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The map label for this gene is acdA [H]

Identifier: 77460169

GI number: 77460169

Start: 4475507

End: 4476664

Strand: Direct

Name: acdA [H]

Synonym: Pfl01_3948

Alternate gene names: 77460169

Gene position: 4475507-4476664 (Clockwise)

Preceding gene: 77460168

Following gene: 77460170

Centisome position: 69.51

GC content: 61.14

Gene sequence:

>1158_bases
ATGATCTTCACCCCGGAACACGAAGCTCTGCGCCGCACCGTCCGCCAGTTCGTCGAGCACGAGATCAACCCCCATGTCGA
TGAATGGGAAAAGGCCGGGCGCTTTCCGATCCACGAGATTTTCCGCAAGGCCGGCGACCTCGGTCTGCTGGGGATTTCCA
AGCCGGAAAAATTCGGCGGCATGGGTCTGGATTACAGCTATTCGATCGTCGCGGCCGAAGAGTTCGGCACCATCCACTGC
GGCGGCATTCCGATGTCGATCGGCGTGCAGACCGACATGTGCACTCCGGCCCTCGCCCGCTTCGGTTCCGATGAGTTGCG
CGAAGAGTTTCTGCGCCCAGCCATCACTGGCGAGCAGGTCGGCTGCATCGGTGTCTCGGAAGTCGGCGCCGGCTCCGATG
TCGCCGGGCTCAAGACCACCGCGCGCAAGGATGGCGACGACTATGTGATCAACGGCAGCAAGATGTGGATCACCAACTCG
CCGAGCGCCGACTTCATCTGCCTGCTGGCCAACACCTCGGACGACAAGCCGCACATCAACAAATCGCTGATCATGGTGCC
GATGAACACGCCGGGTATCAGCCTCAGTTCGCACCTGGACAAGCTCGGCATGCGCAGCTCGGAAACCGCCCAGGTGTTTT
TCGACAACGTGCGCGTGCCCCAGCGCAATCGCATCGGCCACGAAGGCGCCGGGTTCATGATGCAGATGCTGCAGTTCCAG
GAGGAACGCCTGTTCGGTGCGGCCAACATGATCAAGGGCCTGGAATACTGCGTCGACAGCACCATCGAGTACTGCAAGGA
GCGCAAGACCTTCGGCAACGCGCTGATCGACAATCAGGTGATTCACTTCCGCCTCGCCGAGTTGCAGACCGAAATCGAAT
GCCTGCGGGCGCTGGTCTATCAGGCCACCGAGCAATACGTCAAAGGCCAGGACGTCACCCGACTGGCGTCGATGGCCAAG
CTCAAGGCCGGACGTCTCGGTCGGGAAGTCAGCGACAGTTGCCTGCAATACTGGGGCGGCATGGGCTTCATGTGGGACAA
CCCGGTGGCCCGCGCCTACCGCGACGTGCGGCTGGTATCGATTGGCGGCGGCGCCGATGAAATCATGCTGGGGATCATCT
GCAAACTGATGGGCATTCTGCCGGGGAAAAAGAAATGA

Upstream 100 bases:

>100_bases
TGCTGGACATCTGCCACGAAGCCGACGTACGCAGGCTGCAACCCAACAGCTTCGGCGTCAGCCGGTTCTGATCGCCTCGG
ATCAAAGGAGAACAACAACA

Downstream 100 bases:

>100_bases
GCGCCCTGCCCGATTGCCAGACGCTGCTGCTGGAACGGCACAACGGCGTGTTGCACATCACCCTCAATCGCCCGGAAAGC
CGCAACGCCATGAGCCTGCA

Product: acyl-CoA dehydrogenase-like protein

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MIFTPEHEALRRTVRQFVEHEINPHVDEWEKAGRFPIHEIFRKAGDLGLLGISKPEKFGGMGLDYSYSIVAAEEFGTIHC
GGIPMSIGVQTDMCTPALARFGSDELREEFLRPAITGEQVGCIGVSEVGAGSDVAGLKTTARKDGDDYVINGSKMWITNS
PSADFICLLANTSDDKPHINKSLIMVPMNTPGISLSSHLDKLGMRSSETAQVFFDNVRVPQRNRIGHEGAGFMMQMLQFQ
EERLFGAANMIKGLEYCVDSTIEYCKERKTFGNALIDNQVIHFRLAELQTEIECLRALVYQATEQYVKGQDVTRLASMAK
LKAGRLGREVSDSCLQYWGGMGFMWDNPVARAYRDVRLVSIGGGADEIMLGIICKLMGILPGKKK

Sequences:

>Translated_385_residues
MIFTPEHEALRRTVRQFVEHEINPHVDEWEKAGRFPIHEIFRKAGDLGLLGISKPEKFGGMGLDYSYSIVAAEEFGTIHC
GGIPMSIGVQTDMCTPALARFGSDELREEFLRPAITGEQVGCIGVSEVGAGSDVAGLKTTARKDGDDYVINGSKMWITNS
PSADFICLLANTSDDKPHINKSLIMVPMNTPGISLSSHLDKLGMRSSETAQVFFDNVRVPQRNRIGHEGAGFMMQMLQFQ
EERLFGAANMIKGLEYCVDSTIEYCKERKTFGNALIDNQVIHFRLAELQTEIECLRALVYQATEQYVKGQDVTRLASMAK
LKAGRLGREVSDSCLQYWGGMGFMWDNPVARAYRDVRLVSIGGGADEIMLGIICKLMGILPGKKK
>Mature_385_residues
MIFTPEHEALRRTVRQFVEHEINPHVDEWEKAGRFPIHEIFRKAGDLGLLGISKPEKFGGMGLDYSYSIVAAEEFGTIHC
GGIPMSIGVQTDMCTPALARFGSDELREEFLRPAITGEQVGCIGVSEVGAGSDVAGLKTTARKDGDDYVINGSKMWITNS
PSADFICLLANTSDDKPHINKSLIMVPMNTPGISLSSHLDKLGMRSSETAQVFFDNVRVPQRNRIGHEGAGFMMQMLQFQ
EERLFGAANMIKGLEYCVDSTIEYCKERKTFGNALIDNQVIHFRLAELQTEIECLRALVYQATEQYVKGQDVTRLASMAK
LKAGRLGREVSDSCLQYWGGMGFMWDNPVARAYRDVRLVSIGGGADEIMLGIICKLMGILPGKKK

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=376, Percent_Identity=36.1702127659575, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI4557233, Length=373, Percent_Identity=35.1206434316354, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI4501859, Length=376, Percent_Identity=32.9787234042553, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI226958412, Length=369, Percent_Identity=31.4363143631436, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=34.7480106100796, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=34.7480106100796, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI226958414, Length=364, Percent_Identity=31.5934065934066, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI7656849, Length=376, Percent_Identity=31.6489361702128, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI76496475, Length=332, Percent_Identity=28.6144578313253, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI4557235, Length=332, Percent_Identity=28.6144578313253, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI21361497, Length=367, Percent_Identity=26.9754768392371, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI38505218, Length=363, Percent_Identity=27.2727272727273, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI48976061, Length=395, Percent_Identity=25.8227848101266, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI211971008, Length=395, Percent_Identity=25.8227848101266, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI7669494, Length=293, Percent_Identity=28.6689419795222, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI4503943, Length=293, Percent_Identity=28.6689419795222, Blast_Score=109, Evalue=5e-24,
Organism=Escherichia coli, GI87081958, Length=374, Percent_Identity=32.3529411764706, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI1786223, Length=372, Percent_Identity=29.5698924731183, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17551932, Length=376, Percent_Identity=51.063829787234, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17505929, Length=376, Percent_Identity=51.8617021276596, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17508101, Length=378, Percent_Identity=35.1851851851852, Blast_Score=235, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17538396, Length=376, Percent_Identity=34.0425531914894, Blast_Score=234, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI17506239, Length=366, Percent_Identity=33.3333333333333, Blast_Score=210, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=33.509234828496, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71990804, Length=276, Percent_Identity=37.6811594202899, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17533517, Length=371, Percent_Identity=32.3450134770889, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17569725, Length=369, Percent_Identity=32.2493224932249, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17534899, Length=368, Percent_Identity=31.7934782608696, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71982178, Length=271, Percent_Identity=33.9483394833948, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=33.1896551724138, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71985184, Length=338, Percent_Identity=27.5147928994083, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=30.2904564315353, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17534353, Length=390, Percent_Identity=24.6153846153846, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71985192, Length=306, Percent_Identity=25.4901960784314, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17562446, Length=289, Percent_Identity=26.643598615917, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17531913, Length=178, Percent_Identity=28.0898876404494, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=32.3450134770889, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=32.8877005347594, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=30.3763440860215, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI21355753, Length=373, Percent_Identity=31.9034852546917, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=32.5396825396825, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI281363737, Length=348, Percent_Identity=28.448275862069, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI19920834, Length=295, Percent_Identity=29.4915254237288, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42630; Mature: 42630

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFTPEHEALRRTVRQFVEHEINPHVDEWEKAGRFPIHEIFRKAGDLGLLGISKPEKFGG
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHCCCEEEEECCCCHHHCC
MGLDYSYSIVAAEEFGTIHCGGIPMSIGVQTDMCTPALARFGSDELREEFLRPAITGEQV
CCCCCEEEEEEECCCCEEEECCEEEEECCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCC
GCIGVSEVGAGSDVAGLKTTARKDGDDYVINGSKMWITNSPSADFICLLANTSDDKPHIN
CEEECCCCCCCCCCCCCHHHHCCCCCCEEECCCEEEEECCCCCCEEEEEECCCCCCCCCC
KSLIMVPMNTPGISLSSHLDKLGMRSSETAQVFFDNVRVPQRNRIGHEGAGFMMQMLQFQ
CEEEEEECCCCCCCHHHHHHHHCCCCCCCHHHHECCCCCCHHHCCCCCHHHHHHHHHHHH
EERLFGAANMIKGLEYCVDSTIEYCKERKTFGNALIDNQVIHFRLAELQTEIECLRALVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
QATEQYVKGQDVTRLASMAKLKAGRLGREVSDSCLQYWGGMGFMWDNPVARAYRDVRLVS
HHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCEEEEE
IGGGADEIMLGIICKLMGILPGKKK
ECCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIFTPEHEALRRTVRQFVEHEINPHVDEWEKAGRFPIHEIFRKAGDLGLLGISKPEKFGG
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHCCCEEEEECCCCHHHCC
MGLDYSYSIVAAEEFGTIHCGGIPMSIGVQTDMCTPALARFGSDELREEFLRPAITGEQV
CCCCCEEEEEEECCCCEEEECCEEEEECCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCC
GCIGVSEVGAGSDVAGLKTTARKDGDDYVINGSKMWITNSPSADFICLLANTSDDKPHIN
CEEECCCCCCCCCCCCCHHHHCCCCCCEEECCCEEEEECCCCCCEEEEEECCCCCCCCCC
KSLIMVPMNTPGISLSSHLDKLGMRSSETAQVFFDNVRVPQRNRIGHEGAGFMMQMLQFQ
CEEEEEECCCCCCCHHHHHHHHCCCCCCCHHHHECCCCCCHHHCCCCCHHHHHHHHHHHH
EERLFGAANMIKGLEYCVDSTIEYCKERKTFGNALIDNQVIHFRLAELQTEIECLRALVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
QATEQYVKGQDVTRLASMAKLKAGRLGREVSDSCLQYWGGMGFMWDNPVARAYRDVRLVS
HHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCEEEEE
IGGGADEIMLGIICKLMGILPGKKK
ECCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]