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The map label for this gene is moeA [H]

Identifier: 77458378

GI number: 77458378

Start: 2433918

End: 2435123

Strand: Direct

Name: moeA [H]

Synonym: Pfl01_2151

Alternate gene names: 77458378

Gene position: 2433918-2435123 (Clockwise)

Preceding gene: 77458377

Following gene: 77458380

Centisome position: 37.8

GC content: 66.33

Gene sequence:

>1206_bases
ATGAGCAAGCCGGGGTTGATGCCGGTCGAGGACGCCCTCGACCAACTGTTGGCGATGGCCGATGAACAACGTCTACCGGA
CAGCGAATCGGTGCCGCTCAATGAAGCGCGCGGGCGCGTGCTGGCCAGCGATCTGGTCGCCACACTCGATCTGCCGCCGT
GGCCGAACAGCGCCATGGACGGTTATGCCTTGAACCTCCCCGACCTGCATCGCCAGCCGTTGAGCGTGTCACAGCGGGTC
TACGCCGGGATGGCGCCGGACGCCTTGCTGCCCGGCACCTGCGCACGGATTTTCACGGGTGCGCCGTTGCCGCCCGGTGC
CAATTGCGTGGAGATGCAGGAAAACGTCGAGGTGCTCGAAGACGGCCGCGTACGTTTCCTGCAACCGCTTAAGGCCGGCC
AGAACATCCGCGCCCAGGGCCAGGAGAACCGCGTCGGCGACACCTTGCTGCGCGCCGGCAAACGCCTCGGCCCGTTCGAA
CTGGCCGTCGCCGCCGGGCAGGGCATGACTCATTTGCCGTTGGTGCGTCGTCCGCGCGTGGCGTTGCTGTCGACCGGTGA
TGAGCTGGTGGAACCTGGCCAGCCGCTGCGTCCCGGCAGCATCTACAACAGCAACCGCACCTTGCTCGACCACTGGTTGC
GCGAACTGGGTTGCGAAGTGATCGACGCCGGGATTCTGCCCGATCGCCCGGCGCAGACCCGGCTCAAACTCGAGCAACTG
CAAGTGGCGGCCGATCTGATTCTGACCACCGGCGGCGTGTCTGCCGGCGATGCCGACTGCCTCGGCCAAGTGCTGCGCGA
CAACGGCAAACCGCTGCTGTGGAAACTCGCGATCAAGCCCGGTAAACCGCTGACGGTCGGGCATTTCGGCTCGGTGCCGG
TGATCGGCCTGCCGGGCAATCCGACCTCGGCGCTGGTGACCTTCGGCCTGCTGGCGCGCCCGTACCTGCTGCGCATTCAA
GGCGTGGAAGAGGTGATGCCGCTGAGCTTCACGGTCAACGCCGGCTTCGATTGGCCGAAGCCCGGCAGCCGTCGCGAATA
CCTGCGGGTACGCCTGGAGGGCGGGCAGGCGGCGCTGTATCCGAACCAGAGTTCCGGGGTTCTGCTCGGCGCGACCTGGG
CCGACGGATTGGTGGAAATCCCCGAGAACAGCACCTTGCAGAGGGGGGCTCCGCTGCGTTTCATTCCGTTCAGCGAGCTG
TTCTGA

Upstream 100 bases:

>100_bases
CCGCGTGGGAAGGCATCCTCGCCGAACAACTGGATAACCGTCATCGCCCTTGCAACTTCGTTCCGCACCTCAAACCGGTG
CAAGCCTGCGGGCCGCGCGG

Downstream 100 bases:

>100_bases
GCGCGATCAAAAGGTGCAAACCGCTTGCCGGGAAACTGTCGAAGACTGTGAAGACGGCTATCGGGTCAATCCCAGCCGTT
CATGCCACTGGGCGATGGAC

Product: molybdopterin biosynthesis MoeA protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSKPGLMPVEDALDQLLAMADEQRLPDSESVPLNEARGRVLASDLVATLDLPPWPNSAMDGYALNLPDLHRQPLSVSQRV
YAGMAPDALLPGTCARIFTGAPLPPGANCVEMQENVEVLEDGRVRFLQPLKAGQNIRAQGQENRVGDTLLRAGKRLGPFE
LAVAAGQGMTHLPLVRRPRVALLSTGDELVEPGQPLRPGSIYNSNRTLLDHWLRELGCEVIDAGILPDRPAQTRLKLEQL
QVAADLILTTGGVSAGDADCLGQVLRDNGKPLLWKLAIKPGKPLTVGHFGSVPVIGLPGNPTSALVTFGLLARPYLLRIQ
GVEEVMPLSFTVNAGFDWPKPGSRREYLRVRLEGGQAALYPNQSSGVLLGATWADGLVEIPENSTLQRGAPLRFIPFSEL
F

Sequences:

>Translated_401_residues
MSKPGLMPVEDALDQLLAMADEQRLPDSESVPLNEARGRVLASDLVATLDLPPWPNSAMDGYALNLPDLHRQPLSVSQRV
YAGMAPDALLPGTCARIFTGAPLPPGANCVEMQENVEVLEDGRVRFLQPLKAGQNIRAQGQENRVGDTLLRAGKRLGPFE
LAVAAGQGMTHLPLVRRPRVALLSTGDELVEPGQPLRPGSIYNSNRTLLDHWLRELGCEVIDAGILPDRPAQTRLKLEQL
QVAADLILTTGGVSAGDADCLGQVLRDNGKPLLWKLAIKPGKPLTVGHFGSVPVIGLPGNPTSALVTFGLLARPYLLRIQ
GVEEVMPLSFTVNAGFDWPKPGSRREYLRVRLEGGQAALYPNQSSGVLLGATWADGLVEIPENSTLQRGAPLRFIPFSEL
F
>Mature_400_residues
SKPGLMPVEDALDQLLAMADEQRLPDSESVPLNEARGRVLASDLVATLDLPPWPNSAMDGYALNLPDLHRQPLSVSQRVY
AGMAPDALLPGTCARIFTGAPLPPGANCVEMQENVEVLEDGRVRFLQPLKAGQNIRAQGQENRVGDTLLRAGKRLGPFEL
AVAAGQGMTHLPLVRRPRVALLSTGDELVEPGQPLRPGSIYNSNRTLLDHWLRELGCEVIDAGILPDRPAQTRLKLEQLQ
VAADLILTTGGVSAGDADCLGQVLRDNGKPLLWKLAIKPGKPLTVGHFGSVPVIGLPGNPTSALVTFGLLARPYLLRIQG
VEEVMPLSFTVNAGFDWPKPGSRREYLRVRLEGGQAALYPNQSSGVLLGATWADGLVEIPENSTLQRGAPLRFIPFSELF

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=376, Percent_Identity=33.5106382978723, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI10880983, Length=376, Percent_Identity=33.5106382978723, Blast_Score=172, Evalue=4e-43,
Organism=Escherichia coli, GI1787049, Length=319, Percent_Identity=44.8275862068966, Blast_Score=257, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI25147659, Length=344, Percent_Identity=31.9767441860465, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17562606, Length=414, Percent_Identity=26.3285024154589, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17136978, Length=366, Percent_Identity=30.6010928961749, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24638841, Length=366, Percent_Identity=30.6010928961749, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43225; Mature: 43094

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00178 AA_TRNA_LIGASE_I ; PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPGLMPVEDALDQLLAMADEQRLPDSESVPLNEARGRVLASDLVATLDLPPWPNSAMD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEHHHHHHHCCCCCCCCCCCC
GYALNLPDLHRQPLSVSQRVYAGMAPDALLPGTCARIFTGAPLPPGANCVEMQENVEVLE
CEEECCCHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHCHHHHH
DGRVRFLQPLKAGQNIRAQGQENRVGDTLLRAGKRLGPFELAVAAGQGMTHLPLVRRPRV
CCCEEEHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCE
ALLSTGDELVEPGQPLRPGSIYNSNRTLLDHWLRELGCEVIDAGILPDRPAQTRLKLEQL
EEEECCHHHHCCCCCCCCCCEECCCCHHHHHHHHHHCHHEEECCCCCCCCHHHHHHHHHH
QVAADLILTTGGVSAGDADCLGQVLRDNGKPLLWKLAIKPGKPLTVGHFGSVPVIGLPGN
HHHHHHHEECCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCCEEECCCC
PTSALVTFGLLARPYLLRIQGVEEVMPLSFTVNAGFDWPKPGSRREYLRVRLEGGQAALY
CHHHHHHHHHHHCCCEEEECCHHHHCCEEEEEECCCCCCCCCCCCEEEEEEEECCEEEEC
PNQSSGVLLGATWADGLVEIPENSTLQRGAPLRFIPFSELF
CCCCCCEEEEEECCCCEEECCCCCCCCCCCCEEECCHHHCC
>Mature Secondary Structure 
SKPGLMPVEDALDQLLAMADEQRLPDSESVPLNEARGRVLASDLVATLDLPPWPNSAMD
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEHHHHHHHCCCCCCCCCCCC
GYALNLPDLHRQPLSVSQRVYAGMAPDALLPGTCARIFTGAPLPPGANCVEMQENVEVLE
CEEECCCHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHCHHHHH
DGRVRFLQPLKAGQNIRAQGQENRVGDTLLRAGKRLGPFELAVAAGQGMTHLPLVRRPRV
CCCEEEHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCE
ALLSTGDELVEPGQPLRPGSIYNSNRTLLDHWLRELGCEVIDAGILPDRPAQTRLKLEQL
EEEECCHHHHCCCCCCCCCCEECCCCHHHHHHHHHHCHHEEECCCCCCCCHHHHHHHHHH
QVAADLILTTGGVSAGDADCLGQVLRDNGKPLLWKLAIKPGKPLTVGHFGSVPVIGLPGN
HHHHHHHEECCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCCEEECCCC
PTSALVTFGLLARPYLLRIQGVEEVMPLSFTVNAGFDWPKPGSRREYLRVRLEGGQAALY
CHHHHHHHHHHHCCCEEEECCHHHHCCEEEEEECCCCCCCCCCCCEEEEEEEECCEEEEC
PNQSSGVLLGATWADGLVEIPENSTLQRGAPLRFIPFSELF
CCCCCCEEEEEECCCCEEECCCCCCCCCCCCEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]