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The map label for this gene is metC [H]

Identifier: 77459471

GI number: 77459471

Start: 3729948

End: 3731126

Strand: Direct

Name: metC [H]

Synonym: Pfl01_3249

Alternate gene names: 77459471

Gene position: 3729948-3731126 (Clockwise)

Preceding gene: 77459470

Following gene: 77459472

Centisome position: 57.93

GC content: 64.04

Gene sequence:

>1179_bases
ATGAGCCAGCACGACAAGAACGCCCGTCAACAAGGCTTCGCCACCCGCGTGATCCATGCCGGGCAAACGCCGGATCCGAC
CACCGGCGCGCTGATGCCGCCGATCTACGCCAACTCCACGTACCTGCAAGACAGCCCTGGCGTGCACAAGGGTTTCGACT
ATGGCCGCTCGCACAACCCGACGCGTTTTGCCCTGGAGCGCTGCGTGGCGGATCTGGAGGGCGGCACCCAGGCGTTCGCC
TTCGCGTCTGGGCTGGCGACGATTTCCACCGTACTCGAACTGATCGATGCCGGCTCGCACATCGTGTCCGGCAATGACCT
GTACGGCGGCACGTTCCGCCTGTTCGACAAGGTGCGCCAGCGCAGTGCCGGGCATCGTTTCAGCTACGTCGATCTGGCCG
ATCTGTCAGCGTTCGAAGCCTCGCTGCAGGACGACACGCGCATGGTCATGGTCGAGACTCCGACCAACCCGCTGCTGAGC
CTGTCCGACCTCGCCGCCATTGCGCGCATCTGCAAGGCCCGCGGGATCATCTGCGTGGCCGACAACACCTTTGCCAGCCC
ATGGATTCAGCGTCCTCTGGAACTGGGCTTCGACATCGTGCTGCACTCGACCACCAAGTACCTGAACGGTCACTCCGACG
TGATCGGCGGGATCGCGGTCGTTGGCGACAATCCTGCGCTGGCCGAACGTCTGGGCTTTCTGCAGAACGCCGTCGGCGCC
ATCTCCGGCCCGTTCGACGCGTTCCTCACCCTGCGCGGCGTGAAAACCCTGGCGCTGCGTATGGAGCGTCACTGCAGCAA
CGCGCTGGAGCTGGCGCGCTGGCTGGAGCAGCAGCCGCAGGTCAAACGCGTCTACTACCCGGGTCTGGAATCCCACCCGC
AACACGAACTGGCCAAGCGTCAGATGCGTGGTTTCGGCGGAATGATTTCCCTGGATCTGAACAGTGATCTGGCAGGCGCC
CGGCGTTTCCTGGAGAACGTGCAGATCTTCGCCCTGGCCGAAAGCCTCGGTGGTGTGGAAAGCCTGATCGAGCACCCGGC
GATCATGACTCACGCGACCATTCCGGCGGAAACCCGCGCCAAACTTGGCATCGGTGACAGCCTGGTGCGTCTGTCGGTGG
GCGTCGAGGACATCGAGGACCTGCGTGCGGATCTGGCGCAGGCGTTGGCCAGTATCTAA

Upstream 100 bases:

>100_bases
TGCTCAGCAGCGGTCTGGTGGCCATCATCGCCGACGCTTCAGGCTTCCACGGCCTGATCACCCGCGTCGACATGCTCAAT
CAATTACGGAGATCCCTGGC

Downstream 100 bases:

>100_bases
CGCCGGAAAACGTCAAAGCCCGCGCGAGGCGGGCTTTGGTATTTGAGTAGGCGGCCAGTGCTGGTCTCTGGCTTACGAGG
TTTCTCAGGACTCCCACAGT

Product: cystathionine gamma-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSQHDKNARQQGFATRVIHAGQTPDPTTGALMPPIYANSTYLQDSPGVHKGFDYGRSHNPTRFALERCVADLEGGTQAFA
FASGLATISTVLELIDAGSHIVSGNDLYGGTFRLFDKVRQRSAGHRFSYVDLADLSAFEASLQDDTRMVMVETPTNPLLS
LSDLAAIARICKARGIICVADNTFASPWIQRPLELGFDIVLHSTTKYLNGHSDVIGGIAVVGDNPALAERLGFLQNAVGA
ISGPFDAFLTLRGVKTLALRMERHCSNALELARWLEQQPQVKRVYYPGLESHPQHELAKRQMRGFGGMISLDLNSDLAGA
RRFLENVQIFALAESLGGVESLIEHPAIMTHATIPAETRAKLGIGDSLVRLSVGVEDIEDLRADLAQALASI

Sequences:

>Translated_392_residues
MSQHDKNARQQGFATRVIHAGQTPDPTTGALMPPIYANSTYLQDSPGVHKGFDYGRSHNPTRFALERCVADLEGGTQAFA
FASGLATISTVLELIDAGSHIVSGNDLYGGTFRLFDKVRQRSAGHRFSYVDLADLSAFEASLQDDTRMVMVETPTNPLLS
LSDLAAIARICKARGIICVADNTFASPWIQRPLELGFDIVLHSTTKYLNGHSDVIGGIAVVGDNPALAERLGFLQNAVGA
ISGPFDAFLTLRGVKTLALRMERHCSNALELARWLEQQPQVKRVYYPGLESHPQHELAKRQMRGFGGMISLDLNSDLAGA
RRFLENVQIFALAESLGGVESLIEHPAIMTHATIPAETRAKLGIGDSLVRLSVGVEDIEDLRADLAQALASI
>Mature_391_residues
SQHDKNARQQGFATRVIHAGQTPDPTTGALMPPIYANSTYLQDSPGVHKGFDYGRSHNPTRFALERCVADLEGGTQAFAF
ASGLATISTVLELIDAGSHIVSGNDLYGGTFRLFDKVRQRSAGHRFSYVDLADLSAFEASLQDDTRMVMVETPTNPLLSL
SDLAAIARICKARGIICVADNTFASPWIQRPLELGFDIVLHSTTKYLNGHSDVIGGIAVVGDNPALAERLGFLQNAVGAI
SGPFDAFLTLRGVKTLALRMERHCSNALELARWLEQQPQVKRVYYPGLESHPQHELAKRQMRGFGGMISLDLNSDLAGAR
RFLENVQIFALAESLGGVESLIEHPAIMTHATIPAETRAKLGIGDSLVRLSVGVEDIEDLRADLAQALASI

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=396, Percent_Identity=48.989898989899, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI299473759, Length=396, Percent_Identity=44.9494949494949, Blast_Score=308, Evalue=4e-84,
Organism=Homo sapiens, GI25453487, Length=395, Percent_Identity=43.7974683544304, Blast_Score=298, Evalue=8e-81,
Organism=Escherichia coli, GI1790375, Length=378, Percent_Identity=44.1798941798942, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1789383, Length=399, Percent_Identity=30.5764411027569, Blast_Score=172, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17538055, Length=380, Percent_Identity=49.2105263157895, Blast_Score=360, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI17560056, Length=380, Percent_Identity=47.3684210526316, Blast_Score=353, Evalue=9e-98,
Organism=Caenorhabditis elegans, GI71980708, Length=393, Percent_Identity=36.3867684478371, Blast_Score=242, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319307, Length=387, Percent_Identity=45.9948320413437, Blast_Score=322, Evalue=8e-89,
Organism=Saccharomyces cerevisiae, GI6321254, Length=403, Percent_Identity=34.7394540942928, Blast_Score=210, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6323333, Length=436, Percent_Identity=33.9449541284404, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6321170, Length=333, Percent_Identity=31.8318318318318, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6321904, Length=398, Percent_Identity=28.643216080402, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322970, Length=364, Percent_Identity=23.3516483516484, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922554, Length=382, Percent_Identity=47.6439790575916, Blast_Score=370, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42475; Mature: 42344

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQHDKNARQQGFATRVIHAGQTPDPTTGALMPPIYANSTYLQDSPGVHKGFDYGRSHNP
CCCCCCHHHHHCCHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TRFALERCVADLEGGTQAFAFASGLATISTVLELIDAGSHIVSGNDLYGGTFRLFDKVRQ
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHH
RSAGHRFSYVDLADLSAFEASLQDDTRMVMVETPTNPLLSLSDLAAIARICKARGIICVA
HCCCCCEEEEEHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEE
DNTFASPWIQRPLELGFDIVLHSTTKYLNGHSDVIGGIAVVGDNPALAERLGFLQNAVGA
CCCCCCHHHHHHHHCCCEEEEECHHHHHCCCCHHHCCEEEECCCHHHHHHHHHHHHHHHH
ISGPFDAFLTLRGVKTLALRMERHCSNALELARWLEQQPQVKRVYYPGLESHPQHELAKR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHH
QMRGFGGMISLDLNSDLAGARRFLENVQIFALAESLGGVESLIEHPAIMTHATIPAETRA
HHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCEEECCCCCHHHH
KLGIGDSLVRLSVGVEDIEDLRADLAQALASI
HCCCCCHHHEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQHDKNARQQGFATRVIHAGQTPDPTTGALMPPIYANSTYLQDSPGVHKGFDYGRSHNP
CCCCCHHHHHCCHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TRFALERCVADLEGGTQAFAFASGLATISTVLELIDAGSHIVSGNDLYGGTFRLFDKVRQ
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHH
RSAGHRFSYVDLADLSAFEASLQDDTRMVMVETPTNPLLSLSDLAAIARICKARGIICVA
HCCCCCEEEEEHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEE
DNTFASPWIQRPLELGFDIVLHSTTKYLNGHSDVIGGIAVVGDNPALAERLGFLQNAVGA
CCCCCCHHHHHHHHCCCEEEEECHHHHHCCCCHHHCCEEEECCCHHHHHHHHHHHHHHHH
ISGPFDAFLTLRGVKTLALRMERHCSNALELARWLEQQPQVKRVYYPGLESHPQHELAKR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHH
QMRGFGGMISLDLNSDLAGARRFLENVQIFALAESLGGVESLIEHPAIMTHATIPAETRA
HHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCEEECCCCCHHHH
KLGIGDSLVRLSVGVEDIEDLRADLAQALASI
HCCCCCHHHEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]