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The map label for this gene is msrA [H]

Identifier: 77459003

GI number: 77459003

Start: 3202581

End: 3203048

Strand: Reverse

Name: msrA [H]

Synonym: Pfl01_2778

Alternate gene names: 77459003

Gene position: 3203048-3202581 (Counterclockwise)

Preceding gene: 77459004

Following gene: 77459001

Centisome position: 49.75

GC content: 59.83

Gene sequence:

>468_bases
ATGAGTGATTTTCCAGGCGACGTTCTGTCAGAGCAGGCGACATTCGGTGCCGGCTGTTTCTGGGGGGCGGAAGCCTCATT
CCGGGCATTGCCGGGTGTGCTCGACACCCGTGTCGGGTTCGCGCGGTCAGACTTGGGCGACGCCACCCTGATCGAAGTCG
TGCAAGTCGACTTCGACCCCCGACTCATTTCCTACAGCCGTCTCGTCGAGCACTTCTGGACACTGCACGATCCAACGTCA
GTCGACCGGCAGGGTGCGGACGTCGGGGCGAAATACCGTTCCGCGCTGTTTTTCAACAGTGCCGAGCAGTCCCGACTGGC
ACTTGTCGCCAGGCAGCAGCTGGACGCCAGTGGCCAGTTGGGCAAGCCAGTGGCTACGGTGATCCTGCCACTGGGTGAGT
TTCAAAAGGCAAATGAAGAACATCAGCGCTACCTTGAAAAGCATGGTGGCAGCGCCTGTTCCATTTGA

Upstream 100 bases:

>100_bases
GCAGGGGCCAGCATTGTCGGCGGATGCTGTGGGATCGGCCCGGAGCATATCGCCCAGTTGCATTTGCACCTGCACTATCA
AAAGGGTGAGGAGGCCGCGC

Downstream 100 bases:

>100_bases
TGCATAGGCAACGCTTTTGCCGCCTGGGCCGGGGCGTTGCAATTGCTCGGCGAGGTACTGGTCGCGGGGACGCGGATCGA
TCTGCGGAAAAGGTGCCGTT

Product: protein-methionine-S-oxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 155; Mature: 154

Protein sequence:

>155_residues
MSDFPGDVLSEQATFGAGCFWGAEASFRALPGVLDTRVGFARSDLGDATLIEVVQVDFDPRLISYSRLVEHFWTLHDPTS
VDRQGADVGAKYRSALFFNSAEQSRLALVARQQLDASGQLGKPVATVILPLGEFQKANEEHQRYLEKHGGSACSI

Sequences:

>Translated_155_residues
MSDFPGDVLSEQATFGAGCFWGAEASFRALPGVLDTRVGFARSDLGDATLIEVVQVDFDPRLISYSRLVEHFWTLHDPTS
VDRQGADVGAKYRSALFFNSAEQSRLALVARQQLDASGQLGKPVATVILPLGEFQKANEEHQRYLEKHGGSACSI
>Mature_154_residues
SDFPGDVLSEQATFGAGCFWGAEASFRALPGVLDTRVGFARSDLGDATLIEVVQVDFDPRLISYSRLVEHFWTLHDPTSV
DRQGADVGAKYRSALFFNSAEQSRLALVARQQLDASGQLGKPVATVILPLGEFQKANEEHQRYLEKHGGSACSI

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=37.7358490566038, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=37.7358490566038, Blast_Score=100, Evalue=4e-22,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=37.3831775700935, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1790665, Length=161, Percent_Identity=34.1614906832298, Blast_Score=90, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17533973, Length=142, Percent_Identity=33.0985915492958, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=159, Percent_Identity=34.5911949685535, Blast_Score=98, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24664631, Length=155, Percent_Identity=34.1935483870968, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24664627, Length=161, Percent_Identity=34.7826086956522, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45553131, Length=150, Percent_Identity=34, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 16903; Mature: 16772

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFPGDVLSEQATFGAGCFWGAEASFRALPGVLDTRVGFARSDLGDATLIEVVQVDFDP
CCCCCCHHHHHCCCCCCCEEECCCCCHHHCCCHHHHHHCHHHCCCCCHHHHHHHHCCCCC
RLISYSRLVEHFWTLHDPTSVDRQGADVGAKYRSALFFNSAEQSRLALVARQQLDASGQL
CHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCC
GKPVATVILPLGEFQKANEEHQRYLEKHGGSACSI
CCCHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SDFPGDVLSEQATFGAGCFWGAEASFRALPGVLDTRVGFARSDLGDATLIEVVQVDFDP
CCCCCHHHHHCCCCCCCEEECCCCCHHHCCCHHHHHHCHHHCCCCCHHHHHHHHCCCCC
RLISYSRLVEHFWTLHDPTSVDRQGADVGAKYRSALFFNSAEQSRLALVARQQLDASGQL
CHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCC
GKPVATVILPLGEFQKANEEHQRYLEKHGGSACSI
CCCHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]