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The map label for this gene is mmuM [H]

Identifier: 77459004

GI number: 77459004

Start: 3203041

End: 3203967

Strand: Reverse

Name: mmuM [H]

Synonym: Pfl01_2779

Alternate gene names: 77459004

Gene position: 3203967-3203041 (Counterclockwise)

Preceding gene: 77459005

Following gene: 77459003

Centisome position: 49.76

GC content: 61.92

Gene sequence:

>927_bases
ATGACCAGAGCGAACGTACGTGTACTCGATGGTGGCATGGGGCGCGAGTTGAAGCGAATCGGCGCGCCGTTCCGTCAACC
GGAATGGTCGGCCCTCGCGCTGATCGAAGCGCCTGAGTATGTACTGCAGGCGCATCAGGCGTTCGTGACAGCGGGCGCCC
GGATCATCACCACCAACAGCTATGCGGTGGTGCCTTTTCATATTGGCGACGAGCGATTTGCCGAGCAGGGAAGAGCGCTG
GCTGAGCGCGCCGGACGCTTGGCGCGGCAGGCCGCCGGCGAAAGTACCGATCCGGTCACCGTGGCCGGGTCGTTGCCGCC
GGCACTGGGGTCGTACCGGCCGGATCTGTTCGATCATCAGGGTTCAGTAGCTATTCACCGCGAACTGATTGCCGGATTGC
AGGCGCACGTCGATGTGTGGCTGGCCGAAACGCACAGCTCCATTGCTGAAGTGCGTGCGGTGGTCGAAGCCCTCGGAACG
GATCCCGCGCCACTCTGGGTGTCATTCACGCTGTTGGACGAAGAGGGCCGGGAACCGCGATTACGCTCAAACGAGGCCGT
TGCCGATGCGGTTCGCGTGGCGGCTGAGCTGGGGGCCAAGGCGGTGCTCTTCAATTGCAGCCAGCCGGAAGTGATGGCCG
CGGCCTTGATTGAGGCACGCGCTGTGATTGAAAACCTGGATCATCCTGTCGAACTGGGGGTTTATGCCAATGCTTTCCCC
CCTGTCAGTGCCAAAGCCGAGGCCAATAGCGATTTGTTGGAAATTCGGCGCGATCTGGGCCCCGAGTCCTATCTGGACTG
GTCGAAATCATGGGTTGCCGCAGGGGCCAGCATTGTCGGCGGATGCTGTGGGATCGGCCCGGAGCATATCGCCCAGTTGC
ATTTGCACCTGCACTATCAAAAGGGTGAGGAGGCCGCGCATGAGTGA

Upstream 100 bases:

>100_bases
AACAGCCAGCAGACGTCGCCGCCAAGGCCTGGGTTCAAGCCAACCCTTCTACTGTTGATCAGTGGTTTGCAGGGCAGGCG
CAGCAAGTGAGTTCAGCCCA

Downstream 100 bases:

>100_bases
TTTTCCAGGCGACGTTCTGTCAGAGCAGGCGACATTCGGTGCCGGCTGTTTCTGGGGGGCGGAAGCCTCATTCCGGGCAT
TGCCGGGTGTGCTCGACACC

Product: homocysteine S-methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTRANVRVLDGGMGRELKRIGAPFRQPEWSALALIEAPEYVLQAHQAFVTAGARIITTNSYAVVPFHIGDERFAEQGRAL
AERAGRLARQAAGESTDPVTVAGSLPPALGSYRPDLFDHQGSVAIHRELIAGLQAHVDVWLAETHSSIAEVRAVVEALGT
DPAPLWVSFTLLDEEGREPRLRSNEAVADAVRVAAELGAKAVLFNCSQPEVMAAALIEARAVIENLDHPVELGVYANAFP
PVSAKAEANSDLLEIRRDLGPESYLDWSKSWVAAGASIVGGCCGIGPEHIAQLHLHLHYQKGEEAAHE

Sequences:

>Translated_308_residues
MTRANVRVLDGGMGRELKRIGAPFRQPEWSALALIEAPEYVLQAHQAFVTAGARIITTNSYAVVPFHIGDERFAEQGRAL
AERAGRLARQAAGESTDPVTVAGSLPPALGSYRPDLFDHQGSVAIHRELIAGLQAHVDVWLAETHSSIAEVRAVVEALGT
DPAPLWVSFTLLDEEGREPRLRSNEAVADAVRVAAELGAKAVLFNCSQPEVMAAALIEARAVIENLDHPVELGVYANAFP
PVSAKAEANSDLLEIRRDLGPESYLDWSKSWVAAGASIVGGCCGIGPEHIAQLHLHLHYQKGEEAAHE
>Mature_307_residues
TRANVRVLDGGMGRELKRIGAPFRQPEWSALALIEAPEYVLQAHQAFVTAGARIITTNSYAVVPFHIGDERFAEQGRALA
ERAGRLARQAAGESTDPVTVAGSLPPALGSYRPDLFDHQGSVAIHRELIAGLQAHVDVWLAETHSSIAEVRAVVEALGTD
PAPLWVSFTLLDEEGREPRLRSNEAVADAVRVAAELGAKAVLFNCSQPEVMAAALIEARAVIENLDHPVELGVYANAFPP
VSAKAEANSDLLEIRRDLGPESYLDWSKSWVAAGASIVGGCCGIGPEHIAQLHLHLHYQKGEEAAHE

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786456, Length=311, Percent_Identity=30.5466237942122, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1790450, Length=324, Percent_Identity=29.320987654321, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 33088; Mature: 32956

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRANVRVLDGGMGRELKRIGAPFRQPEWSALALIEAPEYVLQAHQAFVTAGARIITTNS
CCCCCEEEECCCCCHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECC
YAVVPFHIGDERFAEQGRALAERAGRLARQAAGESTDPVTVAGSLPPALGSYRPDLFDHQ
EEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCHHCCC
GSVAIHRELIAGLQAHVDVWLAETHSSIAEVRAVVEALGTDPAPLWVSFTLLDEEGREPR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCC
LRSNEAVADAVRVAAELGAKAVLFNCSQPEVMAAALIEARAVIENLDHPVELGVYANAFP
CCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECEEECCCC
PVSAKAEANSDLLEIRRDLGPESYLDWSKSWVAAGASIVGGCCGIGPEHIAQLHLHLHYQ
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHEEHHEEEEC
KGEEAAHE
CCCCCCCC
>Mature Secondary Structure 
TRANVRVLDGGMGRELKRIGAPFRQPEWSALALIEAPEYVLQAHQAFVTAGARIITTNS
CCCCEEEECCCCCHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECC
YAVVPFHIGDERFAEQGRALAERAGRLARQAAGESTDPVTVAGSLPPALGSYRPDLFDHQ
EEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCHHCCC
GSVAIHRELIAGLQAHVDVWLAETHSSIAEVRAVVEALGTDPAPLWVSFTLLDEEGREPR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCC
LRSNEAVADAVRVAAELGAKAVLFNCSQPEVMAAALIEARAVIENLDHPVELGVYANAFP
CCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECEEECCCC
PVSAKAEANSDLLEIRRDLGPESYLDWSKSWVAAGASIVGGCCGIGPEHIAQLHLHLHYQ
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHEEHHEEEEC
KGEEAAHE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]