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The map label for this gene is ubiE [C]

Identifier: 77458319

GI number: 77458319

Start: 2377230

End: 2378042

Strand: Direct

Name: ubiE [C]

Synonym: Pfl01_2092

Alternate gene names: 77458319

Gene position: 2377230-2378042 (Clockwise)

Preceding gene: 77458318

Following gene: 77458321

Centisome position: 36.92

GC content: 65.31

Gene sequence:

>813_bases
ATGAGTACCCCCATTGATCTCACTGCCCTGAAGGAACGCCAGAAAGTCGCCTGGGCCAGTGGCGACTACGCCGTGATCGG
CACCACCTTGCAGATCGTCGGCGAAACCCTCGCCGAAGCCTGCGACCTGCGCTGCGATGAAGAAGTGCTGGACGTTGCTG
CCGGTAACGGCAATGCCACGCTGGCGGCGGCGCGCCGGGGTTGTCTGGTGACGTCCACCGACTATGTCGCGGCGCTGCTG
GAACGCGGCCAGGACCGGGCGCGCGCCGAGCATCTGGACGTGACCTTTCAGGTCGCCGATGCCGAAGCGCTGCCGTTTGC
CGACTCCAGTTTCGACGCGGTGCTGTCGACCTTCGGCGTGATGTTCGCCCCGGATCAGGCGAAGGCGGCCAAGGAGCTGG
CGCGGGTCTGCCGCCGTGGTGGCCGGATCGGCCTGGCCAACTGGACACCGGAAGGTTTCGTCGGCCAGATGTTCAAGACC
CTCGGGCGCTATCTGCCACCGCCACCCGGTTCGCAACCGCCCTCGAACTGGGGCGCGGAAGCCTGGCTGCATTCGCATTT
CGACGATCGCCAGTTTCAGGTGCAGGTGACTCGCCGCCACTTCAACTTTCGCTACCGCTCGGCGGCGCATTTCATTGATG
TGTTTCGCCACTGGTACGGCCCGGTACACAAGGCGTTCGCGGCGTTGCCGCCGGAGAGCGGGCAGGCGCTGGAGACGGAT
CTGACGCTACTGATCGACGGGCTGAACCGGGCGGGGGCGGAATCGATGGTGGTGCCGAGCGAGTATCTGGAGGTGGTGAT
AACCAAACGCTGA

Upstream 100 bases:

>100_bases
GCCAAGCGTGGGGGATTTCCGGCCAACAGCGTGTCCCGGGTGACGAGCATCATCGACCCGACCACCGCCGATTGACCCCT
CTGCCGCGGAGCACCCATTC

Downstream 100 bases:

>100_bases
GCGTCATGCAAAACAACTGTGGGAGCGAGCTTGCTCGCTCCCACAGGGATTGCGACAGGGCTTCTATTTCAGATGCGCAC
CGTCAAACCACTCCAACGCC

Product: UbiE/COQ5 methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MSTPIDLTALKERQKVAWASGDYAVIGTTLQIVGETLAEACDLRCDEEVLDVAAGNGNATLAAARRGCLVTSTDYVAALL
ERGQDRARAEHLDVTFQVADAEALPFADSSFDAVLSTFGVMFAPDQAKAAKELARVCRRGGRIGLANWTPEGFVGQMFKT
LGRYLPPPPGSQPPSNWGAEAWLHSHFDDRQFQVQVTRRHFNFRYRSAAHFIDVFRHWYGPVHKAFAALPPESGQALETD
LTLLIDGLNRAGAESMVVPSEYLEVVITKR

Sequences:

>Translated_270_residues
MSTPIDLTALKERQKVAWASGDYAVIGTTLQIVGETLAEACDLRCDEEVLDVAAGNGNATLAAARRGCLVTSTDYVAALL
ERGQDRARAEHLDVTFQVADAEALPFADSSFDAVLSTFGVMFAPDQAKAAKELARVCRRGGRIGLANWTPEGFVGQMFKT
LGRYLPPPPGSQPPSNWGAEAWLHSHFDDRQFQVQVTRRHFNFRYRSAAHFIDVFRHWYGPVHKAFAALPPESGQALETD
LTLLIDGLNRAGAESMVVPSEYLEVVITKR
>Mature_269_residues
STPIDLTALKERQKVAWASGDYAVIGTTLQIVGETLAEACDLRCDEEVLDVAAGNGNATLAAARRGCLVTSTDYVAALLE
RGQDRARAEHLDVTFQVADAEALPFADSSFDAVLSTFGVMFAPDQAKAAKELARVCRRGGRIGLANWTPEGFVGQMFKTL
GRYLPPPPGSQPPSNWGAEAWLHSHFDDRQFQVQVTRRHFNFRYRSAAHFIDVFRHWYGPVHKAFAALPPESGQALETDL
TLLIDGLNRAGAESMVVPSEYLEVVITKR

Specific function: Methyltransferase Required For The Conversion Of Dimethylmenaquinone (Dmkh2) To Menaquinone (Mkh2) And The Conversion Of 2-Polyprenyl-6-Methoxy-1,4-Benzoquinol (Ddmqh2) To 2-Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol (Dmqh2). [C]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To M.tuberculosis Rv1403c [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 29607; Mature: 29475

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPIDLTALKERQKVAWASGDYAVIGTTLQIVGETLAEACDLRCDEEVLDVAAGNGNAT
CCCCCCHHHHHHHHHHEECCCCEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEE
LAAARRGCLVTSTDYVAALLERGQDRARAEHLDVTFQVADAEALPFADSSFDAVLSTFGV
EHHHHCCCEEECHHHHHHHHHCCHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHC
MFAPDQAKAAKELARVCRRGGRIGLANWTPEGFVGQMFKTLGRYLPPPPGSQPPSNWGAE
EECCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
AWLHSHFDDRQFQVQVTRRHFNFRYRSAAHFIDVFRHWYGPVHKAFAALPPESGQALETD
HHHHCCCCCCEEEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
LTLLIDGLNRAGAESMVVPSEYLEVVITKR
HHHHHHCCCCCCCCCCCCCHHHHHEEECCC
>Mature Secondary Structure 
STPIDLTALKERQKVAWASGDYAVIGTTLQIVGETLAEACDLRCDEEVLDVAAGNGNAT
CCCCCHHHHHHHHHHEECCCCEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEE
LAAARRGCLVTSTDYVAALLERGQDRARAEHLDVTFQVADAEALPFADSSFDAVLSTFGV
EHHHHCCCEEECHHHHHHHHHCCHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHC
MFAPDQAKAAKELARVCRRGGRIGLANWTPEGFVGQMFKTLGRYLPPPPGSQPPSNWGAE
EECCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
AWLHSHFDDRQFQVQVTRRHFNFRYRSAAHFIDVFRHWYGPVHKAFAALPPESGQALETD
HHHHCCCCCCEEEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
LTLLIDGLNRAGAESMVVPSEYLEVVITKR
HHHHHHCCCCCCCCCCCCCHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]