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The map label for this gene is serS [H]

Identifier: 77459804

GI number: 77459804

Start: 4047794

End: 4049074

Strand: Reverse

Name: serS [H]

Synonym: Pfl01_3582

Alternate gene names: 77459804

Gene position: 4049074-4047794 (Counterclockwise)

Preceding gene: 77459805

Following gene: 77459803

Centisome position: 62.89

GC content: 61.98

Gene sequence:

>1281_bases
ATGCTCGATTCCAAACTGTTACGTAGCAACCTTCAGGACGTAGCGGACCGCCTGGCTTCCCGTGGCTTTGCCCTGGATGT
CGCGCGCATCGAAGCGCTGGAAGAACAGCGCAAGACCGTCCAGACCCGCACCGAAGCACTGCAGGCTGAGCGTAACGCGC
GTTCCAAGTCCATCGGTCAGGCCAAGCAGCGCGGCGAAGACATCGCGCCGCTGATGGCGGACGTCGAGCGCATGGCGGGC
GAACTGAGCGCCGGTAAAGTCGAGCTGGAAGCGATCCAGACCGAACTGGATTCGATCCTGCTGGGCATCCCGAACCTGCC
GCACGAATCGGTGCCGGTCGGTGAAGACGAAGACGGCAACGTTGAAGTCCGCCGTTGGGGCACGCCGACCGCGTTCGATT
TCCCGGTTCAGGATCACGTGGCCCTGGGCGAGAAGTTCGGCTGGCTCGACTTCGAAACCGCCGCCAAGCTGTCCGGCGCA
CGCTTTGCACTGCTGCGCGGCCCGATTGCCCGCCTGCACCGCGCACTGGCGCAGTTCATGATCAACCTGCACGTCACCGA
GCACGGCTACGAAGAGGCCTACACGCCTTATCTGGTTCAGGCTCCGGCGCTGCAAGGCACCGGTCAATTGCCGAAGTTCG
AAGAAGACCTGTTCAAGATCGCTCGCGAAGGCGAAGCCGATCTGTACCTGATCCCGACCGCCGAAGTGTCGCTGACCAAC
ATCGTGGCTGGTGAAATCGTCGATTCGAAACAGCTGCCGATCAAGTTCGTCGCTCACACTCCGTGCTTCCGCAGCGAAGC
CGGCGCGTCGGGTCGTGACACTCGCGGCATGATCCGTCAGCACCAGTTCGACAAAGTTGAAATGGTCCAGATCGTCGAGC
CGTCGAAGTCGATGGAAGCGCTGGAAAGCCTCACCGCCAACGCCGAGAAAGTTCTGCAACTGCTGGGTCTGCCTTACCGT
ACCCTGGCGCTGTGCACCGGCGACATGGGCTTCAGCGCGGTCAAGACTTACGACCTTGAAGTGTGGATCCCGAGCCAGGA
CAAATACCGCGAAATCTCGTCGTGCTCCAACTGCGGCGACTTCCAGGCCCGCCGCATGCAGGCGCGTTTCCGCAATCCGG
AAACCGGCAAGCCCGAGCTGGTGCACACCCTGAACGGTTCCGGTCTGGCAGTCGGTCGTACCCTGGTGGCCGTGCTGGAA
AACTACCAGCAGGCCGACGGTTCGATCCGTGTGCCGGACGTGCTGAAGCCGTACATGGGTGGCCTTGAGGTCATCGGTTA
A

Upstream 100 bases:

>100_bases
GCCGCTGGCCCTGGGCTATGCGGCCATCAGCGTATTCGGCGGGCTGCTCGCGACCTGGGCTGGCCTGTCCCTGACCAAAC
TTTGATAACGAGAAACCGAC

Downstream 100 bases:

>100_bases
ATGAAATATCTGCCGCTGTTTCACAACCTGCGCGGCAGTCGTGTGTTGGTTGTTGGTGGGGGGGAGATTGCCTTGCGCAA
GTCCCGCCTGCTGGCCGATG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLDSKLLRSNLQDVADRLASRGFALDVARIEALEEQRKTVQTRTEALQAERNARSKSIGQAKQRGEDIAPLMADVERMAG
ELSAGKVELEAIQTELDSILLGIPNLPHESVPVGEDEDGNVEVRRWGTPTAFDFPVQDHVALGEKFGWLDFETAAKLSGA
RFALLRGPIARLHRALAQFMINLHVTEHGYEEAYTPYLVQAPALQGTGQLPKFEEDLFKIAREGEADLYLIPTAEVSLTN
IVAGEIVDSKQLPIKFVAHTPCFRSEAGASGRDTRGMIRQHQFDKVEMVQIVEPSKSMEALESLTANAEKVLQLLGLPYR
TLALCTGDMGFSAVKTYDLEVWIPSQDKYREISSCSNCGDFQARRMQARFRNPETGKPELVHTLNGSGLAVGRTLVAVLE
NYQQADGSIRVPDVLKPYMGGLEVIG

Sequences:

>Translated_426_residues
MLDSKLLRSNLQDVADRLASRGFALDVARIEALEEQRKTVQTRTEALQAERNARSKSIGQAKQRGEDIAPLMADVERMAG
ELSAGKVELEAIQTELDSILLGIPNLPHESVPVGEDEDGNVEVRRWGTPTAFDFPVQDHVALGEKFGWLDFETAAKLSGA
RFALLRGPIARLHRALAQFMINLHVTEHGYEEAYTPYLVQAPALQGTGQLPKFEEDLFKIAREGEADLYLIPTAEVSLTN
IVAGEIVDSKQLPIKFVAHTPCFRSEAGASGRDTRGMIRQHQFDKVEMVQIVEPSKSMEALESLTANAEKVLQLLGLPYR
TLALCTGDMGFSAVKTYDLEVWIPSQDKYREISSCSNCGDFQARRMQARFRNPETGKPELVHTLNGSGLAVGRTLVAVLE
NYQQADGSIRVPDVLKPYMGGLEVIG
>Mature_426_residues
MLDSKLLRSNLQDVADRLASRGFALDVARIEALEEQRKTVQTRTEALQAERNARSKSIGQAKQRGEDIAPLMADVERMAG
ELSAGKVELEAIQTELDSILLGIPNLPHESVPVGEDEDGNVEVRRWGTPTAFDFPVQDHVALGEKFGWLDFETAAKLSGA
RFALLRGPIARLHRALAQFMINLHVTEHGYEEAYTPYLVQAPALQGTGQLPKFEEDLFKIAREGEADLYLIPTAEVSLTN
IVAGEIVDSKQLPIKFVAHTPCFRSEAGASGRDTRGMIRQHQFDKVEMVQIVEPSKSMEALESLTANAEKVLQLLGLPYR
TLALCTGDMGFSAVKTYDLEVWIPSQDKYREISSCSNCGDFQARRMQARFRNPETGKPELVHTLNGSGLAVGRTLVAVLE
NYQQADGSIRVPDVLKPYMGGLEVIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=366, Percent_Identity=36.3387978142077, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI8923421, Length=399, Percent_Identity=31.077694235589, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI225579074, Length=323, Percent_Identity=33.7461300309598, Blast_Score=188, Evalue=6e-48,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=66.7441860465116, Blast_Score=582, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI17539260, Length=429, Percent_Identity=31.002331002331, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=304, Percent_Identity=30.5921052631579, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=412, Percent_Identity=32.0388349514563, Blast_Score=216, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6321799, Length=445, Percent_Identity=30.3370786516854, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24581334, Length=464, Percent_Identity=32.3275862068966, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI17737985, Length=354, Percent_Identity=31.3559322033898, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 46989; Mature: 46989

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSKLLRSNLQDVADRLASRGFALDVARIEALEEQRKTVQTRTEALQAERNARSKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKQRGEDIAPLMADVERMAGELSAGKVELEAIQTELDSILLGIPNLPHESVPVGEDEDGN
HHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPTAFDFPVQDHVALGEKFGWLDFETAAKLSGARFALLRGPIARLHRALAQFM
EEEEECCCCCEECCCCHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHCHHHHHHHHHHHHH
INLHVTEHGYEEAYTPYLVQAPALQGTGQLPKFEEDLFKIAREGEADLYLIPTAEVSLTN
HHHEEECCCCHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCEEHHH
IVAGEIVDSKQLPIKFVAHTPCFRSEAGASGRDTRGMIRQHQFDKVEMVQIVEPSKSMEA
HHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHEEECCCHHHHH
LESLTANAEKVLQLLGLPYRTLALCTGDMGFSAVKTYDLEVWIPSQDKYREISSCSNCGD
HHHHHCCHHHHHHHHCCCHHHHHHCCCCCCCCEEEEEEEEEEECCCHHHHHHHHCCCCCH
FQARRMQARFRNPETGKPELVHTLNGSGLAVGRTLVAVLENYQQADGSIRVPDVLKPYMG
HHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHC
GLEVIG
CEEECC
>Mature Secondary Structure
MLDSKLLRSNLQDVADRLASRGFALDVARIEALEEQRKTVQTRTEALQAERNARSKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKQRGEDIAPLMADVERMAGELSAGKVELEAIQTELDSILLGIPNLPHESVPVGEDEDGN
HHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPTAFDFPVQDHVALGEKFGWLDFETAAKLSGARFALLRGPIARLHRALAQFM
EEEEECCCCCEECCCCHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHCHHHHHHHHHHHHH
INLHVTEHGYEEAYTPYLVQAPALQGTGQLPKFEEDLFKIAREGEADLYLIPTAEVSLTN
HHHEEECCCCHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCEEHHH
IVAGEIVDSKQLPIKFVAHTPCFRSEAGASGRDTRGMIRQHQFDKVEMVQIVEPSKSMEA
HHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHEEECCCHHHHH
LESLTANAEKVLQLLGLPYRTLALCTGDMGFSAVKTYDLEVWIPSQDKYREISSCSNCGD
HHHHHCCHHHHHHHHCCCHHHHHHCCCCCCCCEEEEEEEEEEECCCHHHHHHHHCCCCCH
FQARRMQARFRNPETGKPELVHTLNGSGLAVGRTLVAVLENYQQADGSIRVPDVLKPYMG
HHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHC
GLEVIG
CEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA