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The map label for this gene is accA1 [H]

Identifier: 77460171

GI number: 77460171

Start: 4477576

End: 4479537

Strand: Direct

Name: accA1 [H]

Synonym: Pfl01_3950

Alternate gene names: 77460171

Gene position: 4477576-4479537 (Clockwise)

Preceding gene: 77460170

Following gene: 77460172

Centisome position: 69.54

GC content: 62.13

Gene sequence:

>1962_bases
ATGCCCGTCATCCATAAAATCCTGATCGCCAACCGCGGTGAAATCGCCTGCCGCATCCAGCGCACCGCCCAGGCCCTCGG
TTATCGCACCGTCGCCGTTTTCAGCGATGCCGACGCTGACGCACTGCATGTCGAAATGGCGGACGAGGCCGTGAACATCG
GTCCGGCACCCGTGCAACAGTCCTACCTGAACATCCCGGCCATTCTCGACGCCGCCCGCCGCAGCGGCGCCGACGCCATC
CATCCGGGCTACGGTTTTCTCTCGGAAAATGCCGAATTCGCCCGCGCCTGCAAACAGGCCGGCCTGACCTTCATCGGCCC
CAGCGTCGAAGCCATCGAACTGATGGGCAGCAAACGCCAATCGAAAATCGCCATGCTCGCCGCCGGTGTGCCATGTATCG
CCGGCTATCAAGGTGCCGAGCAGGACGACGCAACCCTGACACGCGAAGCTGAACGCATCGGTTATCCATTGATGATCAAG
GCCAGCGCCGGCGGTGGCGGACGCGGCATGCGGCTGGTGCACAGCGCCGAAGAATTGCCGGCGCAATTGCGCACGGCGCG
CTCCGAAGCCTTGAACGGATTCGGCAGCGATGAACTGATCCTCGAACAGGCGCTGATCGAGCCGCGCCATGTCGAAGTTC
AGCTGTTCGGCGATCACCACGGCCAGCTGATCTACCTCGGTGAGCGCGACTGTTCGATTCAGCGCCGCCATCAGAAAGTC
ATTGAAGAAGCGCCCTGCCCGGTGATGACCGAAGAACTGCGCCAGGCGATGGGCGAAGCGGCACTCAAGGCCGGGCGTGC
GGTGAACTATGTCGGTGCCGGCACTGTAGAATTCCTGCTCGACACTGATGGCCGGTTCTACTTTCTGGAGATGAACACCC
GGTTGCAGGTCGAACACCCGGTGACTGAACTGATTACCGGGCTGGACCTGGTGGCATGGCAACTGTCGGTCGCCGAAGGT
CAGCCGCTGCCGCTGACCCAGGCACAGGTGAAACTCGATGGCCACGCGATGGAAGTGCGCCTCTACGCCGAAGATCCGAC
CCAGGGTTTTCTTCCACAGACCGGGCGTGTCGAAGCCTGGGCGCCGGCACTGGATCGCGGTTCACGGATTGATCACGGGC
TGATCGAAGGGCAGTCGATCTCACCGTTCTACGACCCGATGCTCGGCAAACTGATTGCTCATGGCGCAACCCGTGAAGAG
GCCCGGCGCAAACTGCTGTGCGCAGTTCAGGACAGCGTGTTGCTTGGCGTGCAAAGCAATCAGCGGTTGCTCGCCAGCCT
GTTGCAGCATCCGCAATTCATCAGCGGCGAGTTCGGTACTGGCTTCATCCCTCAACATTTCGCCGATCACGATTGCCTGC
ACGCCTATTCGCCCAGTAACGAAGAGCTGGCCATCGCGGCGCTGCTGTTTTACCGATCCGCCGCACAGCAACACCGCGCC
ACGTTGTCCGGATGGCGCAACAACGCCGGTGCGCCGTTGCTCTATCGCATCGGTCTCGACGCCCGCGACTGGAACGTGCA
ACTGCGCGCCAGCCCGGACAACGCTTTCGAAGTTCAGGTTGTGGAGCGCGTTATCGAACTCAAACTGATCGAGCACACCG
CCGGGGCCGTGACGCTGGAGGTCGATGGCCTGCGCCAGCGCCGCGCTTATCGCCTGTGCGACGAGCAGCTCTGGCTGTTC
ACCCATCCCGGCAGCCTGCACCTGGTGGATCGAACTCATGCGGTGATCGACAGTCAGACCAGCGTCAGTTCCGGCACGTT
GAAAGCCCCGATGGATGGCGCCATCATCGATGTGCTCGTCAGCGAAGGCAGCCCGGTCAGCAAGGGCCAGTTGCTGGTGG
TGCTGGAGGCGATGAAAATGGAGCACCCGCTCAAGGCCGGCATCGACGGCGTGCTCAAGCGGGTGCAGGTCAAGGTCGGC
GATCAGGTGAAAAATCGTCAGGTTCTGTTGCAGGTCGAGTAG

Upstream 100 bases:

>100_bases
CCGCTCCCACAGTTTTTGTGAGCACCACTGAATCCTGTGGGAGCGGGCTTGCCCGCGATGAGGCCCTTCAATCCACCGCC
AACATTCAGGAAAAACCACC

Downstream 100 bases:

>100_bases
TCGCCGCGCGCATTCGCAAGGTTTGACTACGCTCTGAATAATCAGGACGCGGAAATCAGGAACCCTGCGATGCCCCATTG
GCTGGTCATAGATCTGGAAG

Product: carbamoyl-phosphate synthase L chain, ATP-binding

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 653; Mature: 652

Protein sequence:

>653_residues
MPVIHKILIANRGEIACRIQRTAQALGYRTVAVFSDADADALHVEMADEAVNIGPAPVQQSYLNIPAILDAARRSGADAI
HPGYGFLSENAEFARACKQAGLTFIGPSVEAIELMGSKRQSKIAMLAAGVPCIAGYQGAEQDDATLTREAERIGYPLMIK
ASAGGGGRGMRLVHSAEELPAQLRTARSEALNGFGSDELILEQALIEPRHVEVQLFGDHHGQLIYLGERDCSIQRRHQKV
IEEAPCPVMTEELRQAMGEAALKAGRAVNYVGAGTVEFLLDTDGRFYFLEMNTRLQVEHPVTELITGLDLVAWQLSVAEG
QPLPLTQAQVKLDGHAMEVRLYAEDPTQGFLPQTGRVEAWAPALDRGSRIDHGLIEGQSISPFYDPMLGKLIAHGATREE
ARRKLLCAVQDSVLLGVQSNQRLLASLLQHPQFISGEFGTGFIPQHFADHDCLHAYSPSNEELAIAALLFYRSAAQQHRA
TLSGWRNNAGAPLLYRIGLDARDWNVQLRASPDNAFEVQVVERVIELKLIEHTAGAVTLEVDGLRQRRAYRLCDEQLWLF
THPGSLHLVDRTHAVIDSQTSVSSGTLKAPMDGAIIDVLVSEGSPVSKGQLLVVLEAMKMEHPLKAGIDGVLKRVQVKVG
DQVKNRQVLLQVE

Sequences:

>Translated_653_residues
MPVIHKILIANRGEIACRIQRTAQALGYRTVAVFSDADADALHVEMADEAVNIGPAPVQQSYLNIPAILDAARRSGADAI
HPGYGFLSENAEFARACKQAGLTFIGPSVEAIELMGSKRQSKIAMLAAGVPCIAGYQGAEQDDATLTREAERIGYPLMIK
ASAGGGGRGMRLVHSAEELPAQLRTARSEALNGFGSDELILEQALIEPRHVEVQLFGDHHGQLIYLGERDCSIQRRHQKV
IEEAPCPVMTEELRQAMGEAALKAGRAVNYVGAGTVEFLLDTDGRFYFLEMNTRLQVEHPVTELITGLDLVAWQLSVAEG
QPLPLTQAQVKLDGHAMEVRLYAEDPTQGFLPQTGRVEAWAPALDRGSRIDHGLIEGQSISPFYDPMLGKLIAHGATREE
ARRKLLCAVQDSVLLGVQSNQRLLASLLQHPQFISGEFGTGFIPQHFADHDCLHAYSPSNEELAIAALLFYRSAAQQHRA
TLSGWRNNAGAPLLYRIGLDARDWNVQLRASPDNAFEVQVVERVIELKLIEHTAGAVTLEVDGLRQRRAYRLCDEQLWLF
THPGSLHLVDRTHAVIDSQTSVSSGTLKAPMDGAIIDVLVSEGSPVSKGQLLVVLEAMKMEHPLKAGIDGVLKRVQVKVG
DQVKNRQVLLQVE
>Mature_652_residues
PVIHKILIANRGEIACRIQRTAQALGYRTVAVFSDADADALHVEMADEAVNIGPAPVQQSYLNIPAILDAARRSGADAIH
PGYGFLSENAEFARACKQAGLTFIGPSVEAIELMGSKRQSKIAMLAAGVPCIAGYQGAEQDDATLTREAERIGYPLMIKA
SAGGGGRGMRLVHSAEELPAQLRTARSEALNGFGSDELILEQALIEPRHVEVQLFGDHHGQLIYLGERDCSIQRRHQKVI
EEAPCPVMTEELRQAMGEAALKAGRAVNYVGAGTVEFLLDTDGRFYFLEMNTRLQVEHPVTELITGLDLVAWQLSVAEGQ
PLPLTQAQVKLDGHAMEVRLYAEDPTQGFLPQTGRVEAWAPALDRGSRIDHGLIEGQSISPFYDPMLGKLIAHGATREEA
RRKLLCAVQDSVLLGVQSNQRLLASLLQHPQFISGEFGTGFIPQHFADHDCLHAYSPSNEELAIAALLFYRSAAQQHRAT
LSGWRNNAGAPLLYRIGLDARDWNVQLRASPDNAFEVQVVERVIELKLIEHTAGAVTLEVDGLRQRRAYRLCDEQLWLFT
HPGSLHLVDRTHAVIDSQTSVSSGTLKAPMDGAIIDVLVSEGSPVSKGQLLVVLEAMKMEHPLKAGIDGVLKRVQVKVGD
QVKNRQVLLQVE

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=670, Percent_Identity=44.9253731343284, Blast_Score=561, Evalue=1e-160,
Organism=Homo sapiens, GI189095269, Length=680, Percent_Identity=41.7647058823529, Blast_Score=487, Evalue=1e-137,
Organism=Homo sapiens, GI65506442, Length=675, Percent_Identity=42.0740740740741, Blast_Score=487, Evalue=1e-137,
Organism=Homo sapiens, GI295821183, Length=654, Percent_Identity=41.8960244648318, Blast_Score=475, Evalue=1e-134,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=45.43429844098, Blast_Score=371, Evalue=1e-102,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=45.43429844098, Blast_Score=371, Evalue=1e-102,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=45.43429844098, Blast_Score=371, Evalue=1e-102,
Organism=Homo sapiens, GI38679977, Length=708, Percent_Identity=29.0960451977401, Blast_Score=261, Evalue=2e-69,
Organism=Homo sapiens, GI38679967, Length=708, Percent_Identity=29.0960451977401, Blast_Score=261, Evalue=2e-69,
Organism=Homo sapiens, GI38679960, Length=708, Percent_Identity=29.0960451977401, Blast_Score=261, Evalue=2e-69,
Organism=Homo sapiens, GI38679971, Length=708, Percent_Identity=29.0960451977401, Blast_Score=261, Evalue=2e-69,
Organism=Homo sapiens, GI38679974, Length=708, Percent_Identity=29.0960451977401, Blast_Score=261, Evalue=2e-69,
Organism=Homo sapiens, GI134142062, Length=502, Percent_Identity=31.8725099601594, Blast_Score=242, Evalue=7e-64,
Organism=Escherichia coli, GI1789654, Length=435, Percent_Identity=50.8045977011494, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71987519, Length=660, Percent_Identity=44.3939393939394, Blast_Score=514, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17567343, Length=683, Percent_Identity=42.0204978038067, Blast_Score=470, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=42.4107142857143, Blast_Score=345, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI133931226, Length=672, Percent_Identity=27.827380952381, Blast_Score=216, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI71997168, Length=525, Percent_Identity=29.1428571428571, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=520, Percent_Identity=28.6538461538462, Blast_Score=204, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6319685, Length=494, Percent_Identity=40.2834008097166, Blast_Score=355, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6319695, Length=454, Percent_Identity=42.7312775330396, Blast_Score=333, Evalue=5e-92,
Organism=Saccharomyces cerevisiae, GI6321376, Length=454, Percent_Identity=43.8325991189427, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6323863, Length=666, Percent_Identity=29.5795795795796, Blast_Score=259, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6324343, Length=718, Percent_Identity=28.8300835654596, Blast_Score=255, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24651757, Length=671, Percent_Identity=43.070044709389, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24651759, Length=633, Percent_Identity=41.390205371248, Blast_Score=450, Evalue=1e-126,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=43.5267857142857, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=43.5267857142857, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=43.5267857142857, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=43.5267857142857, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=43.5267857142857, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=43.5267857142857, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=43.5267857142857, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=43.5267857142857, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=43.5267857142857, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=43.5267857142857, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24586458, Length=706, Percent_Identity=29.6033994334278, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI161076407, Length=706, Percent_Identity=29.6033994334278, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24586460, Length=706, Percent_Identity=29.6033994334278, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI161076409, Length=706, Percent_Identity=29.6033994334278, Blast_Score=264, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 71321; Mature: 71190

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVIHKILIANRGEIACRIQRTAQALGYRTVAVFSDADADALHVEMADEAVNIGPAPVQQ
CCHHEEEEECCCCCEEEEEHHHHHHHCCEEEEEEECCCCCEEEEEECCCCCCCCCCCHHH
SYLNIPAILDAARRSGADAIHPGYGFLSENAEFARACKQAGLTFIGPSVEAIELMGSKRQ
HHCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCHHHHHHHCCCCH
SKIAMLAAGVPCIAGYQGAEQDDATLTREAERIGYPLMIKASAGGGGRGMRLVHSAEELP
HHEEEEECCCCCEECCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCEECCHHHHH
AQLRTARSEALNGFGSDELILEQALIEPRHVEVQLFGDHHGQLIYLGERDCSIQRRHQKV
HHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCHHHHHHHHH
IEEAPCPVMTEELRQAMGEAALKAGRAVNYVGAGTVEFLLDTDGRFYFLEMNTRLQVEHP
HHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEECCCCEEEEEECCEEEECCC
VTELITGLDLVAWQLSVAEGQPLPLTQAQVKLDGHAMEVRLYAEDPTQGFLPQTGRVEAW
HHHHHHHHHHEEEEEEECCCCCCCCCCEEEEECCEEEEEEEEECCCCCCCCCCCCCCEEC
APALDRGSRIDHGLIEGQSISPFYDPMLGKLIAHGATREEARRKLLCAVQDSVLLGVQSN
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHEECCCEEEEECCC
QRLLASLLQHPQFISGEFGTGFIPQHFADHDCLHAYSPSNEELAIAALLFYRSAAQQHRA
HHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHH
TLSGWRNNAGAPLLYRIGLDARDWNVQLRASPDNAFEVQVVERVIELKLIEHTAGAVTLE
HHHCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHEEECCCEEEEE
VDGLRQRRAYRLCDEQLWLFTHPGSLHLVDRTHAVIDSQTSVSSGTLKAPMDGAIIDVLV
ECCHHHHHHHHHHCCCEEEEECCCCEEEEECHHHHCCCCCCCCCCCEECCCCCEEEEEEE
SEGSPVSKGQLLVVLEAMKMEHPLKAGIDGVLKRVQVKVGDQVKNRQVLLQVE
CCCCCCCCCCEEEEEEHHHCCCCHHHCHHHHHHHHHHHCCCCCCCCEEEEEEC
>Mature Secondary Structure 
PVIHKILIANRGEIACRIQRTAQALGYRTVAVFSDADADALHVEMADEAVNIGPAPVQQ
CHHEEEEECCCCCEEEEEHHHHHHHCCEEEEEEECCCCCEEEEEECCCCCCCCCCCHHH
SYLNIPAILDAARRSGADAIHPGYGFLSENAEFARACKQAGLTFIGPSVEAIELMGSKRQ
HHCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCHHHHHHHCCCCH
SKIAMLAAGVPCIAGYQGAEQDDATLTREAERIGYPLMIKASAGGGGRGMRLVHSAEELP
HHEEEEECCCCCEECCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCEECCHHHHH
AQLRTARSEALNGFGSDELILEQALIEPRHVEVQLFGDHHGQLIYLGERDCSIQRRHQKV
HHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCHHHHHHHHH
IEEAPCPVMTEELRQAMGEAALKAGRAVNYVGAGTVEFLLDTDGRFYFLEMNTRLQVEHP
HHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEECCCCEEEEEECCEEEECCC
VTELITGLDLVAWQLSVAEGQPLPLTQAQVKLDGHAMEVRLYAEDPTQGFLPQTGRVEAW
HHHHHHHHHHEEEEEEECCCCCCCCCCEEEEECCEEEEEEEEECCCCCCCCCCCCCCEEC
APALDRGSRIDHGLIEGQSISPFYDPMLGKLIAHGATREEARRKLLCAVQDSVLLGVQSN
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHEECCCEEEEECCC
QRLLASLLQHPQFISGEFGTGFIPQHFADHDCLHAYSPSNEELAIAALLFYRSAAQQHRA
HHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHH
TLSGWRNNAGAPLLYRIGLDARDWNVQLRASPDNAFEVQVVERVIELKLIEHTAGAVTLE
HHHCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHEEECCCEEEEE
VDGLRQRRAYRLCDEQLWLFTHPGSLHLVDRTHAVIDSQTSVSSGTLKAPMDGAIIDVLV
ECCHHHHHHHHHHCCCEEEEECCCCEEEEECHHHHCCCCCCCCCCCEECCCCCEEEEEEE
SEGSPVSKGQLLVVLEAMKMEHPLKAGIDGVLKRVQVKVGDQVKNRQVLLQVE
CCCCCCCCCCEEEEEEHHHCCCCHHHCHHHHHHHHHHHCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]