGTTGTCGGTACTGATGCTGGCCGGCATGCGTGAAA
TCCTGATTATCTCCACGCCGGAAGATTTGCCCTGTTTCAAGAAGCTGCTGGGTGACGGCAGCCTGTACGGTATCAAGTTG
AGCTATGCCGAACAGCCATCTCCGGATGGTCTGGCGCAGGCGTTCATCATCGGCGAAGAGTTCATCGGCAAGGATCCTTG
CTGCCTGATTCTGGGCGACAACATCTTTTACGGTCAGCACTTCTCGGACAATCTGCGTTCTGCCAGTGCCCAGGCGTCCG
GTGCTACCGTGTTTGGCTACCACGTTTCCGATCCGGAGCGTTTCGGTGTCGTCGAGTTCGACAAGACGGGCCAGGCACTG
AGTATTGAAGAGAAGCCACTGAAGCCGAAGTCCAACTACGCTGTTACCGGCTTGTACTTCTACGACAACGATGTGGTCAA
GATCGCCAAAGGCATCAAGCCATCGGAGCGCGGAGAGCTGGAAATCACCGACGTCAACCGTGCCTATCTCGAGCAGAAGT
CGCTCAAGGTGGAGATGTTGGGTCGTGGTTTTGCGTGGCTCGACACCGGTACGCATGACTCGCTGCTTGAGGCCAGTCAC
TTCGTTCATACGATCGAGCAGCGTCAGGGCTTGAAAGTGGCATGTCTCGAAGAGATCGCCTATCACAATGGCTGGATCAC
TGCCGAGCAGCTGTCCGCTCAGGCCGACGCGTTGAAGAAAACCGGATACGGGCAATACCTGCAGAAACTGCTGGATTCAC
CTGCTCACTGA

Upstream 100 bases:

>100_bases
ATTCGCGATTGAATACCCGGAAGCTGCGTGACAATTTTTCTCTACACTTGCCGGATTGGCAAAGTGGTGTAACCCGAATG
CTTATGGAAGTTCTGAATAA

Downstream 100 bases:

>100_bases
TTGGAAATTCGTTTTCCTTTCAATGCTGCGTTCAACCGGTAAGCAGGATAGGCATGCCAGTAAACCCTCCTAAAGTTGCC
GTGTTGCTGGCGGCCTACAA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTTTNRKGIILAGGSGTRLHPLTLGVSKQMLPIYDKPMIFYPLSVLMLAGMREILIISTPEDLPCFKKLLGDGSLYGIKL
SYAEQPSPDGLAQAFIIGEEFIGKDPCCLILGDNIFYGQHFSDNLRSASAQASGATVFGYHVSDPERFGVVEFDKTGQAL
SIEEKPLKPKSNYAVTGLYFYDNDVVKIAKGIKPSERGELEITDVNRAYLEQKSLKVEMLGRGFAWLDTGTHDSLLEASH
FVHTIEQRQGLKVACLEEIAYHNGWITAEQLSAQADALKKTGYGQYLQKLLDSPAH

Sequences:

>Translated_296_residues
MTTTNRKGIILAGGSGTRLHPLTLGVSKQMLPIYDKPMIFYPLSVLMLAGMREILIISTPEDLPCFKKLLGDGSLYGIKL
SYAEQPSPDGLAQAFIIGEEFIGKDPCCLILGDNIFYGQHFSDNLRSASAQASGATVFGYHVSDPERFGVVEFDKTGQAL
SIEEKPLKPKSNYAVTGLYFYDNDVVKIAKGIKPSERGELEITDVNRAYLEQKSLKVEMLGRGFAWLDTGTHDSLLEASH
FVHTIEQRQGLKVACLEEIAYHNGWITAEQLSAQADALKKTGYGQYLQKLLDSPAH
>Mature_295_residues
TTTNRKGIILAGGSGTRLHPLTLGVSKQMLPIYDKPMIFYPLSVLMLAGMREILIISTPEDLPCFKKLLGDGSLYGIKLS
YAEQPSPDGLAQAFIIGEEFIGKDPCCLILGDNIFYGQHFSDNLRSASAQASGATVFGYHVSDPERFGVVEFDKTGQALS
IEEKPLKPKSNYAVTGLYFYDNDVVKIAKGIKPSERGELEITDVNRAYLEQKSLKVEMLGRGFAWLDTGTHDSLLEASHF
VHTIEQRQGLKVACLEEIAYHNGWITAEQLSAQADALKKTGYGQYLQKLLDSPAH

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=250, Percent_Identity=23.6, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI11761619, Length=250, Percent_Identity=23.6, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790224, Length=287, Percent_Identity=71.4285714285714, Blast_Score=432, Evalue=1e-123,
Organism=Escherichia coli, GI1788351, Length=285, Percent_Identity=70.5263157894737, Blast_Score=427, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI133931050, Length=235, Percent_Identity=22.5531914893617, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320148, Length=255, Percent_Identity=26.6666666666667, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355443, Length=253, Percent_Identity=23.7154150197628, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24644084, Length=253, Percent_Identity=23.7154150197628, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32595; Mature: 32464

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTNRKGIILAGGSGTRLHPLTLGVSKQMLPIYDKPMIFYPLSVLMLAGMREILIISTP
CCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECC
EDLPCFKKLLGDGSLYGIKLSYAEQPSPDGLAQAFIIGEEFIGKDPCCLILGDNIFYGQH
CCCHHHHHHHCCCCEEEEEEECCCCCCCCCHHEEEEECHHHCCCCCEEEEECCCEEECCC
FSDNLRSASAQASGATVFGYHVSDPERFGVVEFDKTGQALSIEEKPLKPKSNYAVTGLYF
CCHHHHHCCCCCCCCEEEEEECCCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEE
YDNDVVKIAKGIKPSERGELEITDVNRAYLEQKSLKVEMLGRGFAWLDTGTHDSLLEASH
ECCCHHHHHHCCCCCCCCCEEEEECHHHHHHHHCCEEEEECCCEEEEECCCCHHHHHHHH
FVHTIEQRQGLKVACLEEIAYHNGWITAEQLSAQADALKKTGYGQYLQKLLDSPAH
HHHHHHHHCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
TTTNRKGIILAGGSGTRLHPLTLGVSKQMLPIYDKPMIFYPLSVLMLAGMREILIISTP
CCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECC
EDLPCFKKLLGDGSLYGIKLSYAEQPSPDGLAQAFIIGEEFIGKDPCCLILGDNIFYGQH
CCCHHHHHHHCCCCEEEEEEECCCCCCCCCHHEEEEECHHHCCCCCEEEEECCCEEECCC
FSDNLRSASAQASGATVFGYHVSDPERFGVVEFDKTGQALSIEEKPLKPKSNYAVTGLYF
CCHHHHHCCCCCCCCEEEEEECCCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEE
YDNDVVKIAKGIKPSERGELEITDVNRAYLEQKSLKVEMLGRGFAWLDTGTHDSLLEASH
ECCCHHHHHHCCCCCCCCCEEEEECHHHHHHHHCCEEEEECCCEEEEECCCCHHHHHHHH
FVHTIEQRQGLKVACLEEIAYHNGWITAEQLSAQADALKKTGYGQYLQKLLDSPAH
HHHHHHHHCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7692217 [H]