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The map label for this gene is lolC [H]

Identifier: 77460080

GI number: 77460080

Start: 4360284

End: 4361534

Strand: Reverse

Name: lolC [H]

Synonym: Pfl01_3859

Alternate gene names: 77460080

Gene position: 4361534-4360284 (Counterclockwise)

Preceding gene: 77460083

Following gene: 77460079

Centisome position: 67.74

GC content: 61.63

Gene sequence:

>1251_bases
ATGTTCAGACCTCTCTTCGTATTTATCGGCACGCGTTATACCCGTGCAAAGCGTCGCAATCATTTTGTGTCATTCATTTC
CCTGACTTCGATGATCGGGCTCGCCCTTGGCGTGGTCGTGATGATCGTGGTGCTGTCGGTGATGAACGGCTTCGATCATG
AGATGCGCACCCGCGTGCTGGGCATGGTGCCCCACGCGACCATCGAGTCCGGTGAAGCCATCAACGACTGGCCGAGCCTG
GCCGCCAAGGTCAAGCAGAACCCGCAGGTGGCGGCCGTCGCGCCTTTCACCCAGATGCAGGGGTTGCTGACCAACAACGG
CCAGGTGTCCAAGGTGTTGCTCAATGCCATCGACCCTGCGCTGGAGCGCAACGTCTCGATCATCGACAACTTCATGAAGC
AGGGCAAACTCGACGATCTGACGCCGGGCAGCTTCGGCATCGTGATCGGCGACAAGGCCGCGACCAAGCTCGGCGTAGGC
ATCGGTGACAAGATCACCTTCGTCGCACCGGAAGTCAGTGTGACCCCGGCCGGGATGTTCCCGCGCATGAAGCGCTTCAC
TGTGGTCGGCATCTTCCATGTCGGCGCCGGCGAGCTGGACGGCTATCTGGGCGTCACCAACCTGCAGGATCTGGCGAAGA
TGCACCGCTGGAAGCCTGATCAGGTACAGGGTCTGCGTCTGAAGTTCGACGATCTGTTCCAGGCGCCGCGTGAAGCGTGG
AACATCGCCCAGCGCCTCGGCGAGGACCGTTACTACGCCCGCGACTGGACCCGTACCCACGGCAACCTGTATCAGGCGAT
CCGCATGGAAAAAGCCATGATCGGCCTGCTGTTGCTGCTGATCGTCGCCGTGGCGGCGTTCAACATCATTTCCACGCTGG
TGATGGTGGTGAACGACAAGAAGGGCGACATCGCCATTCTGCGCACACTGGGCGCCACACCGGGCACGATCATGCGCACA
TTCATGGTGCAAGGCACGGTGATCGGCGTGGTCGGCACGGCCATCGGCGCCGTGGTCGGGATCTTCGCCGCGCTCAACGT
CAGCGCCGCGATTTCGGCCCTCGAAGGCGTGATCGGACACAAATTCCTCAACGCCGACGTGTATTTCATCGATTACCTGC
CGTCGCAGGTGCAGAGCCAGGACGTGGTCATGGTCTGCGCCGCTGCGTTGGTCCTGAGTTTCCTCGCCACCCTGTATCCA
GCCTGGCGTGCCGCGCGCACCCAGCCGGCGGAGGCGCTACGTTATGAGTGA

Upstream 100 bases:

>100_bases
CGACATGGCGAACCCATGGTAGCGGCGGTGGTCTGAGTGTAAAGCTGGTTATCGACCCCCGCCACAAGGACGTTCCTTTT
CCCTCCGAACAAGCCCCGAC

Downstream 100 bases:

>100_bases
GTCGGGCATGAGTGAAAAAGCAATCTTGAGCTGCCGCAACCTGGGCAAATCCTACGAGGAAGGCCCGGAGTCGGTGGAAG
TGCTGGCCAACCTGCAACTG

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MFRPLFVFIGTRYTRAKRRNHFVSFISLTSMIGLALGVVVMIVVLSVMNGFDHEMRTRVLGMVPHATIESGEAINDWPSL
AAKVKQNPQVAAVAPFTQMQGLLTNNGQVSKVLLNAIDPALERNVSIIDNFMKQGKLDDLTPGSFGIVIGDKAATKLGVG
IGDKITFVAPEVSVTPAGMFPRMKRFTVVGIFHVGAGELDGYLGVTNLQDLAKMHRWKPDQVQGLRLKFDDLFQAPREAW
NIAQRLGEDRYYARDWTRTHGNLYQAIRMEKAMIGLLLLLIVAVAAFNIISTLVMVVNDKKGDIAILRTLGATPGTIMRT
FMVQGTVIGVVGTAIGAVVGIFAALNVSAAISALEGVIGHKFLNADVYFIDYLPSQVQSQDVVMVCAAALVLSFLATLYP
AWRAARTQPAEALRYE

Sequences:

>Translated_416_residues
MFRPLFVFIGTRYTRAKRRNHFVSFISLTSMIGLALGVVVMIVVLSVMNGFDHEMRTRVLGMVPHATIESGEAINDWPSL
AAKVKQNPQVAAVAPFTQMQGLLTNNGQVSKVLLNAIDPALERNVSIIDNFMKQGKLDDLTPGSFGIVIGDKAATKLGVG
IGDKITFVAPEVSVTPAGMFPRMKRFTVVGIFHVGAGELDGYLGVTNLQDLAKMHRWKPDQVQGLRLKFDDLFQAPREAW
NIAQRLGEDRYYARDWTRTHGNLYQAIRMEKAMIGLLLLLIVAVAAFNIISTLVMVVNDKKGDIAILRTLGATPGTIMRT
FMVQGTVIGVVGTAIGAVVGIFAALNVSAAISALEGVIGHKFLNADVYFIDYLPSQVQSQDVVMVCAAALVLSFLATLYP
AWRAARTQPAEALRYE
>Mature_416_residues
MFRPLFVFIGTRYTRAKRRNHFVSFISLTSMIGLALGVVVMIVVLSVMNGFDHEMRTRVLGMVPHATIESGEAINDWPSL
AAKVKQNPQVAAVAPFTQMQGLLTNNGQVSKVLLNAIDPALERNVSIIDNFMKQGKLDDLTPGSFGIVIGDKAATKLGVG
IGDKITFVAPEVSVTPAGMFPRMKRFTVVGIFHVGAGELDGYLGVTNLQDLAKMHRWKPDQVQGLRLKFDDLFQAPREAW
NIAQRLGEDRYYARDWTRTHGNLYQAIRMEKAMIGLLLLLIVAVAAFNIISTLVMVVNDKKGDIAILRTLGATPGTIMRT
FMVQGTVIGVVGTAIGAVVGIFAALNVSAAISALEGVIGHKFLNADVYFIDYLPSQVQSQDVVMVCAAALVLSFLATLYP
AWRAARTQPAEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=417, Percent_Identity=36.9304556354916, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI1787362, Length=414, Percent_Identity=37.1980676328502, Blast_Score=250, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45380; Mature: 45380

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRPLFVFIGTRYTRAKRRNHFVSFISLTSMIGLALGVVVMIVVLSVMNGFDHEMRTRVL
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GMVPHATIESGEAINDWPSLAAKVKQNPQVAAVAPFTQMQGLLTNNGQVSKVLLNAIDPA
HCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHCHH
LERNVSIIDNFMKQGKLDDLTPGSFGIVIGDKAATKLGVGIGDKITFVAPEVSVTPAGMF
HHCCHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHCCCCCCCEEEECCCCCCCCCCCC
PRMKRFTVVGIFHVGAGELDGYLGVTNLQDLAKMHRWKPDQVQGLRLKFDDLFQAPREAW
CHHHHEEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCHHCCCEEEHHHHHHCHHHHH
NIAQRLGEDRYYARDWTRTHGNLYQAIRMEKAMIGLLLLLIVAVAAFNIISTLVMVVNDK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KGDIAILRTLGATPGTIMRTFMVQGTVIGVVGTAIGAVVGIFAALNVSAAISALEGVIGH
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFLNADVYFIDYLPSQVQSQDVVMVCAAALVLSFLATLYPAWRAARTQPAEALRYE
HHHCCCEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
>Mature Secondary Structure
MFRPLFVFIGTRYTRAKRRNHFVSFISLTSMIGLALGVVVMIVVLSVMNGFDHEMRTRVL
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GMVPHATIESGEAINDWPSLAAKVKQNPQVAAVAPFTQMQGLLTNNGQVSKVLLNAIDPA
HCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHCHH
LERNVSIIDNFMKQGKLDDLTPGSFGIVIGDKAATKLGVGIGDKITFVAPEVSVTPAGMF
HHCCHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHCCCCCCCEEEECCCCCCCCCCCC
PRMKRFTVVGIFHVGAGELDGYLGVTNLQDLAKMHRWKPDQVQGLRLKFDDLFQAPREAW
CHHHHEEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCHHCCCEEEHHHHHHCHHHHH
NIAQRLGEDRYYARDWTRTHGNLYQAIRMEKAMIGLLLLLIVAVAAFNIISTLVMVVNDK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KGDIAILRTLGATPGTIMRTFMVQGTVIGVVGTAIGAVVGIFAALNVSAAISALEGVIGH
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFLNADVYFIDYLPSQVQSQDVVMVCAAALVLSFLATLYPAWRAARTQPAEALRYE
HHHCCCEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]