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The map label for this gene is sthA [H]

Identifier: 77460083

GI number: 77460083

Start: 4362990

End: 4364384

Strand: Reverse

Name: sthA [H]

Synonym: Pfl01_3862

Alternate gene names: 77460083

Gene position: 4364384-4362990 (Counterclockwise)

Preceding gene: 77460084

Following gene: 77460080

Centisome position: 67.79

GC content: 60.0

Gene sequence:

>1395_bases
ATGGCTGTCTACAACTACGACGTGGTGGTGCTGGGTTCCGGCCCGGCGGGAGAAGGCGCGGCAATGAACGCCGCCAAAGC
AGGGCGCAAGGTGGCGATGGTCGATAGCCGTCGCCAGGTCGGCGGCAACTGCACCCACCTGGGCACCATCCCGTCCAAGG
CCCTGCGTCACTCGGTGCGGCAGATCATGCAGTTCAACACCAATCCGATGTTCCGTGCGATCGGCGAGCCGCGCTGGTTC
TCCTTCCCGGATGTGTTGAAAAGCGCCGAGAAAGTCATCTCCAAGCAAGTCGCTTCGCGTACCGGCTACTACGCCCGTAA
CCGCGTCGACGTGTTTTTCGGCACCGGCAGCTTTGCCGACGAGCAAACCATCGAAGTGGTCTGCGCCAACGGCGTGGTCG
AAAAACTGGTGGCCAAGCACATCATCATCGCCACCGGTTCGCGTCCTTATCGCCCGGCGGACATCGATTTCCACCACCCG
CGTATCTACGATAGCGACACTATCCTCAGCCTCGGCCACACCCCGCGCAAACTGATCGTTTACGGCGCCGGCGTGATCGG
TTGCGAATACGCTTCTATCTTCAGTGGTCTGGGCGTGCTGGTCGAGCTGGTGGACAACCGCGGCCAGTTGCTGAGCTTCC
TCGACTCGGAAATCTCCCAGGCGTTGAGCTACCACTTCAGCAACAACAACATCACCGTGCGTCACAACGAAGAATATGAC
CGCGTCGAAGGCGTGGACAACGGCGTGATCCTGCACCTGAAGTCCGGCAAGAAGATCAAGGCCGATGCCTTGCTCTGGTG
CAACGGCCGTACCGGTAACACCGATCAGTTGGGTCTGGAAAACATCGGGGTCAAGGTCAACAGCCGTGGCCAGATCGAAG
TCGACGAGAATTACCGTACCTGCGTGCAGAACATCTATGGCGCCGGTGACGTGATCGGCTGGCCGAGCCTGGCCAGTGCC
GCCCACGACCAGGGCCGTTCGGCCGCTGGCAGCATCGTCGACAATGGCAGCTGGCGCTTCGTGAATGACGTGCCGACCGG
CATCTACACCATTCCGGAGATCAGCTCGATCGGCAAGAACGAGCAGGAACTGACCCAGGCCAAAGTGCCGTATGAAGTGG
GCAAGGCGTTCTTCAAGAGCATGGCGCGGGCACAGATCGCCGGCGAGCCGCAAGGCATGCTGAAGATCCTGTTCCACCGT
GAAACCCTGGAAGTGCTGGGCGTTCACTGCTTCGGTTATCAGGCGTCGGAGATCGTGCACATCGGTCAGGCGATCATGAA
CCAGCCAGGTGAGCTGAATACTCTGAAATACTTCGTCAACACGACGTTCAACTACCCGACCATGGCCGAAGCCTATCGGG
TAGCGGCGTACGACGGCCTCAACCGGCTTTTTTGA

Upstream 100 bases:

>100_bases
CCGGGTTTTCTACTGGCCCCCAATTGTTCCTTCGCGCCGTCGTTCGGCGTGATTTAGCCGCCGGTGCTGCTGGCACCGCG
GCCTGTTCTGAGGAGTACGC

Downstream 100 bases:

>100_bases
CGGGCTCCGGCCGGTGGCCTGAGCCGGCCGGGGAGACCGATTTCAGCAATTCCCGAGGGTGGCAGTGGCCAAACCGGGAA
AGTCTGTAATCAGGCTGTCA

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MAVYNYDVVVLGSGPAGEGAAMNAAKAGRKVAMVDSRRQVGGNCTHLGTIPSKALRHSVRQIMQFNTNPMFRAIGEPRWF
SFPDVLKSAEKVISKQVASRTGYYARNRVDVFFGTGSFADEQTIEVVCANGVVEKLVAKHIIIATGSRPYRPADIDFHHP
RIYDSDTILSLGHTPRKLIVYGAGVIGCEYASIFSGLGVLVELVDNRGQLLSFLDSEISQALSYHFSNNNITVRHNEEYD
RVEGVDNGVILHLKSGKKIKADALLWCNGRTGNTDQLGLENIGVKVNSRGQIEVDENYRTCVQNIYGAGDVIGWPSLASA
AHDQGRSAAGSIVDNGSWRFVNDVPTGIYTIPEISSIGKNEQELTQAKVPYEVGKAFFKSMARAQIAGEPQGMLKILFHR
ETLEVLGVHCFGYQASEIVHIGQAIMNQPGELNTLKYFVNTTFNYPTMAEAYRVAAYDGLNRLF

Sequences:

>Translated_464_residues
MAVYNYDVVVLGSGPAGEGAAMNAAKAGRKVAMVDSRRQVGGNCTHLGTIPSKALRHSVRQIMQFNTNPMFRAIGEPRWF
SFPDVLKSAEKVISKQVASRTGYYARNRVDVFFGTGSFADEQTIEVVCANGVVEKLVAKHIIIATGSRPYRPADIDFHHP
RIYDSDTILSLGHTPRKLIVYGAGVIGCEYASIFSGLGVLVELVDNRGQLLSFLDSEISQALSYHFSNNNITVRHNEEYD
RVEGVDNGVILHLKSGKKIKADALLWCNGRTGNTDQLGLENIGVKVNSRGQIEVDENYRTCVQNIYGAGDVIGWPSLASA
AHDQGRSAAGSIVDNGSWRFVNDVPTGIYTIPEISSIGKNEQELTQAKVPYEVGKAFFKSMARAQIAGEPQGMLKILFHR
ETLEVLGVHCFGYQASEIVHIGQAIMNQPGELNTLKYFVNTTFNYPTMAEAYRVAAYDGLNRLF
>Mature_463_residues
AVYNYDVVVLGSGPAGEGAAMNAAKAGRKVAMVDSRRQVGGNCTHLGTIPSKALRHSVRQIMQFNTNPMFRAIGEPRWFS
FPDVLKSAEKVISKQVASRTGYYARNRVDVFFGTGSFADEQTIEVVCANGVVEKLVAKHIIIATGSRPYRPADIDFHHPR
IYDSDTILSLGHTPRKLIVYGAGVIGCEYASIFSGLGVLVELVDNRGQLLSFLDSEISQALSYHFSNNNITVRHNEEYDR
VEGVDNGVILHLKSGKKIKADALLWCNGRTGNTDQLGLENIGVKVNSRGQIEVDENYRTCVQNIYGAGDVIGWPSLASAA
HDQGRSAAGSIVDNGSWRFVNDVPTGIYTIPEISSIGKNEQELTQAKVPYEVGKAFFKSMARAQIAGEPQGMLKILFHRE
TLEVLGVHCFGYQASEIVHIGQAIMNQPGELNTLKYFVNTTFNYPTMAEAYRVAAYDGLNRLF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=468, Percent_Identity=31.4102564102564, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI50301238, Length=467, Percent_Identity=26.9807280513919, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI22035672, Length=487, Percent_Identity=29.1581108829569, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI291045266, Length=501, Percent_Identity=23.75249500998, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI33519430, Length=446, Percent_Identity=24.2152466367713, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI33519428, Length=446, Percent_Identity=24.2152466367713, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI33519426, Length=446, Percent_Identity=24.2152466367713, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI148277065, Length=388, Percent_Identity=25, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI148277071, Length=393, Percent_Identity=25.4452926208651, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI291045268, Length=370, Percent_Identity=24.5945945945946, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87082354, Length=462, Percent_Identity=59.95670995671, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI1786307, Length=459, Percent_Identity=31.8082788671024, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=29.3849658314351, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87081717, Length=474, Percent_Identity=26.5822784810127, Blast_Score=143, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI32565766, Length=467, Percent_Identity=30.6209850107066, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17557007, Length=481, Percent_Identity=24.1164241164241, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71983429, Length=414, Percent_Identity=26.8115942028986, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71983419, Length=414, Percent_Identity=26.8115942028986, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17559934, Length=221, Percent_Identity=28.0542986425339, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=477, Percent_Identity=29.979035639413, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6325166, Length=468, Percent_Identity=29.4871794871795, Blast_Score=156, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=472, Percent_Identity=28.1779661016949, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21358499, Length=471, Percent_Identity=32.0594479830149, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24640553, Length=479, Percent_Identity=28.6012526096033, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24640549, Length=479, Percent_Identity=28.6012526096033, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24640551, Length=479, Percent_Identity=28.6012526096033, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI17737741, Length=495, Percent_Identity=28.2828282828283, Blast_Score=119, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 50891; Mature: 50760

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVYNYDVVVLGSGPAGEGAAMNAAKAGRKVAMVDSRRQVGGNCTHLGTIPSKALRHSVR
CEEEEEEEEEECCCCCCCCCCCCHHHCCCEEEEECCHHHCCCCEEEECCCCHHHHHHHHH
QIMQFNTNPMFRAIGEPRWFSFPDVLKSAEKVISKQVASRTGYYARNRVDVFFGTGSFAD
HHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCEEEEEEECCCCCC
EQTIEVVCANGVVEKLVAKHIIIATGSRPYRPADIDFHHPRIYDSDTILSLGHTPRKLIV
CCEEEEEECCHHHHHHHHCEEEEEECCCCCCCCCCCCCCCEEECCCCEEECCCCCCEEEE
YGAGVIGCEYASIFSGLGVLVELVDNRGQLLSFLDSEISQALSYHFSNNNITVRHNEEYD
EECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCEEEEEECCCHH
RVEGVDNGVILHLKSGKKIKADALLWCNGRTGNTDQLGLENIGVKVNSRGQIEVDENYRT
HHCCCCCCEEEEECCCCEEECCEEEEECCCCCCCCCCCHHHCCEEECCCCCEEECCHHHH
CVQNIYGAGDVIGWPSLASAAHDQGRSAAGSIVDNGSWRFVNDVPTGIYTIPEISSIGKN
HHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCEEECCCEEEECCCCCCEEECCCHHHCCCC
EQELTQAKVPYEVGKAFFKSMARAQIAGEPQGMLKILFHRETLEVLGVHCFGYQASEIVH
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCHHHHHH
IGQAIMNQPGELNTLKYFVNTTFNYPTMAEAYRVAAYDGLNRLF
HHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AVYNYDVVVLGSGPAGEGAAMNAAKAGRKVAMVDSRRQVGGNCTHLGTIPSKALRHSVR
EEEEEEEEEECCCCCCCCCCCCHHHCCCEEEEECCHHHCCCCEEEECCCCHHHHHHHHH
QIMQFNTNPMFRAIGEPRWFSFPDVLKSAEKVISKQVASRTGYYARNRVDVFFGTGSFAD
HHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCEEEEEEECCCCCC
EQTIEVVCANGVVEKLVAKHIIIATGSRPYRPADIDFHHPRIYDSDTILSLGHTPRKLIV
CCEEEEEECCHHHHHHHHCEEEEEECCCCCCCCCCCCCCCEEECCCCEEECCCCCCEEEE
YGAGVIGCEYASIFSGLGVLVELVDNRGQLLSFLDSEISQALSYHFSNNNITVRHNEEYD
EECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCEEEEEECCCHH
RVEGVDNGVILHLKSGKKIKADALLWCNGRTGNTDQLGLENIGVKVNSRGQIEVDENYRT
HHCCCCCCEEEEECCCCEEECCEEEEECCCCCCCCCCCHHHCCEEECCCCCEEECCHHHH
CVQNIYGAGDVIGWPSLASAAHDQGRSAAGSIVDNGSWRFVNDVPTGIYTIPEISSIGKN
HHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCEEECCCEEEECCCCCCEEECCCHHHCCCC
EQELTQAKVPYEVGKAFFKSMARAQIAGEPQGMLKILFHRETLEVLGVHCFGYQASEIVH
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCHHHHHH
IGQAIMNQPGELNTLKYFVNTTFNYPTMAEAYRVAAYDGLNRLF
HHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA