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The map label for this gene is copS [H]

Identifier: 77460077

GI number: 77460077

Start: 4356915

End: 4358255

Strand: Direct

Name: copS [H]

Synonym: Pfl01_3856

Alternate gene names: 77460077

Gene position: 4356915-4358255 (Clockwise)

Preceding gene: 77460076

Following gene: 77460081

Centisome position: 67.67

GC content: 62.34

Gene sequence:

>1341_bases
ATGCGCCGACTGTCCTTGAGCGGCCGATTGGTGCTGTTGTTCGCCGGCTGCACCGCAGTGGTTTCGCTGGTCGCCGGGGT
GGTGTTCAATCGGGCCAGCGAAGGCCACTTCATCGAACTCGACCAGCAATTGCTCGAAGGAAAACTGCTCAGCGTGCGTC
AGACGCTGCGCAGCGGTAGCGACGCCGCGCACATCACCGATGAATTGAGCCAACAGGGCGATGTTTCGTTGCGTATCAGC
AGCTCTGAGGGGCAGCGCTGGTTCGGTCGCTCGTTGCATACCCCGGCGAATCTGCCGCAACAGCCCGGCCTGGCCACCAT
CAACGACAACGGCACCGACTATCGCCTGCTCAACGCCGCGCTTGAACCGGGAAAACCCGATTCCCCGCAATTGACCTTGC
TGCTGGACATCACCCACCACCAGCACTTCCTGCAACGCATGCAGCATCTGATCTGGCTGACCGTCGGCCTGTCGGCGCTG
GCCACTGCGCTGCTCGGCGCCTGGGCTGCCCGCAGCGGTCTTCGCCCGTTACGCCGCATGAGTGCGGTCGCCCGGGGGAT
TTCGGCGCAATCGCTGAATGCCCGACTGCCGGACGCACGGATGCCTGCAGAACTCGCGGAATTGGCCCACAGCTTCAACG
CCATGCTCGGACGCCTCGATGACTCCTTTCAGCGGCTGTCAGCGTTTTCCGCCGACATCGCCCATGAACTGCGCACCCCA
TTGTCAAACCTGCTGACTCAAACTCAGGTCACCCTGACCCGCCCTCGCCCCCTCGAAGACTATCGCGAGGCACTGCACAG
CAACCTCGAAGAGCTGCAATGGATGGCGCAGTTGGTGAACGACATGCTTTATCTGGCCAAGGCTGACCACGGCTTGCTGG
TGCCCAAGCGTGAACCGCTGGAGCTGGCGGAAGAAGCCGATGCGTTGCTGGAGTTTTTTGCGCCGCTGGCCGAAGACGCT
CAGGTCAGCCTCAGCCGTGACGGTGCGGGGCGGTTCGAGGGTGATCGCGCGATGTTGCGTCGGGCGCTGTCGAATCTGCT
GGATAACGCGTTGCGCTTTACCCCGGCCGCCGGCGAAGTGCGTGTAAAGGTGGTCGAGCAGGCGAAATTCTTGAGCGTGA
CTGTGGAGAACAGTGGTGAGGGGATTTCTGTCGAGTTGTTGCCGCGCTTGTTCGACCGCTTCTACCGGGCGGATCCGGCG
CGCCAGGAAGGCAGCAGCGAGCATGCGGGATTGGGGCTGGCGATCACTCAGTCGATCATCCGGGCCCATGGCGGGCAGAT
TCATTGCGAATCGGCTCAGGGCTGGACGCGGTTTGTGATTGAGTTGCCGAAAAACGATTGA

Upstream 100 bases:

>100_bases
CGATTCGTCGACTGCGCCTGAAGATCGATGACGACTTCCCCAACAAGCTGATCCACACCGTACGCGGCATGGGTTACGTC
CTTGAAGAGCGTGCCGACTG

Downstream 100 bases:

>100_bases
GGCCGGCAATGCCGGCCTCAATGGGGAACTTACGAATAGCGCAATGCGTGCGCCGGTTCGATCTTCGCCGCCCGCCAGGC
CGGGTAAACCGTGGCCAGGA

Product: heavy metal sensor Signal transduction histidine kinase (STHK)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MRRLSLSGRLVLLFAGCTAVVSLVAGVVFNRASEGHFIELDQQLLEGKLLSVRQTLRSGSDAAHITDELSQQGDVSLRIS
SSEGQRWFGRSLHTPANLPQQPGLATINDNGTDYRLLNAALEPGKPDSPQLTLLLDITHHQHFLQRMQHLIWLTVGLSAL
ATALLGAWAARSGLRPLRRMSAVARGISAQSLNARLPDARMPAELAELAHSFNAMLGRLDDSFQRLSAFSADIAHELRTP
LSNLLTQTQVTLTRPRPLEDYREALHSNLEELQWMAQLVNDMLYLAKADHGLLVPKREPLELAEEADALLEFFAPLAEDA
QVSLSRDGAGRFEGDRAMLRRALSNLLDNALRFTPAAGEVRVKVVEQAKFLSVTVENSGEGISVELLPRLFDRFYRADPA
RQEGSSEHAGLGLAITQSIIRAHGGQIHCESAQGWTRFVIELPKND

Sequences:

>Translated_446_residues
MRRLSLSGRLVLLFAGCTAVVSLVAGVVFNRASEGHFIELDQQLLEGKLLSVRQTLRSGSDAAHITDELSQQGDVSLRIS
SSEGQRWFGRSLHTPANLPQQPGLATINDNGTDYRLLNAALEPGKPDSPQLTLLLDITHHQHFLQRMQHLIWLTVGLSAL
ATALLGAWAARSGLRPLRRMSAVARGISAQSLNARLPDARMPAELAELAHSFNAMLGRLDDSFQRLSAFSADIAHELRTP
LSNLLTQTQVTLTRPRPLEDYREALHSNLEELQWMAQLVNDMLYLAKADHGLLVPKREPLELAEEADALLEFFAPLAEDA
QVSLSRDGAGRFEGDRAMLRRALSNLLDNALRFTPAAGEVRVKVVEQAKFLSVTVENSGEGISVELLPRLFDRFYRADPA
RQEGSSEHAGLGLAITQSIIRAHGGQIHCESAQGWTRFVIELPKND
>Mature_446_residues
MRRLSLSGRLVLLFAGCTAVVSLVAGVVFNRASEGHFIELDQQLLEGKLLSVRQTLRSGSDAAHITDELSQQGDVSLRIS
SSEGQRWFGRSLHTPANLPQQPGLATINDNGTDYRLLNAALEPGKPDSPQLTLLLDITHHQHFLQRMQHLIWLTVGLSAL
ATALLGAWAARSGLRPLRRMSAVARGISAQSLNARLPDARMPAELAELAHSFNAMLGRLDDSFQRLSAFSADIAHELRTP
LSNLLTQTQVTLTRPRPLEDYREALHSNLEELQWMAQLVNDMLYLAKADHGLLVPKREPLELAEEADALLEFFAPLAEDA
QVSLSRDGAGRFEGDRAMLRRALSNLLDNALRFTPAAGEVRVKVVEQAKFLSVTVENSGEGISVELLPRLFDRFYRADPA
RQEGSSEHAGLGLAITQSIIRAHGGQIHCESAQGWTRFVIELPKND

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon copABCD. Specifically recognizes or transduces a signal only in response to copper. This would lead to phosphorylation of CopR in the cyto

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=336, Percent_Identity=42.5595238095238, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1788279, Length=458, Percent_Identity=27.9475982532751, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788393, Length=307, Percent_Identity=32.2475570032573, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=33.1877729257642, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=31.021897810219, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=27.9352226720648, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1789149, Length=224, Percent_Identity=29.9107142857143, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787894, Length=312, Percent_Identity=26.9230769230769, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=28.0542986425339, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788549, Length=230, Percent_Identity=27.3913043478261, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790551, Length=305, Percent_Identity=27.8688524590164, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789403, Length=258, Percent_Identity=29.0697674418605, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI48994928, Length=240, Percent_Identity=27.5, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=26.431718061674, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=380, Percent_Identity=23.9473684210526, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87081816, Length=248, Percent_Identity=27.4193548387097, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=25, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1787374, Length=310, Percent_Identity=24.1935483870968, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49093; Mature: 49093

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLSLSGRLVLLFAGCTAVVSLVAGVVFNRASEGHFIELDQQLLEGKLLSVRQTLRSGS
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCC
DAAHITDELSQQGDVSLRISSSEGQRWFGRSLHTPANLPQQPGLATINDNGTDYRLLNAA
CCHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHH
LEPGKPDSPQLTLLLDITHHQHFLQRMQHLIWLTVGLSALATALLGAWAARSGLRPLRRM
CCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
SAVARGISAQSLNARLPDARMPAELAELAHSFNAMLGRLDDSFQRLSAFSADIAHELRTP
HHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSNLLTQTQVTLTRPRPLEDYREALHSNLEELQWMAQLVNDMLYLAKADHGLLVPKREPL
HHHHHHHHHEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
ELAEEADALLEFFAPLAEDAQVSLSRDGAGRFEGDRAMLRRALSNLLDNALRFTPAAGEV
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCE
RVKVVEQAKFLSVTVENSGEGISVELLPRLFDRFYRADPARQEGSSEHAGLGLAITQSII
EEEEECCCEEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
RAHGGQIHCESAQGWTRFVIELPKND
HHCCCEEEEECCCCCEEEEEECCCCC
>Mature Secondary Structure
MRRLSLSGRLVLLFAGCTAVVSLVAGVVFNRASEGHFIELDQQLLEGKLLSVRQTLRSGS
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCC
DAAHITDELSQQGDVSLRISSSEGQRWFGRSLHTPANLPQQPGLATINDNGTDYRLLNAA
CCHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHH
LEPGKPDSPQLTLLLDITHHQHFLQRMQHLIWLTVGLSALATALLGAWAARSGLRPLRRM
CCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
SAVARGISAQSLNARLPDARMPAELAELAHSFNAMLGRLDDSFQRLSAFSADIAHELRTP
HHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSNLLTQTQVTLTRPRPLEDYREALHSNLEELQWMAQLVNDMLYLAKADHGLLVPKREPL
HHHHHHHHHEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
ELAEEADALLEFFAPLAEDAQVSLSRDGAGRFEGDRAMLRRALSNLLDNALRFTPAAGEV
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCE
RVKVVEQAKFLSVTVENSGEGISVELLPRLFDRFYRADPARQEGSSEHAGLGLAITQSII
EEEEECCCEEEEEEEECCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
RAHGGQIHCESAQGWTRFVIELPKND
HHCCCEEEEECCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8449873 [H]