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The map label for this gene is cobB3 [H]

Identifier: 77458305

GI number: 77458305

Start: 2363299

End: 2364141

Strand: Reverse

Name: cobB3 [H]

Synonym: Pfl01_2078

Alternate gene names: 77458305

Gene position: 2364141-2363299 (Counterclockwise)

Preceding gene: 77458306

Following gene: 77458303

Centisome position: 36.72

GC content: 64.18

Gene sequence:

>843_bases
ATGCTCGACCGTCCCCTCCCCGACCCGCTCGACTATCTGCAACAGGTCATGGCCGACGGCGACTTCATTGTGCTGACCGG
CGCCGGCATCAGCACGCCGTCGGGCATCCCGGACTACCGCGACACCGACGGTGTGCGCCGGGGCCGGCAGCCGATGATGT
ACCAGGAATTCCTCGCTGCCCCGCAATCGCGCCGGCGCTACTGGGCCCGGGCCATGCTCGGCTGGCCACGGGTGCGCCAG
GCACGGCCGAACGCTGCCCATGAGGCGCTGGCCAGTCTGCAAAGCCACGGGCGGATCGGCGGTTTGATTACTCAGAATGT
CGACACCTTGCACGATCAGGCCGGCAGTCACGACGTCATCGAACTGCACGGCAGCCTGCACCGGGTGTTGTGCCTGGATT
GCGGCCAGCGCAGCGAGCGGGATTCGATTCAGCAATTGATGGAAACGCAGAACCCGTATCTGGCAGGCGTCGATGCCGTG
CAGGCACCGGACGGCGACACCCTGCTCGACCCGGCTTTCGAGGCGCGCTTTCAGGTGCCGCATTGCCCGCATTGCGCAGG
GGAACGAATGAAACCGGACGTGGTGTTTTTTGGTGAGAACGTGGCGCAGCCAACGGCGGCGCGGGCCATGGCGCTGGCGG
AAAATGCCGCCGGGATGCTGGTGGTGGGTTCGTCGCTGATGGCGTATTCGGCGTTTCGCCTGTGCCGGGTGATTGCGGAC
CGGGGCAAGCCGCTGATTGCGATCAATCTGGGGAAGACGCGGGCGGATGAGTTGCTGGATTTGAAGATTGAGGGGTGTTG
TGAGGAATTGTTACCGCTGTTGGCTCAAGCAATGAATGGTTGA

Upstream 100 bases:

>100_bases
CTGGAGGCGCGCAAGTAAAAACCGGGCACAGGACGCGCCTGCCGGGGAGCGTCCGTCAGTGCTAACCTGCAAGGCACTTT
TCGCCTGCGGAGCGCTGATC

Downstream 100 bases:

>100_bases
TGGTGGGAGGGAGATGTCCGGCTTGCGATCCCTAACCCCTCACCCTAGCCCTCTCCCAAGGGAGAGGGAACTGACCACGC
TGAATATAAGAGTTACATCG

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 3 [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MLDRPLPDPLDYLQQVMADGDFIVLTGAGISTPSGIPDYRDTDGVRRGRQPMMYQEFLAAPQSRRRYWARAMLGWPRVRQ
ARPNAAHEALASLQSHGRIGGLITQNVDTLHDQAGSHDVIELHGSLHRVLCLDCGQRSERDSIQQLMETQNPYLAGVDAV
QAPDGDTLLDPAFEARFQVPHCPHCAGERMKPDVVFFGENVAQPTAARAMALAENAAGMLVVGSSLMAYSAFRLCRVIAD
RGKPLIAINLGKTRADELLDLKIEGCCEELLPLLAQAMNG

Sequences:

>Translated_280_residues
MLDRPLPDPLDYLQQVMADGDFIVLTGAGISTPSGIPDYRDTDGVRRGRQPMMYQEFLAAPQSRRRYWARAMLGWPRVRQ
ARPNAAHEALASLQSHGRIGGLITQNVDTLHDQAGSHDVIELHGSLHRVLCLDCGQRSERDSIQQLMETQNPYLAGVDAV
QAPDGDTLLDPAFEARFQVPHCPHCAGERMKPDVVFFGENVAQPTAARAMALAENAAGMLVVGSSLMAYSAFRLCRVIAD
RGKPLIAINLGKTRADELLDLKIEGCCEELLPLLAQAMNG
>Mature_280_residues
MLDRPLPDPLDYLQQVMADGDFIVLTGAGISTPSGIPDYRDTDGVRRGRQPMMYQEFLAAPQSRRRYWARAMLGWPRVRQ
ARPNAAHEALASLQSHGRIGGLITQNVDTLHDQAGSHDVIELHGSLHRVLCLDCGQRSERDSIQQLMETQNPYLAGVDAV
QAPDGDTLLDPAFEARFQVPHCPHCAGERMKPDVVFFGENVAQPTAARAMALAENAAGMLVVGSSLMAYSAFRLCRVIAD
RGKPLIAINLGKTRADELLDLKIEGCCEELLPLLAQAMNG

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=272, Percent_Identity=41.5441176470588, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI6912664, Length=279, Percent_Identity=27.9569892473118, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI13787215, Length=262, Percent_Identity=28.2442748091603, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI300795542, Length=275, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI308199517, Length=272, Percent_Identity=29.0441176470588, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71990482, Length=259, Percent_Identity=40.5405405405405, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71990487, Length=261, Percent_Identity=40.2298850574713, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17567771, Length=249, Percent_Identity=36.5461847389558, Blast_Score=174, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17541892, Length=280, Percent_Identity=25.7142857142857, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI28571445, Length=269, Percent_Identity=39.4052044609665, Blast_Score=204, Evalue=6e-53,
Organism=Drosophila melanogaster, GI28571443, Length=225, Percent_Identity=38.2222222222222, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI28571441, Length=225, Percent_Identity=38.2222222222222, Blast_Score=171, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 30652; Mature: 30652

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRPLPDPLDYLQQVMADGDFIVLTGAGISTPSGIPDYRDTDGVRRGRQPMMYQEFLAA
CCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHC
PQSRRRYWARAMLGWPRVRQARPNAAHEALASLQSHGRIGGLITQNVDTLHDQAGSHDVI
CHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCCHHHCCHHHHHHCCCCCCHH
ELHGSLHRVLCLDCGQRSERDSIQQLMETQNPYLAGVDAVQAPDGDTLLDPAFEARFQVP
HHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCHHHHCCCCC
HCPHCAGERMKPDVVFFGENVAQPTAARAMALAENAAGMLVVGSSLMAYSAFRLCRVIAD
CCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHH
RGKPLIAINLGKTRADELLDLKIEGCCEELLPLLAQAMNG
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDRPLPDPLDYLQQVMADGDFIVLTGAGISTPSGIPDYRDTDGVRRGRQPMMYQEFLAA
CCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHC
PQSRRRYWARAMLGWPRVRQARPNAAHEALASLQSHGRIGGLITQNVDTLHDQAGSHDVI
CHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCCHHHCCHHHHHHCCCCCCHH
ELHGSLHRVLCLDCGQRSERDSIQQLMETQNPYLAGVDAVQAPDGDTLLDPAFEARFQVP
HHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCHHHHCCCCC
HCPHCAGERMKPDVVFFGENVAQPTAARAMALAENAAGMLVVGSSLMAYSAFRLCRVIAD
CCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHH
RGKPLIAINLGKTRADELLDLKIEGCCEELLPLLAQAMNG
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]