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The map label for this gene is copR [H]

Identifier: 77460076

GI number: 77460076

Start: 4356235

End: 4356915

Strand: Direct

Name: copR [H]

Synonym: Pfl01_3855

Alternate gene names: 77460076

Gene position: 4356235-4356915 (Clockwise)

Preceding gene: 77460073

Following gene: 77460077

Centisome position: 67.66

GC content: 61.82

Gene sequence:

>681_bases
ATGAAACTGCTGATCGTCGAAGACCAACCCAAAACCGGCCAGTACCTGCGCCAGGGCCTGACCGAGGCCGGTTTCAACAC
CGAACTGGTGGCCGACGGCACCACCGGCCAGCAATTGGCGTTGAGTGGCGACTATGCGCTGCTGATCCTCGATGTGATGC
TGCCCGGACGCAATGGCTGGCAGATCCTGCAGGCGGTGCGCAGCGCCGGCCTGGAAACACCGATCCTGTTTTTGACCGCC
AAGGACACCGTGGAAGATAGGGTTCACGGCCTCGAACTGGGCGCCGACGACTACCTGGTCAAACCGTTCGCTTTCTCCGA
ACTGCTGGCGCGGGTGCGCAGCCTGTTACGCCGCGGCAGTTCCACGCCCCAGGAAACCAGCCTGCGCCTGGCCGATCTGA
GTCTGGATCTGATCCGCCGCCGGGTCGAACGCAGCGGTCAACGCATCGACCTCACCGCCAAAGAGTTCGCCCTGCTGGAA
ATGCTCCTGCGCCGTCAGGGCGAAGTGCTGCCCAAGTCACTGATCGCCTCGCAGGTCTGGGACATGAACTTCGACAGCGA
CACCAATGTGATCGAAGTGGCGATTCGTCGACTGCGCCTGAAGATCGATGACGACTTCCCCAACAAGCTGATCCACACCG
TACGCGGCATGGGTTACGTCCTTGAAGAGCGTGCCGACTGA

Upstream 100 bases:

>100_bases
GCTGGCAGCGACCTGACAGAGAGATTACAACTTTGTCAGTTTGGCGCTCACCGCGTGAGCCCACGGTATAACGTCCTCGT
TCCCGCTACCCGAGTTGCCC

Downstream 100 bases:

>100_bases
TGCGCCGACTGTCCTTGAGCGGCCGATTGGTGCTGTTGTTCGCCGGCTGCACCGCAGTGGTTTCGCTGGTCGCCGGGGTG
GTGTTCAATCGGGCCAGCGA

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MKLLIVEDQPKTGQYLRQGLTEAGFNTELVADGTTGQQLALSGDYALLILDVMLPGRNGWQILQAVRSAGLETPILFLTA
KDTVEDRVHGLELGADDYLVKPFAFSELLARVRSLLRRGSSTPQETSLRLADLSLDLIRRRVERSGQRIDLTAKEFALLE
MLLRRQGEVLPKSLIASQVWDMNFDSDTNVIEVAIRRLRLKIDDDFPNKLIHTVRGMGYVLEERAD

Sequences:

>Translated_226_residues
MKLLIVEDQPKTGQYLRQGLTEAGFNTELVADGTTGQQLALSGDYALLILDVMLPGRNGWQILQAVRSAGLETPILFLTA
KDTVEDRVHGLELGADDYLVKPFAFSELLARVRSLLRRGSSTPQETSLRLADLSLDLIRRRVERSGQRIDLTAKEFALLE
MLLRRQGEVLPKSLIASQVWDMNFDSDTNVIEVAIRRLRLKIDDDFPNKLIHTVRGMGYVLEERAD
>Mature_226_residues
MKLLIVEDQPKTGQYLRQGLTEAGFNTELVADGTTGQQLALSGDYALLILDVMLPGRNGWQILQAVRSAGLETPILFLTA
KDTVEDRVHGLELGADDYLVKPFAFSELLARVRSLLRRGSSTPQETSLRLADLSLDLIRRRVERSGQRIDLTAKEFALLE
MLLRRQGEVLPKSLIASQVWDMNFDSDTNVIEVAIRRLRLKIDDDFPNKLIHTVRGMGYVLEERAD

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=66.6666666666667, Blast_Score=300, Evalue=7e-83,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=54.7945205479452, Blast_Score=248, Evalue=3e-67,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=39.2857142857143, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=38.4615384615385, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=35.2422907488987, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=33.0357142857143, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=31.5555555555556, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=34.4978165938865, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=31.7180616740088, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.5263157894737, Blast_Score=107, Evalue=4e-25,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=33.4841628959276, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=34.5454545454545, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=28.9473684210526, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=27.9661016949153, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=31.7757009345794, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25419; Mature: 25419

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLIVEDQPKTGQYLRQGLTEAGFNTELVADGTTGQQLALSGDYALLILDVMLPGRNGW
CEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCCCEEEECCCHHEEHEEHHCCCCCHH
QILQAVRSAGLETPILFLTAKDTVEDRVHGLELGADDYLVKPFAFSELLARVRSLLRRGS
HHHHHHHHCCCCCCEEEEEECHHHHHHHHHHEECCCCCEECHHHHHHHHHHHHHHHHCCC
STPQETSLRLADLSLDLIRRRVERSGQRIDLTAKEFALLEMLLRRQGEVLPKSLIASQVW
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
DMNFDSDTNVIEVAIRRLRLKIDDDFPNKLIHTVRGMGYVLEERAD
CCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLLIVEDQPKTGQYLRQGLTEAGFNTELVADGTTGQQLALSGDYALLILDVMLPGRNGW
CEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCCCEEEECCCHHEEHEEHHCCCCCHH
QILQAVRSAGLETPILFLTAKDTVEDRVHGLELGADDYLVKPFAFSELLARVRSLLRRGS
HHHHHHHHCCCCCCEEEEEECHHHHHHHHHHEECCCCCEECHHHHHHHHHHHHHHHHCCC
STPQETSLRLADLSLDLIRRRVERSGQRIDLTAKEFALLEMLLRRQGEVLPKSLIASQVW
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
DMNFDSDTNVIEVAIRRLRLKIDDDFPNKLIHTVRGMGYVLEERAD
CCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]