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The map label for this gene is ilvE [H]

Identifier: 77459689

GI number: 77459689

Start: 3952437

End: 3953456

Strand: Direct

Name: ilvE [H]

Synonym: Pfl01_3467

Alternate gene names: 77459689

Gene position: 3952437-3953456 (Clockwise)

Preceding gene: 77459688

Following gene: 77459692

Centisome position: 61.39

GC content: 60.49

Gene sequence:

>1020_bases
ATGGGTAACGAAAGCATCAACTGGGACAAGCTGGGTTTTGACTACATCAAGACCGACAAACGCTATCTGTCGTACTTTCG
CAACGGCGAGTGGGACAAAGGCACCCTGACCGAAGACAACGTGCTGCACATCAGCGAAGGCTCCACTGCCCTTCACTATG
GCCAGCAATGCTTCGAAGGCCTGAAGGCCTATCGTTGCAAGGACGGCTCGATCAACCTGTTCCGTCCGGACCAGAACGCC
GCGCGCATGCAACGCAGCTGCGCCCGCCTGCTGATGCCGCATGTATCCACCGAGCAGTTCATCGAAGCGTGCAAGGAAGT
GGTTCGCGCCAACGAGCGCTTCATCCCGCCTTACGGCACCGGTGGCGCGCTGTACCTGCGTCCGTTCGTGATCGGCGTGG
GTGACAACATCGGCGTGCGTACCGCACCTGAGTTCATCTTCTCGGTGTTCGCGATCCCGGTCGGTGCCTACTTCAAGGGC
GGCCTGACCCCGCACAACTTCCAGATTTCCACCTTCGACCGCGCCGCGCCACAAGGCACCGGTGCCGCCAAGGTCGGTGG
CAACTACGCGGCCAGCCTGATGCCTGGCTCCCAGGCCAAGAAAGCGCACTTCGCTGACGCCATCTACCTGGATCCGCTGA
CCCACAAGAAGATCGAAGAAGTCGGTTCGGCCAACTTCTTCGGGATCACCCACGACAACAAGTTCGTGACCCCGAACTCG
CCATCGGTACTGCCGGGTATCACCCGTCTGTCGCTGATCGAACTGGCCAAGTCCCGTCTGGGCCTGGAAGTGGTCGAAGG
CGACGTATTCATCGACAAGCTGTCGGACTTCAAAGAGGCCGGCGCCTGCGGTACTGCGGCGGTGATCACCCCGATCGGTG
GCATCAGCTACAACGACCACCTGCACGTATTCCACAGCGAAACAGAAGTCGGCCCTGTGACCCAGAAGCTCTACAAAGAG
CTGACCGGCGTGCAGACCGGCGACGTCGAAGCGCCAGCCGGCTGGATCGTCAAGGTTTGA

Upstream 100 bases:

>100_bases
GGCTGCGAAACCGCTCAAGAATGAAGTATTGTTGTGCCCATCCAAAAAAACGTCAGAAGCCTTGAACCGCTTCGGCGGTT
GTTCAGTGATAGAGGGTGTC

Downstream 100 bases:

>100_bases
TCTGACGGCCAGATGCACAAAAGCCCCCATCGAGTGATCGATGGGGGCTTTTTTATTCGCCTCGCTCGCTGGCCTTCATG
GCAATCCGTTTGCCCGCACG

Product: branched-chain amino acid aminotransferase

Products: NA

Alternate protein names: BCAT [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MGNESINWDKLGFDYIKTDKRYLSYFRNGEWDKGTLTEDNVLHISEGSTALHYGQQCFEGLKAYRCKDGSINLFRPDQNA
ARMQRSCARLLMPHVSTEQFIEACKEVVRANERFIPPYGTGGALYLRPFVIGVGDNIGVRTAPEFIFSVFAIPVGAYFKG
GLTPHNFQISTFDRAAPQGTGAAKVGGNYAASLMPGSQAKKAHFADAIYLDPLTHKKIEEVGSANFFGITHDNKFVTPNS
PSVLPGITRLSLIELAKSRLGLEVVEGDVFIDKLSDFKEAGACGTAAVITPIGGISYNDHLHVFHSETEVGPVTQKLYKE
LTGVQTGDVEAPAGWIVKV

Sequences:

>Translated_339_residues
MGNESINWDKLGFDYIKTDKRYLSYFRNGEWDKGTLTEDNVLHISEGSTALHYGQQCFEGLKAYRCKDGSINLFRPDQNA
ARMQRSCARLLMPHVSTEQFIEACKEVVRANERFIPPYGTGGALYLRPFVIGVGDNIGVRTAPEFIFSVFAIPVGAYFKG
GLTPHNFQISTFDRAAPQGTGAAKVGGNYAASLMPGSQAKKAHFADAIYLDPLTHKKIEEVGSANFFGITHDNKFVTPNS
PSVLPGITRLSLIELAKSRLGLEVVEGDVFIDKLSDFKEAGACGTAAVITPIGGISYNDHLHVFHSETEVGPVTQKLYKE
LTGVQTGDVEAPAGWIVKV
>Mature_338_residues
GNESINWDKLGFDYIKTDKRYLSYFRNGEWDKGTLTEDNVLHISEGSTALHYGQQCFEGLKAYRCKDGSINLFRPDQNAA
RMQRSCARLLMPHVSTEQFIEACKEVVRANERFIPPYGTGGALYLRPFVIGVGDNIGVRTAPEFIFSVFAIPVGAYFKGG
LTPHNFQISTFDRAAPQGTGAAKVGGNYAASLMPGSQAKKAHFADAIYLDPLTHKKIEEVGSANFFGITHDNKFVTPNSP
SVLPGITRLSLIELAKSRLGLEVVEGDVFIDKLSDFKEAGACGTAAVITPIGGISYNDHLHVFHSETEVGPVTQKLYKEL
TGVQTGDVEAPAGWIVKV

Specific function: Acts on leucine, isoleucine and valine [H]

COG id: COG0115

COG function: function code EH; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI296010906, Length=316, Percent_Identity=32.2784810126582, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI296010904, Length=316, Percent_Identity=32.2784810126582, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI38176287, Length=316, Percent_Identity=32.2784810126582, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI50658084, Length=334, Percent_Identity=31.7365269461078, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI258614015, Length=287, Percent_Identity=33.4494773519164, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI296010902, Length=316, Percent_Identity=26.5822784810127, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI296010900, Length=316, Percent_Identity=26.5822784810127, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI48994963, Length=319, Percent_Identity=33.5423197492163, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17568601, Length=315, Percent_Identity=33.015873015873, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17565728, Length=305, Percent_Identity=29.5081967213115, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322002, Length=308, Percent_Identity=32.7922077922078, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322608, Length=336, Percent_Identity=29.7619047619048, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24641779, Length=349, Percent_Identity=29.7994269340974, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: 2342 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 11,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001544
- InterPro:   IPR018300
- InterPro:   IPR005786 [H]

Pfam domain/function: PF01063 Aminotran_4 [H]

EC number: =2.6.1.42 [H]

Molecular weight: Translated: 37028; Mature: 36897

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00770 AA_TRANSFER_CLASS_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNESINWDKLGFDYIKTDKRYLSYFRNGEWDKGTLTEDNVLHISEGSTALHYGQQCFEG
CCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
LKAYRCKDGSINLFRPDQNAARMQRSCARLLMPHVSTEQFIEACKEVVRANERFIPPYGT
HHHEECCCCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
GGALYLRPFVIGVGDNIGVRTAPEFIFSVFAIPVGAYFKGGLTPHNFQISTFDRAAPQGT
CCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCC
GAAKVGGNYAASLMPGSQAKKAHFADAIYLDPLTHKKIEEVGSANFFGITHDNKFVTPNS
CCEECCCCEEEECCCCCCCCHHHHCCEEEECCCCHHHHHHHCCCCEEEEECCCEEECCCC
PSVLPGITRLSLIELAKSRLGLEVVEGDVFIDKLSDFKEAGACGTAAVITPIGGISYNDH
CCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
LHVFHSETEVGPVTQKLYKELTGVQTGDVEAPAGWIVKV
EEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEC
>Mature Secondary Structure 
GNESINWDKLGFDYIKTDKRYLSYFRNGEWDKGTLTEDNVLHISEGSTALHYGQQCFEG
CCCCCCHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
LKAYRCKDGSINLFRPDQNAARMQRSCARLLMPHVSTEQFIEACKEVVRANERFIPPYGT
HHHEECCCCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
GGALYLRPFVIGVGDNIGVRTAPEFIFSVFAIPVGAYFKGGLTPHNFQISTFDRAAPQGT
CCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCC
GAAKVGGNYAASLMPGSQAKKAHFADAIYLDPLTHKKIEEVGSANFFGITHDNKFVTPNS
CCEECCCCEEEECCCCCCCCHHHHCCEEEECCCCHHHHHHHCCCCEEEEECCCEEECCCC
PSVLPGITRLSLIELAKSRLGLEVVEGDVFIDKLSDFKEAGACGTAAVITPIGGISYNDH
CCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
LHVFHSETEVGPVTQKLYKELTGVQTGDVEAPAGWIVKV
EEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]