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The map label for this gene is gpo [H]

Identifier: 77460202

GI number: 77460202

Start: 4510522

End: 4511007

Strand: Reverse

Name: gpo [H]

Synonym: Pfl01_3981

Alternate gene names: 77460202

Gene position: 4511007-4510522 (Counterclockwise)

Preceding gene: 77460203

Following gene: 77460201

Centisome position: 70.06

GC content: 59.26

Gene sequence:

>486_bases
ATGAGCGATAACCTGCTGAATATTCCGTGCACCACCATCAAGGGCGAGCAGAAGACCCTCGCCGATTTCGCCGGCAAGGC
GGTGCTGGTGGTTAATACCGCCAGCAAATGCGGTTTCACTCCGCAGTACAAAGGCCTTGAGGAACTGTGGCAGACCTACA
AGGATCAGGGCCTGGTGGTGCTGGGTTTTCCGTGCAATCAGTTCGGCAAGCAGGAGCCGGGCAACGAAGGCGCCATCAGC
GAGTTCTGCGAGCTGAACTACGGTGTCAGCTTCCCGCTGTTCAAGAAGATCGAAGTCAACGGTACCGGCGCGCACCCGCT
GTTCGTGCAGTTGAAGAAGCGCGCGCCGGGCGTGCTGGGCTCCCAGGGCATCAAGTGGAACTTCACCAAATTCCTGATCG
GCAAGGACGGCCAGTTGGTCAAGCGCTTCGCCCCGGCCACCAAGCCGCAGGATCTGAGCCGTGAGATCGAAGCCCTGCTC
AAATGA

Upstream 100 bases:

>100_bases
GATACGGGCGATCCACGGGTCGCCTTTCGAATAATTAAATTGCACGCAATTCAATTGCTCGCTATTTTTGCCGTCTATCC
ATTTTTCAAGAGTGCGCACC

Downstream 100 bases:

>100_bases
ACAACCTGTCCGCCGATTCGCTGAAACTCGACAGTCAGCTGTGCTTCAAGTTGTACGCCGCATCGCGGGCGGTGATCCGT
GCCTACAAACCGATGCTCGA

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 161; Mature: 160

Protein sequence:

>161_residues
MSDNLLNIPCTTIKGEQKTLADFAGKAVLVVNTASKCGFTPQYKGLEELWQTYKDQGLVVLGFPCNQFGKQEPGNEGAIS
EFCELNYGVSFPLFKKIEVNGTGAHPLFVQLKKRAPGVLGSQGIKWNFTKFLIGKDGQLVKRFAPATKPQDLSREIEALL
K

Sequences:

>Translated_161_residues
MSDNLLNIPCTTIKGEQKTLADFAGKAVLVVNTASKCGFTPQYKGLEELWQTYKDQGLVVLGFPCNQFGKQEPGNEGAIS
EFCELNYGVSFPLFKKIEVNGTGAHPLFVQLKKRAPGVLGSQGIKWNFTKFLIGKDGQLVKRFAPATKPQDLSREIEALL
K
>Mature_160_residues
SDNLLNIPCTTIKGEQKTLADFAGKAVLVVNTASKCGFTPQYKGLEELWQTYKDQGLVVLGFPCNQFGKQEPGNEGAISE
FCELNYGVSFPLFKKIEVNGTGAHPLFVQLKKRAPGVLGSQGIKWNFTKFLIGKDGQLVKRFAPATKPQDLSREIEALLK

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=159, Percent_Identity=38.3647798742138, Blast_Score=120, Evalue=5e-28,
Organism=Homo sapiens, GI75709200, Length=147, Percent_Identity=44.2176870748299, Blast_Score=116, Evalue=7e-27,
Organism=Homo sapiens, GI90903240, Length=147, Percent_Identity=44.2176870748299, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI192455698, Length=152, Percent_Identity=38.1578947368421, Blast_Score=103, Evalue=6e-23,
Organism=Homo sapiens, GI4557629, Length=167, Percent_Identity=38.9221556886228, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI41406084, Length=171, Percent_Identity=37.4269005847953, Blast_Score=97, Evalue=5e-21,
Organism=Homo sapiens, GI90903238, Length=122, Percent_Identity=45.9016393442623, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI6006001, Length=181, Percent_Identity=34.8066298342541, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI33186887, Length=172, Percent_Identity=37.7906976744186, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI32967607, Length=185, Percent_Identity=32.4324324324324, Blast_Score=87, Evalue=9e-18,
Organism=Escherichia coli, GI1788003, Length=170, Percent_Identity=44.1176470588235, Blast_Score=159, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17535473, Length=155, Percent_Identity=45.8064516129032, Blast_Score=141, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17506887, Length=147, Percent_Identity=46.2585034013605, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71993584, Length=150, Percent_Identity=42.6666666666667, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI193210707, Length=151, Percent_Identity=42.3841059602649, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17550320, Length=172, Percent_Identity=31.9767441860465, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193209493, Length=172, Percent_Identity=29.6511627906977, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71993573, Length=86, Percent_Identity=38.3720930232558, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507603, Length=108, Percent_Identity=36.1111111111111, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71999642, Length=63, Percent_Identity=44.4444444444444, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319721, Length=160, Percent_Identity=55, Blast_Score=196, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6322228, Length=148, Percent_Identity=55.4054054054054, Blast_Score=178, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6322826, Length=136, Percent_Identity=48.5294117647059, Blast_Score=139, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24656772, Length=149, Percent_Identity=47.6510067114094, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24656767, Length=149, Percent_Identity=47.6510067114094, Blast_Score=133, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24656777, Length=149, Percent_Identity=47.6510067114094, Blast_Score=133, Evalue=4e-32,
Organism=Drosophila melanogaster, GI85726443, Length=160, Percent_Identity=40.625, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 17696; Mature: 17564

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1 ; PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNLLNIPCTTIKGEQKTLADFAGKAVLVVNTASKCGFTPQYKGLEELWQTYKDQGLVV
CCCCEECCCCCCCCCCHHHHHHHCCCEEEEEECHHHCCCCCCCCCHHHHHHHHHHCCEEE
LGFPCNQFGKQEPGNEGAISEFCELNYGVSFPLFKKIEVNGTGAHPLFVQLKKRAPGVLG
EECCCHHHCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCHHEEEEHHHCCCCCC
SQGIKWNFTKFLIGKDGQLVKRFAPATKPQDLSREIEALLK
CCCCEEEEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SDNLLNIPCTTIKGEQKTLADFAGKAVLVVNTASKCGFTPQYKGLEELWQTYKDQGLVV
CCCEECCCCCCCCCCHHHHHHHCCCEEEEEECHHHCCCCCCCCCHHHHHHHHHHCCEEE
LGFPCNQFGKQEPGNEGAISEFCELNYGVSFPLFKKIEVNGTGAHPLFVQLKKRAPGVLG
EECCCHHHCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCHHEEEEHHHCCCCCC
SQGIKWNFTKFLIGKDGQLVKRFAPATKPQDLSREIEALLK
CCCCEEEEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]