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The map label for this gene is czcR [H]

Identifier: 77458208

GI number: 77458208

Start: 2262916

End: 2263449

Strand: Direct

Name: czcR [H]

Synonym: Pfl01_1981

Alternate gene names: 77458208

Gene position: 2262916-2263449 (Clockwise)

Preceding gene: 77458207

Following gene: 77458209

Centisome position: 35.15

GC content: 60.3

Gene sequence:

>534_bases
TTGGTTAACAAAGTACTGGTTGTCGAAGACGAACAGCTGCTTGCACAGAACCTTCAGGATTATCTGTCGGCGCAAGGGCT
GGAAGTCCGGATTGCACATGACGGCGCAGAGGGAATCGGCCTGGCCGAGACTTTCGCCCCCGACGTGCTGGTGTTCGATT
ACCGCTTGCCCGATATGGAAGGGTTCGAGGTGCTCGACGCGGTCCGCCAGAACAGGACGTGTCATTTCGTGCTGATAACG
GGTCACCCGACCGCTGAAGTCTGTGAGCGGGCGCGGCAACTGGGGGTCAGTCACATCCTGTTCAAACCGTTTCCTTTGGC
GGAACTGGCCCGAGCTGTCTGCGACCTTCTGGGGATCCAGCGCGAAGCGAAACCCGGTGCGAGCCCATCCGAAGGCTTCG
TCGAACGACGCCAGAGCAGGACCGAGAGCTTCCCGTTGCAGTTGTACGATGGCAGTTGGGTGCTGGCGGACCGCCGACGA
AACCGGTCGGAGGCCATGGCACCGGACGACGATCAAATGCTCACCGGGGAGTAA

Upstream 100 bases:

>100_bases
GCCTGGCATGAAGTGTGCGTTACCTCTTGTGAGGCGCACTCCAGCAGGTTCGGGTCATTGAATTTCAATTGCCGGCACTT
GAGGTTTCAGGGAGTCCACC

Downstream 100 bases:

>100_bases
TGGCGCGATAGACGTTCCGGCACTCGCCGAATTCGCCTCCCGCGCCGTCAGGGCCTCAAGCCCCGGGTGTTGGAGAGCAA
GCCATGGATCGTCTGTCCGT

Product: response regulator receiver domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MVNKVLVVEDEQLLAQNLQDYLSAQGLEVRIAHDGAEGIGLAETFAPDVLVFDYRLPDMEGFEVLDAVRQNRTCHFVLIT
GHPTAEVCERARQLGVSHILFKPFPLAELARAVCDLLGIQREAKPGASPSEGFVERRQSRTESFPLQLYDGSWVLADRRR
NRSEAMAPDDDQMLTGE

Sequences:

>Translated_177_residues
MVNKVLVVEDEQLLAQNLQDYLSAQGLEVRIAHDGAEGIGLAETFAPDVLVFDYRLPDMEGFEVLDAVRQNRTCHFVLIT
GHPTAEVCERARQLGVSHILFKPFPLAELARAVCDLLGIQREAKPGASPSEGFVERRQSRTESFPLQLYDGSWVLADRRR
NRSEAMAPDDDQMLTGE
>Mature_177_residues
MVNKVLVVEDEQLLAQNLQDYLSAQGLEVRIAHDGAEGIGLAETFAPDVLVFDYRLPDMEGFEVLDAVRQNRTCHFVLIT
GHPTAEVCERARQLGVSHILFKPFPLAELARAVCDLLGIQREAKPGASPSEGFVERRQSRTESFPLQLYDGSWVLADRRR
NRSEAMAPDDDQMLTGE

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=124, Percent_Identity=30.6451612903226, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1786784, Length=115, Percent_Identity=34.7826086956522, Blast_Score=64, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 19781; Mature: 19781

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNKVLVVEDEQLLAQNLQDYLSAQGLEVRIAHDGAEGIGLAETFAPDVLVFDYRLPDME
CCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHCCCCEEEEEEECCCCC
GFEVLDAVRQNRTCHFVLITGHPTAEVCERARQLGVSHILFKPFPLAELARAVCDLLGIQ
HHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCC
REAKPGASPSEGFVERRQSRTESFPLQLYDGSWVLADRRRNRSEAMAPDDDQMLTGE
CCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCCCCCCCCCCCCEECCC
>Mature Secondary Structure
MVNKVLVVEDEQLLAQNLQDYLSAQGLEVRIAHDGAEGIGLAETFAPDVLVFDYRLPDME
CCCCEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHCCCCEEEEEEECCCCC
GFEVLDAVRQNRTCHFVLITGHPTAEVCERARQLGVSHILFKPFPLAELARAVCDLLGIQ
HHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCC
REAKPGASPSEGFVERRQSRTESFPLQLYDGSWVLADRRRNRSEAMAPDDDQMLTGE
CCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCCCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]