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The map label for this gene is yngE [H]

Identifier: 77460168

GI number: 77460168

Start: 4473861

End: 4475477

Strand: Direct

Name: yngE [H]

Synonym: Pfl01_3947

Alternate gene names: 77460168

Gene position: 4473861-4475477 (Clockwise)

Preceding gene: 77460167

Following gene: 77460169

Centisome position: 69.49

GC content: 62.77

Gene sequence:

>1617_bases
ATGCCGCAGATCCAGTCCCAACTCGACCCGCACAGCGAAGCCTTCGCCCGCAATCGCGCAGCGATGCTCGCCGCCATCGA
GCAAGTCCAGCAGCTGGAACAGAACCTGCTGCACAAGGCCGCCGAAGCCAAACCCAAATTCGACAAACGCGGACAATTGT
TGCCCCGTGAACGTCTGAATCTGTTGCTCGACCCCGGCGCGCCATTCCTCGAACTGGCGAGCCTGGCCGGCTACAAGCTC
CACGACGACAAGGACGGCAGCTCGGCCGGTGGCGGCTTGATCGCCGGCATTGGCTATGTGTCCGGCGTGCGCGCCTTGAT
CGTGGCGAACAACAGCGCGATCAAGGGCGGGACGATTTCCCCGTCGGGCCTGAAAAAATCCCTGCGCCTGCAACAGATCG
CCCAGGAAAACAAACTGCCGGTCATCACTCTCGCCGAAAGCGGTGGCGCCAACCTCAATTACGCGGCGGAGATTTTCGTC
GAAGGCGCGCGCAGTTTTGCCAATCAGGCGCGGATGTCAGCCATGGGTTTGCCGCAGATCACCGTAGTGCACGGCTCGGC
TACGGCTGGCGGAGCGTATCAGCCGGGGCTGTCGGATTACGTGGTGGTGGTGCGCGGCAAGGCCAAGCTGTTTCTTGCCG
GCCCGCCGTTGCTTAAAGCAGCGACCGGTGAAGTCGCCACCGACGAAGAACTGGGCGGTGCCGAGATGCACGCGCAAGTC
GCCGGCACCGCGGAATACCTGGCCGAAAACGATGCCGACGGCGTGCGTCAGGTACGGGAAATCGTCAGCCTGCTGAACTG
GAACGAGCAACTGCCGTGGCTGCCCGAACCACAATTCAAGGAGCCGCTGTACCCCATCGACGAACTCCTCGGGCTGATCC
CGGACGACCCGAAAAAACCCTACGACGTGCGCGAAATCATTGCGCGGATCGCCGATGAATCACGCTTCCTGGAATTCAAA
GGCGAGTTCGATCAGCAGACCGTTTGTGGCCACCTGAAAATTCAGGGCCGCGCCTGCGGTTTCATCGGCAACAACGGCCC
GATCACGCCCAACGGCGCGAGCAAGGCGGCGCAGTTCATTCAACTGTGCGACCAGAGCCAGACGCCGCTGCTGTTTTTCC
ACAACACCACCGGGTTCATGGTCGGCACCGAATCGGAACAGCACGGCGTGATCAAGCATGGCTCGAAATTGATCCAGGCC
GTGGCCAATGCGCGGGTGCCGAAACTGACGATAGTGGTCGGCGGCTCCTACGGCGCGGGCAACTACGCGATGTGCGGACG
CGGGCTTGATCCGCGTTTCATCTTCGCCTGGCCCAACAGCCGCACCGCCGTGATGGGTGGCGCCCAGGCCGGCAAGGTGT
TGCGCATCGTCACCGAAGCCAAACAGCTCAAGGACGGCCTGGTGCCCGACCCGAAAATGCTCGACATGCTGGAGCAGGTC
ACCGCGCAGAAACTCGACAGCCAGTCCACCGCCCTCTACGGCAGCGCCAACCTGTGGGATGACGGGCTGATCGATCCGCG
CGACACCCGCACCCTGCTCGGCTACCTGCTGGACATCTGCCACGAAGCCGACGTACGCAGGCTGCAACCCAACAGCTTCG
GCGTCAGCCGGTTCTGA

Upstream 100 bases:

>100_bases
CAACCGCGCATGGCCGTTGCACAAGGCGACCCACAGCGAATCCTTCAACGGTTTTCACCGGGCCTACATGCCAGACGTTT
TGAAGGACAAGGAGTAAGCC

Downstream 100 bases:

>100_bases
TCGCCTCGGATCAAAGGAGAACAACAACAATGATCTTCACCCCGGAACACGAAGCTCTGCGCCGCACCGTCCGCCAGTTC
GTCGAGCACGAGATCAACCC

Product: carboxyl transferase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MPQIQSQLDPHSEAFARNRAAMLAAIEQVQQLEQNLLHKAAEAKPKFDKRGQLLPRERLNLLLDPGAPFLELASLAGYKL
HDDKDGSSAGGGLIAGIGYVSGVRALIVANNSAIKGGTISPSGLKKSLRLQQIAQENKLPVITLAESGGANLNYAAEIFV
EGARSFANQARMSAMGLPQITVVHGSATAGGAYQPGLSDYVVVVRGKAKLFLAGPPLLKAATGEVATDEELGGAEMHAQV
AGTAEYLAENDADGVRQVREIVSLLNWNEQLPWLPEPQFKEPLYPIDELLGLIPDDPKKPYDVREIIARIADESRFLEFK
GEFDQQTVCGHLKIQGRACGFIGNNGPITPNGASKAAQFIQLCDQSQTPLLFFHNTTGFMVGTESEQHGVIKHGSKLIQA
VANARVPKLTIVVGGSYGAGNYAMCGRGLDPRFIFAWPNSRTAVMGGAQAGKVLRIVTEAKQLKDGLVPDPKMLDMLEQV
TAQKLDSQSTALYGSANLWDDGLIDPRDTRTLLGYLLDICHEADVRRLQPNSFGVSRF

Sequences:

>Translated_538_residues
MPQIQSQLDPHSEAFARNRAAMLAAIEQVQQLEQNLLHKAAEAKPKFDKRGQLLPRERLNLLLDPGAPFLELASLAGYKL
HDDKDGSSAGGGLIAGIGYVSGVRALIVANNSAIKGGTISPSGLKKSLRLQQIAQENKLPVITLAESGGANLNYAAEIFV
EGARSFANQARMSAMGLPQITVVHGSATAGGAYQPGLSDYVVVVRGKAKLFLAGPPLLKAATGEVATDEELGGAEMHAQV
AGTAEYLAENDADGVRQVREIVSLLNWNEQLPWLPEPQFKEPLYPIDELLGLIPDDPKKPYDVREIIARIADESRFLEFK
GEFDQQTVCGHLKIQGRACGFIGNNGPITPNGASKAAQFIQLCDQSQTPLLFFHNTTGFMVGTESEQHGVIKHGSKLIQA
VANARVPKLTIVVGGSYGAGNYAMCGRGLDPRFIFAWPNSRTAVMGGAQAGKVLRIVTEAKQLKDGLVPDPKMLDMLEQV
TAQKLDSQSTALYGSANLWDDGLIDPRDTRTLLGYLLDICHEADVRRLQPNSFGVSRF
>Mature_537_residues
PQIQSQLDPHSEAFARNRAAMLAAIEQVQQLEQNLLHKAAEAKPKFDKRGQLLPRERLNLLLDPGAPFLELASLAGYKLH
DDKDGSSAGGGLIAGIGYVSGVRALIVANNSAIKGGTISPSGLKKSLRLQQIAQENKLPVITLAESGGANLNYAAEIFVE
GARSFANQARMSAMGLPQITVVHGSATAGGAYQPGLSDYVVVVRGKAKLFLAGPPLLKAATGEVATDEELGGAEMHAQVA
GTAEYLAENDADGVRQVREIVSLLNWNEQLPWLPEPQFKEPLYPIDELLGLIPDDPKKPYDVREIIARIADESRFLEFKG
EFDQQTVCGHLKIQGRACGFIGNNGPITPNGASKAAQFIQLCDQSQTPLLFFHNTTGFMVGTESEQHGVIKHGSKLIQAV
ANARVPKLTIVVGGSYGAGNYAMCGRGLDPRFIFAWPNSRTAVMGGAQAGKVLRIVTEAKQLKDGLVPDPKMLDMLEQVT
AQKLDSQSTALYGSANLWDDGLIDPRDTRTLLGYLLDICHEADVRRLQPNSFGVSRF

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=537, Percent_Identity=43.7616387337058, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI119943100, Length=530, Percent_Identity=29.0566037735849, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI295821216, Length=550, Percent_Identity=28.5454545454545, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI310133460, Length=143, Percent_Identity=42.6573426573427, Blast_Score=99, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17552936, Length=541, Percent_Identity=44.916820702403, Blast_Score=463, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI25147359, Length=413, Percent_Identity=30.7506053268765, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI25147362, Length=413, Percent_Identity=30.7506053268765, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24586065, Length=533, Percent_Identity=43.9024390243902, Blast_Score=462, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57922; Mature: 57791

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQIQSQLDPHSEAFARNRAAMLAAIEQVQQLEQNLLHKAAEAKPKFDKRGQLLPRERLN
CCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCC
LLLDPGAPFLELASLAGYKLHDDKDGSSAGGGLIAGIGYVSGVRALIVANNSAIKGGTIS
EEECCCCCHHHHHHHCCCEEECCCCCCCCCCCCEEHHHHHHCCEEEEEECCCCCCCCCCC
PSGLKKSLRLQQIAQENKLPVITLAESGGANLNYAAEIFVEGARSFANQARMSAMGLPQI
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
TVVHGSATAGGAYQPGLSDYVVVVRGKAKLFLAGPPLLKAATGEVATDEELGGAEMHAQV
EEEECCCCCCCCCCCCCCCEEEEEECCEEEEEECCCHHHHCCCCCCCCCCCCCCHHHHHH
AGTAEYLAENDADGVRQVREIVSLLNWNEQLPWLPEPQFKEPLYPIDELLGLIPDDPKKP
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCC
YDVREIIARIADESRFLEFKGEFDQQTVCGHLKIQGRACGFIGNNGPITPNGASKAAQFI
CHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCEEEEEECCCCCCCCCCHHHHHHHH
QLCDQSQTPLLFFHNTTGFMVGTESEQHGVIKHGSKLIQAVANARVPKLTIVVGGSYGAG
HHHCCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
NYAMCGRGLDPRFIFAWPNSRTAVMGGAQAGKVLRIVTEAKQLKDGLVPDPKMLDMLEQV
CHHEECCCCCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
TAQKLDSQSTALYGSANLWDDGLIDPRDTRTLLGYLLDICHEADVRRLQPNSFGVSRF
HHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PQIQSQLDPHSEAFARNRAAMLAAIEQVQQLEQNLLHKAAEAKPKFDKRGQLLPRERLN
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCC
LLLDPGAPFLELASLAGYKLHDDKDGSSAGGGLIAGIGYVSGVRALIVANNSAIKGGTIS
EEECCCCCHHHHHHHCCCEEECCCCCCCCCCCCEEHHHHHHCCEEEEEECCCCCCCCCCC
PSGLKKSLRLQQIAQENKLPVITLAESGGANLNYAAEIFVEGARSFANQARMSAMGLPQI
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
TVVHGSATAGGAYQPGLSDYVVVVRGKAKLFLAGPPLLKAATGEVATDEELGGAEMHAQV
EEEECCCCCCCCCCCCCCCEEEEEECCEEEEEECCCHHHHCCCCCCCCCCCCCCHHHHHH
AGTAEYLAENDADGVRQVREIVSLLNWNEQLPWLPEPQFKEPLYPIDELLGLIPDDPKKP
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCC
YDVREIIARIADESRFLEFKGEFDQQTVCGHLKIQGRACGFIGNNGPITPNGASKAAQFI
CHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCEEEEEECCCCCCCCCCHHHHHHHH
QLCDQSQTPLLFFHNTTGFMVGTESEQHGVIKHGSKLIQAVANARVPKLTIVVGGSYGAG
HHHCCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
NYAMCGRGLDPRFIFAWPNSRTAVMGGAQAGKVLRIVTEAKQLKDGLVPDPKMLDMLEQV
CHHEECCCCCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
TAQKLDSQSTALYGSANLWDDGLIDPRDTRTLLGYLLDICHEADVRRLQPNSFGVSRF
HHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]