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The map label for this gene is cobW [H]

Identifier: 77459321

GI number: 77459321

Start: 3551265

End: 3552338

Strand: Reverse

Name: cobW [H]

Synonym: Pfl01_3099

Alternate gene names: 77459321

Gene position: 3552338-3551265 (Counterclockwise)

Preceding gene: 77459326

Following gene: 77459320

Centisome position: 55.17

GC content: 63.31

Gene sequence:

>1074_bases
ATGAAAACACTGGCCAAACTCCCCGTCACCATCGTCACCGGCTTCCTCGGCTCGGGCAAAACCACCTTGCTGCGGCACAT
GCTCGACAATGCCCAGGGCCGCCGTATCGCGGTGATCGTCAACGAGTTTGGCGAGTTGGGCATCGACGGTGAAATCCTCA
AGCAGTGCACCATCGGCTGCACCGAAGAAGAAGCCACCGGCCGCGTCTACGAGCTGGCCAACGGCTGCCTGTGCTGCACG
GTTCAGGAAGAGTTCTTCCCGGTGATGCGCGAGCTGGTGGCCCGTCGCGGCGACCTCGACCACATCCTGATCGAAACCTC
GGGCCTGGCCCTGCCAAAGCCGCTGGTGCAAGCCTTCCAGTGGCCGGAAATCCGCAGTGCCTGCACCGTCGACGCGGTGA
TCACGGTGGTCGACAGCCCGGCTGTGGCCGCTGGCACCTTCGCCGCGTTCCCGGATCAGGTTGATGCCCAGCGCAAGCTC
GATCCGAACCTGGATCACGAATCTCCGCTGCACGAACTGTTCGCTGACCAACTGGCCAGCGCCGATCTGGTGATCCTCAA
CAAGGCCGACCAGACCAGCCCTGAAGACCTCGCGCGTGTCCGCCTGGAAGTCGCCGAAGAGCTGCCGCCAGCCGTGAAAA
TCATCGAAGCAAGCAACGGTCGCCTGCCGCTGGACGTGCTGATCGGCCTCGGTGCCGGTTCCGAAGAACACATCGACGGC
CGCCACAGCCATCACGATCACCACCACGGTGAAGGCGATGACGATCACGACGACCACGATCACGACGCCTTCGATTCGAT
CTCCATCGAACTGCCGCAAGCTGACGAAAGCCTGCTGCTCGACGCGCTGACGCAACTGGTGGTTCAGCACGGCATCCTGC
GGGTCAAAGGCTTCGCGGCGATCCCGAATAAGCCGATGCGCCTGCTGATCCAGGGCGTGGGCACGCGTTTCGACAAGCAC
TTCGATCGTCAGTGGGGCGCCGACGAGGTACGCGTGACGCGTCTGGTGTTGATCGGTCAGGCACTGGACGCTGCCCAGCT
CGAAGCGCAACTGCGCGCCGCGCTCAGCGTTTAA

Upstream 100 bases:

>100_bases
CTTTCAACCGGGCGGGGTGATCCGGTGGCGAACTCTCCAGGCACGCACCCGCGTTGCCGGTCTCGTCCCGTATGCCCGCC
ACCTTGCCAAAGGGCATCCG

Downstream 100 bases:

>100_bases
GCCATGCACCTGCTCAGGACCCAGCCCGGCGGATTCGTGTCGGACGACAACATTGCCGACCTTGGACAAACCCCCGCCGA
GCTGGTGATCCTGTGCAGCG

Product: cobalamin synthesis protein/P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKTLAKLPVTIVTGFLGSGKTTLLRHMLDNAQGRRIAVIVNEFGELGIDGEILKQCTIGCTEEEATGRVYELANGCLCCT
VQEEFFPVMRELVARRGDLDHILIETSGLALPKPLVQAFQWPEIRSACTVDAVITVVDSPAVAAGTFAAFPDQVDAQRKL
DPNLDHESPLHELFADQLASADLVILNKADQTSPEDLARVRLEVAEELPPAVKIIEASNGRLPLDVLIGLGAGSEEHIDG
RHSHHDHHHGEGDDDHDDHDHDAFDSISIELPQADESLLLDALTQLVVQHGILRVKGFAAIPNKPMRLLIQGVGTRFDKH
FDRQWGADEVRVTRLVLIGQALDAAQLEAQLRAALSV

Sequences:

>Translated_357_residues
MKTLAKLPVTIVTGFLGSGKTTLLRHMLDNAQGRRIAVIVNEFGELGIDGEILKQCTIGCTEEEATGRVYELANGCLCCT
VQEEFFPVMRELVARRGDLDHILIETSGLALPKPLVQAFQWPEIRSACTVDAVITVVDSPAVAAGTFAAFPDQVDAQRKL
DPNLDHESPLHELFADQLASADLVILNKADQTSPEDLARVRLEVAEELPPAVKIIEASNGRLPLDVLIGLGAGSEEHIDG
RHSHHDHHHGEGDDDHDDHDHDAFDSISIELPQADESLLLDALTQLVVQHGILRVKGFAAIPNKPMRLLIQGVGTRFDKH
FDRQWGADEVRVTRLVLIGQALDAAQLEAQLRAALSV
>Mature_357_residues
MKTLAKLPVTIVTGFLGSGKTTLLRHMLDNAQGRRIAVIVNEFGELGIDGEILKQCTIGCTEEEATGRVYELANGCLCCT
VQEEFFPVMRELVARRGDLDHILIETSGLALPKPLVQAFQWPEIRSACTVDAVITVVDSPAVAAGTFAAFPDQVDAQRKL
DPNLDHESPLHELFADQLASADLVILNKADQTSPEDLARVRLEVAEELPPAVKIIEASNGRLPLDVLIGLGAGSEEHIDG
RHSHHDHHHGEGDDDHDDHDHDAFDSISIELPQADESLLLDALTQLVVQHGILRVKGFAAIPNKPMRLLIQGVGTRFDKH
FDRQWGADEVRVTRLVLIGQALDAAQLEAQLRAALSV

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=353, Percent_Identity=31.1614730878187, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI33469141, Length=353, Percent_Identity=31.1614730878187, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI148727351, Length=368, Percent_Identity=30.4347826086957, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI223941779, Length=353, Percent_Identity=30.028328611898, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI146231952, Length=366, Percent_Identity=30.327868852459, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI223941776, Length=341, Percent_Identity=29.6187683284457, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI119120938, Length=137, Percent_Identity=42.3357664233577, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI87082430, Length=365, Percent_Identity=30.1369863013699, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788499, Length=188, Percent_Identity=32.9787234042553, Blast_Score=96, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324356, Length=373, Percent_Identity=27.6139410187668, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 38943; Mature: 38943

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLAKLPVTIVTGFLGSGKTTLLRHMLDNAQGRRIAVIVNEFGELGIDGEILKQCTIGC
CCCHHHCCHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEECHHCCCCCHHHHHHHHCCC
TEEEATGRVYELANGCLCCTVQEEFFPVMRELVARRGDLDHILIETSGLALPKPLVQAFQ
CCHHHCCHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHC
WPEIRSACTVDAVITVVDSPAVAAGTFAAFPDQVDAQRKLDPNLDHESPLHELFADQLAS
CCHHHHHHHHHHHEEEECCCCHHHCHHHCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHCC
ADLVILNKADQTSPEDLARVRLEVAEELPPAVKIIEASNGRLPLDVLIGLGAGSEEHIDG
CCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHEEECCCCCCCCCCC
RHSHHDHHHGEGDDDHDDHDHDAFDSISIELPQADESLLLDALTQLVVQHGILRVKGFAA
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCEEEECEEC
IPNKPMRLLIQGVGTRFDKHFDRQWGADEVRVTRLVLIGQALDAAQLEAQLRAALSV
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTLAKLPVTIVTGFLGSGKTTLLRHMLDNAQGRRIAVIVNEFGELGIDGEILKQCTIGC
CCCHHHCCHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEECHHCCCCCHHHHHHHHCCC
TEEEATGRVYELANGCLCCTVQEEFFPVMRELVARRGDLDHILIETSGLALPKPLVQAFQ
CCHHHCCHHHHHCCCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHC
WPEIRSACTVDAVITVVDSPAVAAGTFAAFPDQVDAQRKLDPNLDHESPLHELFADQLAS
CCHHHHHHHHHHHEEEECCCCHHHCHHHCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHCC
ADLVILNKADQTSPEDLARVRLEVAEELPPAVKIIEASNGRLPLDVLIGLGAGSEEHIDG
CCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHEEECCCCCCCCCCC
RHSHHDHHHGEGDDDHDDHDHDAFDSISIELPQADESLLLDALTQLVVQHGILRVKGFAA
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCEEEECEEC
IPNKPMRLLIQGVGTRFDKHFDRQWGADEVRVTRLVLIGQALDAAQLEAQLRAALSV
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]