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The map label for this gene is cbs [H]

Identifier: 77459470

GI number: 77459470

Start: 3728512

End: 3729951

Strand: Direct

Name: cbs [H]

Synonym: Pfl01_3248

Alternate gene names: 77459470

Gene position: 3728512-3729951 (Clockwise)

Preceding gene: 77459469

Following gene: 77459471

Centisome position: 57.91

GC content: 62.5

Gene sequence:

>1440_bases
ATGTTGCACGCGAGCTTTTTCCCCGCGAATGGAACGCGATCAACACCACAAAGAGGTGAAGAGATGTCAAAGGATTCACG
CCCTGCCGTACTTGGGCTGATCGGCAATACGCCGCTGGTACAAGTCACCCGCTTCGATACCGGTCCCTGCACCCTGTTTC
TCAAACTCGAATCACAAAACCCCGGCGGTTCGATCAAGGACCGCATCGGTCTGGCCATGATCGACGCCGCTGAGCGCGAT
GGTCGCCTGCAACCCGGCGGCACGATCGTCGAGGCCACCGCCGGCAACACCGGTCTGGGCCTGGCCCTGGTCGGCCGCGC
CAAGGGCTACCGCGTCGTGCTGGTGGTGCCGGACAAAATGTCCACCGAAAAAGTCCTGCACCTCAAAGCCATGGGCGCCG
AAGTGCACATCACCCGCTCCGATGTCGGCAAGGGCCATCCCGAGTATTACCAGGATGTCGCCGCGCGTCTGGCCAAGGAC
ATTCCCGGCGCGTTCTTCGCCGACCAGTTCAACAACCCCGCCAACCCACTGGCCCACGAGTTCAGCACTGGACCAGAAAT
CTGGGCCCAGACCGAGCATGACCTCGACGCGATCGTGGTCGGTGTCGGCTCGGCCGGCACGCTGACCGGCCTGACACGCT
TCTTCAAGCGCGTGCAACCGGATCTGGAAATGGTCCTGGCCGACCCGGTCGGTTCGGTGATGGCTGAATACAGCCGTAGC
AAGCATCTAGGCACCGCAGGTTCGTGGGCGGTGGAAGGCATCGGCGAGGACTTCATTCCGTCGATCACCGACCTGTCGAG
CGTGCGCAGCGCCTACTCGATCAGCGACGAAGAAAGCTTCGATCACGCCCGTCAGCTGCTGAAAGCCGAAGGCATCCTCG
GTGGTTCGTCCACCGGCACCCTGCTCGCCGCCGCGCTGCGCTACTGCCGCGAACAGACCGAGCCGAAACGCGTGGTCAGC
TTTGTCTGCGACACCGGGACTCGCTACCTGTCGAAGGTCTACAACGACCAGTGGATGACCGATCAGGGACTGCTGCAGCG
CAAACGCTACGGCGACTTGCGCGACCTGATCGCCCGACGCTTCGAAGACGGCAAAGTCGTCAGCGTCGGCCCGGACGATA
CGCTGATGACCGCGTTCCAGCGCATGCGCCTGGCCGACGTTTCACAACTGCCGGTGCTGGTGGATGGCAAGCAACTGGTC
GGTGTGATCGACGAGTCGGACATTCTGGTGCGTGTGCACGAAGACGCTTCGCTCTTCAGCAAACCCGTTTCCAGCGCGAT
GACCGACAAGTTGCAAACCCTCGCCCCCGGCGCGACGCTGGCTGAACTGGAAGCCGTGCTCAGCAGCGGTCTGGTGGCCA
TCATCGCCGACGCTTCAGGCTTCCACGGCCTGATCACCCGCGTCGACATGCTCAATCAATTACGGAGATCCCTGGCATGA

Upstream 100 bases:

>100_bases
GCAAATCACTTCCTTCCCCTCTCCGATTTCGTTCTATCGTTAGATCGAAATGGCAGTATTTCCGGCCGTTTAAAGGTTGC
GACAGCGCAGGTCTGAGCCT

Downstream 100 bases:

>100_bases
GCCAGCACGACAAGAACGCCCGTCAACAAGGCTTCGCCACCCGCGTGATCCATGCCGGGCAAACGCCGGATCCGACCACC
GGCGCGCTGATGCCGCCGAT

Product: cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MLHASFFPANGTRSTPQRGEEMSKDSRPAVLGLIGNTPLVQVTRFDTGPCTLFLKLESQNPGGSIKDRIGLAMIDAAERD
GRLQPGGTIVEATAGNTGLGLALVGRAKGYRVVLVVPDKMSTEKVLHLKAMGAEVHITRSDVGKGHPEYYQDVAARLAKD
IPGAFFADQFNNPANPLAHEFSTGPEIWAQTEHDLDAIVVGVGSAGTLTGLTRFFKRVQPDLEMVLADPVGSVMAEYSRS
KHLGTAGSWAVEGIGEDFIPSITDLSSVRSAYSISDEESFDHARQLLKAEGILGGSSTGTLLAAALRYCREQTEPKRVVS
FVCDTGTRYLSKVYNDQWMTDQGLLQRKRYGDLRDLIARRFEDGKVVSVGPDDTLMTAFQRMRLADVSQLPVLVDGKQLV
GVIDESDILVRVHEDASLFSKPVSSAMTDKLQTLAPGATLAELEAVLSSGLVAIIADASGFHGLITRVDMLNQLRRSLA

Sequences:

>Translated_479_residues
MLHASFFPANGTRSTPQRGEEMSKDSRPAVLGLIGNTPLVQVTRFDTGPCTLFLKLESQNPGGSIKDRIGLAMIDAAERD
GRLQPGGTIVEATAGNTGLGLALVGRAKGYRVVLVVPDKMSTEKVLHLKAMGAEVHITRSDVGKGHPEYYQDVAARLAKD
IPGAFFADQFNNPANPLAHEFSTGPEIWAQTEHDLDAIVVGVGSAGTLTGLTRFFKRVQPDLEMVLADPVGSVMAEYSRS
KHLGTAGSWAVEGIGEDFIPSITDLSSVRSAYSISDEESFDHARQLLKAEGILGGSSTGTLLAAALRYCREQTEPKRVVS
FVCDTGTRYLSKVYNDQWMTDQGLLQRKRYGDLRDLIARRFEDGKVVSVGPDDTLMTAFQRMRLADVSQLPVLVDGKQLV
GVIDESDILVRVHEDASLFSKPVSSAMTDKLQTLAPGATLAELEAVLSSGLVAIIADASGFHGLITRVDMLNQLRRSLA
>Mature_479_residues
MLHASFFPANGTRSTPQRGEEMSKDSRPAVLGLIGNTPLVQVTRFDTGPCTLFLKLESQNPGGSIKDRIGLAMIDAAERD
GRLQPGGTIVEATAGNTGLGLALVGRAKGYRVVLVVPDKMSTEKVLHLKAMGAEVHITRSDVGKGHPEYYQDVAARLAKD
IPGAFFADQFNNPANPLAHEFSTGPEIWAQTEHDLDAIVVGVGSAGTLTGLTRFFKRVQPDLEMVLADPVGSVMAEYSRS
KHLGTAGSWAVEGIGEDFIPSITDLSSVRSAYSISDEESFDHARQLLKAEGILGGSSTGTLLAAALRYCREQTEPKRVVS
FVCDTGTRYLSKVYNDQWMTDQGLLQRKRYGDLRDLIARRFEDGKVVSVGPDDTLMTAFQRMRLADVSQLPVLVDGKQLV
GVIDESDILVRVHEDASLFSKPVSSAMTDKLQTLAPGATLAELEAVLSSGLVAIIADASGFHGLITRVDMLNQLRRSLA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=465, Percent_Identity=33.9784946236559, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI295821200, Length=465, Percent_Identity=33.9784946236559, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI4557415, Length=465, Percent_Identity=33.9784946236559, Blast_Score=262, Evalue=4e-70,
Organism=Escherichia coli, GI2367138, Length=301, Percent_Identity=38.8704318936877, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=38.9240506329114, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17562970, Length=308, Percent_Identity=39.2857142857143, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=39.8671096345515, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=39.672131147541, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI115535073, Length=334, Percent_Identity=39.2215568862275, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17534315, Length=328, Percent_Identity=39.0243902439024, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI25147552, Length=325, Percent_Identity=36.3076923076923, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17561720, Length=302, Percent_Identity=38.0794701986755, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI32566672, Length=224, Percent_Identity=36.6071428571429, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71996324, Length=379, Percent_Identity=27.7044854881267, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321594, Length=503, Percent_Identity=33.2007952286282, Blast_Score=265, Evalue=9e-72,
Organism=Saccharomyces cerevisiae, GI6321449, Length=342, Percent_Identity=33.6257309941521, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24643623, Length=440, Percent_Identity=34.3181818181818, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI20129101, Length=440, Percent_Identity=34.3181818181818, Blast_Score=224, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 51640; Mature: 51640

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHASFFPANGTRSTPQRGEEMSKDSRPAVLGLIGNTPLVQVTRFDTGPCTLFLKLESQN
CCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCEEEEEEEECCC
PGGSIKDRIGLAMIDAAERDGRLQPGGTIVEATAGNTGLGLALVGRAKGYRVVLVVPDKM
CCCCHHHHHCEEEEECCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCCC
STEKVLHLKAMGAEVHITRSDVGKGHPEYYQDVAARLAKDIPGAFFADQFNNPANPLAHE
CHHHHHEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHH
FSTGPEIWAQTEHDLDAIVVGVGSAGTLTGLTRFFKRVQPDLEMVLADPVGSVMAEYSRS
CCCCCHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHH
KHLGTAGSWAVEGIGEDFIPSITDLSSVRSAYSISDEESFDHARQLLKAEGILGGSSTGT
CCCCCCCCHHHHCCCCHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHH
LLAAALRYCREQTEPKRVVSFVCDTGTRYLSKVYNDQWMTDQGLLQRKRYGDLRDLIARR
HHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHH
FEDGKVVSVGPDDTLMTAFQRMRLADVSQLPVLVDGKQLVGVIDESDILVRVHEDASLFS
CCCCEEEEECCCHHHHHHHHHHHHHHHHHCCEEECCHHEEEEECCCCEEEEEECCHHHHH
KPVSSAMTDKLQTLAPGATLAELEAVLSSGLVAIIADASGFHGLITRVDMLNQLRRSLA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLHASFFPANGTRSTPQRGEEMSKDSRPAVLGLIGNTPLVQVTRFDTGPCTLFLKLESQN
CCCCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCEEEEEEEECCC
PGGSIKDRIGLAMIDAAERDGRLQPGGTIVEATAGNTGLGLALVGRAKGYRVVLVVPDKM
CCCCHHHHHCEEEEECCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCCC
STEKVLHLKAMGAEVHITRSDVGKGHPEYYQDVAARLAKDIPGAFFADQFNNPANPLAHE
CHHHHHEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHH
FSTGPEIWAQTEHDLDAIVVGVGSAGTLTGLTRFFKRVQPDLEMVLADPVGSVMAEYSRS
CCCCCHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHH
KHLGTAGSWAVEGIGEDFIPSITDLSSVRSAYSISDEESFDHARQLLKAEGILGGSSTGT
CCCCCCCCHHHHCCCCHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHH
LLAAALRYCREQTEPKRVVSFVCDTGTRYLSKVYNDQWMTDQGLLQRKRYGDLRDLIARR
HHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHH
FEDGKVVSVGPDDTLMTAFQRMRLADVSQLPVLVDGKQLVGVIDESDILVRVHEDASLFS
CCCCEEEEECCCHHHHHHHHHHHHHHHHHCCEEECCHHEEEEECCCCEEEEEECCHHHHH
KPVSSAMTDKLQTLAPGATLAELEAVLSSGLVAIIADASGFHGLITRVDMLNQLRRSLA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]