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The map label for this gene is uvrC [H]

Identifier: 77459288

GI number: 77459288

Start: 3507583

End: 3509406

Strand: Reverse

Name: uvrC [H]

Synonym: Pfl01_3066

Alternate gene names: 77459288

Gene position: 3509406-3507583 (Counterclockwise)

Preceding gene: 77459289

Following gene: 77459287

Centisome position: 54.51

GC content: 59.21

Gene sequence:

>1824_bases
ATGACTGAAGCATTCGATTCGGGCGCCTTTCTATCGACCGTCAGCGGGCGCCCCGGCGTGTATCGCATGTTCGACAGCGA
TGCGCGTTTGCTGTACGTCGGCAAGGCGAAGAGCCTCAAAAAACGCCTCGCCAGCTACTTTCGCAAGACAGGCCTGGCGC
CGAAAACCGCAGCACTGGTCGGGCGTATCGCCCAGGTCGAAACCACCATCACGTCCAACGAGACAGAGGCGTTGCTGCTC
GAGCAAACCCTCATCAAGGAGTGGCGGCCGCCGTACAACATCCTGTTGCGCGACGATAAATCCTATCCCTATGTCTTTTT
GTCTGACGGGCAATTTCCGCGCCTGAGCATTCATCGCGGGGCCAAGAAGGCCAAGGGCAAGTATTTCGGTCCCTATCCGA
GTGCCGGGGCTATTCGCGAAAGCCTCAGCCTTTTGCAGAAGACTTTTTTCGTGCGTCAGTGCGAGGACAGTTACTACAAG
AACCGGACCCGTCCGTGCCTGCAATATCAGATCAAGCGTTGCAAGGCGCCTTGTGTCGGACTCGTCGAGCCTGAGGTTTA
CGCCGAGGATGTGCGTCACTCGGTGATGTTCCTCGAAGGACGAAGCCATGCGTTGACCAATGAACTGTCGACGGCGATGG
AAGAGGCTGCAATCAACCTGGAATTCGAACGCGCCGCCGAACTGCGCGACCAGATTGCCTTGCTGCGGCGGGTGCAGGAT
CAACAGAGCATGGAAGGCGGAACGGGCGATATCGATGTGATCGCCGCGTTCGTCAATCCGGGTGGCGCCTGTGTCCATCT
GATCAGCGTGCGTGGAGGGCGGGTGCTTGGCAGCAAGAATTTCTTCCCGCAAGTCGGGATTGAAGAGGAAGTGGCCGAGG
TCATGGCCGCTTTCCTCGGGCAATATTTCATCAGTAGCCCGGAGCGCGATTTGCCGAGCGAACTGATCGTCAACGTCGTG
CACGAAGACTTCCCTGCACTGATCGAGGCCATTCAGGCGCTGCGCGGGCGTGAATTGAGCATCAGTCATCGGGTGCGCGG
AACACGGGCGCGCTGGCAGCAACTGGCCGTGACCAATGCCGAACAGGCGCTGGGTGCGCGGCTGGCCAATCGTCAGCATG
TTGCCGCACGTTTCGAAGCGCTGGCTGAAGTGTTGAACCTCGATGAGCCGCCACAACGGCTGGAGTGCTATGACATCAGT
CACTCCAGCGGTGAAGCCACGGTTGCGTCCTGTGTGGTGTTCGGCCCGGAAGGGGCGATCAAGTCGGATTACCGTCGTTA
CAACATCGAAGGTGTGACCGCCGGCGACGATTACGCCGCCATGCATCAGGCCCTGACCCGACGCTTCAGCAAGCTGAAAG
AAGGCGAGGGCAAACTGCCGGACATCCTGTTGGTGGACGGCGGCAAGGGGCAGCTGTCGATGGCGCGTGATGTGCTCAAC
GAACTGGCGGTTCCGGATCTGATCTTGCTGGGGGTCGCGAAAGGCGCCACGCGCAAGGCGGGATTCGAGACTTTGTATCT
AAATGATGCGGCAAACGAGTTCACCTTGCGGGGGGATTCGCCGGCGCTGCACCTGATCCAGCAGATTCGTGACGAAGCCC
ACCGCTTTGCAATTACAGGCCACCGTGCACGACGCGGCAAGACCCGCCGCACGTCAACGCTGGAAGGTGTGGCAGGCGTC
GGGCCGACCCGGCGTCGGGACTTGTTGAAACATTTTGGTGGATTGCAGGAGCTGTCTCGTGCAAGCATCGAAGAGATCGC
CAAAGCACCGGGGATCAGCAAAAAGCTAGCAGAGTCGATTTATGCAAACCTGCATAGTGAGTAG

Upstream 100 bases:

>100_bases
CCTACCGCTACCGCATATTCGAGAAGCTCTCGATCAGCAGCGATGTCGAACTGACGCTTCTTGCGGTTCGTCACGGCATG
GTTGATGCCAGCCTCTGACC

Downstream 100 bases:

>100_bases
AATGCCCATTCACCTCGTAGCCAGTTGTGCCGATGAATATCCCTAATCTGATTACCGTTCTCCGCGTCCTGCTCATCCCG
ATCTTCATTCTGTTGTTCTA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MTEAFDSGAFLSTVSGRPGVYRMFDSDARLLYVGKAKSLKKRLASYFRKTGLAPKTAALVGRIAQVETTITSNETEALLL
EQTLIKEWRPPYNILLRDDKSYPYVFLSDGQFPRLSIHRGAKKAKGKYFGPYPSAGAIRESLSLLQKTFFVRQCEDSYYK
NRTRPCLQYQIKRCKAPCVGLVEPEVYAEDVRHSVMFLEGRSHALTNELSTAMEEAAINLEFERAAELRDQIALLRRVQD
QQSMEGGTGDIDVIAAFVNPGGACVHLISVRGGRVLGSKNFFPQVGIEEEVAEVMAAFLGQYFISSPERDLPSELIVNVV
HEDFPALIEAIQALRGRELSISHRVRGTRARWQQLAVTNAEQALGARLANRQHVAARFEALAEVLNLDEPPQRLECYDIS
HSSGEATVASCVVFGPEGAIKSDYRRYNIEGVTAGDDYAAMHQALTRRFSKLKEGEGKLPDILLVDGGKGQLSMARDVLN
ELAVPDLILLGVAKGATRKAGFETLYLNDAANEFTLRGDSPALHLIQQIRDEAHRFAITGHRARRGKTRRTSTLEGVAGV
GPTRRRDLLKHFGGLQELSRASIEEIAKAPGISKKLAESIYANLHSE

Sequences:

>Translated_607_residues
MTEAFDSGAFLSTVSGRPGVYRMFDSDARLLYVGKAKSLKKRLASYFRKTGLAPKTAALVGRIAQVETTITSNETEALLL
EQTLIKEWRPPYNILLRDDKSYPYVFLSDGQFPRLSIHRGAKKAKGKYFGPYPSAGAIRESLSLLQKTFFVRQCEDSYYK
NRTRPCLQYQIKRCKAPCVGLVEPEVYAEDVRHSVMFLEGRSHALTNELSTAMEEAAINLEFERAAELRDQIALLRRVQD
QQSMEGGTGDIDVIAAFVNPGGACVHLISVRGGRVLGSKNFFPQVGIEEEVAEVMAAFLGQYFISSPERDLPSELIVNVV
HEDFPALIEAIQALRGRELSISHRVRGTRARWQQLAVTNAEQALGARLANRQHVAARFEALAEVLNLDEPPQRLECYDIS
HSSGEATVASCVVFGPEGAIKSDYRRYNIEGVTAGDDYAAMHQALTRRFSKLKEGEGKLPDILLVDGGKGQLSMARDVLN
ELAVPDLILLGVAKGATRKAGFETLYLNDAANEFTLRGDSPALHLIQQIRDEAHRFAITGHRARRGKTRRTSTLEGVAGV
GPTRRRDLLKHFGGLQELSRASIEEIAKAPGISKKLAESIYANLHSE
>Mature_606_residues
TEAFDSGAFLSTVSGRPGVYRMFDSDARLLYVGKAKSLKKRLASYFRKTGLAPKTAALVGRIAQVETTITSNETEALLLE
QTLIKEWRPPYNILLRDDKSYPYVFLSDGQFPRLSIHRGAKKAKGKYFGPYPSAGAIRESLSLLQKTFFVRQCEDSYYKN
RTRPCLQYQIKRCKAPCVGLVEPEVYAEDVRHSVMFLEGRSHALTNELSTAMEEAAINLEFERAAELRDQIALLRRVQDQ
QSMEGGTGDIDVIAAFVNPGGACVHLISVRGGRVLGSKNFFPQVGIEEEVAEVMAAFLGQYFISSPERDLPSELIVNVVH
EDFPALIEAIQALRGRELSISHRVRGTRARWQQLAVTNAEQALGARLANRQHVAARFEALAEVLNLDEPPQRLECYDISH
SSGEATVASCVVFGPEGAIKSDYRRYNIEGVTAGDDYAAMHQALTRRFSKLKEGEGKLPDILLVDGGKGQLSMARDVLNE
LAVPDLILLGVAKGATRKAGFETLYLNDAANEFTLRGDSPALHLIQQIRDEAHRFAITGHRARRGKTRRTSTLEGVAGVG
PTRRRDLLKHFGGLQELSRASIEEIAKAPGISKKLAESIYANLHSE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=610, Percent_Identity=52.4590163934426, Blast_Score=642, Evalue=0.0,
Organism=Escherichia coli, GI1788037, Length=191, Percent_Identity=27.7486910994764, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 67163; Mature: 67032

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAFDSGAFLSTVSGRPGVYRMFDSDARLLYVGKAKSLKKRLASYFRKTGLAPKTAALV
CCCCCCCCCEEEECCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHH
GRIAQVETTITSNETEALLLEQTLIKEWRPPYNILLRDDKSYPYVFLSDGQFPRLSIHRG
HHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCEEHHHCC
AKKAKGKYFGPYPSAGAIRESLSLLQKTFFVRQCEDSYYKNRTRPCLQYQIKRCKAPCVG
CHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
LVEPEVYAEDVRHSVMFLEGRSHALTNELSTAMEEAAINLEFERAAELRDQIALLRRVQD
CCCCHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
QQSMEGGTGDIDVIAAFVNPGGACVHLISVRGGRVLGSKNFFPQVGIEEEVAEVMAAFLG
HHHCCCCCCCCEEEEEEECCCCCEEEEEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHH
QYFISSPERDLPSELIVNVVHEDFPALIEAIQALRGRELSISHRVRGTRARWQQLAVTNA
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHCCH
EQALGARLANRQHVAARFEALAEVLNLDEPPQRLECYDISHSSGEATVASCVVFGPEGAI
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEEEECCCCCC
KSDYRRYNIEGVTAGDDYAAMHQALTRRFSKLKEGEGKLPDILLVDGGKGQLSMARDVLN
CCCHHEECCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHH
ELAVPDLILLGVAKGATRKAGFETLYLNDAANEFTLRGDSPALHLIQQIRDEAHRFAITG
HHCCCCEEEHHCCCCCCCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHEEEEC
HRARRGKTRRTSTLEGVAGVGPTRRRDLLKHFGGLQELSRASIEEIAKAPGISKKLAESI
CHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHH
YANLHSE
HHHCCCC
>Mature Secondary Structure 
TEAFDSGAFLSTVSGRPGVYRMFDSDARLLYVGKAKSLKKRLASYFRKTGLAPKTAALV
CCCCCCCCEEEECCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHH
GRIAQVETTITSNETEALLLEQTLIKEWRPPYNILLRDDKSYPYVFLSDGQFPRLSIHRG
HHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCEEHHHCC
AKKAKGKYFGPYPSAGAIRESLSLLQKTFFVRQCEDSYYKNRTRPCLQYQIKRCKAPCVG
CHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
LVEPEVYAEDVRHSVMFLEGRSHALTNELSTAMEEAAINLEFERAAELRDQIALLRRVQD
CCCCHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
QQSMEGGTGDIDVIAAFVNPGGACVHLISVRGGRVLGSKNFFPQVGIEEEVAEVMAAFLG
HHHCCCCCCCCEEEEEEECCCCCEEEEEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHH
QYFISSPERDLPSELIVNVVHEDFPALIEAIQALRGRELSISHRVRGTRARWQQLAVTNA
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHCCH
EQALGARLANRQHVAARFEALAEVLNLDEPPQRLECYDISHSSGEATVASCVVFGPEGAI
HHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEEEECCCCCC
KSDYRRYNIEGVTAGDDYAAMHQALTRRFSKLKEGEGKLPDILLVDGGKGQLSMARDVLN
CCCHHEECCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHH
ELAVPDLILLGVAKGATRKAGFETLYLNDAANEFTLRGDSPALHLIQQIRDEAHRFAITG
HHCCCCEEEHHCCCCCCCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHEEEEC
HRARRGKTRRTSTLEGVAGVGPTRRRDLLKHFGGLQELSRASIEEIAKAPGISKKLAESI
CHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHH
YANLHSE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA